Acute Aortic Dissection in Pregnancy in a Woman with Undiagnosed Marfan Syndrome by Mandana Master, Gavin Day

“…On later examination, our patient fulfilled the diagnostic criteria for phenotypic expression of Marfan syndrome. Genetic testing also confirmed that she has a mutation of the fibrillin (FBN 1) gene associated with the disease.…”
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Genotyping of potato samples from the GenAgro ICG SB RAS collection using DNA markers of genes conferring resistance to phytopathogens by I. V. Totsky, I. V. Rozanova, A. D. Safonova, A. S. Batov, Yu. A. Gureeva, E. K. Khlestkina, A. V. Kochetov

“…Conducting a permanent phenotypic evaluation is associated with difficulties, for example, it is not always possible to work with pathogens, and phenotypic evaluation is very costly and time consuming. …”
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Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…Abstract A risk assessment framework was developed to evaluate the zoonotic potential of avian influenza (AI), focusing on virus mutations linked to phenotypic traits related to mammalian adaptation identified in the literature. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Bispecific antibodies, but not anti-PD-1, significantly increased the abundance of a proliferating natural killer cell subset, which exhibited enrichment for a tissue-residency signature. Key phenotypic and transcriptional changes occurred in a PD-1+CXCL13+CD4+ T cell subset, in response to all treatments, including increased interleukin-17 secretion and signaling toward plasma cells. …”
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Identification of 39 stripe rust resistance loci in a panel of 465 winter wheat entries presumed to have high-temperature adult-plant resistance through genome-wide association map... by Fangjie Yao, Fangjie Yao, Meinan Wang, Deven R. See, Deven R. See, Ennian Yang, Guoyue Chen, Guoyue Chen, Xianming Chen, Xianming Chen

“…The 465 entries were also phenotyped for stripe rust responses at the adult-plant stage under natural infection of Pst in multiple field locations from 2018 to 2021 in the Washington state, and 345 entries were found to have stable resistance. …”
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Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…BAX emerged as the most responsive gene to NaB, while TP53 showed minimal sensitivity, supporting NaB’s effectiveness in p53-compromised phenotypes. Nuclear condensation and fragmentation at higher NaB doses confirmed apoptotic induction. …”
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Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…We analyze numerically the conditions for the existence of steady states of the mathematical model of HIV-1 infection for the numerical values of model parameters corresponding to phenotypically different variants of the infectious disease course. …”
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis by Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian

“…Little is known about the modulatory role of serum exosomes in phenotypic switching of VSMC and vascular remodeling in TAK. …”
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Relationship between BMI, indicators of lipid metabolism and diabetic neuropathy: a Mendelian randomization study by Yuanyuan Jia, Guanying Liu, Xuesong Li, Lijun Duan, Lifeng Zhao

“…Methods Body constitution-related phenotypes, namely BMI (kg/m2), total cholesterol (TC), and triglyceride (TG), were investigated in this study. …”
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Evaluation of Diversity of Newly Bred Czech Sweet Cherry Cultivars in Extensive Plantations by Jiří Sedlák, Boris Krška, Liliia Pavliuk, Jana Čmejlová, František Paprštein, Jitka Blažková

“…The cultivars were evaluated phenotypically using standard descriptors for sweet cherries. …”
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Peritonitis due to Moraxella Osloensis: An Emerging Pathogen by Sreedhar Adapa, Purva Gumaste, Venu Madhav Konala, Nikhil Agrawal, Amarinder Singh Garcha, Hemant Dhingra

“…M. osloensis was identified by 16 S PCR phenotypic and sequencing techniques. Patient responded well to the treatment, with intraperitoneal cephalosporin, and repeat peritoneal fluid culture yielded no growth. …”
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Challenges in classifying human chromosomal heteromorphisms using banding cytogenetics: From controversial guidelines to the need for a universal scoring system by Sílvia Pires, Paula Jorge, Thomas Liehr, Natália Oliva-Teles

