CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…Therefore, we conclude that targeting CD40 directly on adipocytes, B-cells, T-cells, or CD40L on platelets is not a promising target to prevent hypertension complications.In summary, TRAF6 inhibition but not adipocyte, B-cell, or T-cell-specific CD40 or platelet-specific CD40L deficiency reduces pathophysiological vascular inflammation in hypertensive mice, suggesting TRAF6 inhibition as a potential therapeutic target in hypertensive patients.…”
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Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans by Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang

“…The potential usage of Sema3A for OA treatment was validated in mouse and Rhesus macaque OA models through intra-articular injection of Sema3A, and also in patients by administering Sema3A containing platelet-rich plasma into the knee joints. Our studies demonstrated that Sema3A exerts a critical role in inhibiting neurite ingrowth and preventing chondrocyte hypertrophy in cartilage, and could be potentially used for OA treatment.…”
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Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients by Jiayi Wang, Lingyao Du, Dongmei Zhang, Chen Zhou, Yilan Zeng, Miao Liu, Xing Cheng, Xiaona Song, Han Chen, Ning Han, Enqiang Chen, Hong Tang

“…. −3.18 P < 0.001), Fibrosis-4 (FIB4) Index (2.53 vs. 1.88, P = 0.004) and AST to Platelet Ratio Index (APRI) (0.99 vs. 0.44, P < 0.001) scores showed a significant decrease from baseline to SVR12. …”
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The prognosis and metabolite changes of NSCLC patients receiving first‐line immunotherapy combined chemotherapy in different M1c categories according to 9th edition of TNM classifi... by Liang Zheng, Fang Hu, Wei Nie, Jun Lu, Bo Zhang, Jianlin Xu, Shuyuan Wang, Ying Li, Xiaoxuan Zheng, Wei Zhang, Yinchen Shen, Runbo Zhong, Tianqing Chu, Baohui Han, Hua Zhong, Xueyan Zhang

“…In comparison to M1c1 patients, M1c2 patients exhibited alterations in various pathways pretreatment, including platelet activation, linoleic acid metabolism, and the VEGF signaling pathway. …”
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The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics by Arwa M. Amin, Lim Sheau Chin, Dzul Azri Mohamed Noor, Muhamad Ali SK Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim

“…However, the variable platelets reactivity response to clopidogrel may lead to outcome failure and recurrence of cardiovascular events. …”
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Treatment of Knee Osteochondral Lesions Using a Novel Clot of Autologous Plasma Rich in Growth Factors Mixed with Healthy Hyaline Cartilage Chips and Intra-Articular Injection of P... by Ramón Cugat, Eduard Alentorn-Geli, Gilbert Steinbacher, Pedro Álvarez-Díaz, Xavier Cuscó, Roberto Seijas, David Barastegui, Jordi Navarro, Patricia Laiz, Montserrat García-Balletbó

“…The use of a clot of autologous plasma poor in platelets with healthy hyaline cartilage chips and intra-articular injection of plasma rich in platelets is an effective, easy, and cheap option to treat knee cartilage injuries in young and athletic patients.…”
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The Effect of Feeding Different Levels of Mineral Biochar on Performance, Blood Parameters, Production and Milk Composition of Holstein Dairy Cows by Ali Khatibi Bardsiri, Reza Valizadeh, Seyed Hadi Ebrahimi, Pirouz Shakeri, Abbas Ali Naserian

“…Therefore, the antibacterial, anti-inflammatory and anti-stress properties of biochar may have caused the reduction of platelets and the ratio of non-fibrinogen proteins to fibrinogen or increase the average volume of platelets. …”
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Haematological Features of White Rats (Rattus norvegicus) Infected with S. pyogenes and Administered with Probiotics (Yogurt) by Novina Rahmawati, Maimun Syukri, Darmawi Darmawi, Indra Zachreini, Utari Zulfiani, Muhammad Yusuf, Rinaldi Idroes

“…Based on the haematology examination, the probiotic yogurt could maintain the number of platelets, leukocytes, lymphocytes, neutrophils, and monocytes. …”
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Microstructures and Toughening of TiC-TiB2 Ceramic Composites with Cr-Based Alloy Phase Prepared by Combustion Synthesis in High-Gravity Field by Xuegang Huang, Chun Yin, Zhongmin Zhao, Long Zhang, Junyan Wu

“…Micro-nanocrystalline microstructures which are characterized by TiB2 platelets of the average thickness close to or smaller than 1 μm can be achieved in nearly full-density solidified TiC-TiB2 ceramic composites with Cr-based alloy phases by combustion synthesis in ultra-high gravity field of 2500 g. …”
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Development of Sr modified Al–Si–Mg–Fe based alloys for automotive components by H.R. Ammar, E. Samuel, A.M. Samuel, E. Elsharkawi, H.W. Doty, F.H. Samuel

“…The unmodified alloy shows a maximum reduction in the length of the β-phase platelets after 30 h of solution treatment, compared to 10 h for the modified alloy. …”
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Clinical Practice Guidelines for Transfusion of Patients in Critical Condition. by Rafael Alejandro Gómez Baute, Diosdania Alfonso Falcón, Liermis Dita Salabert, Luciano Núñez Almoguea.

