Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation by Rosaria Santoro, Gianluca Lorenzo Perrucci, Aoife Gowran, Giulio Pompilio

“…In particular, mechanotransduction is of growing importance in groundbreaking cellular models such as induced pluripotent stem cells (iPSC), since this process may strongly influence cell fate and, thus, augment the precision of differentiation into specific cell types, e.g., cardiomyocytes. …”
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Intestinal organoids: The path towards clinical application by Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

“…In this review, we outline the current state of translational research involving adult stem cell and pluripotent stem cell derived intestinal organoids, highlighting the advances and limitations in disease modeling, drug-screening, personalized medicine, and stem cell therapy. …”
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Amniotic Fluid Stem Cells: Future Perspectives by Margit Rosner, Katharina Schipany, Bharanidharan Shanmugasundaram, Gert Lubec, Markus Hengstschläger

“…Of special importance for the latter is the fact that AFS cells are less tumorigenic than other pluripotent stem cell types. In this paper, we have summarized the current knowledge about this relatively young scientific field. …”
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Primordial Germ Cells: Current Knowledge and Perspectives by Aleksandar Nikolic, Vladislav Volarevic, Lyle Armstrong, Majlinda Lako, Miodrag Stojkovic

“…With the development of stem cell biology and differentiation protocols, PGC can be obtained from pluripotent stem cells providing a new therapeutic possibility to treat infertile couples. …”
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Organoids and spheroids: advanced in vitro models for liver cancer research by Mirella Pastore, Alessia Giachi, Elena Spínola-Lasso, Fabio Marra, Chiara Raggi

“…They can be generated from pluripotent and adult stem cells, as well as from liver tumor specimens, providing personalized models for studying tumor behavior and drug responses. …”
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Parthenogenesis and Human Assisted Reproduction by Adriana Bos-Mikich, Fabiana F. Bressan, Rafael R. Ruggeri, Yeda Watanabe, Flávio V. Meirelles

“…Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. …”
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Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources by Yoojin Seo, Kyung-Hwa Shin, Hyung Hoi Kim, Hyung-Sik Kim

“…In this review, we provide a general overview regarding the current strategies for generating RBCs from various stem cell sources including pluripotent stem cells (PSCs) as well as circulating blood stem cells and the remaining challenges that must be overcome prior to their practical application.…”
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Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering by Gaskon Ibarretxe, Antonia Alvarez, Maria-Luz Cañavate, Enrique Hilario, Maitane Aurrekoetxea, Fernando Unda

“…The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. …”
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Stem cells for age-related macular degeneration by L.K. Moshetova, O.I. Abramova, I.N. Saburina, K.I. Turkina

“…., mesenchymal, embryonic, and induced pluripotent stem cells). This paper first gives a brief overview of age-related macu lar degeneration and then describes the methods of retinal cell generation.…”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…This was parallel to laboratory molecular investigations of in vitro GABAergic neurons derived from induced human pluripotent stem cells (hiPSCs) of SSADHD subjects and biochemical analyses performed on a versatile murine model that uses an inducible and reversible rescue strategy allowing on-demand and cell-specific gene therapy. …”
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Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies by Hana Yeh, Matthew A. De Cruz, Yang You, Seiko Ikezu, Tsuneya Ikezu

“…Recent approaches include the human induced pluripotent stem cell model, but these can be challenging for large-scale assays and may lead to batch variability. …”
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Living biobank: Standardization of organoid construction and challenges by Ruixin Yang, Yao Qi, Xiaoyan Zhang, Hengjun Gao, Yingyan Yu, Yuanyuan Ji

“…Organoids cover two mainstream fields: Adult stem cell-derived organoids (also known as patient-derived organoids) and induced pluripotent stem cell-derived and/or embryonic stem cell-derived organoids. …”
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The effect of culture media and seeding densities on the human malignant testicular germ cell line (NT2/D1) growth pattern by Rawabi S. Altuwayjiri, Ibtesam S. Almami

“…The NT2/D1 cell line, a pluripotent embryonal carcinoma, is valuable in cancer and developmental biology research due to its differentiation potential into neurons and glial cells. …”
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Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy by Peter Gee, Huaigeng Xu, Akitsu Hotta

“…In the past decade, the development of two innovative technologies, namely, induced pluripotent stem cells (iPSCs) and the CRISPR Cas9 system, has enabled researchers to model diseases derived from patient cells and precisely edit DNA sequences of interest, respectively. …”
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Synthetic embryology of the human heart by Maria Belen Paredes-Espinosa, Janet L. Paluh

“…The evolution of stem cell-based heart models from cells and tissues to organoids and assembloids and recently synthetic embryology gastruloids, is poised to revolutionize our understanding of cardiac development, congenital to adult diseases, and patient customized therapies. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have already been integrated into transplantable patches and are in preclinical efforts to reverse fibrotic scarring from myocardial infarctions. …”
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The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming by Bharathi Suresh, Junwon Lee, Kye-Seong Kim, Suresh Ramakrishna

“…We also discuss the possibility of using DUBs, along with core transcription factors, to efficiently generate induced pluripotent stem cells. Our review provides a relatively new understanding regarding the importance of ubiquitination/deubiquitination of stem cell transcription factors for efficient cellular reprogramming.…”
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Regeneration in the absence of canonical neoblasts in an early branching flatworm by Ludwik Gąsiorowski, Chew Chai, Andrei Rozanski, Gargi Purandare, Fruzsina Ficze, Athanasia Mizi, Bo Wang, Jochen C. Rink

“…Abstract The remarkable regenerative abilities of flatworms are closely linked to neoblasts – adult pluripotent stem cells that are the only division-competent cell type outside of the reproductive system. …”
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Supramolecular Biopolymers for Tissue Engineering by Rosario Pérez-Pedroza, Alan Ávila-Ramírez, Zainab Khan, Manola Moretti, Charlotte A. E. Hauser

“…These characteristics are vital for the further development of current trends in TE, such as the use of pluripotent cells for organoid generation, cell-free scaffolds for tissue regeneration, patient-derived organ models, and controlled delivery systems of small molecules. …”
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Existence of Neural Stem Cells in Mouse Spleen by Koichi Tomita, Hiroshi Ishikawa

“…Pluripotent stem cells are used in regenerative medicine and exist in various internal organs. …”
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Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration by Yoojun Nam, Yeri Alice Rim, Jennifer Lee, Ji Hyeon Ju

“…We also review the chondrogenic potential of cells according to their origin, including autologous chondrocytes, mesenchymal stem cells, and induced pluripotent stem cells.…”
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