Genetic divergence studies in little millet (Panicum sumatrense Roth. ex. Roem. & Schult) using D2 statistics and molecular markers by Kinal Patel, Arna Das*, Dhrumi Dalsaniya, Hadassah Mamidipalli, Sanjith Vasala and Harshal E. Patil2

“…Variability parameters revealed considerable variation among the genotypes for all the traits studied. Phenotypic parameters being higher than genotypic ones indicated only little environmental influence which was confirmed from high heritability and genetic advance. …”
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Advances in Murine Models of Diabetic Nephropathy by Li-li Kong, Hao Wu, Wen-peng Cui, Wen-hua Zhou, Ping Luo, Jing Sun, Hang Yuan, Li-ning Miao

“…Here we review the identified murine models of DN from the aspects of genetic background, type of diabetes, method of induction, gene deficiency, animal age and gender, kidney histopathology, and phenotypic alterations in the hope of enhancing our comprehension of genetic susceptibility and molecular mechanisms responsible for this disease and providing new clues as to how to choose appropriate animal models of DN.…”
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Expression of a mammalian RNA demethylase increases flower number and floral stem branching in Arabidopsis thaliana by Kasey Markel, Lucas Waldburger, Patrick M. Shih

“…In nearly all cases, perturbation of the RNA methylation machinery results in deleterious phenotypes. However, a recent landmark paper reported that transcriptome‐wide use of the human RNA demethylase FTO substantially increased the yield of rice and potatoes. …”
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Water quality and neurodegenerative disease risk in the middle-aged and elderly population by Yujia Bao, Yongxuan Li, Yanqiu Zhou, Jingqi Zhou, Wei Mu, Xiaobei Deng, Chen Shen, Lefei Han, Jinjun Ran

“…We assembled a cohort of 397,265 participants from the UK Biobank to investigate the associations of water hardness with neurodegenerative diseases and brain imaging phenotypes through modeling. We found water hardness in 0–120 mg/L elevated the incidence risks of Alzheimer’s disease and vascular dementia compared to that in 120–300 mg/L, with hazard ratios of 1.13 (1.01, 1.27) and 1.24 (1.05, 1.46), respectively. …”
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Clinical Manifestations and Distribution of Cutaneous Leishmaniasis in Pakistan by Abaseen Khan Afghan, Masoom Kassi, Pashtoon Murtaza Kasi, Adil Ayub, Niamatullah Kakar, Shah Muhammad Marri

“…The increased clinical diversity and the spectrum of phenotypic manifestations noted underscore the fact that the diagnosis of CL should be not only considered when dealing with common skin lesions, but also highly suspected by dermatologists and even primary care physicians even when encountering uncommon pathologies. …”
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Targeted Next-Generation Resequencing of Gene Identifies Novel Multiple Variants Pattern in Severe Hereditary Factor V Deficiency by Piotr K. Janicki, Sonia Vaida, Hamid A. B. AL-Mondhiry

“…Each of the three missense variants was previously associated with separate phenotypes, including Factor V deficiency (R2102H), thrombosis (R513K) and frequent miscarriages (D107H). …”
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Genomic analysis of antimicrobial resistant Escherichia coli isolated from manure and manured agricultural grasslands by C. Tyrrell, C. M. Burgess, F. P. Brennan, D. Münzenmaier, D. Drissner, R. J. Leigh, F. Walsh

“…The E. coli isolates were phenotypically antimicrobial resistant, predominantly multidrug resistant. …”
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SOD1 Is Essential for the Viability of DT40 Cells and Nuclear SOD1 Functions as a Guardian of Genomic DNA by Eri Inoue, Keizo Tano, Hanako Yoshii, Jun Nakamura, Shusuke Tada, Masami Watanabe, Masayuki Seki, Takemi Enomoto

“…We generated conditional SOD1 knockout cells from chicken DT40 cells and analyzed their phenotypes. The results revealed that SOD1 was essential for viability and that depletion of SOD1, especially nuclear SOD1, increased sister chromatid exchange (SCE) frequency, suggesting that superoxide is generated in or near the nucleus and that nuclear SOD1 functions as a guardian of the genome. …”
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Strategies for the Development of Bioprotective Cultures in Food Preservation by Luana Virgínia Souza, Evandro Martins, Isabella Maria Fernandes Botelho Moreira, Antônio Fernandes de Carvalho

