Prognostic value of inflammatory markers for all-cause mortality in patients with acute myocardial infarction in the coronary care unit: a retrospective study based on MIMIC-IV dat... by Fen Cao, Jun-jun Jiang, Gui Zhang, Jun Liu, Ping Xiao, Yang Tian, Wei Zhang, Sheng Zhang, Feng Hou, Zhong-Wu Bao, Kun Wu, Yong-zhi Zhu

“…This paper was to verify the correlation of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), and systemic inflammation response index (SIRI) with all-cause mortality for AMI patients in the CCU.MethodsAdult patients diagnosed with AMI and admitted to CCU were selected from the MIMIC-IV database. …”
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Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma by Eun Seop Seo, Eun Seop Seo, In Hwa Jeong, In Hwa Jeong, Hee Young Ju, Ju Kyung Hyun, Ji Won Lee, Keon Hee Yoo, Won Young Heo, Ki Woong Sung, Hee Won Cho, Eun-Suk Kang

“…IntroductionThe Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) model is a recently developed algorithm that predicts indirect T-cell recognition by calculating the number of such epitopes in donor-recipient pairs.MethodsIn this study, the clinical significance of PIRCHE was evaluated in pediatric patients with relapsed/progressed neuroblastoma undergoing haploidentical stem cell transplantation (haplo-SCT).ResultsA higher PIRCHE-I score was associated with faster platelet recovery (P = 0.007) and lower incidence of hemorrhagic cystitis (13% vs. 41%, P = 0.028) and invasive fungal infections (0% vs. 18%, P = 0.045). …”
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

“…Furthermore, Met cells showed robust overexpression of Tbxas1, a thromboxane A synthase 1 gene that catalyzes the conversion of prostaglandin H2 to thromboxane A2 (TXA2), a potent inducer of platelet aggregation. Application of aspirin, a TXA2 inhibitor, significantly reduced lung metastases. …”
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Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model by Risheng Hao, Haobo Li, Xincheng Li, Jixiang Liu, Xiaofan Ji, Hong Zhang, Zhu Zhang, Peiran Yang, Zhenguo Zhai

“…Enrichment analyses revealed significant pathways, including HIF-1α signaling, glycolysis/gluconeogenesis, and platelet activation. A lncRNA-miRNA-mRNA network highlighted key regulatory interactions. …”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Baseline demographic data, comorbidities, inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6], ferritin, neutrophil-to-lymphocyte ratio [NLR], platelet count, albumin, and derived indices such as the CRP-to-Albumin Ratio [CAR] and Prognostic Nutritional Index [PNI]) were recorded. …”
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Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients by Rayra P. Santiago, Magda O. S. Carvalho, Camylla V. B. Figueiredo, Luciana M. Fiuza, Rodrigo M. Oliveira, Sètondji C. M. A. Yahouédéhou, Valma M. L. Nascimento, Isa M. Lyra, Théo Araujo-Santos, Nívea F. Luz, Milena M. Aleluia, Caroline C. Guarda, Valéria M. Borges, Marilda S. Goncalves

“…In patients with HbSC, TGF-β1 levels were positively correlated with leukocytes, eosinophils, lymphocytes, monocytes, and platelets, as well as levels of TIMP-1, VLDL-C, triglycerides, heme, and AST. …”
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Outcomes of percutaneous endoscopic gastrostomy (PEG) in HIV patients by Nikhitha Mantri, Haozhe Sun, Sameer Datta Kandhi, Nishant Allena, Muhammad Yasir Anwar, Vibha Hayagreev, Shalini Penikilapate, Ahmed Alemam, Hassan A Muntazir, Trishna Acherjee, Harish Patel, Jasbir Makker

“…This difference occurred despite no notable variations in laboratory parameters such as platelet count and (international normalized ratio), as well as similar usage of anticoagulant or antiplatelet medications between the two groups. …”
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Safety and efficacy of oral edible bird’s nest supplementation: Anti-inflammatory and immunomodulatory benefits for Arabian race stallions during exercise by Khalid Obaid AL-Khaldi, Khalid Hamed Al-Ruzaiqi, Abdul Salam Babji, Seng Joe Lim, Mohammed Babatunde Sadiq, Nurhusien Yimer

