Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model by Deyu Zheng, Xiaohua Jiang, Junpeng Zhao, Deyi Duan, Huanying Zhao, Qunyuan Xu

“…The results of immunohistochemistry showed that hGAD65 gene delivery by AAV2 successfully led to phenotypic changes of neurons in STN. And the levels of glutamic acid and GABA in the internal segment of the globus pallidus (GPi) and substantia nigra pars reticulata (SNr) were obviously lower than the control groups. …”
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Ultrastructural Changes in Clinical and Microbiota Isolates of Klebsiella pneumoniae Carriers of Genes blaSHV, blaTEM, blaCTX-M, or blaKPC When Subject to β-Lactam Antibiotics by Dyana Leal Veras, Ana Catarina de Souza Lopes, Grasielle Vaz da Silva, Gabriel Gazzoni Araújo Gonçalves, Catarina Fernandes de Freitas, Fernanda Cristina Gomes de Lima, Maria Amélia Vieira Maciel, Ana Paula Sampaio Feitosa, Luiz Carlos Alves, Fábio André Brayner

“…Our results demonstrate that K. pneumoniae isolates harboring different genes that encode for β-lactamases show cell alterations when subjected to different β-lactam antibiotics, thus suggesting that they possess residual activity in vitro, despite the phenotypic resistance presented in the isolates analyzed.…”
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Divergence of gut bacteria through the selection of genomic variants implicated in the metabolism of sugars, amino acids, and purines by small extracellular vesicles in milk by Fang Zhou, Peerzada Tajamul Mumtaz, Haluk Dogan, Roland Madadjim, Juan Cui, Janos Zempleni

“…Evidence is particularly strong that selection of genomic variants by milk sEV changes the metabolism of sugars, amino acids, and purines which might contribute to the development of spatial learning and memory deficiencies and seizure phenotypes reported for milk sEV-depleted infants and mice. …”
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A Novel Spontaneous Mutation of the SOX10 Gene Associated with Waardenburg Syndrome Type II by Sen Chen, Yuan Jin, Le Xie, Wen Xie, Kai Xu, Yue Qiu, Xue Bai, Hui-Min Zhang, Xiao-Zhou Liu, Xiao-Hui Wang, Wei-Jia Kong, Yu Sun

“…WS is classified into four types depending on the clinical phenotypes. Currently, pathogenic mutation of PAX3, MITF, EDNRB, EDN3, SNAI2, or SOX10 can cause corresponding types of WS. …”
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Karyotype uniformity in populations of the endemic Hemiancistrus fuliginosus (Loricariidae: Hypostomini) collected in the upper and middle Uruguai River by Jocicléia Thums Konerat, Vanessa Bueno, Ana Luiza de Brito Portela-Castro, Isabel Cristina Martins-Santos, Vladimir Pavan Margarido

“…Nucleolar organizer regions (NORs) were located on the short arm in terminal position of the subtelocentric chromosome pair 25 in all population, in addition to Antas River population showed a structural polymorphism (three different phenotypes). Physical mapping of 5S rDNA showed cistrons in pericentromeric position on the short arm of the metacentric chromosome pair 12 in all the populations. …”
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Heritability Estimated Using 50K SNPs Indicates Missing Heritability Problem in Holstein Breeding by Donghyun Shin, Kyoung-Do Park, Sojoeng Ka, Heebal Kim, Kwang-hyeon Cho

“…Longer genomic regions tended to provide more phenotypic variation information, with a correlation of 0.46~0.53 between the estimate of variance explained by individual chromosomes and their physical length. …”
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Novel NOTCH3 mutation c.1564 T > A (p.Cys522Ser) presenting with early-onset Parkinsonism and white matter lesions by Nicola Rifino, Silvia Baratta, Esteban Zacarias, Isabella Canavero, Benedetta Storti, Mario Stanziano, Emanuela Maderna, Gianluca Marucci, Franco Taroni, Anna Bersano

“…This case underscores the phenotypic variability of CADASIL and the potential for atypical presentations, including parkinsonism. …”
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Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases by Jiani Li, Chen Guo, Xiaofei Yang, Weinan Xie, Wenjing Mi, Chenglong Hua, Cheng Tang, Han Wang

