Study of the effect of formulation variables on the characteristics of combination tablets containing enalapril maleate and indapamide as active substances using experimental desig... by Szabó Zoltán-István, Székely-Szentmiklósi Blanka, Deák Boglárka, Székely-Szentmiklósi István, Kovács Béla, Zöldi Katalin, Sipos Emese

Subjects: Get full text

Experimental hypothermia by cold air: a randomized, double-blind, placebo-controlled crossover trial by Ane M. Helland, Sigurd Mydske, Jörg Assmus, Guttorm Brattebø, Øystein Wiggen, Haakon K. Kvidaland, Øyvind Thomassen

“…Each participant completed the experimental procedure twice, once receiving active drugs (meperidine and buspirone) and once receiving placebo. The experiments were separated by a one-week wash-out period. …”
Get full text

Use of amantadine in traumatic brain injury: an updated meta-analysis of randomized controlled trials by João Félix, Luísa Araújo, Antônio Henriques, Ana Pereira, Saul Carneiro

Subjects: Get full text

The role of Ashwagandha in modulating gut parameters in dogs—a randomized double-blind placebo-controlled trial by Kala Kumar Bharani, Ashok Kumar Devarasetti, Rajendar Bobbili, Amit Khurana, Donga Durga Veera Hanuman, Roupesh Gudepu, Swapna Guda

“…We hypothesized that ARE might promote a healthy gut by its adaptogenic and anti-inflammatory effects and improve vital parameters for healthy ageing.MethodsA randomized, double-blind, placebo-controlled trial was conducted in Telangana, India. …”
Get full text

Ultra-small phospholipid nanoparticles in the treatment of combined hyperlipidemia: a randomized placebo-controlled clinical trial by Alexander Archakov, Valery Kukharchuk, Andrey Lisitsa, Elena Ponomarenko, Yulia Romashova, Tatiana Pleshakova, Elena Yarovaya, Vladimir Kutsenko, Maria Guseva, Valery Beregovykh, Olga Ipatova, Marina Zubareva, Elena Tikhonova, Sergei Ivanov, Farid Bedretdinov, Sergey Markin

“…Phospholipovit or placebo was randomly administered orally (500 mg) 2 times a day for 12 weeks. …”
Get full text

Caffeine supplement, inflammation, and hepatic function in cirrhotic patients: A randomized, placebo- controlled, clinical trial by Seyed Ali Abbas-Hashemi, Zahra Yari, Behzad Hatami, Amir Anushiravani, Shadi Kolahdoozan, Ali Zamanian, Nadia Akbarzadeh, Azita Hekmatdoost

“…Methods: In this randomized, double-blind, placebo-controlled trial, fifty patients with cirrhosis were randomly assigned to receive either caffeine supplement (400 mg), or placebo for eight weeks. …”
Get full text

Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial by Thunshuda Sumphaongern, Pornchai Jansisyanont

“…The study group received intravenous paracetamol and the control group received a placebo immediately postoperation. The visual analogue pain scale (VAS) at 1-, 4-, 8-, 12-, 16-, 20-, and 24 -h postoperatively, morphine consumption, side effects from morphine, and patient satisfaction were analyzed. …”
Get full text

Vibration therapy as an intervention for trochanteric hip fractures – A randomized double-blinded, placebo-controlled trial by Ronald Man Yeung Wong, Pui Yan Wong, Chaoran Liu, Chun Sing Chui, Wing Hong Liu, Ning Tang, James Griffith, Ning Zhang, Wing Hoi Cheung

“…Methods: A randomized double-blinded, placebo-controlled clinical trial was conducted. Participants were randomly assigned into LMHFV or placebo intervention for 14 days. …”
Get full text

Longitudinal Study on Low-Dose Aspirin versus Placebo Administration in Silent Brain Infarcts: The Silence Study by Ilaria Maestrini, Marta Altieri, Laura Di Clemente, Edoardo Vicenzini, Patrizia Pantano, Eytan Raz, Mauro Silvestrini, Leandro Provinciali, Isabella Paolino, Carmine Marini, Matteo Di Giuseppe, Tommasina Russo, Francesco Federico, Cristiana Coppola, Maria Pia Prontera, Domenico Maria Mezzapesa, Vincenzo Lucivero, Lucilla Parnetti, Paola Sarchielli, Maria Peducci, Domenico Inzitari, Giovanna Carlucci, Carlo Serrati, Carla Zat, Anna Cavallini, Alessandra Persico, Giuseppe Micieli, Stefano Bastianello, Vittorio Di Piero

