Cancer stem-like cells stay in a plastic state ready for tumor evolution by Jiali Xu, Houde Zhang, Zhihao Nie, Wenyou He, Yichao Zhao, Zhenhui Huang, Lin Jia, Zhiye Du, Baotong Zhang, Siyuan Xia

“…Therefore, CSCs are likely the nature of tumor cells that gain cell plasticity. However, the phenotypic plasticity of CSCs has never been systematically discussed. …”
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Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds by André Dutra Messias, Kelly Fernanda Martins, Adriana Cristina Motta, Eliana Aparecida de Rezende Duek

“…PLDLA-TMC scaffolds stimulated the proliferation and normal phenotypic manifestations of cultured osteoblasts. These results show that it was possible to produce a terpolymer from L-lactide, D,L-lactide, and TMC. …”
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Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae by Shiva Kumar Goud Gadila, John R. Caskey, Edward B. Breitschwerdt, Ricardo G. Maggi, Monica E. Embers

“…In this study we performed comparative transcriptomic analyses between the extracellular and intracellular B. henselae phenotypes. Overall, specific genes involved in invasion, virulence, extracellular adhesion of type 4 secretion system were downregulated following intracellular invasion of B. henselae. …”
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Intraspecific epigenomics divergence in brown bears (Ursus arctos): insights from genome-wide DNA methylation patterns by Paolo Colangelo, Paolo Colangelo, Ian Marc Bonapace, Laura Gramolini, Emanuela Solano, Emanuela Solano, Elisa Desiato, Paolo Franchini, Leonardo Gentile, Roberto Guadagnini, Oddmund Kleven, Jonas Kindberg, Jonas Kindberg, Alexander Kopatz, Paolo Ciucci

“…This finding supports previous studies suggesting a role for the alteration of developmental pathways in shaping phenotypic novelties with potential adaptative significance. …”
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Validation of a mouse model with Apoe gene knockout by Petr R. Lebedev

“…This model exhibits clear phenotypic manifestations of the disease and can be used for pharmacological correction of endothelial dysfunction.…”
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Analysis of Direct and Indirect Selection and Indices in Bread Wheat (Triticum aestivum L.) Segregating Progeny by Zine El Abidine Fellahi, Abderrahmane Hannachi, Hamenna Bouzerzour

“…Three selection methods including direct and indirect selection along with selection index based on the phenotypic values of eleven traits of agronomic interest were assessed for their application in F4 bread wheat progenies. …”
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PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs by Serena Vella, Pier Giulio Conaldi, Tullio Florio, Aldo Pagano

“…Neuroblastoma (NB) is the most common and aggressive pediatric cancer, characterized by a remarkable phenotypic diversity and high malignancy. The heterogeneous clinical behavior, ranging from spontaneous remission to fatal metastatic disease, is attributable to NB biology and genetics. …”
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Reproductive Technologies and Genomic Selection in Cattle by Patrice Humblot, Daniel Le Bourhis, Sebastien Fritz, Jean Jacques Colleau, Cyril Gonzalez, Catherine Guyader Joly, Alain Malafosse, Yvan Heyman, Yves Amigues, Michel Tissier, Claire Ponsart

“…Information brought by reproductive physiology will provide new markers and new improved phenotypes that will increase the efficiency of selection schemes for reproductive traits. …”
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Effects of Nuclear Genomes on Anther Development in Cytoplasmic Male Sterile Chicories (Cichorium intybus L.): Morphological Analysis by Ildephonse Habarugira, Theo Hendriks, Marie-Christine Quillet, Jean-Louis Hilbert, Caroline Rambaud

“…The Cichorium intybus flower development in fertile, cytoplasmic male sterility (CMS 524) and various phenotypes carrying the 524 male sterile cytoplasm was investigated macroscopically and by light microscopy. …”
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RNA structure in alternative splicing regulation: from mechanism to therapy by Bao Nengcheng, Wang Zhechao, Fu Jiayan, Dong Haiyang, Jin Yongfeng

“…In this review, the molecular mechanisms of RNA secondary structure-mediated splicing regulation are summarized, with a focus on the complex interplay between aberrant RNA conformations and disease phenotypes resulted from splicing defects. This study also explores additional factors that reshape structural conformations, enriching our understanding of the mechanistic network underlying structure-mediated splicing regulation. …”
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Naxos Disease and Related Cardio-Cutaneous Syndromes by Alexandros Protonotarios, MD, Angeliki Asimaki, Ph.D, Cristina Basso, MD, Zafeirenia Xylouri, MD, Emanuele Monda, MD, Ioannis Protonotarios, MD, Giulia Crisci, MD, Dominic JR. Abrahms, MMBS, MD, MBA, Aris Anastasakis, MD, Loizos Antoniades, MD, Athanasios Bakalakos, MD, Andreina Carbone, MD, Aman S. Coonar, MD, Juan Ramon Gimeno, MD, George Lazaros, MD, Stamatis Lerakis, MD, Luisa Mestroni, MD, George Papadopoulos, MD, Leandro Pecchia, MD, Francesca Romana Prandi, MD, Petros Syrris, MD, Julia Cadrin-Turigny, MD, Anargyros Vasilakis, MSc, Jeffrey E. Saffitz, MD, PhD, Stamatios Gaetano Thiene, MD, Perry M. Elliott, MD, Juan Pablo Kaski, MD, William J. McKenna, MD, Eduardo Bossone, MD, Giuseppe Limongelli, MD, Adalena Tsatsopoulou, MD

