Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis by Hande Guclu, Sadık Altan Ozal, Vuslat Pelitli Gurlu, Ramazan Birgul

“…To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the frequency of the ON episodes. …”
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The Use of Thrombopoietin Receptor Agonists for Correction of Thrombocytopenia prior to Elective Procedures in Chronic Liver Diseases: Review of Current Evidence by Kamran Qureshi, Shyam Patel, Andrew Meillier

“…These agents seem promising in raising platelet counts before elective procedures resulting in reduction in platelet transfusions, and they also enabled more patients to undergo the procedures. …”
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Thrombocytopenia in Plasmodium vivax Malaria: How Significant? by Arti Muley, Jitendra Lakhani, Saurabh Bhirud, Abhinam Patel

“…A total of 66 patients were included. 42 (63%) had platelet count <100000/mm3. Mean platelet count was 1,18,650, range being 8000/mm3–6,10,000/mm3. …”
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A Curious Case of Pseudothrombocytopenia due to In Vitro Agglutination by Le Zhong, Juskaran Chadha, Ali Ameri

“…The EDTA-dependent mechanism of PTCP occurs due to a conformational change of platelet surface glycoprotein IIb/IIIa (GPIIb/IIIa) caused by EDTA, which allows natural IgM or IgG auto-antibodies to bind to GPIIb/IIIa, leading to platelet agglutination. …”
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Impact of antiplatelet therapy on hemostatic plug formation in the setting of thrombocytopenia by Robert H. Lee, Abigail Ballard-Kordeliski, Summer R. Jones, Wolfgang Bergmeier

“…Objectives: To systematically investigate the combined effect of thrombocytopenia and APT in mouse models of hemostasis and thrombosis. Methods: Platelet-depleted mice were repleted with donor platelets inhibited with aspirin and/or clopidogrel at low (<1 × 108/mL) or normal (>2) platelet counts. …”
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Rivaroxaban Treatment for Heparin-Induced Thrombocytopenia: A Case Report and a Review of the Current Experience by Mohamed Aon, Omar Al-Shammari

“…Direct oral anticoagulants do not cause platelet activation in the presence of heparin-platelet factor 4 antibodies, nor do they provoke autoantibody production. …”
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Anti-HPA-1b Mediated Posttransfusion Purpura: A Case Report by O. P. Arewa, S. Nahirniak, G. Clarke

“…PTP is caused by alloimmunization to human platelet specific antigens following blood component transfusion. …”
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The Role of PPARs in the Endothelium: Implications for Cancer Therapy by David Bishop-Bailey, Karen E. Swales

“…In addition, inflammation, coagulation, and platelet activation are common signals in the growth and metastasis of tumour cells. …”
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Performance of PRP Associated with Porous Chitosan as a Composite Scaffold for Regenerative Medicine by Andréa Arruda Martins Shimojo, Amanda Gomes Marcelino Perez, Sofia Elisa Moraga Galdames, Isabela Cambraia de Souza Brissac, Maria Helena Andrade Santana

“…This study aimed to evaluate the in vitro performance of activated platelet-rich plasma associated with porous sponges of chitosan as a composite scaffold for proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells. …”
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Sustained Remission in Patients with Primary Immune Thrombocytopenia after Romiplostim Tapering and Discontinuation: A Case Series in Real Life Management in Spain by María-Eva Mingot-Castellano, Carlos Grande-García, David Valcárcel-Ferreiras, Clara Conill-Cortés, Loreto de Olivar-Oliver

“…Romiplostim, a thrombopoietin-receptor agonist (TPO-ra), is a highly effective option in primary immune thrombocytopenia (ITP), with 80–90% of patients achieving platelet responses after few weeks of treatment. The evidence showing remissions, that is, sustained platelet counts after romiplostim discontinuation, in patients with ITP refractory to immunosuppressive therapy is steadily increasing. …”
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Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy by Ahmed Sabra Ibrahim Mohammed Sabra, Shreen Naguib Aboelezz Moselhy, Ahmed Kasem Mohamed Zain Eldin

