Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer by Ying-Cheng Chiang, Hsien-Neng Huang, Kuan-Ting Kuo, Wuh-Liang Hwu, Po-Han Lin

“…Patients with positive HRD status defined by WES-based scarHRD test and Myriad MyChoice® CDx test were both highly associated with platinum sensitive response (both Fisher’s exact test, p = 0.002) as well as the superior progression-free survival (both log-rank p = 0.002). …”
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White Kupang Flour (Corbula faba hinds), Fish Meal and Coconut Oil Usage on the Broilers Carcass Percentage and Abdominal Fat by Virgy Dzakina Fahrezy, Mirni Lamid, Setiawan Koesdarto, Emy Koestanti Sabdoningrum, Widya Paramita Lokapirnasari, Sunaryo Hadi Warsito

“…The study used DOC ( Day Old Chick ) with the strain Lohman MB 202 Platinum for 20 animals . The treatment in this study was ration without using white mussel flour (P0), ration using 10% white mussel flour (P1), ration using 12.5% white mussel flour (P2), ration using 15% white mussel flour (P3). …”
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Efficacy and Safety Evaluation of Immune Checkpoint Inhibitors in Combination With Chemotherapy for Extensive Small Cell Lung Cancer: Real‐World Evidence by Yuta Yamanaka, Yukiko Okuno, Keisuke Kamisako, Yuta Okazaki, Kentaro Nakanishi, Yume Sanada, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Utae Katsushima, Hiroshige Yoshioka, Takayasu Kurata

“…We observed no significant differences in age, sex, performance status (PS), liver metastasis, bone metastasis, or platinum‐based agent usage between the treatment cohorts. …”
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Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer by Seungyeul Yoo, Ayushi S. Patel, Sarah Karam, Yi Zhong, Li Wang, Feng Jiang, Ranran Kong, Sharon Bikvan, Wenhui Wang, Abhilasha Sinha, Charles A. Powell, Jun Zhu, Hideo Watanabe

“…Although SCLC initially responds to etoposide and platinum (EP) chemotherapy, nearly all patients relapse with resistant tumors. …”
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An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers by Xiaoliang Qi, Yajing Xiang, Ying Li, Jiajia Wang, Yuxi Chen, Yulong Lan, Jinsong Liu, Jianliang Shen

“…Herein, we present an endogenous ATP-activated prodrug system (termed ISD3) consisting of nanoparticles (indole-3-acetic acid/zeolitic imidazolate framework-8@polydopamine@platinum, IZPP) embedded in a silk fibroin-based hydrogel, aimed at treating multidrug-resistant (MDR) bacteria-infected pressure ulcers. …”
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Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic... by Anna Lethicia L. Oliveira, Gisele G. L. Santos, Renan F. Espirito-Santo, Gessica Sabrina A. Silva, Afrânio F. Evangelista, Daniela N. Silva, Milena B. P. Soares, Cristiane Flora Villarreal

“…Painful neuropathy is a common adverse effect of oxaliplatin (OXL), a platinum-derivative chemotherapeutic agent. Oxidative stress and mitochondrial dysfunction are key factors contributing to the development of OXL-induced peripheral neuropathy (OIPN). …”
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Curcumin ameliorates oxaliplatin-induced allodynia response and melanocortin downregulation in the spinal cord by Alma Nuril Aliya, Luke Wongso, Diah Ayu Wakita Trimanda, Risda Maulida, I Nengah Budi Sumartha, Samirah Samirah, Abdulloh Machin, Long Chiau Ming, Abdelhakim Bouyahya, Mahardian Rahmadi, Junaidi Khotib, Сhrismawan Ardianto

“…Introduction: Oxaliplatin is a platinum-based chemotherapy agent that often causes chemotherapy-induced peripheral neuropathy (CIPN). …”
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A Novel Rubber Composite Sleeper-Deformation-Prediction Model Based on Response Surface Method (RSM) and Machine Learning (ML) Techniques by Abdulmumin Ahmed Shuaibu, Zhiping Zeng, Ibrahim Hayatu Hassan, Wang Weidong, Hassan Suleiman Otuoze, Suleiman Abdulhakeem, Bushrah Baba Abdulrahman

“…This study attempts to develop a novel deformation model of rubber composite sleepers using response surface methodology (RSM) and machine learning (ML) techniques. Platinum temperature (Pt) sensors, embedded at various points on a full-scale rubber composite sleeper model, were used to measure both the sleeper temperature field and ambient temperature in real-time at 30-minute intervals over the period of a year. …”
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Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells by Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu

“…Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered by drug resistance. …”
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New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors by Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis

“…Background Bellmunt Risk Score, based on Eastern Cooperative Oncology Group (ECOG) performance status (PS), hemoglobin levels and presence of liver metastases, is the most established prognostic algorithm for patients with advanced urothelial cancer (aUC) progressing after platinum-based chemotherapy. Nevertheless, existing algorithms may not be sufficient following the introduction of immunotherapy. …”
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The performance status gap in immunotherapy for frail patients with advanced non-small cell lung cancer by Julie Tsu-Yu Wu, June Corrigan, Chloe Su, Clark Dumontier, Jennifer La, Aparjita Khan, Shipra Arya, Alex H. S. Harris, Leah Backhus, Millie Das, Nhan V. Do, Mary T. Brophy, Summer S. Han, Michael Kelley, Nathanael R. Fillmore

