What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? by Nathan Angelo Lecaros Yap, Zahid Khan, Zahid Khan, Xingwei He, Jae-Geun Lee, Soe Maung, Kimberley R. Morgan, Tingquan Zhou, Helle Precht, Patrick W. Serruys, Patrick W. Serruys, Hector M. Garcia-Garcia, Yoshinobu Onuma, Sean Hynes, Sebastian Kelle, Anthony Mathur, Anthony Mathur, Andreas Baumbach, Andreas Baumbach, Christos V. Bourantas, Christos V. Bourantas

“…This review aims to provide a comprehensive evaluation of the performance of intravascular imaging in characterizing plaque phenotypes using histology as a reference standard; it summarizes the studies comparing the available invasive imaging techniques against histology, discusses the findings and limitations of these studies and highlights the potential of novel intravascular imaging approaches that were introduced for a more complete and comprehensive evaluation of plaque pathobiology.…”
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Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD by Randall J. Eck, Paul N. Valdmanis, Nicole F. Liachko, Brian C. Kraemer

“…Together, these findings support both TDP-43 loss and toxic gain-of-function phenotypes as contributors to the neurodegeneration in rNLS8 mice, nominating its continued utility as a preclinical model for investigating mechanisms of neurodegeneration in ALS/FTLD-TDP.…”
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Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition? by Jean-François Viallard, Marie Parrens, Frédéric Rieux-Laucat

“…This observation strengthens the role of FASL gene mutation in severe clinical phenotypes of primary immune deficiency and raises new questions about the genetic background of ITP occurring in young people in a context of immunodeficiency.…”
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Novel Breeding Techniques and Strategies for Enhancing Greenhouse Vegetable Product Quality by Julia Weiss, Nazim S. Gruda

“…These methods accelerate phenotyping and aid in identifying traits and genetic variants linked to quality characteristics. …”
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Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources by Yoojin Seo, Kyung-Hwa Shin, Hyung Hoi Kim, Hyung-Sik Kim

“…Moreover, individuals with severe hematological abnormalities or rare blood phenotypes need alternative therapeutic approaches instead of conventional blood transfusion. …”
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Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring by Tomoaki Takao, Ako Matsui, Chie Kikutake, Keiko Kan-o, Azusa Inoue, Mikita Suyama, Isamu Okamoto, Minako Ito

“…Offspring of asthmatic mothers show phenotypic alteration of their lung ILC2s during fetal life, with increased expression of genes related to activation and glucocorticoid signaling. …”
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Integrated physiological and transcriptomic data revealed the cold-resistant mechanisms in reproductive organs of the ‘Jinguang’ pear cultivar by Mengying Sun, Mengying Sun, Shun Lin, Shun Lin, Zezhao Zhao, Weizhen Guo, Min Jiang, Min Jiang, Ying Li, Jun Zhang, Jun Zhang, Jingxian Zhao, Minsheng Yang, Minsheng Yang

“…In this study, we evaluated the response of the flowers and young fruits of the ‘Jinguang’ pear cultivar to low temperatures from integrated phenotypic, physiological, and molecular approaches. …”
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A toolkit for quantifying individual response to herbal extracts in metabolic and inflammatory stress by Soo-yeon Park, Oran Kwon, Tim van den Broek, Jildau Bouwman, Ji Yeon Kim

“…This research emphasizes the quantification of phenotypic changes for personalized nutrition and health optimization. …”
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Case report: A novel de novo germline loss-of-function mutation in the STAT1 transactivation domain in two Chinese siblings, with the elder sibling presenting with multifocal Bacil... by Qin Ying Lim, Qin Ying Lim, Daniel Leung, Crystal K. Lam, Xingtian Yang, Kai N. Cheong, Kai N. Cheong, Andrew K. H. Yik, Jing Yang, Koon-Wing Chan, Pamela P. W. Lee, Pamela P. W. Lee, Pamela P. W. Lee, Pamela P. W. Lee, Miyuki Tsumura, Elaine Y. L. Au, Jaime S. Rosa Duque, Jaime S. Rosa Duque, Jaime S. Rosa Duque, Satoshi Okada, Yu Lung Lau, Yu Lung Lau, Yu Lung Lau

“…Signal transducer and activator of transcription 1 (STAT1) gene mutations have broad clinical phenotypes, classified by the inheritance pattern and functional state. …”
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IS IT POSSIBLE TO PREDICT TUMOR PROGRESSION THROUGH GENOMIC CHARACTERIZATION OF MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA? by Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Valerio De Stefano

