Comment on “5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity” by Thomas Mørch Frøsig, Sine Reker Hadrup

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Genotype-phenotype correlations for 17 Chinese families with inherited retinal dystrophies due to homozygous variants by Xue Fan, Zhen Li, Lingzhi Sha, Xunlun Sheng, Weining Rong

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Aweak phenotype associated with novel ABO*A allele variant c.106delinsGG by Sanmukh Ratilal Joshi, Glenda Millard, Mayuri Vekariya, Priya Radadiya, Manisha Rajapara, Hiren Dhanani, Gaurav Shastri, Prabhat Sharma, Brett Wilson, Yew-Wah Liew

Subjects: “…aweak phenotype…”
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Hearing Phenotypes of Patients with Hearing Loss Homozygous for the GJB2 c.235delc Mutation by Chang Guo, Sha-Sha Huang, Yong-Yi Yuan, Ying Zhou, Ning Wang, Dong-Yang Kang, Su-Yan Yang, Xin Zhang, Xue Gao, Pu Dai

“…Hereditary hearing loss is characterized by remarkable phenotypic heterogeneity. Patients with the same pathogenic mutations may exhibit various hearing loss phenotypes. …”
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Correction: BerryPortraits: phenotyping of ripening traits in cranberry (Vaccinium macrocarpon Ait.) With YOLOv8 by Jenyne Loarca, Tyr Wiesner-Hanks, Hector Lopez-Moreno, Andrew F. Maule, Michael Liou, Maria Alejandra Torres-Meraz, Luis Diaz-Garcia, Jennifer Johnson-Cicalese, Jeffrey Neyhart, James Polashock, Gina M. Sideli, Christopher F. Strock, Craig T. Beil, Moira J. Sheehan, Massimo Iorizzo, Amaya Atucha, Juan Zalapa

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High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models by Thomas J O'Brien, Ida L Barlow, Luigi Feriani, André EX Brown

“…Success requires a screenable phenotype. However, the right phenotype and assay may not be obvious for pleiotropic neuromuscular disorders. …”
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Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype by Niloufar Rasaei, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Mahsa Samadi, Mohammad Keshavarz Mohammadian, Elnaz Daneshzad, Khadijeh Mirzaei

“…Participants were divided into MHO or MUO phenotypes after the metabolic risk assessment based on the Karelis criteria. …”
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Distinct genome stabilization procedures lead to phenotypic variability in newly generated interspecific yeast hybrids by Pablo Murath, Pablo Murath, Stephanie Hoffmann, Beatriz Herrera-Malaver, Beatriz Herrera-Malaver, Beatriz Herrera-Malaver, Luis Bustamante, Kevin Verstrepen, Kevin Verstrepen, Kevin Verstrepen, Jan Steensels, Jan Steensels, Jan Steensels

“…These interspecific yeast hybrids combine phenotypes of the two parental species and can therefore allow fast adaptation to new niches. …”
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Assessment of the phenotypic and physicochemical traits of nine Iranian endemic fenugreek (Trigonella foenum-graecum L.) by Majid Azizi, Hoda Saeb, Mansoureh Nazari, Hossein Aroiee, Mohammad Reza Morshedloo

“…This study aims to investigate genetic diversity and identify important phenotypic traits in various Iranian fenugreek accessions (“Mashhad”, “Tehran”, “Yazd”, “Shiraz”, “Birjand”, “Isfahan”, “Kerman”, “Kalat”, “Neyshabur”), an experiment was conducted in a randomized complete block design with three replications and nine treatments (accessions) in Iran. …”
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A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits. by Dennis Khodasevich, Nina Holland, Lars van der Laan, Andres Cardenas

“…The SL PCA clocks improved fit with observed phenotypes relative to the PCA clocks or CpG clocks across several datasets. …”
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Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species by Mark E. Hart, Morgan J. Hart, Anna J. Roop

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Elucidating the molecular basis of salt tolerance in potatoes through miRNA expression and phenotypic analysis by Caicai Lin, Shuangshuang Zheng, Kui Liu, Ru Yu, Peiyan Guan, Baigeng Hu, Lingling Jiang, Mengyu Su, Guodong Hu, Qingshuai Chen, Xia Zhang

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Association between the Hypertriglyceridemic Waist Phenotype and Prediabetes in Chinese Adults Aged 40 Years and Older by Kun Zhao, Shan-Shan Yang, Hai-Bin Wang, Kang Chen, Zhao-Hui Lu, Yi-Ming Mu

“…To investigate the association between the hypertriglyceridemic waist (HTGW) phenotype and prediabetes in Chinese adults aged 40 years and older. …”
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Study of Phenotypic and Molecular Approaches of Potyvirus plumpoxi Resistance Evaluation in New Czech Apricot Hybrids by Eliška Zezulová, Tomáš Kiss, Kateřina Baránková, Tomáš Nečas

“…This study investigates the resistance of 17 apricot hybrids to Potyvirus plumpoxi (PPV) with the use of phenotyping, serological assays [double-antibody-sandwich enzyme-linked immunosorbent assay (DAS-ELISA)], and molecular marker analyses. …”
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Exploring the phenotypic and molecular diversity of Calendula officinalis L. cultivars featuring varying flower types by Aleksandra Nucia, Tomasz Ociepa, Beata Król, Sylwia Okoń

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Accurate phenotype-to-genotype mapping of high-diversity yeast libraries by heat-shock-electroporation (HEEL) by Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, Emil Damgaard Jensen

“…HEEL should enable highly accurate phenotype-to-genotype measurements going forward, which could be used to construct better computer-based models.…”
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In vivo regulation of the monocyte phenotype by Mycobacterium marinum and the ESX-1 type VII secretion system by Kristina Munke, Line Wulff, Julia Lienard, Fredric Carlsson, William W. Agace

“…These findings suggest that mycobacterial infection has pleiotropic effects on monocyte phenotype, with potential implications in bacterial growth restriction and granuloma formation.…”
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Phenotypic and transcriptomic analyses reveal major differences between apple and pear scab nonhost resistance by Vergne, Emilie, Chevreau, Elisabeth, Ravon, Elisa, Gaillard, Sylvain, Pelletier, Sandra, Bahut, Muriel, Perchepied, Laure

“…The major objective of our study was to compare the scab nonhost resistance in apple and in European pear, at the phenotypic and transcriptomic levels.  Macro- and microscopic observations after reciprocal scab inoculations indicated that, after a similar germination step, nonhost apple/V. pyrina interaction remained nearly symptomless, whereas more hypersensitive reactions were observed during nonhost pear/V. inaequalis interaction. …”
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Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia by Huiling Guo, Yao Xiao, Shuai Dong, Jingyu Yang, Pengfei Zhao, Tongtong Zhao, Aoling Cai, Lili Tang, Juan Liu, Hui Wang, Ruifang Hua, Rongxun Liu, Yange Wei, Dandan Sun, Zhongchun Liu, Mingrui Xia, Yong He, Yankun Wu, Tianmei Si, Fay Y. Womer, Fuqiang Xu, Yanqing Tang, Jie Wang, Weixiong Zhang, Xizhe Zhang, Fei Wang

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Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure? by Anna C. Roberts, Jai Gohil, Laura Hudson, Kyle Connolly, Philip Warburton, Rakesh Suman, Peter O’Toole, David J. O’Regan, Neil A. Turner, Kirsten Riches, Karen E. Porter

“…This study explored the concept that endothelial cells (EC) cultured from T2DM and nondiabetic (ND) patients are phenotypically and functionally distinct. Cultured human saphenous vein- (SV-) EC were compared between T2DM and ND patients in parallel. …”
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