Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival by Linda Kachuri, Geno A. Guerra, Taishi Nakase, George A. Wendt, Helen M. Hansen, Annette M. Molinaro, Paige Bracci, Lucie McCoy, Terri Rice, John K. Wiencke, Jeanette E. Eckel-Passow, Robert B. Jenkins, Margaret Wrensch, Stephen S. Francis

“…We find that increased platelet to lymphocyte ratio (PLR) confers an increased risk of glioma (odds ratio (OR) = 1.25, p = 0.005), especially tumors with isocitrate dehydrogenase (IDH) mutations (OR = 1.38, p = 0.007) and IDHmut 1p/19q intact (IDHmut-intact OR = 1.53, p = 0.004) tumors. …”
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Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two ca... by Roberto Castelli, Enrico Atzori, Alessandro Palmerio Delitala, Salvatore Antonio Masala, Valentina Micheluzzi, Enrico Ponti, Enrico Ponti, Giuseppe Sanna, Dante Castro, Antonio Gidaro, Mattia Donadoni, Roberto Manetti, Pierluigi Merella, Nicia Isabella Profili, Andrea Maria D'Armini, Gavino Casu, Gavino Casu

“…IntroductionPrimary immune thrombocytopenia is an autoimmune bleeding disorder characterized by variable immune-mediated platelet destruction. These patients have reported thrombotic complications, both venous and arterial, in addition to bleeding. …”
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Contribution of individual phospholipase A2 enzymes to the cleavage of oxidized phospholipids in human blood plasma by Philipp Jokesch, Olga Oskolkova, Maria Fedorova, Bernd Gesslbauer, Valery Bochkov

“…Human plasma contains both genuine phospholipases A2 [platelet activating factor acetyl hydrolase (PAF-AH) (also called Lp-PLA2) and secretory phospholipase A2] and multifunctional enzymes capable of removing sn-2 residues in native and oxidized PLs (lecithin-cholesterol acyltransferase, peroxiredoxin-6). …”
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The Association of Polycystic Ovary Syndrome and Gestational Hypertensive Disorders in a Diverse Community-Based Cohort by Diane Schneider, Joel R. Gonzalez, Miya Yamamoto, Jingrong Yang, Joan C. Lo

“…The development of PIH, including gestational hypertension, preeclampsia/eclampsia, or HELLP (hemolysis, elevated liver enzymes, and low platelet count), was ascertained by chart review. Among women without preexisting hypertension who had a singleton pregnancy, the association of PCOS and PIH was examined using multivariable logistic regression. …”
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Venous thromboembolic events: case history by T.V. Shelkovnikova, Kh.P. Takhchidi, G.V. Vavin, N.Yu. Shishlyannikova

“…Elevated levels of fibrinogen, soluble fibrin monomer complexes, factors V and VIII, von Willebrand factor, and intravascular platelet activation factor were revealed. The presence of two or more genetic markers of thrombophilia as well as antiphospholipid antibodies promote endotheliosis and thrombogenesis. …”
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Symptomatic neurosyphilis in HIV-negative patients: a retrospective cohort study by Qiaoer Chen, Qiaoer Chen, Weiqi Wu, Lu Wang, Honghong Huang, Lingxing Wang

“…Patients with the parenchymal type were younger and had higher platelet-to-lymphocyte ratio (PLR) and lower lymphocyte-to-monocyte ratio (LMR). …”
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The intervention of curcumin on rodent models of hepatic fibrosis: A systematic review and meta-analysis. by Yun-Hang Chu, Bing-Yao Pang, Ming Yang, Qi Meng, Yan Leng

“…The outcome indicators included liver cell structure and function related indicators, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin (ALB), ratio of albumin to globulin (A/G), total bilirubin (TBIL), bax protein, bcl-2 protein and index of liver, as well as the relevant indicators for evaluating the degree of hepatic fibrosis, such as hyaluronic acid (HA), laminin (LN), type I collagen (Collagen I), type III collagen (Collagen III), type III procollagen (PCIII), type III procollagen amino terminal peptide (PIIINP), type IV collagen (IV-C), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), α-Smooth muscle actin (α-SMA), hydroxyproline (HYP), platelet derived factor-BB (PDGF-BB), connective tissue growth factor (CTGF) and transforming growth factor-β1 (TGF-β1), and oxidative stress-related indicators, such as superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px). …”
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Effects of laparoscopic sleeve gastrectomy on nonalcoholic fatty liver disease and TGF-β signaling pathway by Hideki Kumagai, Akira Sasaki, Akira Umemura, Keisuke Kakisaka, Takeshi Iwaya, Satoshi S Nishizuka

“…Among these proteins, we focused on five TGF-β-related proteins: asporin, EMILIN-1, platelet factor-4, serglycin, and thrombospondin-1. …”
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Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study by Michael Che, Sumaiya Ahmed, Ryan Chan, Ayub Akbari, Deborah Zimmerman

“…Background: Patients with end-stage kidney disease (ESKD) have high rates of gastrointestinal bleeding due to several risk factors including platelet dysfunction, comorbid illness, and use of antiplatelet medications. …”
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Clinical Impact of Viral Load on the Development of Hepatocellular Carcinoma and Liver-Related Mortality in Patients with Hepatitis C Virus Infection by Ran Noh, Doo Hyuck Lee, Byoung Woon Kwon, Yong Hyun Kim, Suk Bae Kim, Il Han Song

“…Old age (HR = 9.71, P=0.014), accompanying cirrhosis (HR = 19.34, P=0.004), and low platelet count (HR = 13.97, P=0.009) were other independent risk factors for the development of HCC. …”
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Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction by Xiaolong Qu, Pan Yang, Li Jiao, Yuehui Yin