“…Immunometabolic variations in macrophages critically influence their differentiation into pro-inflammatory or anti-inflammatory phenotypes, thereby contributing to immune homeostasis, defense against infection, and tissue repair. …”
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Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond by Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos

“…Subpopulations with specific phenotypic and functional properties have been characterized both in mouse models and human disease. …”
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Reduced multiscale complexity of daily behavioral dynamics in autism spectrum disorder by Toru Nakamura, Tomiki Sumiyoshi, Yoko Kamio, Hidetoshi Takahashi

“…This study aimed to objectively characterize the behavioral phenotypes of ASD children by exploring the multiscale behavioral dynamics. …”
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First VIM-producing representative of Pseudomonas putida group from the largest Bulgarian hospital by Atanaska Petrova, Ivan N. Ivanov, Liubomir Paunov, Angel Uchikov, Ivan Stoikov, Todor Kantardjiev, Marianna Murdjeva

“…Antibiotic susceptibility testing revealed susceptibility only to tobramycin and colistin. All phenotypic tests for carbapenemase and metallo-beta-lactamase (MBL) production were positive. …”
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Application of Metabolomics in Thyroid Cancer Research by Anna Wojakowska, Mykola Chekan, Piotr Widlak, Monika Pietrowska

“…Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. …”
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The Story of CD4+CD28− T Cells Revisited: Solved or Still Ongoing? by Kathrin Maly, Michael Schirmer

“…Here we focus on CD4+CD28− T cells in chronic immune-mediated diseases, summarizing various phenotypic and functional characteristics, which vary depending on the underlying disease, disease activity, and concurrent treatment. …”
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Determination of extended spectrum beta-lactamase producing escherichia coli strains in chicken meat samples by Güzin İplikçioğlu Çil, Görkem Cengiz, Buse Arslan, Ufuk Tansel Şireli

“…In order to determine the ESBL production of the isolates phenotypically combined disc diffusion test was performed according to the CSLI.…”
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Effects of data transformation and model selection on feature importance in microbiome classification data by Zuzanna Karwowska, Oliver Aasmets, Estonian Biobank research team, Tomasz Kosciolek, Elin Org

“…Abstract Background Accurate classification of host phenotypes from microbiome data is crucial for advancing microbiome-based therapies, with machine learning offering effective solutions. …”
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Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment by Tian Z, Wang X, Chen S, Guo Z, Di J, Xiang C

“…However, a comprehensive summary of biomaterial-driven modulation of mitochondrial function to control macrophage phenotypes is still lacking. This review highlights the critical role of mitochondrial function in macrophage polarization and discusses therapeutic strategies mediated by biomaterials, including mitochondria-targeted biomaterials. …”
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Generation of a genetically double-attenuated Plasmodium berghei parasite that fully arrests growth during late liver stage development. by Melanie Schmid, Raphael Beyeler, Reto Caldelari, Ruth Rehmann, Volker Heussler, Magali Roques

“…Through a comprehensive phenotyping screen, we identified the hscb gene, encoding a putative iron-sulfur protein assembly chaperone, as crucial for liver stage development, making it a suitable candidate gene for GAP generation. …”
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Biophysical Profiling of Tumor Cell Lines by Frederick Coffman, Rachid Hamid, Marion C. Cohen, Ralph Garippa, Stanley Cohen

“…Despite significant differences in genetic profiles, cancer cells share common phenotypic properties, including membrane-associated changes that facilitate invasion and metastasis. …”
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IMPLEMENTATION OF GENOME-WIDE SELECTION IN WHEAT by G. Charmet, E. Storlie

“…We present an example applying DArT markers to the INRA wheat breeding material in an attempt to implement whole genome selection as an alternative to phenotypic selection. This study assesses different models (GBLUP, Ridge Regression BLUP, Bayesian Ridge Regression and Lasso) and their ability to predict the yields of genotypes evaluated in a multi-site network from 2000 to 2009 in a highly unbalanced design. …”
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Effects of Drought Frequency on Growth Performance and Transpiration of Young Black Locust (Robinia pseudoacacia L.) by Dario Mantovani, Maik Veste, Dirk Freese

“…Due to its constant water use efficiency and the high phenotypic plasticity, black locust could become an important species to be cultivated on marginal land.…”
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