Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes. by Ulrich F Prodjinotho, Charlotte von Horn, Alex Y Debrah, Linda Batsa Debrah, Anna Albers, Laura E Layland, Achim Hoerauf, Tomabu Adjobimey

“…Our findings suggest that quantitative and qualitative alterations in IgG4 molecules are associated with the different clinical phenotypes in LF endemic regions.…”
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Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal by Roshan Pandit, Balkrishna Awal, Sumesh Shreekhanda Shrestha, Govardhan Joshi, Basista Prasad Rijal, Narayan Prasad Parajuli

“…Escherichia coli (n = 154), the predominant pathogen associated with UTI, was further investigated for the existence of ESBL enzymes by using conventional phenotypic as well as molecular approaches. Among suspected cases of UTI, we found that 15.2% were having UTI and female patients of the reproductive age group were more affected (p<0.05). …”
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Genetic diversity assessment in pea cultivars and lines using the SSR analysis by K. P. Gainullina, B. R. Kuluev, F. A. Davletov

“…The key role in the breeding of new pea cultivars is played by source material representing the phenotypic and genotypic diversity of Pisum sativum L., searched for in plant genetic resources collections. …”
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Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Moreover, key genes involved in pyrimidine de novo synthesis, such as RRM2, were identified as potential drivers of tumor progression, providing new insights into the molecular mechanisms underlying aggressive prostate cancer phenotypes. In conclusion, pyrimidine metabolism plays a critical role in prostate cancer progression, influencing immune infiltration and drug sensitivity. …”
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Molecular mechanisms and comparative transcriptomics of diapause in two corn rootworm species (Diabrotica spp.) by Melise C. Lecheta, Chad Nielson, B. Wade French, Emily A.W. Nadeau, Nicholas M. Teets

“…Comparative transcriptomic analyses between WCR and NCR indicated that while many gene expression changes were conserved across species, overall gene expression profiles were distinct, indicating that many transcriptional changes are species-specific, despite the close phylogenetic relationship and phenotypic similarity between these species. This study sheds light on the suite of mechanisms that allow some organisms to pause the symphony of cellular events that occur during embryonic development and persist for several months as a tiny egg. …”
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Screening approaches and potential of isolated lactic acid bacteria for improving fermentation of Saccharina latissima by Evangelia Zioga, Susan Løvstad Holdt, Fredrik Gröndahl, Claus Heiner Bang-Berthelsen

“…This approach is directed toward high-throughput (HT) methodologies, employing microwell assays for different phenotypical characteristics of lactic acid bacteria isolated from different sources. …”
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Proteomic and Metabolomic Characterization of Metabolically Healthy Obesity: A Descriptive Study from a Swedish Cohort by J. Korduner, P. M. Nilsson, O. Melander, M. J. Gerl, G. Engström, E. Bachus, M. Magnusson, F. Ottosson

“…This unique and extensive biomarker profiling presents novel data on potentially differentiating traits between these two obese phenotypes.…”
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Optimizing fully-efficient two-stage models for genomic selection using open-source software by Javier Fernández-González, Julio Isidro y Sánchez

“…Single-stage models predict GEBVs from phenotypic observations in one step, fully accounting for the entire variance-covariance structure among genotypes, but face computational challenges. …”
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Regions enriched for DNA repeats in chromosomes of Macrostomum mirumnovem, a species with a recent Whole Genome Duplication by K. S. Zadesenets, N. B. Rubtsov

“…Taking together, karyotype peculiarities (a high level of intraspecific karyotypic diversity associated with chromosome number variation, structural chromosomal rearrangements, and the formation of new regions enriched for DNA repeats) and some phenotypic features of M. mirumnovem (small body size, short lifecycle, easy maintenance in the laboratory) make this species a perspective model in the studies of genomic and karyotypic evolution in species passed through a recent WGD event.…”
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Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation by Jan Kassubek, Francesco Roselli, Simon Witzel, Johannes Dorst, Albert C. Ludolph, Volker Rasche, Ina Vernikouskaya, Hans-Peter Müller