“…Hematological indices, including mean corpuscular volume, red cell distribution width, and platelet counts, were significantly improved in the EBN group, indicating potential immunomodulatory benefits. …”
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Hidden blood loss and risk factors after percutaneous endoscopic transforaminal lumbar interbody fusion by Meng Ge, Meng Ge, Fangbing Zhu, Fangbing Zhu, Weibin Du, Weibin Du, Zhengcong Ye, Zhengcong Ye, Zhenfei Xiong, Zhenfei Xiong, Lukai Zhang, Lukai Zhang, Hua Zhou, Hua Zhou, Jun Yang, Jun Yang

“…The levels of fibrinogen, activated partial thromboplastin time, prothrombin time, thrombin time, and platelet count as well as the pre- and postoperative hematocrit and hemoglobin levels were collected. …”
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A novel nomogram for predicting mortality risk in young and middle-aged patients undergoing maintenance hemodialysis: a retrospective study by Lei Sun, Lei Sun, Yue Zhang, Yue Zhang, Xinliang Zuo, Xinliang Zuo, Yongmei Liu

“…A logistic regression analysis revealed that age, hemoglobin (HB), serum magnesium (Mg), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-albumin ratio (PAR) were significant independent predictors of mortality among these patients. …”
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The Effects of Oral Semaglutide on Hepatic Fibrosis in Subjects with Type 2 Diabetes in Real-World Clinical Practice: A Post Hoc Analysis of the Sapporo-Oral SEMA Study by Hiroya Kitsunai, Yuka Shinozaki, Sho Furusawa, Naoyuki Kitao, Miki Ito, Hiroyoshi Kurihara, Chiho Oba-Yamamoto, Jun Takeuchi, Akinobu Nakamura, Yumi Takiyama, Hiroshi Nomoto

“…Subjects in the original cohort were divided into groups as follows: subjects with suspected MASLD (alanine aminotransferase > 30 U/L) were placed in an overall group; a subpopulation from an overall group at high risk for hepatic fibrosis (fibrosis-4 (FIB-4) index ≥ 1.3 or platelet count < 200,000/µL) was placed in a high-risk group; and the remaining subjects were placed in a low-risk group. …”
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Evidence linking phthalate exposure to alterations of hematologic parameters in Chinese children: A cross-sectional study by Mei-Ting Wei, Ying Wen, Zhu-Xia Zhang, Xiu-Ju Liu, Feng-Xiang Wei, Wei-Qiang Liu, Li Zhou, Ding-Yan Chen, Yao Yao

“…Nine phthalate metabolites (mPAEs) and four hematologic parameters (white blood cell [WBC] count, red blood cell [RBC] count, hemoglobin [Hb], and platelet [PLT] count) were measured at the same time. …”
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Epidemiological Characteristics and Prognostic Scoring in Toxic Epidermal Necrolysis and Stevens–Johnson Syndrome: Insights from a 17-Year Burn Center Experience by David Breidung, Sarina Delavari, Ioannis-Fivos Megas, Alexander Geierlehner, Wolfgang Hitzl, Karl J. Bodenschatz, Konrad Karcz, Denis Ehrl, Moritz Billner

“…Affected body surface area, platelet count, and serum blood urea nitrogen differed significantly between survivors and non-survivors. …”
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Analysis of the effect of initial hemostasis resuscitation with recombinant human coagulation factor VII a on the treatment of postoperative hemorrhage in cardiac surgery by Yan Yu, Maomao Liu, Xuran Lu, Li Yu, Nan Liu

“…In this study, initial hemostatic resuscitation was defined as a platelet count > 50,000 per µL and fibrinogen > 1.5 g/L when rFVIIa was used. …”
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Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection: A Retrospective Analysis Including Subgroups with Diabetes, Cancer, and Elderly by Teodor Cerbulescu, Flavia Ignuta, Uma Shailendri Rayudu, Maliha Afra, Ovidiu Rosca, Adrian Vlad, Stana Loredana

