Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE) by Chi Bun Chan, Keqiang Ye

“…Moreover, the functions of PIKE in peripheral tissues as revealed by the unique phenotypes in PIKE knock-out mice will be discussed as well.…”
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Specific Roles of MicroRNAs in Their Interactions with Environmental Factors by Juan Wang, Qinghua Cui

“…More importantly, the interactions between miRNAs and EFs have been shown to play critical roles in determining abnormal phenotypes and diseases. In this paper, we propose an outline of the current knowledge about specific roles of miRNAs in their interactions with various EFs and analyze the literatures detailing miRNAs-EFs interactions in the context of various of diseases.…”
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Immune Optimization as a Preventive and Therapeutic Adjunct for the Management of Renin–Angiotensin–Aldosterone System Dysfunction Diseases: A Review by Michael T. Okafor, Queenet C. Onyebuchukwu, Germaine A. Okafor, Samuel C. Niteh, Chikere A. Anusiem

“…This review aimed to discuss the putative T cell and RAAS dysfunction-mediated model of diseases using their dysfunction in disease phenotypes as classic examples. Online searches on databases, such as Google Scholar, PubMed, Biomed Central, and SciELO, were carried out. …”
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Challenges of Analysing Gene-Environment Interactions in Mouse Models of Schizophrenia by Peter L. Oliver

“…The conclusions from this work have been varied, due in part to a lack of standardised methodology, although most have illustrated that phenotypes related to disorders such as schizophrenia are consistently modified. …”
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LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis. by Lin Zhu, Qianqian Meng, Weiyi Qian, Weiting Shao, Yuyue Lu, Shuai Jin, Afei Zhang, Shuang G Yan, Jingtao Lu

“…Through cellular experiments such as gene editing and phenotypic functions, we found that LARP3 promotes the occurrence and development of HCC and inhibits apoptosis. …”
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Domestication and varietal diversification of Old World cultivated cottons (Gossypium sp.) in the Antiquity by Christopher Viot

“…Many traditional varieties have been described for each of these two species; an evolution is apparent from perennial, rather primitive forms through to annual varieties and modern phenotypes, with adaptations to cultivation in diverse conditions, including cold climates and short summers. …”
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Priestia megaterium cells are primed for surviving lethal doses of antibiotics and chemical stress by Manisha Guha, Abhyudai Singh, Nicholas C. Butzin

“…However, our findings reveal that primed cells contribute to an increase in persisters during transition and stationary phases, with no evidence supporting distinct phenotypes between Type I and Type II persisters.…”
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Autoinflammation with arthritis and dyskeratosis an inflammasomopathy: Case report and review of literature by Nayan Patel Sureja, Liza Rajasekhar

“…Two of these mutations are associated with “autoinflammation with arthritis and dyskeratosis (AIADK),” a novel Mendelian auto-inflammatory disorder, in the 2017 International Union of Immunological Societies phenotypic classification for primary immunodeficiencies. …”
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Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells by Seulah Choi, Tae Sung Kim, Hui Xuan Lim

“…These results demonstrated that lutein may exhibit immunosuppressive activity by inhibiting the phenotypic and functional maturation of DCs, and provide new evidence for the value of lutein in the search for novel therapeutic agents in the treatment of inflammatory diseases. …”
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TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

“…The implementation of multi-gene panel germline testing in different clinical settings has led to the identification of TP53 PV carriers outside the classic LFS-associated cancer phenotypes, leading to a broader cancer phenotypic redefinition and to the renaming of the condition as “heritable TP53-related cancer syndrome” (hTP53rc). …”
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Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study by Mingqiang Wang, Mingqiang Wang, Yue Jin, Yue Jin, Wenxiao Zhang, Wenxiao Zhang, Ling Ye, Ling Ye, Huanzhang Shao, Huanzhang Shao

“…Among the patients in the two phenotypes, 48.7% and 57.5% received corticosteroid treatment, respectively. …”
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Developmental regression of novel space preference in an autism spectrum disorder model is unlinked to GABAergic and social circuitry by Hirofumi Asano, Hirofumi Asano, Masaya Arai, Masaya Arai, Aito Narita, Takayuki Kuroiwa, Mamoru Fukuchi, Yuhei Yoshimoto, Soichi Oya, Goichi Miyoshi