“…Intensive treatment was defined as concurrent use of platinum-doublet chemotherapy and/or dual checkpoint blockade and non-intensive as ICI monotherapy. …”
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Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…In this scenario, access to a validated diagnostic HRD test can optimize treatment selection and increase the effectiveness of the intervention.ObjectiveTo technically validate an in-house next-generation sequencing (NGS)-based HRD test, QIAseq Custom Panel (QIAGEN), by comparing it with the reference assay, MyChoice CDx® Plus HRD (Myriad Genetics), which is used in routine care.MethodsThis is a prospective cohort study conducted at the Oncoclínicas Precision Medicine (OCPM) laboratory using samples from patients with advanced or relapsed platinum-sensitive ovarian cancer eligible for HRD testing in a diagnostic clinical setting at Oncoclínicas and Co. …”
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Termination-acidity tailoring of molybdenum carbides for alkaline hydrogen evolution reaction by Zhigang Chen, Minghao Yang, Yifan Li, Wenbin Gong, Juan Wang, Tong Liu, Chunyu Zhang, Shuang Hou, Guang Yang, Hao Li, Ye Jin, Chunyan Zhang, Zhongqing Tian, Fancheng Meng, Yi Cui

“…Abstract Transition-metal carbides have been advocated as the promising alternatives to noble-metal platinum-based catalysts in electrocatalytic hydrogen evolution reaction over half a century. …”
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COMBINED TREATMENT OF LOCALLY-ADVANCED BLADDER CANCER by I. V. Chernyshev, Y. V. Samsonov, D. V. Perepechin, A. M. Ulbashev

“…An important component of treatment has been the use of platinum (cisplatin or carboplatin) in Schemes M–VAC and GP. …”
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First-line chemotherapy with selective internal radiation therapy for intrahepatic cholangiocarcinoma: The French ACABi GERCOR PRONOBIL cohort by Nicolas Adamus, Julien Edeline, Julie Henriques, Nadim Fares, Thierry Lecomte, Anthony Turpin, Dewi Vernerey, Mathilde Vincens, Brice Chanez, David Tougeron, Christophe Tournigand, Eric Assenat, Matthieu Delaye, Sylvain Manfredi, Olivier Bouché, Nicolas Williet, Angelique Vienot, Lorraine Blaise, Léo Mas, Cindy Neuzillet, Alice Boilève, Gaël S. Roth

“…Methods: Inclusion criteria were advanced iCCA with limited or no extrahepatic disease, treated with first-line gemcitabine plus platinum chemotherapy +/- concurrent SIRT. All patients treated with chemotherapy and concurrent SIRT were included. …”
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“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer by ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin

“…They deeply analyzed the molecular characteristics of TNBC, leading to the development of a “Fudan subtype” closely related to clinical outcomes: luminal androgen receptor subtype (LAR), which can be targeted with anti-HER2 and CDK4/6 inhibitors; the immunomodulatory subtype (IM), suitable for immunotherapy; basal-like immune-suppressed subtype (BLIS), which can be treated with platinum-based drugs or poly (ADP-ribose) polymerase (PARP) inhibitors; and mesenchymal-like subtype (MES), which can be treated with anti-cancer stem cell and anti-angiogenic therapies. …”
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Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol by Dongying Wang, Chunhua Zhao, Li Fu, Yang Liu, Weiyang Zhang, Tianmin Xu

“…Radical hysterectomy combined with chemotherapy (paclitaxel + platinum) has the ideal short-term curative effect. …”
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Durvalumab as consolidation therapy in patients who received chemoradiotherapy for unresectable stage III NSCLC: Real-world data from an expanded access program in Brazil (LACOG 01... by Mauro Zukin, Victor Gondim, Andrea Kazumi Shimada, Ellias Magalhães e Abreu Lima, Clarissa Mathias, Williams Fernandes Barra, William Nassib William Junior, Mônica Padoan, Yuri Bittencourt, Rosely Yamamura, Carlos Eduardo Baston Silva, Letícia de Jesus Rossato, Caio de Almeida Monteiro, Rafaela Gomes de Jesus, Gustavo Gössling, Ana Caroline Zimmer Gelatti

“…ABSTRACT Objective: The PACIFIC trial established standard therapy for patients with unresectable stage III NSCLC who did not progress after platinum-based concurrent chemoradiation therapy. However, real-world data, particularly from Latin America, remain limited. …”
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Early Effects of Bronchoscopic Cryotherapy in Metastatic Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Single-Center Prospective Study by Gediminas Vasiliauskas, Evelina Žemaitė, Erika Skrodenienė, Lina Poškienė, Gertrūda Maziliauskienė, Aurimas Mačionis, Skaidrius Miliauskas, Donatas Vajauskas, Marius Žemaitis

“…Patients received up to four cycles of pembrolizumab as monotherapy or in combination with platinum-based chemotherapy. Immune-related adverse events (irAEs), complications, tumor size changes, overall response rate (ORR), and disease control rate (DCR) were evaluated. …”
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The value of MRI in differentiating ovarian clear cell carcinoma from other adnexal masses with O-RADS MRI scores of 4–5 by Lingling Lin, Le Fu, Huawei Wu, Saiming Cheng, Guangquan Chen, Lei Chen, Jun Zhu, Yu Wang, Jiejun Cheng

“…Critical relevance statement CCC has a high incidence rate in Asians and has limited sensitivity to platinum chemotherapy. This comprehensive model improves CCC prediction ability and clinical applicability for facilitating individualised clinical decision-making. …”
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