Phenotypic Sorting of Pink Salmon Hatchery Strays May Alleviate Adverse Impacts of Reduced Variation in Fitness‐Associated Traits by Julia McMahon, Samuel A. May, Peter S. Rand, Kristen B. Gorman, Megan V. McPhee, Peter A. H. Westley

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The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…The epigenetic clock ‘Phenotypic Age’ (PhenoAge) represents ‘preclinical ageing’. …”
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Early Recurrence of C3 Glomerulopathy Postrenal Transplant Manifesting as Atypical Hemolytic Uremic Syndrome: A Phenotype Switch by Vishwanath Siddini, Anand Nikumbhe, Mohammed Fahad Khan, Mahesha Vankalakunti, H. Sudarshan Ballal

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Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence by Michele Ramos Valente, Lucas Martins Alcântara, Deborah Santos Cintra, Susana Ruiz Mendoza, Elisa Gonçalves Medeiros, Kamilla Xavier Gomes, Leandro Honorato, Marcos de Abreu Almeida, Carmen Baur Vieira, Joshua Daniel Nosanchuk, Diana Bridon da Graça Sgarbi, Marcia Ribeiro Pinto, Leonardo Nimrichter, Allan Jefferson Guimarães

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Stress-Induced Premature Senescence or Stress-Induced Senescence-Like Phenotype: One In Vivo Reality, Two Possible Definitions? by Olivier Toussaint, Patrick Dumont, Jose Remacle, Jean-Francois Dierick, Thierry Pascal, Christophe Frippiat, Joao Pedro Magalhaes, Stephanie Zdanov, Florence Chainiaux

“…Stress-induced premature senescence-like phenotype and telomere-dependent replicatively senescent cells share basic similarities such as irreversible growth arrest and resistance to apoptosis, which may appear through different pathways. …”
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Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy by Yue Wang, Kevin Chang, Aslan Mansurov, Jun Ishihara, Seounghun Kang, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Brendan T K Berg, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Melody A Swartz, Jeffrey A Hubbell

“…Therefore, the rational design of immune modulators that can control the immune suppressive properties of TAMs and polarize them, as well as dendritic cells (DCs), toward a more proinflammatory phenotype is a principal objective in cancer immunotherapy.Methods Here, using a protein engineering approach to enhance cytokine residence in the tumor microenvironment, we examined combined stimulation of the myeloid compartment via tumor stroma-binding granulocyte–macrophage colony-stimulating factor (GM-CSF) to enhance responses in both DCs and T cells via stroma-binding interleukin-12 (IL-12). …”
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Prediction of Blood Lipid Phenotypes Using Obesity-Related Genetic Polymorphisms and Lifestyle Data in Subjects with Excessive Body Weight by Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro, Marta Cuervo, Leticia Goni, J. A. Martinez

“…Four genetic risk scores (GRS) for each lipid phenotype were calculated by adding the risk genotypes. …”
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Automated Phenotypic Analysis of Mature Soybean Using Multi-View Stereo 3D Reconstruction and Point Cloud Segmentation by Daohan Cui, Pengfei Liu, Yunong Liu, Zhenqing Zhao, Jiang Feng

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Genotype-Phenotype Correlation of G6PD Mutations among Central Thai Children with G6PD Deficiency by Boonchai Boonyawat, Tim Phetthong, Nithipun Suksumek, Chanchai Traivaree

“…This study aimed to characterize the genotype-phenotype correlation of G6PD mutations in Thai pediatric patients who were followed-up in Phramongkutklao Hospital, a tertiary center in central Thailand. …”
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Smooth Muscle Cell Alignment and Phenotype Control by Melt Spun Polycaprolactone Fibers for Seeding of Tissue Engineered Blood Vessels by Animesh Agrawal, Bae Hoon Lee, Scott A. Irvine, Jia An, Ramya Bhuthalingam, Vaishali Singh, Kok Yao Low, Chee Kai Chua, Subbu S. Venkatraman

“…A method has been developed to induce and retain a contractile phenotype for vascular smooth muscle cells, as the first step towards the development of a biomimetic blood vessel construct with minimal compliance mismatch. …”
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Osteosarcopenic Visceral Obesity and Osteosarcopenic Subcutaneous Obesity, Two New Phenotypes of Sarcopenia: Prevalence, Metabolic Profile, and Risk Factors by Simone Perna, Daniele Spadaccini, Mara Nichetti, Ilaria Avanzato, Milena Anna Faliva, Mariangela Rondanelli

