Arrhythmias and Sudden Cardiac Death in Beta-Thalassemia Major Patients: Noninvasive Diagnostic Tools and Early Markers by Vincenzo Russo, Enrico Melillo, Andrea A. Papa, Anna Rago, Celeste Chamberland, Gerardo Nigro

“…Beta-thalassemias are a group of inherited, autosomal recessive diseases, characterized by reduced or absent synthesis of beta-globin chains of the hemoglobin tetramer, resulting in variable phenotypes, ranging from clinically asymptomatic individuals to severe anemia. …”
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Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut by Mehari Endale, H. Ibrahim Aksoylar, Kasper Hoebe

“…Specifically, genome-wide (GWAS) and also next-generation sequencing (NGS)—including whole exome or genome sequencing—have uncovered a large number of susceptibility loci that predispose to autoimmune diseases and/or the two phenotypes of IBD. In addition, the generation of “IBD-prone” animal models using both reverse and forward genetic approaches has not only helped confirm the identification of susceptibility loci but also shed critical insight into the underlying molecular and cellular pathways that drive colitis development. …”
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Simultaneous gains for negatively correlated traits of interest in plantain by Geferson Rocha Santos, Letícia Casseano de Souza Santos, Rafael Nunes de Almeida, Hércules dos Santos Pereira, Inês de Moura Trindade, Irany Rodrigues Pretti, Dimmy Herllen Silveira Gomes Barbosa, Edson Perito Amorim, Sávio da Silva Berilli, Ana Paula Candido Gabriel Berilli

“…Abstract The objective of this work was to identify negative correlations between phenotypic characteristics (agronomic and physicochemical) in plantain (Musa paradisiaca), and to evaluate selection indices to obtain simultaneous gains for agronomically relevant characteristics. …”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…This study evaluated the cytotoxicity of fluorinated quaternary ammonium salts (FQAS) library in CRC-derived cell lines with premetastatic and metastatic phenotypes. The genetic and epigenetic background of the CRC cell lines and the selectivity of cytotoxicity compared to nontumor cells and between different CRC stages were also assessed. …”
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Overexpression of SlGRAS7 Affects Multiple Behaviors Leading to Confer Abiotic Stresses Tolerance and Impacts Gibberellin and Auxin Signaling in Tomato by Sidra Habib, Muhammad Waseem, Ning Li, Lu Yang, Zhengguo Li

“…Plants overexpressing SlGARS7 (SlGRAS7-OE) showed multiple phenotypes related to many behaviors, including plant height, root and shoot length, and flowering time. …”
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Genetic Variability and Selection Criteria in Rice Mutant Lines as Revealed by Quantitative Traits by Yusuff Oladosu, M. Y. Rafii, Norhani Abdullah, Mohammad Abdul Malek, H. A. Rahim, Ghazali Hussin, Mohammad Abdul Latif, Isiaka Kareem

“…Data were taken on vegetative traits and yield and its components, while genotypic and phenotypic coefficients, variance components, expected genetic advance, and heritability were calculated. …”
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Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients... by Ken Sugimoto, Tomohiro Katsuya, Kei Kamide, Tomomi Fujisawa, Izumi Shimaoka, Mitsuru Ohishi, Ryuichi Morishita, Toshio Ogihara, Hiromi Rakugi

“…There was no gene whose expression was associated with BP phenotypes or the polymorphisms of each gene. Conclusions. …”
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Unveiling genetic basis of seedling emergence from deep soil depth under dry direct- seeded conditions in rice (Oryza sativa L.) by Vagish Mishra, Vagish Mishra, Shilpi Dixit, Shilpi Dixit, Swati Tyagi, Swati Tyagi, Challa Venkateswarlu, Challa Venkateswarlu, Pronob J. Paul, Pronob J. Paul, Anoop Kishor Singh Gurjar, Anoop Kishor Singh Gurjar, Shalabh Dixit, Nitika Sandhu, Smita Kurup, Arvind Kumar, Arvind Kumar, Pallavi Sinha, Pallavi Sinha, Vikas Kumar Singh, Vikas Kumar Singh, Uma Maheshwar Singh, Uma Maheshwar Singh

“…A total of 16 QTLs were identified for four traits, with phenotypic variance explained (PVE) ranging from 6.63% to 19.6% in the WS22. …”
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Clinical and genetic characteristics of a total or partial congenital aniridia by N.V. Sukhanova, V.V. Kadyshev, T.A. Vasilieva, A.V. Marakhonov, L.A. Katargina, S.I. Kutsev, R.A. Zinchenko

