Ofatumumab successfully treats myelin oligodendrocyte glycoprotein antibody-associated disease accompanied by Epstein-Barr viral infection: a case series by Chen Min, Bi Zhuajin, Liu Peidong, Li Ruoyu, Liu Ju, Liu Hongbo

“…Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) caused by pathogenic immunoglobulin G antibodies to myelin oligodendrocyte glycoprotein is a rare demyelinating disease of the central nerve system (CNS). The clinical phenotypes of MOGAD include acute disseminated encephalomyelitis, optic neuritis, and transverse myelitis. …”
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NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression by Wenchao Xu, Jianzhou Liu, Qiaofei Liu, Jia Xu, Li Zhou, Zhiyong Liang, Haoran Huang, Bowen Huang, Gary Guishan Xiao, Junchao Guo

“…Mechanistically, our findings indicated that nuclear factor erythroid 2 (NFE2) is a key transcription factor regulating neutrophil phenotypic polarization. Metastatic tumors produce transforming growth factor β to activate the SMAD3 pathway within neutrophils, inducing NFE2-driven polarization. …”
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Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia by Fabian Lang, Bartosch Wojcik, Michael A. Rieger

“…Acute lymphoblastic leukemia (ALL) is a highly malignant cancer of the lymphoid system in the bone marrow with a dismal prognosis after relapse. However, stabile phenotypes and functional data of CSCs in ALL, the so-called leukemia-initiating cells (LICs), are highly controversial and the question remains whether there is evidence for their existence. …”
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Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues by Jeremy C. Tran, Christopher J. Kuffner, Alexander M. Marzilli, Ryan Emily Miller, Zachary E. Silfen, Jeffrey B. McMahan, D. Christopher Sloas, Christopher S. Chen, John T. Ngo

“…To demonstrate the utility of these tools, we apply them to activate dose-dependent gene expression responses and to induce myogenic-like phenotypes in multipotent fibroblasts with spatiotemporal and microenvironmental control. …”
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Sleep in Genetically Confirmed Pantothenate Kinase-Associated Neurodegeneration: A Video-Polysomnographic Study by Maria Livia Fantini, Giovanni Cossu, Andrea Molari, Monia Cabinio, Ozlem Uyanik, Roberto Cilia, Maurizio Melis, Angelo Antonini, Luigi Ferini-Strambi

“…Sleep studies may phenotypically differentiate PKAN from other neurodegenerative disorders.…”
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CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects by Lei Tang, Xin Chen, Jianquan Hou, Xuedong Wei

“…However, previous pan-cancer studies have reported inconsistencies regarding the effects of CXCL14 on tumors, particularly concerning its expression levels in tumor tissues and its influence on various phenotypes of cancer cells. This variability is believed to stem from the context-dependent nature of CXCL14, as different sources of CXCL14 and its secretion within distinct tumor microenvironments may mediate diverse biological effects. …”
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Seasonal Variations in the Structure and Function of the Gut Flora in Adult Male Rhesus Macaques Reared in Outdoor Colonies by Longbao Lv, Feiyan Zhang, Haimei Zhou, Wenxian Xiao, Yingzhou Hu, Wenchao Wang, Zhu Zhu, Fangming Zhu, Dongdong Qin, Xintian Hu

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Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

“…These pathologic alterations were phenotyped by intramyocardial injection of sEV isolated from diabetic adipocytes or HGHL-challenged 3T3L1 adipocytes. …”
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Molecular mapping and validation of quantitative trait loci for content of micronutrients in wheat grain by Xiangdong Chen, Junchao You, Nannan Dong, Di Wu, Die Zhao, Rui Yong, Wenjing Hu

“…The positive alleles of QCu.yaas-1A, QMn.yaas-1B, and QZn.yaas-7D were contributed by YZ1 and explained 7.66–19.92% of the phenotypic variances, while the positive alleles of QFe.yaas-2D, QSe.yaas-2D, QMn.yaas-4D, QZn.yaas-4D, and QCu.yaas-7A were contributed by YM4 and explained 5.77–20.11% of the phenotypic variances. …”
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Antimicrobial Resistance Surveillance of Skin and Soft Tissue Infections: Hospital-Wide Bacterial Species and Antibiograms to Inform Management at a Zonal Tertiary Hospital in Mwan... by Justine BN, Mushi MF, Silago V, Igembe Z, Muyombe J, Kishengena PP, Michael Jnr NS, Maganga MG, Massenga A, Tegete F, Massaga FA, Seni J