“…We collected baseline demographics, comorbidities, and laboratory parameters including C-reactive protein (CRP), Interleukin-6 (IL-6), ferritin, neutrophil and lymphocyte counts, albumin, platelet counts, and calculated indices (C-reactive protein to Albumin Ratio (CAR), Neutrophil-to-Lymphocyte Ratio (NLR), Prognostic Nutritional Index (PNI), SII). …”
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Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis by Juan Hu, Qiao Li, Shiqiu Jiang, Yingying Deng, Lan Yang, Mengyu Du, Shuxuan He, Fuxing Xu, Chaoying Yan, Wei Gao, Yansong Li, Yaomin Zhu

“…Post-transplantation of platelet-derived mitochondria (Mito-Plt), a significant reversal of these biomarkers was noted, coincident with an improvement in cognitive deficits in T2DM mice. …”
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Early Postoperative Safety of Total Hip Arthroplasty in Systemic Lupus Erythematosus Patients by YANG Xingdong, YU Muyang, XU Yiming, ZHU Wei, HU Mingwei, WENG Xisheng, FENG Bin

“…After propensity score matching, 163 cases from SLE and control groups were included for analysis. (1) Regarding medical complications, compared with control group, SLE group showed significant differences in osteoporosis, respiratory system disorders, gastrointestinal diseases, urinary system disorders, hematologic abnormalities, and secondary or concomitant rheumatic diseases (all P < 0.05). (2) In terms of preoperative laboratory tests, SLE group had lower platelet counts, absolute lymphocyte counts, hemoglobin levels, hematocrit, albumin levels, blood glucose levels, and activated partial thromboplastin times than control group, while C-reactive protein, erythrocyte sedimentation rate, and D-dimer levels were higher (all P < 0.05). (3) Regarding surgical-related indicators, a higher proportion of patients in SLE group had an ASA grade > 2 (15.95% vs. 3.07%, P < 0.001), but intraoperative blood loss was significantly smaller [324.7 (200.0, 500.0) mL vs. 421.8 (200.0, 500.0) mL, P=0.005]. (4) In terms of complications, SLE group exhibited a significantly higher incidence of major complications than control group (8.59% vs. 1.23%, P=0.005), with a relative risk of 1.081 (95% CI: 1.028-1.136). …”
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Significance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review by Muhammad Taqi, Haseeb ul Rasool, Mobeen Zaka Haider, Munjed Al Muderis

“…A neutrophil to lymphocyte ratio (NLR) > 2.70, platelet to lymphocyte ratio (PLR) > 215.80, lymphocyte to monocyte ratio (LMR) ≤ 2.80, and albumin to globulin ratio (AGR) < 1.50 were significantly associated with decreased disease-free survival (DFS) (<i>p</i> < 0.05). …”
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Gut microbiota and blood biomarkers in IBD-Related arthritis: insights from mendelian randomization by Wei Yang, Miao Cui, Peng Yang, Chenlin Liu, Xiuzhen Han, Wenyi Yao, Zhenhua Li

“…Among the plasma proteins, pterin-4-alpha-carbinolamine dehydratase, aldo-keto reductase family 1 member C4, cathepsin L2, angiostatin, hepatocyte growth factor-like protein, hepatitis A virus cellular receptor 2, protein O-linked mannose beta-1,4-N-acetylglucosaminyltransferase 2, epididymal-specific alpha-mannosidase, and platelet-derived growth factor receptor-like protein are associated with Crohn’s disease-related arthritis. …”
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Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air... by Bingqian DU, Zhiqiang REN, Peian CHEN, Zhenjun LI

“…ResultsSpearman correlation analysis showed that the concentrations of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and carbon monoxide (CO) were positively correlated with monocyte count (MO#), eosinophil count (EOS#), and red blood cell distribution width standard deviation (RDW-SD), and negatively correlated with mean corpuscular hemoglobin concentration (MCHC) and platelet crit (PCT) (all P < 0.05). Particulate matter with an aerodynamic diameter of less than 10 μm (PM10) concentration was positively correlated with MO# and SIRI, and negatively correlated with mean corpuscular hemoglobin (MCH) and MCHC (all P < 0.01). …”
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