“…</p> <p> <b>Conclusion</b>: the analysis of genotypic and phenotypic correlations has revealed statistical regularities which may underpin the relationship between the clinical pattern of CA and the types of mutations. …”
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Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof... by E. I. Gultyaeva, L. A. Bespalova, I. B. Ablova, E. L. Shaydayuk, Zh. N. Khudokormova, D. R. Yakovleva, Yu. A. Titova

“…Among P. striiformis isolates, three phenotypes were identified using the International and European sets of differentiating cultivars – 111E231 (88 %), 111E247 (6 %) and 78E199 (6 %). …”
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Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer by Nathan D Maulding, Jun Zou, Wei Zhou, Ciara Metcalfe, Joshua M Stuart, Xin Ye, Marc Hafner

“…In conclusion, TraCSED enables associating features with phenotypes in a time-dependent manner from scRNA-seq data.…”
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Ways to improve the gene pool of pigs of the Russian Federation by V. A. Bekenеv

“…When hogging pigs and developing breeding plans with a herd, it was proposed to use such selection and genetic parameters as heritability factors, phenotypic and genetic correlations, selective differential, selective effect, etc. for assessment of animals and prognostication of productivity. …”
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Macular Optical Coherence Tomography Imaging in Glaucoma by Alireza Kamalipour, Sasan Moghimi

“…Risk assessment for glaucoma progression, earlier detection of glaucomatous structural damage, monitoring of glaucoma especially in advanced cases, and glaucoma evaluation in certain ocular conditions including eyes with high myopia, positive history of disc hemorrhage, and certain optic disc phenotypes are specific domains where macular imaging yields complementary information compared to optic nerve head and peripapillary evaluation using optical coherence tomography. …”
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Epigenetic regulation of the inflammatory response in stroke by Jingyi Liang, Fei Yang, Zixiao Li, Qian Li

“…Inhibiting acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic strategies. …”
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Toward <i>Mycobacterium tuberculosis</i> Virulence Inhibition: Beyond Cell Wall by Maria S. Kotliarova, Mikhail S. Shumkov, Anna V. Goncharenko

“…Additionally, models for the search of virulence inhibitors are discussed, such as virtual screening in silico, in vitro enzyme inhibition assay, the use of recombinant Mtb strains with reporter constructs, phenotypic analysis using in vitro cell infection models and specific environments.…”
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Adropin and Preptin Levels in β-Thalassemia Major Complications in Babylon Province by Zinah Abbass Ali, Samar Hasan Shammar

“…Background: Thalassemia refers to a group of diseases in which one or more globin chains are produced less or not at all, causing a wide range of phenotypes from anemia to clinically asymptomatic individuals. …”
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Integrative analysis of ATAC-seq and RNA-seq for cells infected by human T-cell leukemia virus type 1. by Azusa Tanaka, Yasuhiro Ishitsuka, Hiroki Ohta, Norihiro Takenouchi, Masanori Nakagawa, Ki-Ryang Koh, Chiho Onishi, Hiromitsu Tanaka, Akihiro Fujimoto, Jun-Ichirou Yasunaga, Masao Matsuoka

“…These HTLV-1-infected cells typically have phenotypes similar to that of CD4+T cells, but the cell status is not well understood. …”
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Comparison of age-related decline in C57BL/6J and CB6F1J male mice. by Gerald Yu Liao, Christina Pettan-Brewer, Warren Ladiges

“…Examining physiological phenotypes, C57BL/6J mice exhibited lower body fat percentages across ages compared to CB6F1J mice, though cataract severity worsened with age in both strains. …”
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The study of agronomical traits determining productivity of Triticum aestivum/Triticum timopheevii introgression lines with resistance to fungal diseases by I. N. Leonova, E. B. Budashkina

“…A comparative assessment of these lines and initial wheat varieties during four field seasons revealed a significant effect of environmental factors on the phenotypic differences between traits that have relevance to productivity. …”
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Aging-regulated TUG1 is dispensable for endothelial cell function. by Anna Theresa Gimbel, Susanne Koziarek, Kosta Theodorou, Jana Felicitas Schulz, Laura Stanicek, Veerle Kremer, Tamer Ali, Stefan Günther, Sandeep Kumar, Hanjoong Jo, Norbert Hübner, Lars Maegdefessel, Stefanie Dimmeler, Sebastiaan van Heesch, Reinier A Boon

“…We therefore investigated if, and how, TUG1 might function in aging ECs, but despite extensive phenotyping found no alterations in basal EC proliferation, apoptosis, barrier function, migration, mitochondrial function, or monocyte adhesion upon TUG1 silencing in vitro. …”
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