Prevalence and Characterization of Antibiotic-Resistant Staphylococcus aureus Recovered from Pasteurized Cheese Commercialized in Panama City Markets by Fermín Mejía, Nohelia Castro-del Campo, Arleny García, Katerine Rodríguez, Humberto Cornejo, Sara Ahumada-Ruiz, Marcela Soto-Beltrán, Maricela Castillo, Jordi Querol-Audi, Cristobal Chaidez-Quiroz, Alex O. Martínez-Torres

“…Fourteen different resistance phenotypes were found. Fifty-five percent (55%) of the analyzed strains were resistant to erythromycin. …”
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Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model by Lisa M. Weatherly, Hillary L. Shane, Laurel G. Jackson, Ewa Lukomska, Rachel Baur, Madison P. Cooper, Stacey E. Anderson

“…Gene expression changes were observed in the liver, skin, and spleen of genes involved in fatty acid metabolism, necrosis, and inflammation. Immune-cell phenotyping identified significant decreases in B-cells and CD11b+ monocyte and/or macrophages in the spleen along with decreases in eosinophils and dendritic cells in the skin. …”
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Proteomic and N-glycosylation analysis of fertile egg white during storage and incubation in chickens by Daqing Dai, Xiqiong Wang, Kexin Wu, Fangren Lan, Jiaming Jin, Wenxin Zhang, Chaoliang Wen, Junying Li, Ning Yang, Congjiao Sun

“…Here, we measured the phenotypes of eggs at different time points during storage and incubation and used 4D label-free quantitative proteomics technology and liquid chromatography/tandem mass spectrometry (LC-MS/MS)-technique to identify the differential proteins and N-glycosylation sites in egg whites during storage and incubation. …”
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Long read Nanopore sequencing identifies precise breakpoints of a de novo paracentric inversion that disrupt the MEIS2 gene in a Chinese girl with syndromic developmental delay by Jianxin Tan, Mingtao Huang, Xiuqing Ji, An Liu, Fengchang Qiao, Cuiping Zhang, Lulu Meng, Yan Wang, Zhengfeng Xu, Ping Hu

“…Case presentation Herein, we report a Chinese girl with intellectual disability, developmental delay, and congenital heart defect, in whom G-banded karyotype analysis identified a de novo paracentric inversion 46,XX, inv(15)(q15q26.1) and other conventional approaches including chromosomal microarray analysis and whole exome sequencing were failed to detect any pathologic variants that can explain the phenotypes of the proband. Subsequently, long-read Nanopore sequencing was directly conducted and defined the breakpoint position of the inversion, disrupting the MEIS2 gene at intron 8. …”
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Drosulfakinin signaling encodes early-life memory for adaptive social plasticity by Jiwon Jeong, Kujin Kwon, Terezia Klaudia Geisseova, Jongbin Lee, Taejoon Kwon, Chunghun Lim

“…Transcriptome analyses revealed genetic diversity for SD traits, whereas social isolation reprogrammed select genetic pathways, regardless of SD phenotypes. In particular, social deprivation suppressed the expression of the neuropeptide Drosulfakinin (Dsk) in three pairs of adult brain neurons. …”
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Role of sludge biochar immobilized multifunctional microbiome in phytoremediation of lead-zinc composite pollution by Zihao Yang, Lijuan Jiang, Xuejun Li, Qiaoling Ji, Mengyuan Wang, Yi Zhang, Yuanlin Cheng, Xuan Zhang, Hui Li, Chongling Feng

“…Biochar immobilized microbiome (MB) significantly enhanced phytoremediation and showed synergistic effects by improving root phenotypes up to 2.4 times compared to the untreated group (CK). …”
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Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue by Diana Vargas, Jaime Camacho, Juan Duque, Marisol Carreño, Edward Acero, Máximo Pérez, Sergio Ramirez, Juan Umaña, Carlos Obando, Albert Guerrero, Néstor Sandoval, Gina Rodríguez, Fernando Lizcano

“…In this study, biochemical and phenotypical characteristics of adipose tissue from periaortic fat were evaluated. …”
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Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…This study investigates how the progression of acute systemic inflammatory disease influences NP corona compositions and the corresponding effects on innate immune cell interactions, phenotypes, and cytokine responses. NP coronas alter cell associations in a disease-dependent manner, induce differential co-stimulatory and co-inhibitory molecule expression, and influence cytokine release. …”
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Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome by Chandrika Jayakanthi Subasinghe, Noel Somasundaram, Pathmanathan Sivatharshya, Lalana Devi Ranasinghe, Márta Korbonits

“…Sri Lanka requires further studies to describe the genotypic-phenotypic variability of MEN-1 syndrome in this population.…”
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Effects of axylitol-casein complex on insulin resistance and gut microbiota composition in high-fat-diet + streptozotocin-induced type 2 diabetes mellitus mice by Fanhua Kong, Juan Zhang, Shimo Kang, Xinyu Shen, Aicheng Liu, Yan Zheng, Junhua Shao, Xiqing Yue

“…Based on Spearman’s correlation analysis, the relative abundances of Alistipes, Bacteroides, and Faecalibaculum were positively correlated and those of Akkermansia, Lactobacillus, Bifi dobacterium, and Turicibacter were negatively correlated with the phenotypes related to the improvement of T2DM. In conclusion, we found that XC alleviated insulin resistance by restoring the gut microbiota of T2DM mice. …”
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Apigenin is an anoikis sensitizer with strong anti-metastatic properties in experimental breast cancer by Ruijie Xu, Zhijie Yao, Hao Zhang, Haitao Li, Wei Chen

