Machine Learning for Precision Health Economics and Outcomes Research (P-HEOR): Conceptual Review of Applications and Next Steps by Yixi Chen, Viktor V Chirikov, Xiaocong L Marston, Jingang Yang, Haibo Qiu, Jianfeng Xie, Ning Sun, Chengming Gu, Peng Dong, Xin Gao

“…Precision health economics and outcomes research (P-HEOR) integrates economic and clinical value assessment by explicitly discovering distinct clinical and health care utilization phenotypes among patients. Through a conceptualized example, the objective of this review is to highlight the capabilities and limitations of machine learning (ML) applications to P-HEOR and to contextualize the potential opportunities and challenges for the wide adoption of ML for health economics. …”
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Neonatal myoclonus in Bryant-Li-Bhoj syndrome associated with a novel H3F3A variant by Moemi Hojo, Noriko Soma, Kei Yamada, Yu Kobayashi, Masaki Miura, Hitomi Fujii, Hiromi Nyuzuki, Yosuke Nishio, Taichi Oso, Tomoo Ogi, Takeshi Ikeuchi, Jun Tohyama

“…This case helps broaden the phenotypic spectrum of BLBS.…”
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Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest by Julie Mondet, Kais Hussein, Pascal Mossuz

“…In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed.…”
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Semantic Segmentation Method for High-Resolution Tomato Seedling Point Clouds Based on Sparse Convolution by Shizhao Li, Zhichao Yan, Boxiang Ma, Shaoru Guo, Hongxia Song

“…Semantic segmentation of three-dimensional (3D) plant point clouds at the stem-leaf level is foundational and indispensable for high-throughput tomato phenotyping systems. However, existing semantic segmentation methods often suffer from issues such as low precision and slow inference speed. …”
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Multidrug-resistance and extended-spectrum beta-lactamase-producing lactose-fermenting enterobacteriaceae in the human-dairy interface in northwest Ethiopia. by Achenef Melaku Beyene, Mucheye Gizachew, Ahmed E Yousef, Hana Haileyesus, Ahmed G Abdelhamid, Adugna Berju, Meseret Molu Tebeje, Tigest Feleke, Baye Gelaw

“…Genotypically, the majority of the isolates (97.5%), which were positive on the phenotypic test, were carrying one or more of the three genes.…”
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Visualization Methods of 3D Plant Models: A Systematic Mapping Study by Shilin Di, Lingzhi Cao, Yongqi Ge

“…This shows that the focus is on the improvement of original methods or the proposal of new methods in this field; research goals of research plant phenotypic characteristics account for the total 35%; 28% of the research objectives focus on showing the reflection of plant growth process, indicating that the research objective trends in this research field regard plant phenotypic characteristics and visualization of the growth process; static type model visualization also accounts for 83% of the total, indicating that the related research on visualization in this field is mostly static typing. …”
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The Development of Methods of BLOTCHIP^®-MS for Peptidome: Small Samples in Tuberous Sclerosis by Kunio Yui, George Imataka, Kotaro Yuge, Hitomi Sasaki, Tadashi Shiohama, Kyoichi Asada, Hidehisa Tachiki

“…TSC2 mutations were associated with a more severe phenotypic spectrum due to the inhibition of the mTOR cascade. …”
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Analysis of the Genomes and Adaptive Traits of <i>Skermanella cutis</i> sp. nov., a Human Skin Isolate, and the Type Strains <i>Skermanella rosea</i> and <i>Skermanella mucosa</i> by Yujin Choi, Munkhtsatsral Ganzorig, Kyoung Lee

“…Genomic analyses further identified pathways related to hydrogenase and sulfur oxidation. Phenotypic and chemotaxonomic traits of strain TT6^T were also compared with closely related type strains, confirming its genotypic and phenotypic distinctiveness. …”
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USP8‐Dependent Family Tyrosine Kinase Promotes the Malignant Progression of Esophageal Squamous Cell Carcinoma by Upregulating Protein Tyrosine Kinase 2 Expression by Yuechang Wu, Dubiao Xian, Yunzhong Liu, Ding Huang, Qingfeng Liu, Shubo Yang

“…Overexpression of FYN reversed the effects of USP8 silencing on the malignant phenotypes of ESCC cells in vitro and in vivo. FYN upregulated PTK2 expression in both TE1 and KYSE150 cell lines. …”
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Morphophysiological and molecular characterization of millet (Panicum miliaceum L.) varieties for crop improvement in Western Europe by Massimo Vischi, Nicola Zorzin, Maria Bernhart, Johanna Winkler, Dipak Santra, Carla Pappalardo, Stefano Marchetti

