Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives by Anna Chiara Piscaglia, Mariachiara Campanale, Antonio Gasbarrini, Giovanni Gasbarrini

“…These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. …”
Get full text

The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons by Catherine Schaefers, Simone Rothmiller, Horst Thiermann, Theo Rein, Annette Schmidt

“…Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. …”
Get full text

Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells by Vedavathi Madhu, Abhijit S. Dighe, Quanjun Cui, D. Nicole Deal

“…We therefore sought to determine if a simple, one-step, and cost effective method, previously reported to induce neuronal differentiation of embryonic stem cells and induced-pluripotent stem cells, can be applied to adult stem cells. …”
Get full text

Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome by Ons Ben Hamida, Moon Kyu Kim, Young Kwan Sung, Min Kyu Kim, Mi Hee Kwack

“…The hair follicle is enriched with pluripotent stem cells, where dermal papilla (DP) cells and dermal sheath (DS) cells constitute the dermal compartment and the epithelial stem cells existing in the bulge region exert their regenerative role by mediating the epithelial–mesenchymal interaction (EMI). …”
Get full text

Research prospects for kidney xenotransplantation: a bibliometric analysis by Shujun Yang, Mingtao Zhang, Hao Wei, Bin Zhang, Jiang Peng, Panfeng Shang, Shengkun Sun

“…We found that ‘co-stimulation blockade’, ‘xenograft survival’, ‘pluripotent stem cell’, ‘translational research’, and ‘genetic engineering’ were likely to be the focus of attention in the coming years.Conclusions This study screened global publications related to xenogeneic kidney transplantation; analyzed their literature metrology characteristics; identified the most cited articles in the research field; understood the current situation, hot spots, and trends of global research; and provided future development directions for researchers and practitioners.…”
Get full text

Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…Newly developed stem cells, such as amniotic epithelial stem cells and induced pluripotent stem cells, as well as well-known traditional stem cells, such as neural, embryonic, bone marrow mesenchymal, and human umbilical cord blood–derived stem cells, were reported. …”
Get full text

The Potential for Cellular Therapy Combined with Growth Factors in Spinal Cord Injury by Jack Rosner, Pablo Avalos, Frank Acosta, John Liu, Doniel Drazin

“…Research is being conducted in the following areas: pathophysiology, cellular therapies (Schwann cells, embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, olfactory ensheathing cells), growth factors (BDNF), inhibitory molecules (NG2, myelin protein), and combination therapies (cell grafts and neurotrophins, cotransplantation). …”
Get full text

Gut microbiota modulation in cardiac cell therapy with immunosuppression in a nonhuman primate ischemia/reperfusion model by Hung-Chih Chen, Yu-Che Cheng, Marvin L. Hsieh, Po-Ju Lin, Emily F. Wissel, Theodore Steward, Cindy M. C. Chang, Jennifer Coonen, Timothy A. Hacker, Timothy J. Kamp, Patrick C. H. Hsieh

“…We investigated gut microbiota dynamics in a nonhuman primate (NHP) cardiac ischemia/reperfusion model while under immunosuppression and receiving cell therapy with human induced pluripotent stem cell (hiPSC)-derived endothelial cells (EC) and cardiomyocytes (CM). …”
Get full text

Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy by Hsiao-Chien Ting, Yun-Ting Guo, Hong-Lin Su, Yu-Shuan Chen, Shinn-Zong Lin, Horng-Jyh Harn, Chia-Yu Chang

“…Although human induced pluripotent stem cell (iPSC)-derived models have advanced NMJ research, their application is constrained by challenges such as limited differentiation efficiency, lengthy generation times, and cryopreservation difficulties. …”
Get full text

Occurring of In Vitro Functional Vasculogenic Pericytes from Human Circulating Early Endothelial Precursor Cell Culture by Silvia Cantoni, Francesca Bianchi, Margherita Galletti, Elena Olivi, Francesco Alviano, Nazzareno Galiè, Carlo Ventura

“…In addition, hPPCs can be subcultured and exhibit expression of pluripotent genes (OCT-4, KLF-4, and NANOG) as well as a remarkable vasculogenic potential. …”
Get full text

The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…Epigenetic reprogramming strategies, such as induced pluripotent stem cells, may further complement senolytics by rejuvenating aged cells. …”
Get full text

Organoid models: applications and research advances in colorectal cancer by Yijie Wu, Yijie Wu, Yu Sha, Xingpo Guo, Ling Gao, Jian Huang, Song-Bai Liu, Song-Bai Liu

“…This article further analyzes the applications of adult stem cell-derived and pluripotent stem cell-derived organoids in colorectal cancer research and discusses advancements in organoids for basic research, drug research and development, personalized treatment evaluation and prediction, and regenerative medicine. …”
Get full text

Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts by Corey Heffernan, Huseyin Sumer, Luis F. Malaver-Ortega, Paul J. Verma

“…Thus, the feasibility of substituting cMyc transgene with (non-integrative) recombinant “pTAT-mcMyc” protein delivery was assessed, without compromising reprogramming efficiency or the pluripotent phenotype. Purification and delivery of semisoluble/particulate pTAT-mcMyc maintained Oct4-GFP+ colony formation (i.e., reprogramming efficiency) whilst supporting pluripotency by various criteria. …”
Get full text

The utilisation of biliary organoids for biomedical applications by Zhongwen Lei, Yijun Yang, Yang Xiang, Yang Xiang

“…The main seed cells used to construct biliary tract organoids include primary human biliary tract epithelial cells as well as pluripotent stem cells. The construction of these organoids involves various techniques such as traditional embedding technology, rotary culture technology, hanging drop culture technology, along with emerging approaches like organ chip technology, three-dimensional (3D) printing technology, and four-dimensional (4D) printing technology. …”
Get full text

Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…The cause of neurodegeneration due to mutations in ATM is still an area of investigation, and currently there is no known treatment to slow down or stop the progression of the neurological problems.In this collaboration of the A-T Children's Project (ATCP) with Charles River Discovery, we successfully developed a high-throughput assay using induced pluripotent stem cells (iPSC) from A-T donors to measure DNA damage response (DDR). …”
Get full text

Use of a Sendai virus-based vector for effcient transduction of pinniped fbroblasts by V. R. Beklemisheva, A. G. Menzorov

“…Generation of induced pluripotent stem (iPS) cells expanded possibilities of pluripotency and early development studies. …”
Get full text

Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome by Gema Mondéjar-Parreño, Ana I. Moreno-Manuel, Juan Manuel Ruiz-Robles, José Jalife

“…Finally, we discuss how using human induced pluripotent stem cell technology to model ion channel trafficking and its defects may help accelerate drug discovery toward preventing life-threatening arrhythmias. …”
Get full text

Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review by Lei Lu, Ying Jiang, Ravindran Jaganathan, Yanli Hao

“…Recently, advancements in pluripotent stem cells technology enable restoration of retinal functionalities after transplantation of these cells into animals with retinal degeneration. …”
Get full text

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects by Henning Madry, Liang Gao, Hermann Eichler, Patrick Orth, Magali Cucchiarini

“…A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. …”
Get full text

Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells by Nadine E. Rekittke, Meidjie Ang, Divya Rawat, Rahul Khatri, Thomas Linn

“…MSCs are recognized to meet the demand of an individual therapy not raising the concerns of embryonic or induced pluripotent stem cells for therapy.…”
Get full text