“…This unbiased CNN-based hypothalamus volume quantification study demonstrated similarly reduced hypothalamus volume in PLS and ALS patients, despite the clinical phenotypic differences.…”
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Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains by Jong Whi Kim, Sung Min Nam, Dae Young Yoo, Hyo Young Jung, Il Yong Kim, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoon

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Genome-wide development of simple sequence repeat (SSR) markers at 2-Mb intervals in lotus (Nelumbo Adans.) by Fengluan Liu, Lin Xi, Naifeng Fu

“…Conclusion These SSR markers, which have a density of 1 SSR marker per 1.76 Mb in this study, will act as a bridge connecting lotus phenotypes with the genome. This work reveals a novel and convenient strategy for developing highly polymorphic SSR markers at any location throughout the lotus genome, and it sheds light on the development of SSR molecular markers in other plant species.…”
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Genetic aspects of major blood metabolites in the Italian Simmental cattle population by S. Magro, A. Costa, A. Cesarani, L. Degano, M. De Marchi

“…In the present study, we estimated h2 of BHB, NEFA, and urea in blood predicted from milk mid-infrared spectra and assessed their genetic correlation with milk yield and composition traits in the Italian Simmental cattle breed using phenotypes of 3,549 cows in 207 herds. Two sets were considered: early (1,920 records, 1 per cow, between 5 and 35 DIM) and whole (14,378 records, at least 3 per cow, between 5 and 305 DIM) lactation. …”
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Integrating univariate and multivariate stability indices for breeding clime-resilient barley cultivars by Ammar Elakhdar, Ahmed A. El-Naggar, Sally El-Wakeell, Anas H. Ahmed

“…Abstract Studying genetic variability through the phenotypic performance of genotypes is crucial in the breeding program. …”
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Genetic Variability Analysis and Association of Traits in Common Bean (Phaseolus vulgaris L.) Landraces Collected from Ethiopia at Jimma by Eyuel Mesera, Garome Shifaraw, Sentayehu Alamerew, Birhanu Amsalu

“…This highly significant difference indicates the existence of large variability among genotypes. High phenotypic coefficients of variation and genotypic coefficients of variation were obtained for plant height (19.43, 11.73), pod length (11.27, 10.69), and 100-seed weight (15.42, 12.74). …”
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Molecular Detection and Multidrug Resistance of Shigella spp. Isolated from Wild Waterfowl and Migratory Birds in Bangladesh by Jarna Karmoker, Md. Saiful Islam, Md. Liton Rana, Md. Ashek Ullah, Fahim Haque Neloy, Nahian Muniath Oishy, Pritom Kumar Pramanik, Mahbubul Pratik Siddique, Sukumar Saha, Md. Tanvir Rahman

“…A disk diffusion assay was employed to investigate antibiotic phenotypes, while the resistance genes were detected by PCR. …”
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Chinese cabbage orphan gene BR3 confers bolting resistance to Arabidopsis through the gibberellin pathway by Yuting Zhang, Mingliang Jiang, Shurui Sun, Zongxiang Zhan, Xiaonan Li, Zhongyun Piao

“…BR3OE plants showed no significant phenotypic differences after vernalization treatment. …”
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Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles by D. V. Petrovskii, A. V. Romashchenko, S. Yu. Troitskii, M. P. Moshkin

“…The correlation found between our data and some well-known phenotypic characteristics (phenome.jax.org) of the mouse strains used confirms this hypothesis.…”
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Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacology by Laiyi Wan, Wentao Hao, Leilei Li, Lin Wang, Yanzheng Song

“…Results Our scRNA-seq analysis identified notable heterogeneity among macrophages, revealing predominant M2-like phenotypes within TAMs. Network pharmacology highlighted active TCM ingredients, including quercetin, isorhamnetin, and kaempferol, targeting genes related to macrophage function. …”
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A Mendelian randomization study: physical activities and chronic kidney disease by Rui Xiao, Li Dong, Bo Xie, Beizhong Liu

“…Genome-wide association studies from the UK Biobank baseline data were used for physical activity phenotypes and included 460,376 participants. For kidney function (estimated Glomerular Filtration Rate (eGFR) and CKD, with eGFR < 60 mL/min/1.73 m2), CKDGen Consortium data were used, which included 480,698 CKD participants of European ancestry. …”
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