“…We stress transfusion criteria (blood cells, platelets, granulocyte concentrations, plasma and cryoprecipitate), doses, diagnosis and treatment of post-transfusion reactions. …”
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Subcapsular hepatic hematoma. Serious complication during pregnancy by María Teresa Pérez Hernández, Viviana de la Caridad Sáez Cantero

“…Subcapsular hepatic hematoma is a rare complication during pregnancy, but potentially lethal and usually related to severe pre-eclampsia or HELLP syndrome (hemolysis, elevated liver enzymes and diminished platelets). Maternal and perinatal mortality in these cases is high, hence the importance of early diagnosis and timely and multidisciplinary treatment. …”
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Acute Renal Replacement Therapy in Children with Diarrhea-Associated Hemolytic Uremic Syndrome: A Single Center 16 Years of Experience by Silviu Grisaru, Melissa A. Morgunov, Susan M. Samuel, Julian P. Midgley, Andrew W. Wade, James B. Tee, Lorraine A. Hamiwka

“…There were no bleeding events related to PD despite a mean platelets count of 40.9 (±23.5) × 103/mm3 and rare use of platelets infusions. …”
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Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis by Alexandros Makis, Athanasios Gkoutsias, Theodoros Palianopoulos, Eleni Pappa, Evangelia Papapetrou, Christina Tsaousi, Eleftheria Hatzimichael, Nikolaos Chaliasos

“…Information regarding age, gender, preceding infection, bleeding type, duration of symptoms and platelets at diagnosis, treatment, disease course, and immunological markers was recorded. 39 children had newly diagnosed, 4 persistent, and 14 chronic disease. …”
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Blood Morphology and Hematology of Adult Baikal Seals (<i>Pusa sibirica</i> Gmelin, 1788) Under Professional Care by Polina Esipova, Irina Suvorova, Veronika Yachmen, Igor Pushchin

“…The morphological features of neutrophils, eosinophils, basophils, and platelets were described. Inter-individual and sex differences in the counts of basophils, platelets, red blood cells, and levels of hemoglobin, the mean corpuscular volume, and the mean corpuscular hemoglobin concentration were statistically observed. …”
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Evaluation of the Zirconium Hydride Morphology at the Flaws in the CANDU Pressure Tube Using a Novel Metric by Alexandra Ion Jinga, Mărioara Abrudeanu, Vasile Radu, Alexandru Niţu, Livia Stoica, Denisa Toma, Mircea Ionuţ Petrescu

“…Analysis of the hydrogen accumulation circumstances, the creation of zirconium hydride platelets, evaluation of the platelets’ reorientation in the thermo–mechanical field at volumetric flaws, and determination of the hydrogen morphology are therefore significant goals of the worldwide research being conducted in this field. …”
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A Combination of Surgical Techniques to Repair a Giant Traumatic Macular Hole by Soon Wai Ch’ng, Ibrahim Elaraoud, David Karl, Dimitrios Kalogeropoulos, Rynn Lee, Elisa Carreras

“…Pars plana vitrectomy combined with large inverted internal limiting membrane (ILM) peel flap, 5000 Cs silicone oil tamponade, and autologous platelets implantation was performed. Follow-up visits revealed that the FTMH was closed under silicone oil. …”
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Cardiac and Pulmonary Ultrasound for Diagnosing TRALI by J. I. Alonso-Fernández, J. R. Prieto-Recio, C. García-Bernardo, I. García-Saiz, J. Rico-Feijoo, C. Aldecoa

“…We report a suspected case of a transfusion related acute lung injury (TRALI) following administration of platelets. The usefulness of lung and cardiac ultrasound is discussed to facilitate the challenging diagnosis of the acute early postoperative respiratory failure.…”
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Hemophagocytic Lymphohistiocytosis and Gastrointestinal Bleeding: What a Surgeon Should Know by S. Popeskou, M. Gavillet, N. Demartines, D. Christoforidis

“…Hemophagocytic syndrome or hemophagocytic lymphohistiocytosis (HLH) is a rare medical entity characterized by phagocytosis of red blood cells, leucocytes, platelets, and their precursors in the bone marrow by activated macrophages. …”
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A Rare Case of Acute Methotrexate Toxicity Leading to Bone Marrow Suppression by Samreen Khuwaja, Matthew Lyons, Beenish Zulfiqar

“…Complete blood count was suggestive of pancytopenia with hemoglobin of 10.8 g/dL, total white cell count 3.36 (1000/uL) (absolute neutrophil count 490 micro/L), platelets 19,000, serum albumin 3.1 g/dL, ESR elevated at 83 mm/hr, CRP elevated at 86.6 mg/L, and ferritin mildly elevated at 625 ng/mL. …”
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