“…Abstract Objective: Included evaluation of the possibility of using the systemic inflammatory indices for preoperative screening for the presence and severity of endometriosis (EM) in comparison to the findings of the exploratory laparoscopy Methods: 88 women with clinical manifestations suggestive of EM were evaluated clinically and by US and gave blood samples for estimation of serum cancer antigen-125 (CA125), platelet and total and differential leucocytic counts for calculation of inflammatory indices; the Systemic Immune-Inflammation index, the Systemic Inflammation Response Index (SIRI), the Neutrophil-Lymphocyte ratio (NLR), the Neutrophil-Monocyte ratio, the Neutrophil-Platelet ratio and the Platelet-Lymphocyte ratio. …”
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A nonactivating ITGB3 mutation in the β3 cytoplasmic region causes macrothrombocytopenia with an impaired αIIbβ3/RhoA pathway by Keiichi Nakata, Keigo Akuta, Takaya Endo, Midori Koike, Daisuke Motooka, Daisuke Okuzaki, Hisashi Kato, Yoshiaki Tomiyama, Naoki Hosen, Hirokazu Kashiwagi

“…Platelet αIIbβ3 and GPVI expression were decreased in KI mice, and αIIbβ3 activation was not detected in nonstimulated KI platelets. …”
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Recurrent Gastrointestinal Hemorrhage in Children with Philadelphia-Positive B-Cell Acute Lymphoblastic Leukemia Treated with Dasatinib: Case Reports by Xin Liao, Yuxia Guo, Yali Shen, Jianwen Xiao

“…We report three Chinese children with Ph + B-ALL who received a combination treatment of chemotherapy and dasatinib and developed gastrointestinal bleeding several months later. The platelet count and clotting tests were normal, and these patients presented with dasatinib-induced platelet dysfunction. …”
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An Unusual Cause of Secondary ITP in a 34-Year-Old Hispanic Male by Ayrton Bangolo, Mohamed Ahmed, Ali Atoot, Ashraf Mahmoud, Chibuzo Agbakwuru-Onyike, Maria Karina Larni Y. Palad, Michael Sciarra, Adam Atoot

“…H. pylori eradication has been recommended in the management of ITP with studies showing improvement in the platelet count in some patients. Substantial platelet count increases in patients with severe thrombocytopenia (platelet counts <30 × 103 microliter), however, are uncommon with H. pylori treatment alone. …”
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Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein by Pooja Gogia, Yiqing Xu

“…Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. …”
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Successful Management of Acute Catastrophic Juvenile Vaginal Bleeding in Glanzmann’s Thromboasthenia by Uterine Tamponade: A Case Report and Review of The Literature by Nazli Hossain, Tahir S. Shamsi, Adeel Feroz

“…Glanzmann’s thromboasthenia (GT) is a rare platelet disorder, due to membrane defects involving glycoprotein GP IIb/IIIa complex. …”
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Association of haplotypes for SNPs in the LTR regions of bovine leukemia virus with hematological indices of cattle by N. V. Blazhko, S. Kh. Vyshegurov, A. S. Donchenko, K. S. Shatokhin, T. I. Krytsyna, V. A. Ryabinina

“…We performed the total count of white blood cells (WBC), lymphocyte (lymf), granulocyte (gran), monocyte (mon), red blood cell (RBC), hemoglobin (HGB), hematocrit (HTC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit count (PCT). …”
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Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura by Zakaria Hindi, Nirmal Onteddu, Christopher A. Ching, Abdallah A. Khaled

“…Although stroke in patients with ITP is very rare due to thrombocytopenia, it has been reported in several other published cases and is likely associated with increased platelet microparticle levels, a byproduct of platelet destruction. …”
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Acute Immune-Mediated Thrombocytopenia due to Oxaliplatin and Irinotecan Therapy by Eric L. Tam, Padma L. Draksharam, Jennifer A. Park, Gurinder S. Sidhu

“…After supportive care, the platelet counts rapidly improved to 76,000/μL. Upon initiation of FOLFIRI and cetuximab chemotherapy, she again developed rectal bleeding and severe thrombocytopenia with a platelet count of 6000/μL. …”
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Oxford-AstraZeneca Coronavirus Disease-2019 Vaccine-Induced Immune Thrombocytopenia on Day Two by Azhar Kareem Razzaq, Ameer Al-Jasim

“…Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by platelet damage, life-threatening thrombocytopenia, and haemorrhage when the platelet count reaches below 20 × 109/mcL. …”
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