Myocardial Infarction-Associated Shock: A Comprehensive Analysis of Phenotypes, SCAI Classification, and Outcome Assessment by Stanislav Dil, Maria Kercheva, Oleg Panteleev, Sergey Demianov, Aleksandr Kanev, Nina Belich, Boris Kornienko, Vyacheslav Ryabov

“…<i>Conclusions</i>: MS in the context of MI-CS represents a distinct clinical phenotype with specific hemodynamic features and significantly worsened outcomes. …”
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High throughput phenotyping in soybean breeding using RGB image vegetation indices based on drone by Andressa K. S. Alves, Maurício S. Araújo, Saulo F. S. Chaves, Luiz Antônio S. Dias, Lucas P. Corrêdo, Gabriel G. F. A. Pessoa, André R. G. Bezerra

“…Abstract This study investigates the effectiveness of high-throughput phenotyping (HTP) using RGB images from unmanned aerial vehicles (UAVs) to assess vegetation indices (VIs) in different soybean pure lines. …”
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Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease by Lisa Budzinski, Gi-Ung Kang, René Riedel, Toni Sempert, Leonie Lietz, René Maier, Janine Büttner, Bettina Bochow, Marcell T. Tordai, Aayushi Shah, Amro Abbas, Tanisha Momtaz, Jannike L. Krause, Robin Kempkens, Katrin Lehman, Gitta A. Heinz, Anne E. Benken, Stefanie Bartsch, Kathleen Necke, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen, Tilmann Kallinich, Tobias Alexander, Bosse Jessen, Carl Weidinger, Britta Siegmund, Andreas Radbruch, Anja Schirbel, Benjamin Moser, Hyun-Dong Chang

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Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury by Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong

“…The modulation of macrophage phenotypes is thus considered a promising therapeutic strategy to mitigate inflammation and promote regeneration. …”
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Comparison of frontal QRS-T angle in mitral valve prolapse without arrhythmic phenotype with healthy individuals by Celal Kilit

“…Patients with the arrhythmic MVP (AMVP) phenotype have an increased risk of ventricular arrhythmia and sudden cardiac death. …”
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Cardiac Micro–Computed Tomography for Morphological and Functional Phenotyping of Muscle LIM Protein Null Mice by Cristian T. Badea, Laurence W. Hedlund, Julie F. Boslego Mackel, Lan Mao, Howard A. Rockman, G. Allan Johnson

“…The purpose of this study was to investigate the use of micro–computed tomography (micro-CT) for morphological and functional phenotyping of muscle LIM protein (MLP) null mice and to compare micro-CT with M-mode echocardiography. …”
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Prevalence and causes of rifampicin-resistance genotypic/phenotypic discrepancy detected on Xpert MTB/RIF in Singapore by Caroline Victoria Choong, Lovel Galamay, Jerlyn Huixian Woo, Angeline Jie-Yin Tey, Cynthia Bin Eng Chee

“…With a high specificity rate (98%) in detecting RIF resistance, Xpert has a positive predictive value (PPV) exceeding 90% in settings where the prevalence of RIF resistance is above 15%.3 However, in Singapore, a country with medium-incidence of TB and low prevalence of RIF resistance (<1% among individuals born in Singapore), 4 the PPV of detecting RIF resistance via Xpert is substantially lower.3 Phenotypic-genotypic discrepant RIF resistance have been reported to result from technical errors, false-positive results in paucibacillary samples,5 silent mutations6 or disputed mutations where minimal inhibitory concentrations (MICs) fall below critical concentrations in phenotypic drug susceptibility testing (pDST) systems.7 We conducted a quality assessment of sputum samples which tested positive for TB and RIF resistance using point-of-care Xpert at the Singapore National Tuberculosis Care Centre (NTBCC) to determine the prevalence and causes of false-positive RIF resistance.…”
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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

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Prenatal ultrasound phenotype of fetuses with recurrent 1q21.1 deletion and duplication syndrome by Fengyang Wang, Huijuan Peng, Guiyu Lou, Yanxin Ren, Shixiu Liao

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The effect of high-sugar feeding on rodent metabolic phenotype: a systematic review and meta-analysis by Sophie Lucic Fisher, G. Jean Campbell, Alistair Senior, Kim Bell-Anderson

