Macrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming by Rongqi Guo PhD, Rui Wang PhD, Weisong Zhang PhD, Yangyang Li PhD, Yihao Wang PhD, Hao Wang PhD, Xia Li PhD, Jianxiang Song PhD

“…Results Macrophage reprogramming in the tumour microenvironment involves complex mechanisms, including phenotypic and functional alterations. These processes are influenced by M1/M2 polarisation, metabolic and epigenetic reprogramming, and various signalling pathways. …”
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Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment by T. Mikalauskas, B. Burnytė

“…The disease is divided into two types: the first type occurs in 95% of patients and the second type occurs in 5%. The phenotypic differences between the two types are not distinct, both resulting from dysregulation of DUX4 expression leading to skeletal muscle toxicity. …”
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Dynamic collateral sensitivity profiles highlight opportunities and challenges for optimizing antibiotic treatments. by Jeff Maltas, Anh Huynh, Kevin B Wood

“…Here, we use laboratory evolution in the opportunistic pathogen Enterococcus faecalis to phenotypically characterize collateral profiles through evolutionary time. …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Following metformin treatment with a low concentration range, senescence phenotypes induced by D-gal significantly changed, including generation of reactive oxygen species (ROS), loss of mitochondrial membrane potential (MMP), and cell cycle arrest. …”
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Assessment of Molecular Imaging of Angiogenesis with Three-Dimensional Ultrasonography by Jason E. Streeter, Ryan C. Gessner, James Tsuruta, Steven Feingold, Paul A. Dayton

“…It is projected that ultrasonic (US) MI can provide information about tumor therapeutic response before the detection of phenotypic changes. One of the limitations of preclinical US MI is that it lacks a comprehensive field of view. …”
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Cell-Type-Specific Differentiation and Molecular Profiles in Skin Transplantation: Implication of Medical Approach for Genetic Skin Diseases by Noritaka Oyama, Fumio Kaneko

“…Moreover, particular cell lineages from bone marrow (BM) cells have been shown to harbour the diferentiation capacity into multiple skin cell phenotypes, including epidermal keratinocytes and dermal endothelial cells and pericytes, undercontrolled by chemokines or cytokines. …”
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Rice Breeding for High Grain Yield under Drought: A Strategic Solution to a Complex Problem by Shalabh Dixit, Anshuman Singh, Arvind Kumar

“…The use of grain yield as a selection criterion at the International Rice Research Institute (IRRI), through proper population development and precise phenotyping techniques, has allowed the development of several high-yielding rice cultivars that have been released in major rainfed rice-growing areas. …”
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Marfan Syndrome and Autosomal Dominant Polycystic Kidney Disease: A Case of Rare Co-occurrence or Coincidence? by Arjun Sekar

“…More frequent screening of vascular abnormalities might be warranted in those with both phenotypes.…”
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Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats by Olivia A. Ortelli, Jeffrey L. Weiner

“…These experiments demonstrate the utility of two concurrent choice paradigms that can more accurately capture AUD-like phenotypes, such as ethanol-directed choice in the face of alternative reinforcers. …”
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Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL/6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location by Kang-Hoon Lee, Debora Lim, David Greenhalgh, Kiho Cho

“…Perhaps, the mouse-, gender-, and tissue/cell-dependent MLV-ERV landscapes are linked to the individual-specific and dynamic phenotypes of the C57BL/6J inbred population.…”
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Sickness behaviour and the effect of sex, age, and immune status on individual behavioural variation in Tenebrio molitor. by Antoine Bour, Clint D Kelly

“…There was very little evidence that age, sex, and immune status affect behavioural variation among and within individuals but the phenotypic correlation between activity and exploration is driven by a correlation within individuals. …”
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Functional investigation suggests CNTNAP5 involvement in glaucomatous neurodegeneration obtained from a GWAS in primary angle closure glaucoma. by Sudipta Chakraborty, Jyotishman Sarma, Shantanu Saha Roy, Sukanya Mitra, Sayani Bagchi, Sankhadip Das, Sreemoyee Saha, Surajit Mahapatra, Samsiddhi Bhattacharjee, Mahua Maulik, Moulinath Acharya