“…Disease progression necessitates holistic care with risk management and lifestyle adjustments, often needing treatment for arrhythmia and heart failure. Similar phenotypes have been linked to desmoplakin and rarely desmocollin2 gene variants, highlighting the importance of familial and genetic evaluation. …”
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Blue light promotes conjunctival epithelial-mesenchymal transition and collagen deposition through ITGB4 by Qianjie Yang, Kuangqi Chen, Siyi Chen, Yinhao Wang, Yutong Xia, Jinbo Chen, Ye Shen

“…Western blotting, wound healing assays, transwell assay, and phalloidin staining assessed phenotypes of epithelial-mesenchymal transition (EMT). …”
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Dysmorphological Delineation of Orofaciodigital Syndrome Type I. Presentation of a Case and Literature Review by Noel Taboada Lugo, Ana María Rodríguez Díaz, Tairí Borges García

“…Its interest lies in presenting the phenotypic delineation of a rare syndrome, which can manifest with a mild clinical expression or associated with important dysmorphological alterations.…”
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Beyond Hormone Receptors: liquid biopsy tools to unveil new clinical meanings and empower therapeutic decision-making in Luminal-like metastatic breast cancer by Brenno Pastò, Riccardo Vida, Arianna Dri, Lorenzo Foffano, Serena Della Rossa, Lorenzo Gerratana, Fabio Puglisi

“…Immunohistochemical (IHC) tissue profiling is a standard practice in the management of metastatic breast cancer (mBC), that enables the identification of distinct biological phenotypes based on hormone receptors' expression. Luminal-like tumors primarily benefit from a first line treatment strategy combining endocrine therapy and cyclin-dependent kinase 4/6 inhibitors. …”
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Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration by Kangkang Zha, Zhiqiang Sun, Yu Yang, Mingxue Chen, Cangjiang Gao, Liwei Fu, Hao Li, Xiang Sui, Quanyi Guo, Shuyun Liu

“…Thus, there is an urgent need to develop strategies that promote MSC chondrogenic differentiation to give rise to durable and phenotypically correct regenerated cartilage. This review provides an overview of recent advances in enhancement strategies for MSC chondrogenic differentiation, including optimization of bioactive factors, culture conditions, cell type selection, coculture, gene editing, scaffolds, and physical stimulation. …”
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Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens by Paras Famta, Saurabh Shah, Biswajit Dey, Kondasingh Charan Kumar, Deepkumar Bagasariya, Ganesh Vambhurkar, Giriraj Pandey, Anamika Sharma, Dadi A. Srinivasarao, Rahul Kumar, Santosh Kumar Guru, Rajeev Singh Raghuvanshi, Saurabh Srivastava

“…This highly regulated event causes phenotypic, genetic, and epigenetic changes in the tumor microenvironment (TME). …”
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Morphofunctional variations of the Echinometra lucunter (Echinoidea) on Bahia Coast, Brazil by Walter Ramos Pinto Cerqueira, Yara Aparecida Garcia Tavares, Natalie Petrovna Semanovschi, Daniele Nascimento de Jesus

“…The environments with distinct characteristics and wide food availability associated with a broad spectrum of the trophic niche occupied by the populations point out modulations and specializations of morphofunctional strategies and the expression of phenotypes.…”
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Decoding the mechanisms behind second primary cancers by Meiyuan Zeng, Anqi Lin, Aimin Jiang, Zhengang Qiu, Hongman Zhang, Shifu Chen, Mingyan Xu, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo

“…This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. …”
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Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells by Nicolas Espagnolle, Benjamin Hebraud, Jean-Gérard Descamps, Mélanie Gadelorge, Marie-Véronique Joubert, Laura Do Souto Ferreira, Murielle Roussel, Anne Huynh, Luc Sensébé, Louis Casteilla, Michel Attal, Hervé Avet-Loiseau, Frederic Deschaseaux, Philippe Bourin, Jill Corre

“…For the first time, we present a transcriptomic, phenotypic, and functional comparison of ASCs from MM patients and healthy donors (HDs) relying on their autologous MSC counterparts. …”
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Underscoring long-term host-microbiome interactions in a physiologically relevant gingival tissue model by M. Adelfio, G. E. Callen, A. R. Diaz, B. J. Paster, X. He, H. Hasturk, C. E. Ghezzi

“…Our results indicated long-term host and microbiome viability, host barrier integrity, phenotypic functional response, and preservation of healthy microbial populations and interbacterial dialogs. …”
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