Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders by Methichit Wattanapanitch

“…Over the past decade, enormous progress has been made in the field of induced pluripotent stem cells (iPSCs). Patients’ somatic cells such as skin fibroblasts or blood cells can be used to generate disease-specific pluripotent stem cells, which have unlimited proliferation and can differentiate into all cell types of the body. …”
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Derivation of Pluripotent Cells from Mouse SSCs Seems to Be Age Dependent by Hossein Azizi, Sabine Conrad, Ursula Hinz, Behrouz Asgari, Daniel Nanus, Heike Peterziel, Akbar Hajizadeh Moghaddam, Hossein Baharvand, Thomas Skutella

“…The inability of real adult SSCs to shift to a pluripotent state coincides with a decline in expression of the core pluripotency genes Oct4, Nanog, and Sox2 in SSCs with age. …”
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Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming by James Spyrou, David K. Gardner, Alexandra J. Harvey

“…Reprogramming to pluripotency involves drastic restructuring of both metabolism and the epigenome. …”
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Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation by Satish Kumar, Joanne E. Curran, David C. Glahn, John Blangero

“…Here, we report a new optimized LCL-to-iPSC reprogramming protocol using episomal plasmids encoding pluripotency transcription factors and mouse p53DD (p53 carboxy-terminal dominant-negative fragment) and commercially available reprogramming media. …”
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Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression by Lizhan Xiao, Zifen Huang, Zixuan Wu, Yongzheng Yang, Zhen Zhang, Manish Kumar, Haokaifeng Wu, Huiping Mao, Lihui Lin, Runxia Lin, Jingxian Long, Lihua Zeng, Jing Guo, Rongping Luo, Yi Li, Ping Zhu, Baojian Liao, Luqin Wang, Jing Liu

“…Abstract Somatic cells can be reprogrammed into pluripotent stem cells (iPSCs) by overexpressing defined transcription factors. …”
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Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming by Dilip Dey, Gregory R. D. Evans

“…During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. …”
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BRD8 Guards the Pluripotent State by Sensing and Maintaining Histone Acetylation by Li Sun, Xiuling Fu, Zhen Xiao, Gang Ma, Yibin Zhou, Haoqing Hu, Liyang Shi, Dongwei Li, Ralf Jauch, Andrew Paul Hutchins

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Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells by Hidehito Saito, Keisuke Okita, Noemi Fusaki, Michael S. Sabel, Alfred E. Chang, Fumito Ito

“…Induced pluripotent stem cells (iPSCs) derived from somatic cells of patients hold great promise for autologous cell therapies. …”
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Generation of American mink induced pluripotent stem cells: a protocol by I. E. Pristyazhnyuk, A. G. Menzorov

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Advances in Female Germ Cell Induction from Pluripotent Stem Cells by Maisumu Gulimiheranmu, Xinjie Wang, Junmei Zhou

“…In addition, pluripotent stem cells could potentially provide promising applications for female fertility preservation after proper in vitro differentiation. …”
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Biomedical Application of Dental Tissue-Derived Induced Pluripotent Stem Cells by Jung-Hwan Lee, Seog-Jin Seo

“…The academic researches and clinical applications in recent years found interest in induced pluripotent stem cells (iPSCs-) based regenerative medicine due to their pluripotency able to differentiate into any cell types in the body without using embryo. …”
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Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases by Jeanne Adiwinata Pawitan

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Editorial: Induced pluripotent stem cells (iPSCs) for skeletal muscle diseases by Hidetoshi Sakurai, Masatoshi Suzuki, Masatoshi Suzuki, Atsushi Asakura

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Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes by Aniela Skrzypczyk, Stephanie Kehr, Ilona Krystel, Stephan H. Bernhart, Shibashish Giri, Augustinus Bader, Peter F. Stadler

“…However, hepatic differentiation of induced pluripotent stem cells (iPSCs) still remains challenging. …”
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Corrigendum to “Biomedical Application of Dental Tissue-Derived Induced Pluripotent Stem Cells” by Jung-Hwan Lee, Hae-Won Kim, Seog-Jin Seo

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When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells by Fuquan Chen, Jiaojiao Ji, Jian Shen, Xinyi Lu

“…The physiological functions of protein-coding genes have been extensively characterized through genome editing in pluripotent stem cells (PSCs) in the past 30 years; however, the study of lncRNAs with genome editing technologies only came into attentions in recent years. …”
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Induced Pluripotent Stem Cells: Generation Strategy and Epigenetic Mystery behind Reprogramming by Pengfei Ji, Sasicha Manupipatpong, Nina Xie, Yujing Li

“…However, such studies of ESC have been hampered by the ethical issues and technological challenges surrounding them, therefore dramatically inhibiting the potential applications of ESC in basic biomedical studies and clinical medicine. Induced pluripotent stem cells (iPSCs), generated from the reprogrammed somatic cells, share similar characteristics including but not limited to the morphology and growth of ESC, self-renewal, and potential differentiation into various cell types. …”
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Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells by Damián Hernández, Rodney Millard, Priyadharshini Sivakumaran, Raymond C. B. Wong, Duncan E. Crombie, Alex W. Hewitt, Helena Liang, Sandy S. C. Hung, Alice Pébay, Robert K. Shepherd, Gregory J. Dusting, Shiang Y. Lim

“…Background. Human induced pluripotent stem cells (iPSCs) are an attractive source of cardiomyocytes for cardiac repair and regeneration. …”
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Pluripotency-State-Dependent Role of Dax1 in Embryonic Stem Cells Self-Renewal by Jianrong He, Yuda Cheng, Yan Ruan, Jiali Wang, Yanping Tian, Jiaqi Wang, Fengsheng Wang, Chen Zhang, Yixiao Xu, Lianlian Liu, Meng Yu, Jiangjun Wang, Binyu Zhao, Yue Zhang, Yi Yang, Gaoke Liu, Wei Wu, Ping He, Jiaxiang Xiong, He Huang, Junlei Zhang, Rui Jian

“…The expression of most proapoptotic genes and lineage-commitment genes were drastically increased, while the downregulated expression of antiapoptotic genes and many pluripotency genes was observed. Our research on the pluripotent state-dependent role of Dax1 provides clues to understand the molecular regulation mechanism at different stages of early embryonic development.…”
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Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy by Casimir de Rham, Jean Villard

“…The problem could be circumvented by using autologous stem cells, like induced pluripotent stem (iPS) cells, derived directly from the patient. …”
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