“…Griess reaction method, immunofluorescence, and western blotting (WB) were employed to detect the expressions of nitric oxide (NO), platelet endothelial cell adhesion molecule-1 (CD31) and vascular endothelial (VE)-cadherin, zonula occludens protein 1 (ZO-1), occludin, vascular endothelial growth factor (VEGF) and adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling-related proteins in endothelial cells and mouse cardiomyocytes. …”
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Dynamic Changes in Parameters of Complete Blood Count Predict Disease Severity and Prognosis in Patients with COVID-19; A Prospective Study by Toktam Alirezaei, Mahdi Baratnia, Rama Bozorgmehr, Yasamansadat Keshmiri, Faezeh Ebrahimpour, Maryam Arefnia, Mohammadali Ghodsirad

“…Considering dynamic changes in blood elements, repeated measured ANOVA showed patients who survived had a decrease in WBC and Neutrophil count as well as Neutrophil to lymphocyte ratio (NLR) compared to expired patients; in contrast, platelet and lymphocyte count increased in survivors while dropped in deceased ones. …”
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The Effect of Diacerein on Type 2 Diabetic Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis by Shizhe Guo, Xianshan Guo, Hongya Zhang, Xuan’e Zhang, Zhen Li

“…Secondary outcomes were glycosylated hemoglobin A1c (HbA1c), body mass index (BMI), lipid profiles, hematological indexes including hematocrit and platelet count, and systematic inflammatory level expressed as a C-reactive protein (CRP) level. …”
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Contrast-Enhanced CT May Be a Diagnostic Alternative for Gastroesophageal Varices in Cirrhosis with and without Previous Endoscopic Variceal Therapy by Qianqian Li, Ran Wang, Xiaozhong Guo, Hongyu Li, Xiaodong Shao, Kexin Zheng, Xiaolong Qi, Yingying Li, Xingshun Qi

“…Liver fibrosis blood tests, platelet count/spleen diameter ratio (PSR), and contrast-enhanced CT are diagnostic alternatives for gastroesophageal varices, but they have heterogeneous diagnostic performance among different study populations. …”
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Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors by Shivangi Sharma, Sadashivamurthy Shamanth, Humaira Siddiqua, Laijau Goyary, Kunigal S. Sagar, Susmita Kumari, Divya Sathees, Gudapureddy Radha, Bibha Choudhary, Sathees C. Raghavan, Kempegowda Mantelingu

“…Previously, we reported a novel BCL2 inhibitor, Disarib, which inhibited BCL2 by predominantly binding to its BH1 domain and exhibited platelet-sparing ability like ABT199, the only FDA-approved BCL2 inhibitor. …”
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Assessment of Knowledge, Attitude, and Practices toward Knee Pain and Its Various Treatment Modalities among Patients by Akhil Bhalla, Sidharth Verma, Sanjog Ramrao Mekewar, Sasmit Dipak Lotliker, Aanchal Sharma, Oshin Agrawal, Maitri Shah, Hritik Madan, Dhriti Sood

“…A significant knowledge gap existed regarding advanced interventional procedures, with only a small fraction aware of options such as platelet-rich plasma injections and other minimally invasive interventions. …”
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PI3Kδ inhibitor linperlisib combined with gemcitabine and oxaliplatin for relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm phase Ib/II trial by Peng Sun, Hong Cen, Haiyan Yang, Rui Huang, Zhen Cai, Xuekui Gu, Hanying Bao, Zusheng Xu, Zuhong Xu, Zhi-Ming Li

“…Frequently observed adverse events included decreases in neutrophil counts (74.4%), white blood cell counts (64.1%) and platelet counts (64.1%). Conclusions This study highlights the potential of linperlisib plus GEMOX as a treatment for R/R DLBCL, demonstrating a tolerable safety profile and encouraging efficacy results. …”
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Inflammatory-Driven Angiogenesis in Bone Augmentation with Bovine Hydroxyapatite, B-Tricalcium Phosphate, and Bioglasses: A Comparative Study by Vlad M. Anghelescu, Ioana Neculae, Octavian Dincă, Cristian Vlădan, Claudiu Socoliuc, Mirela Cioplea, Luciana Nichita, Cristiana Popp, Sabina Zurac, Alexandru Bucur

“…The purpose of this study was to analyse the ability to integrate bone substitutes by evaluating the immunohistochemical expression of the platelet endothelial cell adhesion molecules, vascular endothelial growth factor, collagen IV, laminin, and osteonectin, in the vicinity of bone grafts, enabling tissue revascularization and appearance of bone lamellae. …”
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Persistent Mortality Risk From Device-related Healthcare-associated Infection in Kidney Transplant Recipients Despite Multifaceted Interventions Action Calls for a Zero-tolerance P... by Maria Bethânia Peruzzo, MD, Luana Oliveira Calegari, MSc, Renato Demarchi Foresto, MD, PhD, Helio Tedesco-Silva, MD, PhD, José Medina Pestana, MD, PhD, Lúcio Requião-Moura, MD, PhD

“…Additional variables associated with increased risk of death included age (HR, 1.03; P < 0.001), baseline immunosuppression (HR based on mycophenolate versus others 0.74; P = 0.02), time since transplantation (HR, 1.003; P < 0.001), platelet count at ICU admission (HR, 0.998; P < 0.001), and sepsis as the reason for ICU admission (HR, 1.67; P < 0.001). …”
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The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche by Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza

“…Human blood derivatives, for example, platelet-rich plasma (PRP) releasates, are potential replacements of FCS; however, it is unclear which serum variant has the best effect on the given cell or tissue type. …”
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