“…Among 19 tested dietary phytochemicals, the best results were obtained with apigenin, a natural component of celery. Phenotypically, apigenin sensitized breast cancer cells to anoikis, lowered the number of circulating tumor cells, and protected against breast cancer metastasis to lung in mice. …”
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Antimicrobial Resistance Associated with Mass Gatherings: A Systematic Review by Linda Tong Pao, Mohamed Tashani, Catherine King, Harunor Rashid, Ameneh Khatami

“…There appears to be an association between attendance at mass gatherings and the acquisition of some AMR phenotypes and genotypes in some significant human pathogens, including <i>E. coli</i> and <i>S. pneumoniae</i>.…”
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Monosomy 21 Seen in Live Born Is Unlikely to Represent True Monosomy 21: A Case Report and Review of the Literature by Trent Burgess, Lilian Downie, Mark D. Pertile, David Francis, Melissa Glass, Sara Nouri, Rosalynn Pszczola

“…Whilst this patient had a provisional clinical diagnosis of trisomy 21, the patient also had phenotypic features consistent with monosomy 21, such as prominent epicanthic folds, broad nasal bridge, anteverted nares, simple ears, and bilateral overlapping fifth fingers, features which can also be present in individuals with Down syndrome. …”
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Enhancing human ACE2 expression in mouse models to improve COVID‐19 research by Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming

“…Notably, opt‐hACE2 mice displayed more active immune responses and severe COVID‐19 phenotypes following SARS‐CoV‐2 challenge compared to other models. …”
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VIPAS39 related arthrogryposis-renal dysfunction-cholestasis syndrome—case report and systematic review by Jan Kafol, Barbara Gnidovec Strazisar, Ana Drole Torkar, Matjaz Homan, Sara Bertok, Matej Mlinaric, Jaka Sikonja, Jernej Kovač, Mirjana Perkovic Benedik, Tanja Kersnik Levart, Mojca Zerjav Tansek, Marina Praprotnik, Tadej Battelino, Maruša Debeljak, Urh Groselj

“…The identified novel VIPAS39 pathological variants (c.762G > A; c.1064_1082delinsAGTG) emphasize the complex phenotypic expression of ARC syndrome. A systematic literature review identified 8 VIPAS39-related ARC cases with notable variability in clinical features. …”
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Gain-of-Function Mutations in STAT1: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies by Sanem Eren Akarcan, Ezgi Ulusoy Severcan, Neslihan Edeer Karaca, Esra Isik, Guzide Aksu, Mélanie Migaud, Ferda Evin Gurkan, Elif Azarsiz, Anne Puel, Jean-Laurent Casanova, Necil Kutukculer

“…Patients with STAT1 GOF mutations may exhibit diverse phenotypes including infectious and noninfectious findings. …”
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Ribosomal Protein L40e Fused With a Ubiquitin Moiety Is Essential for the Vegetative Growth, Morphological Homeostasis, Cell Cycle Progression, and Pathogenicity of Cryptococcus ne... by Jingyu Zhao, Jingyu Zhao, Yali Yang, Yali Yang, Yibin Fan, Jiu Yi, Chao Zhang, Zhongkai Gu, Weihua Pan, Julin Gu, Wanqing Liao, Wei Fang

“…In addition, the ubi1Δ mutant also displayed increased cell ploidy, cell cycle arrest, and decreased intracellular survival inside macrophages. All these phenotypes were reversed by the reconstitution of the full-length UBI1 gene or RPL40a domain. …”
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Increased RTN3 phenocopies nonalcoholic fatty liver disease by inhibiting the AMPK–IDH2 pathway by Hao Huang, Shuai Guo, Ya‐Qin Chen, Yu‐Xing Liu, Jie‐Yuan Jin, Yun Liang, Liang‐Liang Fan, Rong Xiang

“…The RTN3 transgenic mice exhibited the phenotypes of fatty liver and lipid accumulation. Single‐cell RNA sequencing analysis indicated that increased RTN3 might induce mitochondrial dysfunction. …”
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Use of machine learning in osteoarthritis research: a systematic literature review by Francis Berenbaum, Jérémie Sellam, David Klatzmann, Atul J Butte, Karine Louati, Encarnita Mariotti-Ferrandiz, Marie Binvignat, Valentina Pedoia

“…Twelve articles were related to diagnosis, 7 to prediction, 4 to phenotyping, 12 to severity and 11 to progression. The number of patients included ranged from 18 to 5749. …”
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Classification by production: an alternative criterion to categorization by Luis Yáñez, Nidia Rojas, Ricardo Aparicio, Manuel Mazzei, Eugenio Maldonado, Jairo Fernández, Nicola Fabbozzo, Rafael Rincón, Rafael Urdaneta

“…However, it was well known that the origin of the national inventory was mainly pure and of high genetic value, reasons for which it was considered justifiable to establish an alternative criterion, based on the simultaneous fulfillment of two principles: 1) The phenotypic approximation to the pattern of the corresponding breed; 2) Production adjusted to 244 days and standardized, as explained: LA1 0.5≤z<1; LA2 1≤z<1.5; LA3 1.5≤z. …”
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