“…In the current study, we have extended our perception of CNTNAP5 involvement in glaucomatous neurodegeneration in a zebrafish model, through investigating phenotypic consequences pertinent to retinal degeneration upon knockdown of cntnap5 by translation-blocking morpholinos. …”
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Immunological Regulation of Fibrosis During Heart Failure: It Takes Two to Tango by Vinay Kumar, Shyam S. Bansal

“…The aims of this review are to (i) briefly summarize the role of key immune cells that regulate wound healing during MI and fibrosis during LV remodeling; (ii) underscore phenotypic diversities in immune cells and their subsets to underscore their role in regulating fibrotic responses, and, last but not the least, (iii) highlight gaps in our understanding that restrict the translation of immuno-modulatory therapies from the preclinical models to heart failure patients.…”
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The Role of Epigenetic in Dental and Oral Regenerative Medicine by Different Types of Dental Stem Cells: A Comprehensive Overview by Ahmed Hussain, Hamid Tebyaniyan, Danial Khayatan

“…Several lines of evidence have shown that epigenetic modification of DNA and DNA-correlated histones are necessary for determining cells’ phenotypes and regulating stem cells’ pluripotency and renewal capacity. …”
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Polymer interaction of the genes SHY2 and MSG1, NPH4 and IAR2 in the inheritance of the Arabidopsis thaliana (L.) Heynh. root system by S. G. Hablak

“…The segregation ratio of the phenotypes in F2 is 15:1. The results presented are of interest for practical use of the economically valuable trait «branching roots» in plant breeding to create varieties and hybrids with the desired properties of mineral nutrition. …”
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Decreased Susceptibility of Shigella Isolates to Azithromycin in Children in Tehran, Iran by Parisa Behruznia, Mehrzad Sadredinamin, Ali Hashemi, Bahareh Hajikhani, Neda Yousefi Nojookambari, Mahboobeh Behruznia, Zohreh Ghalavand

“…., only the mph(A) gene (49.2%) was detected and other macrolide resistance genes were absent. The phenotypic activity of efflux pump was observed in 1.9% of isolates which were associated with over expression of both omp(A) and omp(W) genes. …”
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Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease by Eunju Shin, Elisabetta Tronci, Manolo Carta

“…These patients experience graft-induced dyskinesia (GID), a type of dyskinesia phenotypically similar to the one induced by L-DOPA but independent from its administration. …”
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The Relevance of HLA Sequencing in Population Genetics Studies by Alicia Sanchez-Mazas, Diogo Meyer

“…Boosting the molecular characterization of the HLA genes through efficient, rapid, and low-cost technologies is expected to amplify the success of tissue transplantation by enabling us to find donor-recipient matching for rare phenotypes. But the application of NGS technologies to the molecular mapping of the MHC region also anticipates essential changes in population genetic studies. …”
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Expanding Yarrowia lipolytica’s metabolic potential for detoxification of cyanogenic glycosides in edible plants by Fidelis Azi, Zhiyu Li, Peng Xu

“…Abstract Cyanides are highly toxic chemicals in several edible plants that threaten food safety and human health. A phenotypically distinct Yarrowia lipolytica strain that efficiently detoxifies multiple cyanogenic glycosides from edible plants was constructed using a family 1 glycosyl-hydrolase (GH1). …”
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Comparaison de deux « populations » de la deuxième moitié du Ve millénaire avant notre ère : approche anthropométrique by Aude Civetta, Aurore Schmitt, Bérangère Saliba-serre, Jean-Luc Gisclon, Gilles Loison

“…Recently, some phenotypic features of Middle Neolithic populations, observed on series from old archaeological excavations, have been challenged. …”
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