“…MGUS and SMM are heterogeneous conditions with the presence of tumors with distinct pathogenic phenotypes and clinical outcomes. The identification of MGUS and SMM patients with a molecularly defined high risk of progression to MM offers the unique opportunity of early intervention with a therapeutic approach on a low tumor burden.   …”
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Morphological evaluations in buffaloes (Bubal- us bubalis) in Venezuela by Luis Alfredo Pacheco-Díaz, José Atilio Aranguren-Méndez, Rafael Román-Bravo, Sharon Rivero-Hernández, Luis Edgardo Tovar-Briceño

“… The buffalo herds in Venezuela are characterized by a high phenotypic polymorphism, showing high diversity among individuals. …”
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Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system by Hailey Pineau, Valerie L. Sim

“…Different conformations of misfolded prions can occur, leading to distinct disease phenotypes or strains and the accumulation of prions in distinct brain regions. …”
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Sensitivity of coronary hemodynamics to vascular structure variations in health and disease by Arnav Garcha, Noelia Grande Gutiérrez

“…Our results suggest that the diameter ratio between left coronary branches plays a substantial role in generating adverse hemodynamic phenotypes and can amplify the effect of other geometric features such as bifurcation position and angle, and vessel tortuosity. …”
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Prediction of Associations between OMIM Diseases and MicroRNAs by Random Walk on OMIM Disease Similarity Network by Hailin Chen, Zuping Zhang

“…In this paper, random walk on OMIM disease similarity network is applied to predict potential OMIM disease-miRNA associations under the assumption that functionally related miRNAs are often associated with phenotypically similar diseases. Our method makes full use of global disease similarity values. …”
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Comparisons of performances of structural variants detection algorithms in solitary or combination strategy. by De-Min Duan, Chinyi Cheng, Yu-Shu Huang, An-Ko Chung, Pin-Xuan Chen, Yu-An Chen, Jacob Shujui Hsu, Pei-Lung Chen

“…Structural variants (SVs) have been associated with changes in gene expression, which may contribute to alterations in phenotypes and disease development. However, the precise identification and characterization of SVs remain challenging. …”
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Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review by Clarissa Loureiro das Chagas Campêlo, Regina Helena Silva

“…However, the role of SNCA variants in individual traits or phenotypes of PD is unknown. Here, we reviewed the current literature and identified 57 studies, performed in fourteen different countries, that investigated SNCA variants and susceptibility to PD. …”
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Rare Case of Leiomyoma and Adenomyosis in Mayer-Rokitansky-Kuster-Hauser Syndrome by P. S. Hoo, A. R. Norhaslinda, J. N. Shah Reza

“…A 45-year-old Malay female with primary amenorrhoea and primary infertility presented with abdominal mass and abdominal pain. She is phenotypically female, has well developed secondary sexual characteristics, and has normal female external genitalia with shallow vagina dimple. …”
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Unraveling the metabolic landscape of Exophiala spinifera strain FM: Model reconstruction, insights into biodesulfurization and beyond. by Hamta Babaei Naeij, Zahra Etemadifar, John Kilbane, Mohammad Hossein Karimi-Jafari, Sepideh Mofidifar

“…The model was rigorously validated against growth phenotypes and gene essentiality data. Through shadow price analysis, we identified costly metabolites such as 3'-phospho-5'-adenylyl sulfate, 5'-adenylyl sulfate, and choline sulfate when DBT was used as the sulfur source. iEsp1694 encompasses the degradation of aromatic compounds, which serves as a crucial first step in comprehending the pan metabolic capabilities of this strain.…”
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Comprehensive genome-scale CRISPR knockout screening of CHO cells by Sung Wook Shin, Su Hyun Kim, Aghiles Gasselin, Gyun Min Lee, Jae Seong Lee

“…Genome-wide guide RNA (gRNA) amplicon sequencing data were generated from cell libraries, as well as short- and long-term KO libraries, and validated through phenotypic assessment and gRNA read count distribution. …”
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Trait and plasticity evolution under competition and mutualism in evolving pairwise yeast communities. by ShengPei Wang, Renuka Agarwal, Kari A Segraves, David M Althoff

“…Although we have a good understanding of how phenotypic plasticity evolves in response to abiotic environments, we know comparatively less about responses to biotic interactions. …”
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