Construction and Optimization of Integrated Yield Prediction Model Based on Phenotypic Characteristics of Rice Grown in Small–Scale Plantations by Jihong Sun, Peng Tian, Zhaowen Li, Xinrui Wang, Haokai Zhang, Jiangquan Chen, Ye Qian

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Impact of dapagliflozin on metabolic phenotype, hormone levels, and fertility in female mice after prolonged high-fat diet by Xiaolin Chen, Zhuoni Xiao, Na Dai, Mingxia Fan

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Exploring New Delhi Metallo Beta Lactamases in Klebsiella pneumoniae and Escherichia coli: genotypic vs. phenotypic insights by Noor Ul Ain, Linzy Elton, Zahra Sadouki, Timothy D. McHugh, Saba Riaz

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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…The resulting T-cell products were assessed for phenotypic and functional characteristics.Results We identified an optimal Ag-scaffold for expansion of T-cells for ACT, carrying pMHC and interleukin-2 (IL-2) and IL-21, with which we efficiently expanded both virus-specific and tumor-specific CD8+ T cells from peripheral blood of healthy donors and patients, respectively. …”
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PHENOTYPIC CHARACTERISATION OF F1 HYBRIDS DERIVED FROM CROSS-BREEDING DOUBLE AND SINGLE PETUNIAS (PETUNIA HYBRIDA) by A. A. Sharef, J. M. Faraj, H. A. Mustafa, H. S. Othman, N. H. Abdul, N. H. Samsulrizal

“…Besides, data clustering analysis also identified distinct clusters based on phenotypic traits in the petunia population, which can be exploited for future breeding programs.…”
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LEAF-Net: A Unified Framework for Leaf Extraction and Analysis in Multi-Crop Phenotyping Using YOLOv11 by Ameer Tamoor Khan, Signe Marie Jensen

Subjects: “…plant phenotyping…”
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Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype by Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa Chapa, Karthik Ramachandran, Rahul S. Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh

“…Notably, the Mg2+ deficient diet or addition of TRPM7 agonist Naltriben suppresses the M1 phenotype while promoting angiogenic factors and fostering tumor growth. …”
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Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract by Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu

“…In the present study, an innovative natural product virtual screening-interaction-phenotype (NP-VIP) strategy that integrates virtual screening, chemical proteomics, and metabolomics to identify and validate the bioactive targets of NPs. …”
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GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling by Fan Zhang, Jingfei Meng, Hong Jiang, Xing Feng, Dongshan Wei, Wen Meng

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Homozygous CALR Mutation in Primary Myelofibrosis and Its Effect on Disease Phenotype: A Case Report and Review of the Literature by Qurratulain Rizvi, Uzma Zaidi, Saba Shahid, Shariq Ahmed, Tahir Shamsi

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CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Conclusion Our study presents the first in vivo evidence that CD2AP deficiency exacerbates the phenotypes and pathology of AD through the p38 MAPK pathway, identifying CD2AP/p38 MAPK as promising therapeutic targets for AD.…”
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Obesity phenotypes and dyslipidemia in adults from four African countries: An H3Africa AWI-Gen study. by Engelbert A Nonterah, Godfred Agongo, Nigel J Crowther, Shukri F Mohamed, Lisa K Micklesfield, Palwendé Romuald Boua, Alisha N Wade, Solomon S R Choma, Hermann Sorgho, Isaac Kissiangani, Gershim Asiki, Patrick Ansah, Abraham R Oduro, Shane A Norris, Stephen M Tollman, Frederick J Raal, Marianne Alberts, Michele Ramsay, as members of AWI-Gen and the H3Africa Consortium

“…<h4>Introduction</h4>The contribution of obesity phenotypes to dyslipidaemia in middle-aged adults from four sub-Saharan African (SSA) countries at different stages of the epidemiological transition has not been reported. …”
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CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization by Gowtham A. Rao, Azza Shoaibi, Rupa Makadia, Jill Hardin, Joel Swerdel, James Weaver, Erica A. Voss, Mitchell M. Conover, Stephen Fortin, Anthony G. Sena, Chris Knoll, Nigel Hughes, James P. Gilbert, Clair Blacketer, Alan Andryc, Frank DeFalco, Anthony Molinaro, Jenna Reps, Martijn J. Schuemie, Patrick B. Ryan

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Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage by Mira Hanna, Ahmed M. A. Akabawy, Mohamed Mansour Khalifa, Mohamed Mansour Khalifa, Marawan Abd Elbaset, Reda Abdelnasser Imam, Hanan Seddiek

“…There was a correlation between iron overload and M1 macrophage polarization with CD163+ phenotype, together with fibrotic changes. The intracellular iron overload with downregulation of ferritin was strongly related to macrophage polarization that was exaggerated at 72 h. …”
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High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy. by Yu Zhao, Yuteng Jiang, Fengmei Wang, Li Sun, Mengyuan Ding, Liyuan Zhang, Beibei Wu, Xiaoliang Zhang

“…<h4>Aim</h4>Imbalanced M1/M2 macrophage phenotype activation is a key point in diabetic kidney disease (DKD). …”
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APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence by Jingyi Xie, Daniel G. Chen, William Chour, Rachel H. Ng, Rongyu Zhang, Dan Yuan, Jongchan Choi, Michaela McKasson, Pamela Troisch, Brett Smith, Lesley Jones, Andrew Webster, Yusuf Rasheed, Sarah Li, Rick Edmark, Sunga Hong, Kim M. Murray, Jennifer K. Logue, Nicholas M. Franko, Christopher G. Lausted, Brian Piening, Heather Algren, Julie Wallick, Andrew T. Magis, Kino Watanabe, Phil Mease, Philip D. Greenberg, Helen Chu, Jason D. Goldman, Yapeng Su, James R. Heath

“…We leverage this comprehensive dataset to integrate with peptide antigen properties, TCR CDR3 sequences, and T cell phenotypes to show that distinct physicochemical features of the antigen-TCR pairs strongly associate with both T cell phenotype and T cell persistence. …”
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Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women by Leonie Fleige, Silvia Capellino

“…In monocytes from women, an acute inflammatory stimulus via CpG combined with dopaminergic stimulation caused a switch to a proinflammatory phenotype, which was less pronounced in men. These novel findings in sex-specific responses to dopaminergic stimulation are crucial for understanding DA’s function in the healthy and activated immune system and provide evidence to treat DA-related pathologies in a sex-specific manner.…”
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Phenotyping of Chronic Obstructive Pulmonary Disease Using the Modified Bhalla Scoring System for High-Resolution Computed Tomography by Baykal Tulek, Ali Sami Kivrak, Seda Ozbek, Fikret Kanat, Mecit Suerdem

“…BACKGROUND: Identifying different phenotypes of chronic obstructive pulmonary disease (COPD) is important for both therapeutic options and clinical outcome of the disease.…”
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Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel by Rachelle E. Koch, Jackson Barth, Andrew E. Clark, Dhara Desai, Jiwoong Kim, Christine A. Pybus, Xiaowei Zhan, Leonard Leibovici, Dafna Yahav, David E. Greenberg

“…However, a better understanding of the relationship between bacterial genetic markers, phenotypic resistance, and clinical outcomes is needed. …”
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Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division. by Nelio T L Rodrigues, Tom Bland, KangBo Ng, Nisha Hirani, Nathan W Goehring

“…By quantitatively linking alterations in protein dosage to phenotype in individual embryos, we show that spatial information in the zygote is read out in a highly nonlinear fashion and, as a result, phenotypes are highly canalized against substantial variation in input signals. …”
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