655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations by Stefania Tommasi, Vita Fedele, Rosanna Lacalamita, Michele Bruno, Francesco Schittulli, David Ginzinger, Gery Scott, Serenella Eppenberger-Castori, Daniele Calistri, Silvia Casadei, Ian Seymour, Salvatore Longo, Gianluigi Giannelli, Brunella Pilato, Giovanni Simone, Christopher C. Benz, Angelo Paradiso

“…In conclusion, these findings point to the existence of an association of ERBB2 allelic variants at both loci with specific breast tumor phenotypes and to the need of deeply investigate different gene SNPs association for risk defining.…”
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Valorization of rice stubble through biodegradation using hydrolytic enzyme-producing Olivibacter oleidegradans CMB10 and Agrobacterium pusense SFMB9 by Milind Gajbhiye, Sushmita Patil, Sagar Awate, Supriya Kokare, Siddharth Terdale, Manish Kumar Dubey

“…Both were Gram-negative, rod-shaped and non-motile. They were phenotypically characterized concerning Bergey's Manual of Determinative Bacteriology followed by molecular characterization by 16S rRNA gene sequencing and CMB10 and SFMB9 were identified as Olivibacter oleidegradans and Agrobacterium pusense, respectively. …”
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Detection of β-Lactamases and Outer Membrane Porins among Klebsiella pneumoniae Strains Isolated in Iran by Ali Hashemi, Fatemeh Fallah, Soroor Erfanimanesh, Parastu Hamedani, Shadi Alimehr, Hossein Goudarzi

“…ESBLs, MBL, Amp-C, and KPC producing strains were detected by phenotypic confirmatory test, combination disk diffusion test (CDDT), Amp-C detection kit, and modified Hodge test, respectively. …”
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Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein by Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

“…These approaches lack information on protein dynamics, are limited by microscope resolution, and are insensitive to subtle condensation phenotypes missed by overfit analysis pipelines. Here, we evaluate two alternative cell-based assays: high-throughput single molecule tracking (htSMT) and proximity-based condensate biosensors using NanoBIT (split luciferase) and NanoBRET (bioluminescence resonance energy transfer) technologies. …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…A prognostic risk score model based on clinical phenotypic features was built using LASSO regression and step multi-Cox analyses. …”
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The use of molecular-genetic and phytopathological methods to identify genes for effective leaf rust resistance in Aegilops accessions by L. G. Tyryshkin, M. A. Kolesova

“…From a theoretical viewpoint, the presence of a certain amplification fragment can hardly be interpreted as a definite proof of the presence of a resistance gene: during the species evolution, recombinations and mutations could occur, resulting in disturbance of the fragment’s presence and phenotypic expression of its connection with resistance. …”
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Cellular Contractility Profiles of Human Diabetic Corneal Stromal Cells by Thi N. Lam, Sarah E. Nicholas, Alexander Choi, Jian-Xing Ma, Dimitrios Karamichos

“…Overall, both T1DMs and T2DMs exhibited increased contractility associated with fibrotic phenotypes. These findings, and future studies, may contribute to better understanding of the pathobiology of diabetic keratopathy and ultimately the development of new therapeutic approaches.…”
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Screening of local barley accessions for sensitivity to photoperiod by I. A. Zveynek, O. N. Kovaleva

“…., var. ricotense Regel; Genotype Eam8Eam8) responding to a short day.Results and conclusions. Phenotypic screening of barley samples from 26 countries with a short photoperiod resulted in identification of 1379 forms with the Eam8Eam8 genotype (sensitive to a short day), 44 accessions with the eam8eam8 genotype (insensitive to a short photoperiod), and 37 heterogeneous accessions. …”
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Expanding the clinical spectrum of 19p13.3 microduplication syndrome: a case report highlighting nephrotic syndrome and literature review by Wenjie Sun, Hong Yan, Mengxin Sun, Jie Wang, Kunxia Li

“…Conclusion Microduplication in the 19p13.3 region could be one of the genetic factors contributing to the observed clinical phenotypes. However, patients with developmental delay, microcephaly, distinctive facial features, congenital heart defects, and urogenital system disorders may exhibit these manifestations due to various genetic syndromes; therefore, simply considering the possibility of 19p13.3 microduplication syndrome based on these non-specific features is not sufficient. …”
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Prevalence of Malnutrition According to the Global Leadership Initiative on Malnutrition Criteria in Community-dwelling Older Adults in Turkey by Filiz DEMIRDAG, Esma Nur KOLBASI, Ozlem PEHLIVAN

“…The severity of malnutrition was determined as severe or moderate based on the phenotypic criteria of GLIM. Results: Five hundred sixty-nine (69% female, mean age 74.42+-6.58 years) community-dwelling older adults participated in this study. …”
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Lodging in wheat: genetic and environmental factors and ways of overcoming by E. V. Ageeva, I. N. Leonova, I. E. Likhenko

