Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Neither the adenylate cyclase inhibitor SQ22536 nor the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one significantly reversed the Ir-6-mediated inhibition of collagen-induced platelet aggregation. Moreover, Ir-6 did not considerably diminish OH radical signals in collagen-activated platelets or Fenton reaction solution. …”
Get full text

Wound Management Property of a Hydroethanolic Leaf Extract of Cnestis ferruginea DC by Jibira Yakubu, G. A. Koffuor, Talent Atsu-Nunyawu, Jeremiah Aboagye, Irene Aasam Aabeinir, Fasilatu Alhassan, Lord Christian Ocran, Philomena Entsie

“…CFHE (1.6–100 mg/ml) promoted platelet aggregation (p≤0.0001) by 37–67% (IC50: 3.1–6.2 mg/ml). …”
Get full text

Impact of inflammation on recurrent gastroduodenal ulcer bleeding by Oksana N Sulaeva, P. G. Kondratenko, V. Yu. Dely, S. O. Zharikov

“…Effect of leukocytes on platelet aggregation induced by collagen and adenosinediphosphate was estimated in vitro. …”
Get full text

Understanding the Activation of Platelets in Diabetes and Its Modulation by Allyl Methyl Sulfide, an Active Metabolite of Garlic by Navya Malladi, Ebin Johny, Shravan K. Uppulapu, Vikas Tiwari, Md Jahangir Alam, Ramu Adela, Sanjay K. Banerjee

“…We observed an inhibitory effect of allyl methyl sulfide on platelet aggregation, platelet activation, platelet macrophage interaction, and increased ROS levels in type 1 diabetes. …”
Get full text

The Impact of Anti-Diabetics on Platelets Function and Cardiovascular Outcomes in Type 2 Diabetes Mellitus: A Narrative Review by Muthanna Zaki, Mohammed Abed, Fawaz Alassaf

“…We realized various mechanisms responsible for enhanced platelet aggregation in T2DM, represented by immature, large, or activated platelets in the altered metabolic environment, against the background of vascular damage in DM. …”
Get full text

Evaluation of the effect of 48 weeks of BIC/F/TAF and DRV/c/F/TAF on platelet function in the context of rapid ART start by Akif A. Khawaja, Gary Whitlock, Sarah Fidler, Alfredo Soler-Carracedo, Merle Henderson, Graham P. Taylor, Marta Boffito, Michael Emerson

“…Platelet activation was assessed by real-time flow cytometry to examine integrin activation and granule release and platelet aggregation was evaluated by light transmission aggregometry. …”
Get full text

Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy by Qin Qin, Wenxing Wu, Ling Che, Xing Zhou, Diedie Wu, Xiaohui Li, Yumin Yang, Jie Lou

“…Theoretical simulations and experimental studies were combined to optimize their structure and functionality. In vitro platelet aggregation, antibacterial assays, cytotoxicity tests, and hemolysis evaluations were performed. …”
Get full text

Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

“…We simultaneously detected blood lipid levels, observed ventricular function using ultrasound examination, measured platelet aggregation, and checked changes in inflammatory factors, oxidative stress factors, and vascular endothelial injury-related indexes applying ELISA assays. …”
Get full text

Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC) by M. Jäpel, H. Lötzerich, K. Rogalla

“…In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. …”
Get full text

Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports by Xin Liao, Yuxia Guo, Yali Shen, Jianwen Xiao

“…Cases of bleeding disorders ultimately result in thrombocytopenia, but platelet aggregation dysfunction induced by dasatinib has also been demonstrated in Ph + B-ALL and CML patients. …”
Get full text

Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells by Silvia Orisio, Marina Morigi, Carla Zoja, Norberto Perico, Giuseppe Remuzzi

“…These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.…”
Get full text

Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy by Irina Gringauz, Narin Nard Carmel-Neiderman, Tobin Mangel, Orith Portnoy, Gad Segal, Idan Goren

“…Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder involving thrombotic microangiopathy and is characterized by increased platelet aggregation throughout the body. Acquired TTP can be triggered by a variety of conditions including infections. …”
Get full text

Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…However, after adjustment for baseline differences, platelet aggregation and thromboelastography parameters showed no significant differences between patients with CKD and healthy controls. …”
Get full text

Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach by Mohamed. Rizk, Maha Mahmoud Abou El-Alamin, Ola Abd Elkhalek, Hassan A. M. Hendawy

“…Abstract Tirofiban hydrochloride is used to inhibit platelet aggregation, which has a significant impact on the treatment of congestive heart failure the most common cause of death according to WHO. …”
Get full text

Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice by Jui-Chi Tsai, Yi-Wen Lin, Chun-Yao Huang, Feng-Yen Lin, Chien-Sung Tsai

“…However, the mechanism by which TLR4 directly affects platelet aggregation and blood coagulation remains to be explored. …”
Get full text

COVID-19-Induced Fatal Thrombotic Thrombocytopenic Purpura in a Healthy Young Patient by Mariana Codevila Buere Pereira, Bruna Ruschel, Bruna Schneider, Vitor Salomão Gonçalves Melo de Melgar, Tatiana Helena Rech

“…The antibody-mediated reduced activity of the disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) induces the accumulation of ultrahigh-molecular-weight multimers of von Willebrand factor, leading to platelet aggregation and thrombosis. TTP can be an unusual presentation of COVID-19 disease mediated by the virus-induced immune response. …”
Get full text

The Interaction of Src Kinase with β3 Integrin Tails: A Potential Therapeutic Target in Thrombosis and Cancer by Stephan Huveneers, Erik H. J. Danen

“…The same integrin β3-c-Src interaction not only drives platelet aggregation, but it also promotes the oncogenic potential of c-Src and drives tumor growth by αvβ3-expressing tumor cells, which may explain why increased activity of c-Src and elevated levels of integrin αvβ3 are often found in the same tumor types. …”
Get full text

Magnesium and Vascular Changes in Hypertension by Ana Rosa Cunha, Bianca Umbelino, Margarida L. Correia, Mario Fritsch Neves

“…In addition, lower concentrations of magnesium are associated with oxidative stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia. …”
Get full text

Comparison of Modified Chandler, Roller Pump, and Ball Valve Circulation Models for In Vitro Testing in High Blood Flow Conditions: Application in Thrombogenicity Testing of Differ... by Wim van Oeveren, Ignace F. Tielliu, Jurgen de Hart

“…Platelet numbers were reduced in the roller pump and Chandler loop (P<0.05), but remained high in the Hemobile. Platelet aggregation was reduced in all models. The Hemobile was applied for testing vascular graft materials, and allowed different circuits circulated simultaneously at 37°C. ePTFE, Dyneema Purity UHMWPE fiber and PET fiber based tubes, all showed hemolysis below 0.2% and reduced platelet count and function. …”
Get full text

Approach to Management of Thrombotic Thrombocytopenic Purpura at University of Cincinnati by N. Abdel Karim, S. Haider, C. Siegrist, N. Ahmad, A. Zarzour, J. Ying, Z. Yasin, R. Sacher

“…Thrombotic Thrombocytopenic Purpura (TTP) is a rare hematologic emergency, congenital or acquired, characterized by ischemic damage of various organs because of platelet aggregation. It is the common name for adults with microangiopathic hemolytic anemia, thrombocytopenia, with or without neurologic or renal abnormalities, and without another etiology; children without renal failure are also described as TTP. …”
Get full text