“…However, to make LAB cultures available in the market is not that easy, the strains should be characterized phenotypically and genotypically, and studies of safety and technological application are necessary to validate their bioprotection performance. …”
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DiGeorge Syndrome Presenting as Hypocalcaemia-Induced Seizures in Adulthood by Adrian Zammit, Deborah Grech Marguerat, Josephine Psaila, Alexander Attard

“…Presentation in adulthood is rare but must be borne in mind when dealing with cases of hypocalcaemia even in the absence of florid phenotypic features. A link with malignant disease has also been reported and should lead to prompt investigation of concerning masses.…”
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Nephrogenic Syndrome of Inappropriate Antidiuresis by D. Morin, J. Tenenbaum, B. Ranchin, T. Durroux

“…The pathophysiology of the disease requires fuller elucidation as the phenotypic variability observed in patients bearing the same mutations remains unexplained. …”
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Genetic diversity and character association studies for agro-morphological and quality traits of advanced breeding lines in field pea (Pisum sativum L.) by Kommineni Jagadeesh1*, C.S. Mahto1, Niraj Kumar1 and H. C. Lal2

“…The correlation analysis revealed that traits like primary branches per plant, pod length, seeds per pod, harvest index and biological seed yield per plant showed a note-worthy positive association at both genotypic and phenotypic levels. Path analysis revealed the correlation of pod length, harvest index and biological yield per plant was due to direct positive effects. …”
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𝛽-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload by Luca Melchiori, Sara Gardenghi, Stefano Rivella

“…The defects involved are extremely heterogeneous and give rise to a large phenotypic spectrum, with patients that are almost asymptomatic to cases in which regular blood transfusions are required to sustain life. …”
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Sex-related differences in heart failure patients: physiological mechanisms of cardiovascular ageing and evidence-based sex-specific medical therapies by Andra Maria Ciutac, Tiberiu Pana, Dana Dawson, Phyo Kyaw Myint

“…Given the highlighted knowledge gaps, it is paramount for new research efforts to account for the different sex phenotypes in HF.…”
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Underappreciated layers of antibody-mediated immune synapse architecture and dynamics by Benjamin S. Goldberg, Margaret E. Ackerman

“…The emerging model endeavors to explain the phenotypic impact of both antibody intrinsic characteristics and extrinsic features—fitting them within a spatiotemporal paradigm that better accounts for observed antibody activities. …”
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Using the Bayesian Model Averaging Approach for Genomic Selection by Considering Skewed Error Distributions by Azadeh Ghazanfari, Afshin Fayyaz Movaghar

“…The Rice SNP-seek database was used to obtain real data, which included 152 single nucleotide polymorphisms (SNPs) with 6 phenotypes. Results: Numerical studies on simulated and real data showed that, although Occam’s window ran faster than the MC3 method, the latter method suggested better linear models for the data with both skew-normal and skew-t error distributions. …”
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Mediation model with a categorical exposure and a censored mediator with application to a genetic study. by Jian Wang, Jing Ning, Sanjay Shete

“…Mediation models have been widely used to determine direct and indirect contributions of genetic variants in clinical phenotypes. In genetic studies, the additive genetic model is the most commonly used model because it can detect effects from either recessive or dominant models (or any model in between). …”
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Persistent and extended COVID, post-COVID-19. New reflections in 2024 by Alfredo Darío Espinosa Brito

“…Although most therapeutic approaches in patients with persistent COVID are symptomatic and supportive, based on the clinical expertise of the professionals who care for the patients, recent advances in the description of clinical phenotypes, further research into molecular research and the search to identify specific biomarkers could provide new evidence on their pathogenic mechanisms and more personalized approaches to the clinical care of these patients, who constitute a real health and occupational problem in the world today. …”
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Diabetes in HFE Hemochromatosis by James C. Barton, Ronald T. Acton

“…The prevalence of type 2 diabetes diagnosed today in whites of European descent with and without HFE hemochromatosis is similar. Routine iron phenotyping or HFE genotyping of patients with type 2 diabetes is not recommended. …”
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Epigenetics: The New Frontier in the Landscape of Asthma by Bharti Chogtu, Dipanjan Bhattacharjee, Rahul Magazine

“…Though epigenetic research in asthma is in its nascent stages, it has led to very exciting results, especially with regard to explaining the massive influence of environment on development of asthma and its varied phenotypes. However, there remains a lot of work to be done, especially with regard to understanding how the interactions between immune system, epigenome, and environment lead to asthma. …”
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