“…It has been found that loci with high phenotypic effects on lodging tolerance are colocalized with loci responsible for plant height, stem diameter and stem strength. …”
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Prevalence of the polymorphic H-ficolin (FCN3) genes and mannosebinding lectin-associated serine protease-2 (MASP2) in indigenous populations from the Russian Arctic regions by M. V. Smolnikova, S. Yu. Tereshchenko

“…An additional analysis of infectious morbidity in Arctic populations allows one to find phenotypic characteristics related to a high functional activity of the lectin pathway of complement activation as an most important factor for the first-line of anti-infectious defense, including such new viral diseases as COVID-19.…”
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Molecular Epidemiology of Escherichia coli Resistant to Carbapenems, Fluoroquinolones, and Aminoglycosides Isolated from One of the Largest Hospitals in Vietnam in 2014–2019 by Tohru Miyoshi-Akiyama, Do Van Thanh, Truong Thai Phuong, Nguyen Quang Huy, Pham Thi Phuong Thuy, Teruo Kirikae, Pham Hong Nhung, Norio Ohmagari

“…This study was designed to clarify the molecular epidemiology of Escherichia coli isolates resistant to carbapenems, fluoroquinolones, and aminoglycosides isolated from patients admitted to one of the largest hospitals in Vietnam in 2014–2019 based on both whole-genome sequencing (WGS) and phenotypic data. Methodology. Sixty-seven Vietnamese isolates screened by drug resistance by the disk test were subjected to WGS, and their sequences were analyzed to determine their multilocus sequence type (MLST), O-types, H-types, distribution of drug resistance genes, plasmid types, pathogenicity islands (PIs), virulence factor distribution, and phylogenetic evolution using the WGS data. …”
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Shared rare genetic variants in multiplex autism families suggest a social memory gene under selection by Kang Seon Lee, Taeyeop Lee, Mujun Kim, Elizaveta Ignatova, Hyo-Jeong Ban, Min Kyung Sung, Younghoon Kim, Youn-Jae Kim, Jin-Hee Han, Jung Kyoon Choi

“…Various mouse behavioral tests showed that Frrs1l knockout specifically impairs social novelty recognition without altering other behavioral phenotypes. Furthermore, we constructed humanized mice by introducing human sequences into a mouse genome. …”
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The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes by Avia Paz, Kareem Midlej, Osayd Zohud, Iqbal M. Lone, Fuad A. Iraqi

“…Results Our findings demonstrated significant variations in the recorded phenotypes across different CC lines compared to the reference mouse line, C57BL/6J. …”
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Evaluation of genetic differences between two autochthonous Spanish cattle breeds by Paola E. Milia, Alberto Cesarani, Clara Diaz, Cristina Meneses, Juan Carlos Parejo, Laura Falchi, Nicolò P. P. Macciotta, Corrado Dimauro

“…This study confirmed that the two breeds, different at phenotypic level, are different also at genetic level. …”
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Helicobacter pylori Mutations Conferring Resistance to Fluoroquinolones and Clarithromycin among Dyspeptic Patients Attending a Tertiary Hospital, Tanzania by Hyasinta Jaka, Nele Rüttgerodt, Wolfgang Bohne, Andreas Mueller, Uwe Gross, Christa Kasang, Stephen E. Mshana

“…The correlation between A92T fluoroquinolone mutation and phenotypic resistance requires further investigations.…”
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Genome-wide DNA methylation and mRNA transcription analysis revealed aberrant gene regulation pathways in patients with dermatomyositis and polymyositis by Hui Luo, Honglin Zhu, Ding Bao, Yizhi Xiao, Bin Zhou, Gong Xiao, Lihua Zhang, Siming Gao, Liya Li, Yangtengyu Liu, Di Liu, Junjiao Wu, Qiming Meng, Meng Meng, Tao Chen, Xiaoxia Zuo, Quanzhen Li, Huali Zhang, Xiangxiang Pan

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Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling by Rafael Dariolli, Raphael Nir, Tova Mushlam, Glauco R. Souza, Stephen R. Farmer, Miguel L Batista, Jr.

“…However, existing adipose tissue models have limitations, particularly in the stable culture of fat cells that maintain physiologically relevant phenotypes, hindering a deeper understanding of adipocyte biology and the molecular mechanisms behind differentiation. …”
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Invasive Aspergillus niger Is the Sole Etiological Agent for CSOM : A Clinical Case from Nepal by Ajay Kumar Chaurasiya, Rabindra Bhakta Pradhananga, Niranjan Prasad Sah, Basista Prasad Rijal, Bharat Mani Pokhrel, Santosh Dulal

“…Aspergillus niger was microbially conformed by specifically characterizing the specific phenotypic biseriate structure of phialides and the black-coloured conidia. …”
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