“…This study describes the prevalence, metabolic profile, and risk factors of two new phenotypes of sarcopenia: osteosarcopenic visceral obesity (OSVAT) and osteosarcopenic subcutaneous obesity (OSSAT). …”
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Comparison of phenotypic and genetic traits of ESBL-producing UPEC strains causing recurrent or single episode UTI in postmenopausal women by Michelle Kalu, Peter Jorth, Annie Wong-Beringer

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Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheep. by Julie Demars, Stéphane Fabre, Julien Sarry, Raffaella Rossetti, Hélène Gilbert, Luca Persani, Gwenola Tosser-Klopp, Philippe Mulsant, Zuzanna Nowak, Wioleta Drobik, Elzbieta Martyniuk, Loys Bodin

“…The two mutations were associated with the highly prolific phenotype (p FecX (Gr) = 5.98E(-06) and p FecX(O) = 2.55E(-08)). …”
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A New Case of 13q12.2q13.1 Microdeletion Syndrome Contributes to Phenotype Delineation by Giorgia Mandrile, Eleonora Di Gregorio, Alessandro Calcia, Alessandro Brussino, Enrico Grosso, Elisa Savin, Daniela Francesca Giachino, Alfredo Brusco

“…Clinical features resembling those reported in the literature confirm the existence of a distinct 13q12.3 microdeletion syndrome and provide further evidence that is useful to characterize its phenotypic expression during the 5 years of development.…”
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Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer by Yuwei Wang, Yadong Long, Ye Xu, Zuqing Guan, Peng Lian, Junjie Peng, Sanjun Cai, Guoxiang Cai

“…In the present study, the prognostic significance of CpG island methylator phenotype (CIMP) in stage II/III sporadic colorectal cancer was evaluated using a five-gene panel. …”
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Development and Validation of a Prognostic Molecular Phenotype and Clinical Characterization in Grade III Diffuse Gliomas Treatment with Radio-Chemotherapy by Gu W, Tang J, Liu P, Gan J, Lai J, Xu J, Deng J, Liu C, Wang Y, Zhang G, Yu F, Shi C, Fang K, Qiu F

“…Weiguo Gu,1,2,* Jiaming Tang,2,* Penghui Liu,1 Jinyu Gan,1 Jianfei Lai,1 Jinbiao Xu,2 Jianxiong Deng,2 Chaoxing Liu,1 Yuhua Wang,2 Guohua Zhang,3 Feng Yu,1,2 Chao Shi,2,3 Ke Fang,2 Feng Qiu2,3 1Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Oncology, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 3Nanchang Key Laboratory of Tumor Gene Diagnosis and Innovative Treatment Research, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Qiu, Department of Oncology, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China, Email ndyfy01149@ncu.edu.cn Ke Fang, Department of Oncology, Gaoxin Branch of the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, People’s Republic of China, Email fangkeqq88@163.comBackground: The relationship between molecular phenotype and prognosis in high-grade gliomas (WHO III and IV, HGG) treated with radiotherapy and chemotherapy is not fully understood and needs further exploration.Methods: The HGG patients following surgery and treatment with radiotherapy and chemotherapy. …”
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Phenotypic Diversity of Doum Palm (Hyphaene compressa), a Semi‐Domesticated Palm in the Arid and Semi‐Arid Regions of Kenya by Agnes Omire, Nancy L. M. Budambula, Johnstone Neondo, Robert Gituru, Cecilia Mweu

“…All seven quantitative traits were able to effectively discriminate doum palm phenotypically p≤0.001. The 90 accessions clustered into five morphotypes designated as 1, 2, 3, 4, and 5. …”
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High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity by Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Pradeep A. Menon, Subash Babu

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A modified procedure for the evaluation of the amylose and amylopectin content in potato starch by Yu. A. Khoroshavin, V. K. Khlestkin

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Mining functional gene modules by multi-view NMF of phenome-genome association by Xu Jin, WenQian He, MingMing Liu, Lin Wang, YaoGong Zhang, YingJie Xu, Ling Ma, YaLou Huang, MaoQiang Xie

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