“…This study assessed the proportion of laboratory-confirmed SSTIs, identify bacterial species involved, analyze AMR phenotypes, and investigate the risk factors associated with multidrug-resistant (MDR) SSTIs.Patients and Methods: Analytical cross-sectional study was conducted between January and June 2023, involving 614 patients with SSTIs. …”
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Immune infiltrate populations within distinct tumor immune microenvironments predictive of immune checkpoint treatment outcome by Brian Z Ring, Catherine T. Cronister, Huijun Z. Ring, Douglas T. Ross, Robert S. Seitz

“…We have previously validated signatures predictive of checkpoint inhibitor efficacy which distinguish immunomodulatory, mesenchymal stem-like, and mesenchymal phenotypes. Here we use twenty tumor types (7162 samples) to identify potentially conserved immune biology within these TIME spaces, genes co-expressed across distinct cell types involved these immune processes, and the association of these signatures with ICI response. …”
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What does external morphometry tell us about stock discrimination of Sardina pilchardus stocks from Türkiye? by Ozpicak Melek, Saygin Semra

“…In addition, morphometric characteristics can be used to differentiate ‘phenotypic stocks’ as groups with similar growth, mortality, and reproductive rates. …”
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The Pathology of T Cells in Systemic Lupus Erythematosus by Anselm Mak, Nien Yee Kow

“…Recently, a number of phenotypic and functional alterations which increase the propensity to trigger lupus-related inflammation have been identified in lupus T cells. …”
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Imaging Reporters for Proteasome Activity Identify Tumor- and Metastasis-Initiating Cells by Amanda C. Stacer, Hanxiao Wang, Joseph Fenner, Joseph S. Dosch, Anna Salomonnson, Kathryn E. Luker, Gary D. Luker, Alnawaz Rehemtulla, Brian D. Ross

“…Patient-derived glioblastoma cells with low proteasome activity measured by the HaloTag reporter show key phenotypes associated with tumor-initiating cells, including expression of a stem cell transcription factor, reconstitution of the original starting population, and enhanced neurosphere formation. …”
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Evolution of uncontrolled proliferation and the angiogenic switch in cancer by John D. Nagy, Dieter Armbruster

“…An angiogenic clone is vulnerable to 'cheater' lineages that shunt energy from angiogenesis to proliferation, allowing the cheater to outcompete cooperative phenotypes in the environment built by the cooperators. …”
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A Cellular Potts model simulating cell migration on and in matrix environments by Marco Scianna, Luigi Preziosi, Katarina Wolf

“…Wehere present an extended Cellular Potts Model (CPM) able toqualitatively and quantitatively describe cell migrationefficiencies and phenotypes both on two-dimensional substrates andwithin three-dimensional matrices, close to experimental evidence.As distinct features of our approach, cells are modeled ascompartmentalized discrete objects, differentiated into nucleusand cytosolic region, while the extracellular matrix iscomposed of a fibrous mesh and a homogeneous fluid. …”
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Custom exome panel revealed new mutations in MAPK14 and novel mutation in RUNX2 gene in patients with PCOS by Yunus Arikan, Taylan Onat

“…Abstract Polycystic ovary syndrome (PCOS) is the most common endocrinopathy and is both phenotypically and genotypically heterogeneous. A large number of genetic variants have been found in different genes, so far. …”
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Analysis of Signals Leading to Differentiation of Immature HL-60 after Administration of IL-4 by Simon Vassiliadis

“…Treatment of acute myeloid leukaemia (AML) cells with differentiation agents leads not only to the acquisition of normal phenotypes but also contributes to the understanding of special immuno-haematology issues. …”
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Regulatory Role of CD4+ T Cells in Myocarditis by Daria Vdovenko, Urs Eriksson

“…Interestingly, recent observations point out that various CD4+ T cell subsets demonstrate high plasticity in maintaining immune homeostasis and modulating disease phenotypes in myocarditis. These subsets include Th1 and Th17 effector cells and regulatory T cells, despite the fact that there are still sparse and controversial data on the specific role of FOXP3-expressing Treg in myocarditis. …”
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Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy by Shuyan He, Lu Zheng, Chunjian Qi

“…This review describes the origins and phenotypes of MDSCs, their biological roles in tumor progression, and regulatory mechanisms, with a focus on current therapeutic approaches targeting tumor-associated MDSCs. …”
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