METHODS OF CHOOSING PARENTAL PAIRS FOR CROSSES IN THE BREEDING OF SELF-POLLINATING CROPS FOR YIELD by S. B. Lepekhov

“…Meanwhile, as a result of extensive exchange of breeding material, this ecogeographical approach to the matching of pairs has lost its relevance, being replaced by the new methods of finding phenotypic and genotypic differences between parents. …”
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Non-metric variations in individuals who died during the perinatal period in past populations: recording protocol and comparative data by Caroline Partiot, Dominique Castex, Valérie Delattre, Bruno Maureille, Mark Guillon

“…Non-metric variations, also referred to as "epigenetic variations" or asymptomatic bone variants, are bone or dental phenotypic variants of unknown origin, with no known pathological etiology. …”
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A Maternal Loss‐of‐Function Variant in KHDC3L Gene Causes a Range of Adverse Pregnancy Outcomes: A Case Report by Zahra Anvar, Farnoosh Jafarpour, Bahia Namavar Jahromi, Andrea Riccio, Mohammad Hossein Nasr‐Esfahani, Maria Vittoria Cubellis

“…This case report broadens the understanding of KHDC3L's pathogenic variants and phenotypic spectrum, consistent with its crucial role during human pre‐ and post‐implantation development.…”
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Living biobank: Standardization of organoid construction and challenges by Ruixin Yang, Yao Qi, Xiaoyan Zhang, Hengjun Gao, Yingyan Yu, Yuanyuan Ji

“…Because organoids can recapitulate the parental tissues’ morphological phenotypes, cell functions, biological behaviors, and genomic profiles, they are known as renewable “living biobanks”. …”
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Genetic variability, heritability and genetic advance in chrysanthemum (Dendranthema grandiflora) genotypes evaluated for loose flower production by K. Vandana1*, V. Vijaya Bhaskar2, A.V.D. Dorajeerao3, P. Subbaramamma4, M. Paratpara Rao5 and V. Sekhar6

“…Analysis of variance exhibited noteworthy variation in the genetic potential of the genotypes for every trait under study. The magnitude of phenotypic coefficient of variation (PCV) for each trait was discovered to be higher than the genotypic coefficient of variation (GCV), which demonstrated an interaction between the genotype and environment. …”
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Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia by Feng Wang, Luyao Zhao, Yun Tan, Xufeng Cen, Huan Gao, Huimin Jiang, Ying Liu, Yunxuan Li, Tingting Zhang, Chenxi Zhao, Ting Shi, Guilin Xu, Churan Wang, Jiong Hu, Xia Li, Ya-Zhen Qin, Kankan Wang, Hong-Hu Zhu, Ke Li

“…RARG fusions overexpression leads to preleukemic phenotypes but fails to induce oncogenic transformation. …”
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A Case of Chemotherapy-Refractory “THRLBCL like Transformation of NLPHL” Successfully Treated with Lenalidomide by Mamatha Siricilla, Lydia Irwin, Andres Ferber

“…The two major differences are the background cell type and the morphologic pattern. Despite having a phenotypic resemblance, they have distinct biologic behavior and clinical course. …”
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Atypical Features in a Large Turkish Family Affected with Friedreich Ataxia by Semiha Kurt, Betul Cevik, Durdane Aksoy, E. Irmak Sahbaz, Aslı Gundogdu Eken, A. Nazli Basak

“…Description of FRDA families with different ethnic backgrounds may assist in identifying possible phenotypic and genetic features of the disease. Furthermore, the genetic heterogeneity observed in this family draws attention to the difficulty of genetic counseling in an inbred population and to the need for genotyping all affected members before delivering comprehensive genetic counseling.…”
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Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma by Levi van Hijfte, Marjolein Geurts, Iris de Heer, Santoesha A. Ghisai, Hayri E. Balcioglu, Youri Hoogstrate, Wies R. Vallentgoed, Rania Head, Rosa Luning, Thierry van den Bosch, Bart Westerman, Pieter Wesseling, Johanna A. Joyce, Pim French, Reno Debets

“…Abstract Isocitrate dehydrogenase 1/2 mutant (IDHmt) astrocytoma is considered a T cell-deprived tumor, yet little is known regarding the phenotypes underlying T cell exclusion. Using bulk, single nucleus and spatial RNA and protein profiling, we demonstrate that a distinct spatial organization underlies T cell confinement to the perivascular space (T cell cuff) in IDHmt astrocytoma. …”
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Quantification and identification of bacterial presence in salted eggs by Zukhrufa Vista Vindriati, Usamah Afiff, Trioso Purnawarman