“…High-sugar feeding, with fructose in particular, altered liver phenotype; ALT (d = 1.08; 0.66, 1.5), triglyceride content (d = 0.52; 0.25, 0.78), cholesterol (d = 0.59; 0.16, 1.03) and liver mass (d = 0.93; 0.37, 1.48), and glucose tolerance; fasting glucose (d = 0.60; 0.18, 1.01) and fasting insulin (d = 0.42; 0.07, 0.77) but not body weight or energy intake. …”
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Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians. by Danielle Ireland, Christina Rabeler, Sagar Rao, Rudy J Richardson, Eva-Maria S Collins

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Corrigendum to “Genotype-Phenotype Characterization of Novel Variants in Six Italian Patients with Familial Exudative Vitreoretinopathy” by Giancarlo Iarossi, Matteo Bertelli, Paolo Enrico Maltese, Elena Gusson, Giorgio Marchini, Alice Bruson, Sabrina Benedetti, Sabrina Volpetti, Gino Catena, Luca Buzzonetti, Lucia Ziccardi

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Distinct phenotypes of patients and healthcare resource utilization after hospitalization for COVID-19: an observational study by Claire Marant Micallef, Manon Belhassen, Florence Ader, Valeria Martinez, Eric Van Ganse, Marjorie Bérard, Mélanie Née, Mikhail Dziadzko, Frédéric Aubrun

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Evolution of the Macrophage CD163 Phenotype and Cytokine Profiles in a Human Model of Resolving Inflammation by Betsy J. Evans, Dorian O. Haskard, Gregory Sempowksi, R. Clive Landis

“…There was a significant increase in leukocyte infiltrate at 40 h with appearance of a “resolving macrophage” phenotype CD14+CD163+ by flow cytometry. Neutrophils acquired apoptotic markers at 40 h and were observed to be phagocytosed by macrophagic “Reiter’s” cells. …”
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Physiological and image-based phenotyping assessment of waterlogging responses of three kiwifruit rootstocks and grafting combinations by Maria Calabritto, Alba N. Mininni, Roberto Di Biase, Angelo Petrozza, Stephan Summerer, Francesco Cellini, Bartolomeo Dichio

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Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma by Gorkem Odabas, Metin Cetin, Serdar Turhal, Huseyin Baloglu, A. Emre Sayan, Tamer Yagci

“…Plexin C1 distinguishes HCC cells of epithelial characteristics from those with the mesenchymal phenotype. Compared to the nontumoral liver, HCC tissues significantly overexpress Plexin C1. …”
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Phenotypic and genotypic features of the full-term newborns with delayed conjugation jaundices in relation to gender of the child by O. K. Botvin'yev, A. I. Kolotilina, I. N. Razumovskaya, A. V. Yeremeyeva

“…Aim of investigation. To detect phenotypic and genotypic features of the full-term newborns with delayed conjugation jaundice in relation to gender of the patient.Material and methods. …”
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Correction to: Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells by Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang, Lining Wei

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Learned phenotypes emerge during social stress modifying hippocampal orexin receptor gene expression by Jazmine D. W. Yaeger, Justin K. Achua, Clarissa D. Booth, Delan Khalid, Megan M. John, Leighton J. Ledesma, Trent L. Greschke, Ashley M. Potter, Chase B. Howe, Kevin T. Krupp, Justin P. Smith, Patrick J. Ronan, Cliff H. Summers

“…In a social stress/learning paradigm separating mice into stress resilient and vulnerable populations, hippocampal Orx1R and Orx2R transcription is regulated in a phenotype-dependent fashion. We further identified Orx1R as highly expressed in the hilus of DG, while Orx2R is abundant in CA2. …”
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A broad assessment of forty-one skin phenotypes reveals complex dimensions of skin ageing by Jun Yan Ng, Qi Yi Ambrose Wong, Jun Jie Lim, Dingyu Cen, Jia Yi Karen Wong, Yi Ying Eliza Lim, Yang Yie Sio, Kavita Reginald, Yee-How Say, Fook Tim Chew

“…Despite this diversity in skin ageing phenotypes, literature published to date is limited in scope, as many research studies either focus on one single phenotype or just a few specific phenotypes. …”
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