Get full text

Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Methods/design This is a single-center, randomized, placebo-controlled clinical phase 2 trial, investigating the clinical superiority of Salovum® given as a food supplement during 5 days to adults with severe TBI (Glasgow Coma Scale (GCS) < 9), admitted to the neurocritical intensive care unit (NICU) at Skane university hospital, Lund, Sweden. …”
Get full text

Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial by Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou

“…Patients will be randomly divided into two equal groups and treated with a combination of adrenocorticotropic hormone, magnesium sulfate and either melatonin or placebo. Clinical data from the patients in the two groups before and after the treatment will be collected and compared. …”
Get full text

Isosorbide mononitrate for preinduction cervical ripening at or post-term pregnancy: randomised placebo-controlled clinical trial by Ramy Mohamed El-Naggar, Ahmed Nagy Shaker, Mohamed Attia Raslan, Heba Rady El-Bassyouny

“…The ISMN group received 40 mg of intravaginal ISMN in the posterior fornix every 4 hours, up to four doses. The placebo group received intravaginal pyridoxine placebos on the same schedule. …”
Get full text

Risperidone versus placebo for aggression following traumatic brain injury: a feasibility randomised controlled trial by Paul Bassett, Tim Weaver, Shoumitro Deb, Mike Crawford, David Sharp, Lina Aimola, Verity Leeson, Mayur Bodani, Lucia Li

“…Objectives To conduct a feasibility randomised controlled trial of risperidone for the treatment of aggression in adults with traumatic brain injury (TBI).Design Multicentre, parallel design, placebo controlled (1:1 ratio) double-blind feasibility trial with an embedded process evaluation. …”
Get full text

A safety and feasibility randomized placebo controlled trial exploring electroencephalographic effective connectivity neurofeedback treatment for fibromyalgia by Lucy Anderson, Dirk De Ridder, Paul Glue, Ramakrishnan Mani, Cindy van Sleeuwen, Mark Smith, Divya Bharatkumar Adhia

“…Participants with fibromyalgia (N = 30; 15 = active, 15 = placebo) received 12 sessions of neurofeedback. Feasibility and outcome measures of pain (Brief Pain Inventory) and function (Revised Fibromyalgia Impact Questionnaire) were collected at baseline and immediately, ten-days, and one-month post-intervention. …”
Get full text

A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Methods: Outpatients with a typical ALS presentation were enrolled in a randomized, placebo-controlled trial to assess the efficacy of orally administered VPA-Li. …”
Get full text

Controlled-Release Oxycodone and Naloxone in the Treatment of Chronic Low Back Pain: A Placebo-Controlled, Randomized Study by C Cloutier, J Taliano, W O’Mahony, M Csanadi, G Cohen, I Sutton, D Sinclair, M Awde, S Henein, L Robinson, J Eisenhoffer, PS Piraino, Z Harsanyi, KJ Michalko

Get full text

Motion-Cyclo-oxygenase-2 Selective Nonsteroidal Anti-Inflammatory Drugs are as Safe as Placebo for the Stomach: Arguments for the Motion by Richard H Hunt

“…Endoscopic studies have revealed that coxibs are only half as likely to induce upper GI ulceration than are traditional NSAIDs, and are as safe as placebo. Furthermore, the newer drugs do not cause excessive blood loss from the GI tract and do not affect small bowel permeability. …”
Get full text

A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Methods: Outpatients with a typical ALS presentation were enrolled in a randomized, placebo-controlled trial to assess the efficacy of orally administered VPA-Li. …”
Get full text

Antioxidant Supplementation for Erectile Dysfunction: Systematic Review and Meta-Analysis of Double-Blind, Randomized, Placebo-Controlled Trials by Ranjith Ramasamy, Samir Bhattacharyya, Taylor P. Kohn, Larry E. Miller

“…Materials and Methods: We systematically searched MEDLINE, Embase, and the Cochrane Library for double-blind, randomized, placebo-controlled trials of oral antioxidant supplementation in men with ED. …”

Four weeks of slow-paced breathing: a longitudinal, randomized, placebo-controlled study of the autonomic nervous system by Nicolas Bourdillon, Arnaud Rochat, Vanessa Hoop, Grégoire P. Millet

“…The goal of this study was to test a personalized SPB training vs. placebo to help disentangle the effects of SPB from those solely linked to breathing awareness or distraction. …”
Get full text