“…The total bacterial count was determined using the plate count agar method, and bacterial identification was based on phenotypic analysis, which included Gram staining and biochemical tests. …”
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Passive Monitoring of Parkinson Tremor in Daily Life: A Prototypical Network Approach by Luc J. W. Evers, Yordan P. Raykov, Tom M. Heskes, Jesse H. Krijthe, Bastiaan R. Bloem, Max A. Little

“…Specifically, we demonstrate that prototypical networks can be used to enforce robust performance across domain-informed sub-classes, including different tremor phenotypes and daily life activities.…”
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Balancing Inflammation: The Link between Th17 and Regulatory T Cells by Maggie L. Diller, Ragini R. Kudchadkar, Keith A. Delman, David H. Lawson, Mandy L. Ford

“…CD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics. IL-17-producing CD4+ T cells (Th17 cells) represent a distinct subset of the CD4+ T cell lineage. …”
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Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype by Maciej Wojszczyk, Julia Kulbacka, Karol Dziedzic, Filip Arczewski, Michalina Wójcikiewicz, Marta Chuncia-Ileczko, Julia Kacperczyk, Witold Czyż, Piotr Pasek, Julia Ryniecka

“…Diagnostic and therapeutic challenges stemming from the phenotypic similarities between LADA and type 2 diabetes are highlighted, along with potential benefits of early detection. …”
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Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation by Martyna Kaźmierczak, Jakub Parys, Agnieszka Mikosińska, Patrycja Kałuziak, Marta Jajaczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Stanisław Jesionek

“…While it is a cornerstone of therapy, the management of PCOS requires a tailored approach that considers individual clinical symptoms and phenotypes. Additional therapeutic strategies, including non-pharmacological measures and other pharmacological agents, play a vital role in a comprehensive treatment plan for PCOS. …”
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Gene by Sex Interaction for Measures of Obesity in the Framingham Heart Study by Ashlee M. Benjamin, Sunil Suchindran, Kaela Pearce, Jennifer Rowell, Lillian F. Lien, John R. Guyton, Jeanette J. McCarthy

“…We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. …”
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Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse by Luciana Garbugino, Eleonora Centofante, Francesca R. D’Amato

“…Environmental enrichment has been proven to have positive effects on both behavioral and physiological phenotypes in rodent models of mental and neurodevelopmental disorders. …”
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Targeted correction of megabase-scale CNTN6 duplication in induced pluripotent stem cells and impacts on gene expression by Maria Gridina, Polina Orlova, Oleg Serov

“…However, duplication of the full-length human CNTN6 gene presents with variable penetrance, resulting in phenotypes that range from neurodevelopmental disorders to no visible pathologies, even within the same family. …”
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Genome-wide association study unravels mechanisms of brain glymphatic activity by Shu-Yi Huang, Yi-Jun Ge, Peng Ren, Bang-Sheng Wu, Weikang Gong, Jing Du, Shi-Dong Chen, Ju-Jiao Kang, Qing Ma, Arun L. W. Bokde, Sylvane Desrivières, Hugh Garavan, Antoine Grigis, Herve Lemaitre, Michael N. Smolka, Sarah Hohmann, IMAGEN Consortium, Jian-Feng Feng, Ya-Ru Zhang, Wei Cheng, Jin-Tai Yu

“…Our findings enhance the understanding of the genetics of the ALPS-index and provide insight for further research into the neurobiological mechanisms of glymphatic clearance activity across the lifespan and its relation to neuropsychiatric phenotypes.…”
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Inherited Paediatric Motor Neuron Disorders: Beyond Spinal Muscular Atrophy by Hooi Ling Teoh, Kate Carey, Hugo Sampaio, David Mowat, Tony Roscioli, Michelle Farrar

“…This has reinforced the clinical phenotyping and molecular genetic expertise required to navigate the complexities of such diagnoses. …”
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Diversity of TCR repertoire predicts recurrence after CRT followed by durvalumab in patients with NSCLC by Masayuki Shirasawa, Tatsuya Yoshida, Takaji Matsutani, Yuki Takeyasu, Naoko Goto, Shigehiro Yagishita, Shigehisa Kitano, Hiroaki Kuroda, Toyoaki Hida, Takayasu Kurata, Yuichiro Ohe

“…This prospective study, conducted from November 2019 to May 2021 at three institutions in Japan, evaluated the diversity of TCR repertoire (DE50) in PD-1 + CD8 + T-cells and CD8 + T-cell phenotypes in peripheral blood before and after CRT. …”
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