Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations by O. Y. Calhan, V. Seyrantepe

“…These patients present with a broad range of clinical phenotypes, including growth retardation, and neurological deterioration along with the accumulation of the vasoactive peptide, endothelin-1, in the brain. …”
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Early life stress shifts critical periods and causes precocious visual cortex development. by Janet Poplawski, Tony Montina, Gerlinde A S Metz

“…These findings also suggest that shipment of laboratory animals during vulnerable developmental ages may result in long lasting phenotypes, introducing critical confounds to the experimental design.…”
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The diagnosis of DIC: a current overview by Hongyu Yang, Xiaochun Ma, Xu Li

“…In recent years, the understanding of DIC has been continuously improved, including the in-depth understanding of the pathogenesis, the classification of coagulation phenotypes, and the development of the “two-step” diagnosis of DIC, etc. …”
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Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity. by Siddhi Omkar, Megan M Mitchem, Joel R Hoskins, Courtney Shrader, Jake T Kline, Nitika, Luca Fornelli, Sue Wickner, Andrew W Truman

“…By mutating acetylation sites on Ydj1's J-domain to either abolish or mimic constitutive acetylation, we observed that preventing acetylation had no noticeable phenotypic impact, whereas acetyl-mimic mutants exhibited various defects indicative of impaired Ydj1 function. …”
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Unusual Complication of Multidrug Resistant Tuberculosis by Prerna Sharma, Ravindra Nath Sahay

“…Acquired Bartter-like syndrome phenotypically resembles autosomal dominant type 5 Bartter syndrome. …”
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The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…Finally, we present the status of phenotypic and functional characterization of nonhuman primate (NHP) NK cells, essential for studying their role in xenograft rejection using preclinical pig-to-NHP models, and summarize key advances and important perspectives for future research.…”
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Inhibitory control in teleost fish: a methodological and conceptual review by Tyrone Lucon-Xiccato

“…Available results indicate substantial variation in fish IC related to sex, personality, genetic, age, and phenotypic plasticity, aligning with what is observed with other vertebrates. …”
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Homozygous mice with mutant protein FUS[1-359] overexpression: Innovative possibilities for ALS treatment by Nikita S. Zhunusov

“…This model exhibits clear phenotypic manifestations of the disease and can be utilized for investigating gene therapy methods.…”
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A biallelically active embryonic enhancer dictates GNAS imprinting through allele-specific conformations by Yorihiro Iwasaki, Monica Reyes, Harald Jüppner, Murat Bastepe

“…Abnormal imprinting at the GNAS gene causes multiple phenotypes, including pseudohypoparathyroidism type-1B (PHP1B), a disorder of multihormone resistance. …”
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Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells by Cristian Doñas, Macarena Fritz, Valeria Manríquez, Gabriela Tejón, María Rosa Bono, Alejandra Loyola, Mario Rosemblatt

“…Importantly, we also demonstrated that Tregs generated in the presence of TSA have phenotypical and functional differences from the Tregs generated in the absence of TSA. …”
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Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation by Taketomo Kido, Mitsuhiro Yoneda, Yan Cai, Tsutomu Matsubara, Jerrold M. Ward, Shioko Kimura

“…Scgb3a2−/− mice did not exhibit any overt phenotypes. In ovalbumin- (OVA-) induced airway allergy inflammation model, Scgb3a2−/− mice in mixed background showed a decreased OVA-induced airway inflammation, while six times C57BL/6NCr backcrossed congenic Scgb3a2−/− mice showed a slight exacerbation of OVA-induced airway inflammation as compared to wild-type littermates. …”
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An Overview of the Role of Innate Lymphoid Cells in Gut Infections and Inflammation by Silvia Sedda, Irene Marafini, Michele M. Figliuzzi, Francesco Pallone, Giovanni Monteleone

“…Three distinct groups of ILCs have been identified on the basis of phenotypic and functional criteria and termed ILCs1, ILCs2, and ILCs3. …”
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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity by Max Cigrang, Julian Obid, Maguelone Nogaret, Léane Seno, Tao Ye, Guillaume Davidson, Philippe Catez, Pietro Berico, Clara Capelli, Clara Marechal, Amélie Zachayus, Clémence Elly, Marie Jose Guillen Navarro, Marta Martinez Diez, Gema Santamaria Nunez, Tsai-Kun Li, Emmanuel Compe, Pablo Avilés, Irwin Davidson, Jean-Marc Egly, Carmen Cuevas, Frédéric Coin

“…Here we successfully inhibit SE-driven transcription in phenotypically distinct metastatic melanoma cells using next-generation synthetic ecteinascidins. …”
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Multi-omics approach in tea polyphenol research regarding tea plant growth, development and tea processing: current technologies and perspectives by Jingwen Li, Yu Wang, Joon Hyuk Suh

“…Recent advances in multi-omics approaches and data analysis have enabled mining and mapping of enormous number of datasets at different biological scales from genotypes to phenotypes of living organisms. These new technologies combining genomics, metagenomics, transcriptomics, proteomics and/or metabolomics can pave a new avenue to address fundamental questions regarding polyphenol formation and changes in tea plants and products. …”
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Comparative In Vitro Immune Stimulation Analysis of Primary Human B Cells and B Cell Lines by Kristien Van Belle, Jean Herman, Louis Boon, Mark Waer, Ben Sprangers, Thierry Louat

“…The Namalwa cell line proved to be the most responsive upon TLR9 stimulation and hence may serve as a relevant, homogeneous, and stable B cell model in an in vitro phenotypic assay for the discovery of new targets and inhibitors of the B cell activation processes. …”
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A medium-throughput protease assay for screening green plant material by Christina Stonoha-Arther, Andrew Molodchenko, Andrew Molodchenko, Kevin Panke-Buisse

“…This method will allow higher-throughput phenotyping of plant protease activity than is currently feasible: one person can process approximately 120 samples per day, compared to approximately 25 with previous methods. …”
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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention by Kashish Azeem, Sadaf Fatima, Asghar Ali, Ayesha Ubaid, Fohad Mabood Husain, Mohammad Abid

“…This study explores promising avenues for future research, emphasizing the necessity of uncovering the specific genetic and phenotypic adaptations occurring within biofilms. The identification of vulnerabilities in biofilm architecture and the elucidation of key biofilm-specific targets emerge as crucial focal points for the development of targeted therapeutic strategies. …”
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Identification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank by Jason C. Klein, Ruchika Mahapatra, Gary C. Hon, Richard C. Wang

“…The UK Biobank includes genotype information for about 500,000 patients for over 7000 phenotypes. However, owing to multiple testing correction for approximately 200 billion tests, many clinically and statistically significant associations remain unappreciated. …”
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Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10Lt/J and TALLYHO/JngJ by Edward H. Leiter, Marjorie Strobel, Adam O'Neill, David Schultz, Andrew Schile, Peter C. Reifsnyder

“…Moreover, the clinical phenotypes in these new models are less extreme, for example, more moderated development of obesity coupled with less extreme endocrine disturbances. …”
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Epidemiological Analysis of a <i>K. pneumoniae</i> NDM Outbreak in a Temporary Ward for Patients with Primary COVID-19 Infection by Agata Pruss, Klaudia Miładowska, Helena Masiuk, Paweł Kwiatkowski, Joanna Jursa-Kulesza, Bartosz Wojciuk, Stefania Giedrys-Kalemba, Barbara Dołęgowska

“…The drug susceptibility of the strains was determined by the diffusion–circulation method and E-test. Phenotypic and PCR methods confirmed the production of carbapenemases. …”
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