“…Interestingly, unlike social phenotypes, novel space preference was initially established by 3 weeks of age but regressed by 6 weeks. …”
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Investigation of virulence factors in resistance and sensitive pseudomonas aeruginosa clinical isolates by Zeinab Waheed kadim, Hala Mouayed Radif

“…From 102 clinical specimens, only 33 isolates (32.35%) of P. aeruginosa were identified by Phenotypic characteristics, a biochemical test, the Vitek-2 compact system, and confirmed by Conventional Polymerase Chain Reaction (PCR). …”
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Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming by James Spyrou, David K. Gardner, Alexandra J. Harvey

“…The significance of metabolites during the reprogramming process is central to further elucidating how iPSC retain somatic cell characteristics and optimising culture conditions to generate iPSC with physiological phenotypes to ensure their reliable use in basic research and clinical applications. …”
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IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes by Amandine Martin, Solène Caron, Mélissa Marcotte, Pauline Bronnec, Etienne Garneret, Nora Martel, Georgina Maalouf, Pascal Sève, David Saadoun, Yvan Jamilloux, Thomas Henry

“…IFN-γ treatment promoted the phenotypic expression of pathogenic ALPK1 mutations. …”
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Principal Component and Cluster Analysis as a Tool in the Assessment of Tomato Hybrids and Cultivars by G. Evgenidis, E. Traka-Mavrona, M. Koutsika-Sotiriou

“…The Principal Component 2 revealed two smaller groups, a positive one with phenotypic traits and a negative one with tolerance to inbreeding. …”
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Moss-pathogen interactions: a review of the current status and future opportunities by Huan Zhang, Huan Zhang, Qilin Yang, Qilin Yang, Leyi Wang, Leyi Wang, Huawei Liu, Huawei Liu, Daoyuan Zhang, Daoyuan Zhang, Cheng-Guo Duan, Xiaoshuang Li, Xiaoshuang Li

“…This article reviews current research on moss-pathogen interactions, examining host-pathogen specificity, characterizing infection phenotypes and physiological responses, and comparing pathogen susceptibility and defense mechanisms between mosses and angiosperms. …”
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Aura phenomenon: a proposal for an etiology-based clinical classification by Umberto Pensato, Andrew M. Demchuk, Jens P. Dreier, Kevin C. Brennan, Simona Sacco, Michele Romoli

“…Conclusion This nuanced classification aims to aid in the diagnostic evaluation and phenotyping of aura phenomenon, ultimately improving the diagnosis and management of the different associated neurological conditions. …”
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Whole Exome Sequencing Reveals Compound Heterozygosity for Ethnically Distinct PEX7 Mutations Responsible for Rhizomelic Chondrodysplasia Punctata, Type 1 by Jessie C. Jacobsen, Emma Glamuzina, Juliet Taylor, Brendan Swan, Shona Handisides, Callum Wilson, Michael Fietz, Tessa van Dijk, Bart Appelhof, Rosamund Hill, Rosemary Marks, Donald R. Love, Stephen P. Robertson, Russell G. Snell, Klaus Lehnert

“…We describe two brothers who presented at birth with bone growth abnormalities, followed by development of increasingly severe intellectual and physical disability, growth restriction, epilepsy, and cerebellar and brain stem atrophy, but normal ocular phenotypes. Case 1 died at 19 years of age due to chronic respiratory illnesses without a unifying diagnosis. …”
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Reduced Representation Libraries from DNA Pools Analysed with Next Generation Semiconductor Based-Sequencing to Identify SNPs in Extreme and Divergent Pigs for Back Fat Thickness by Samuele Bovo, Francesca Bertolini, Giuseppina Schiavo, Gianluca Mazzoni, Stefania Dall’Olio, Luca Fontanesi

“…Some of these SNPs were close to genes involved in obesity related phenotypes.…”
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