“…Results of SSR genotyping combined with those originating from phenotypic analyses indicated possible crosses to source the genetic variability necessary for selection. …”
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The pneumococcal bacteriocin streptococcin B is produced as part of the early competence cascade and promotes intraspecies competition by J. D. Richardson, Emily Guo, Ryan M. Wyllie, Paul Jensen, Suzanne Dawid

“…Over 20 distinct bacteriocin loci have been identified in pneumococcal genomes, but only a small number have been characterized phenotypically. In this work, we demonstrate that three-fourths of S. pneumoniae strains contain a highly conserved scb locus that encodes an active lactococcin 972-like bacteriocin called streptococcin B. …”
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SSR loci potentially associated with high amylopectine content in maize kernel endosperm by S. I. Vakula, O. A. Orlovskaya, L. V. Khotyleva, A. V. Kilchevsky

“…As a component of functional nutrition, maize cultivars with “non-traditional” kernel composition (waxy, oilbearing, sugar, opaque, etc. phenotypic variants) are promising. Mutations in the waxy gene, which break down the structure and function of the enzyme for amylose biosynthesis, lead to a waxy (with a high content of amylopectin) endosperm formation. …”
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The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation by Ji-wen Fan, Yu Fan, Zheng-li Wan, Lin Yan, Ya-mei Li, Yang-juan Bai, Lan-lan Wang, Jie Chen, Yi Li

“…In this study, the populations of different Tfh cell phenotypes and B cell subsets in CAMR were investigated in a total of 36 patients. …”
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Review: Feed efficiency and metabolic flexibility in livestock by W.M. Rauw, L.H. Baumgard, J.C.M. Dekkers

“…Feed efficiency also depends on processes that are not directly related to economically important phenotypes, which can be considered ‘waste’ from a production point of view but are vital maintenance-related functions that are closely associated with environmental flexibility and adaptation. …”
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Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone by Tiina E. Kähkönen, Mari I. Suominen, Jenni H. E. Mäki-Jouppila, Jussi M. Halleen, Azusa Tanaka, Michael Seiler, Jenni Bernoulli

“…The study was performed using CIEA NOG (NOG) mice engrafted with human CD34+ hematopoietic stem cells (huNOG) and age-matched immunodeficient NOG mice. Bone phenotyping was performed to evaluate baseline differences. …”
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The BLUP method in evaluation of breeding values of Russian spring wheat lines using micro- and macroelements in seeds by N. A. Potapova, A. S. Zlobin, I. N. Leonova, E. A. Salina, Y. A. Tsepilov

“…In this work, the BLUP method was used to assess the breeding value of 149 Russian varieties and introgression lines (4 measurements for each variety or line, 596 phenotypic points) of spring wheat according to the content of seven chemical elements in the grain – K, Ca, Mg, Mn, Fe, Zn, Cu. …”
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Genetic analysis of scab disease resistance in common bean (Phaseolus vulgaris) varieties using GWAS and functional genomics approaches by Shadrack Odikara Oriama, Benard W. Kulohoma, Evans Nyaboga, Y. O. Masheti, Reuben Otsyula

“…Conclusion The significant differences in the phenotypic variability for scab disease indicate wide genetic variability among the common bean accessions. …”
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Virulence is not directly related to strain success in planta in Clavibacter nebraskensis by Molly Veregge, Cory D. Hirsch, Matthew J. Moscou, Liana Burghardt, Peter Tiffin, Devanshi Khokhani

“…We created a community of 13 strains exhibiting diverse virulence phenotypes and used this community to infect the host plant. …”
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Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells by Yan Li, Jingping Ge, Yuanyuan Yin, Ruowen Yang, Jie Kong, Jianping Gu

“…Results. miR-206 overexpression inhibited proliferation, migration, and angiogenesis and promoted apoptosis of EPCs, while miR-206 knockdown exerted an opposite effect on EPC phenotypes. Downregulation of GJA1, the target of miR-206, abolished the influence of miR-206 on EPC phenotypes. …”
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Methicillin-Resistant Coagulase-Negative Staphylococci Carriage is a Protective Factor of Methicillin-Resistant Staphylococcus Aureus Nasal Colonization in HIV-Infected Patients: A... by Ying Li, Jialing Lin, Linghua Li, Weiping Cai, Jiaping Ye, Suiping He, Wencui Zhang, Ning Liu, Zijun Gong, Xiaohua Ye, Zhenjiang Yao

“…Therefore, we aimed to explore whether MRCoNS carriage is a risk factor of MRSA colonization. Phenotypic characteristics were performed to further assess the associations between MRSA and MRCoNS. …”
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