“…Although not completely devoid of genes, these regions are typically not transcribed into proteins and lack obvious phenotypic impact. Nonetheless, their clinical importance is increasingly under scrutiny, with several studies aiming to assess their influence on human diseases and susceptibilities, especially as they are seemingly part of the long noncoding RNAs in certain tissues. …”
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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS by Pamela Milani, Stella Gagliardi, Emanuela Cova, Cristina Cereda

“…Considering that changes in SOD1 mRNA levels have been associated with sporadic ALS (SALS), a molecular understanding of the processes involved in the regulation of SOD1 gene expression could not only unravel novel regulatory pathways that may govern cellular phenotypes and changes in diseases but also might reveal therapeutic targets and treatments. …”
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PDK1/mTOR Signaling in Myeloid Cells Differentially Regulates the Early and Late Stages of Sepsis by Juan Du, Guoli Li, Mingxi Hua, Junyan Han, Yu Hao, Hui Zeng, Ang Li, Yaxian Kong

“…In the CLP mice, the myeloid cells play an important role in septic shock. The phenotypes and the activation state of the macrophage and neutrophil correlate with their metabolism. …”
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Exploring the role of metabolic pathways in TNBC immunotherapy: insights from single-cell and spatial transcriptomics by Shi-liang Chen, Yi-Ran Fei, Yi-Ran Fei, Xin-xian Cai, Xin-xian Cai, Cong Wang, Shi-yuan Tong, Zhe-zhong Zhang, Yan-xia Huang, Dan-dan Bian, Yi-bo He, Xiao-xiao Yang

“…The review emphasizes the crucial role of metabolic reprogramming in modulating immune cell function, discussing how specific metabolic pathways, such as glycolysis, lipid metabolism, and amino acid metabolism, can directly impact the activity and phenotypes of various immune cell populations within the TNBC tumor microenvironment. …”
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Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model by Kathryn M. Buller, Julie A. Wixey, Hanna E. Reinebrant

“…Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-injured neonates. …”
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Gene Polymorphisms in Chronic Periodontitis by Marja L. Laine, Bruno G. Loos, W. Crielaard

“…Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.…”
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Neurological and Neurobehavioral Disorders Associated with Toxoplasma gondii Infection in Humans by Maxwell A. Virus, Evie G. Ehrhorn, LeeAnna M. Lui, Paul H. Davis

“…Although most latent T. gondii infections in humans have traditionally been considered asymptomatic, studies in rodents suggest phenotypic neurological changes are possible. Consequently, several studies have examined the link between T. gondii infection and diseases such as schizophrenia, epilepsy, depression, bipolar disorder, dysphoria, Alzheimer’s disease, Parkinson’s disease, and obsessive-compulsive disorder (OCD). …”
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The Responses of the Quantitative Characteristics of a Ramet Population of the Ephemeroid Rhizomatous Sedge Carex physodes to the Moisture Content of the Soil in Various Locations... by Buhailiqiemu Abudureheman, Huiliang Liu, Daoyuan Zhang, Kaiyun Guan, Yongkuan Zhang

“…In this study, the soil moisture content was measured, and the quantitative characteristics of this sedge species were compared. The phenotypic plasticity of each parameter and the linear regression relationships were analyzed. …”
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Depletion of Regulatory T Cells in a Mouse Experimental Glioma Model through Anti-CD25 Treatment Results in the Infiltration of Non-Immunosuppressive Myeloid Cells in the Brain by Wim Maes, Tina Verschuere, Anaïs Van Hoylandt, Louis Boon, Stefaan Van Gool

“…Interestingly, PC61-treated mice also showed a pronounced infiltration of CD11b+ myeloid cells in the brain. Phenotypically, these cells could not be considered as Gr-1+ myeloid-derived suppressor cells (MDSC) but were identified as F4/80+ macrophages and granulocytes.…”
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