Network analyses of brain tumor multiomic data reveal pharmacological opportunities to alter cell state transitions by Brandon Bumbaca, Jonah R. Huggins, Marc R. Birtwistle, James M. Gallo

“…Simulation results were input into a boosted tree machine learning model which predicted the cell states or phenotypes of GBM patients from an independent public data source, the Glioma Longitudinal Analysis (GLASS) Consortium. …”
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Biomarkers in scleroderma: Current status by Latika Gupta, Sanat Phatak, Sukesh Edavalath

“…Multiplex arrays of biomarkers have ushered an era of targeted or personalized medicine based on phenotypic characteristics in an individual.…”
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Artisanal and farmer bread making practices differently shape fungal species community composition in French sourdoughs by Michel, Elisa, Masson, Estelle, Bubbendorf, Sandrine, Lapicque, Léocadie, Nidelet, Thibault, Segond, Diego, Guézenec, Stéphane, Marlin, Thérèse, Devillers, Hugo, Rué, Olivier, Onno, Bernard, Legrand, Judith, Sicard, Delphine

“…Overall, our results showed that preserving bread making practice diversity allows the preservation of a higher species and phenotypic diversity in microbial communities. …”
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Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo by Melissa de Carvalho Santuchi, Miriane Fernandes Dutra, Juliana Priscila Vago, Kátia Maciel Lima, Izabela Galvão, Fernando Pedro de Souza-Neto, Mario Morais e Silva, Aline Cristina Oliveira, Flávia Carvalho Bittencourt de Oliveira, Ricardo Gonçalves, Mauro Martins Teixeira, Lirlândia Pires Sousa, Robson Augusto Souza dos Santos, Rafaela Fernandes da Silva

“…However, the effects of RAS peptides on different macrophage phenotypes are still emerging. Here, we evaluated the effects of angiotensin-(1-7) (Ang-(1-7)) and the most novel RAS peptide, alamandine, on resting (M0), proinflammatory M(LPS+IFN-γ), and anti-inflammatory M(IL-4) macrophage phenotypes in vitro, as well as on specific immune cell populations and macrophage subsets into the pleural cavity of LPS-induced pleurisy in mice. …”
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Evaluation of the ABC pathway in patients with atrial fibrillation: A machine learning cluster analysis by Jingyang Wang, Haiyang Bian, Jiangshan Tan, Jun Zhu, Lulu Wang, Wei Xu, Lei Wei, Xuegong Zhang, Yanmin Yang

“…We evaluated the management patterns and adverse outcomes of identified phenotypes. We assessed the effectiveness of adherence to the ABC criteria at reducing adverse outcomes of phenotypes. …”
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Polymorphisms of Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Interleukin-10 in Asthma Associated with Olive Pollen Sensitization by Blanca Cárdaba, David Calzada, Selene Baos, Miriam Aguerri, Joaquín Quiralte, Carlos Lahoz

“…These polymorphisms were genotyped by allelic discrimination, in olive pollen-allergic patients (phenotyped for specific Ole e 2 and 10 sensitizations) and healthy controls. …”
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Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility by Sophie Debaenst, Tamara Jarayseh, Hanna De Saffel, Jan Willem Bek, Matthieu Boone, Ivan Josipovic, Pierre Kibleur, Ronald Y Kwon, Paul J Coucke, Andy Willaert

“…Next-generation sequencing confirmed high indel efficiency (mean 88%), mimicking stable knock-out models. Skeletal phenotyping at 7, 14, and 90 days post-fertilization (dpf) using microscopy, Alizarin Red S staining, and microCT was performed. …”
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Reduction in thermal plasticity of life history traits in response to cold selection: an experimental evolution study using Drosophila melanogaster by Rishav Roy, Rishav Roy, Aradhya Chattopadhyay, Sreebes Deb Sharma, Aharna Mondal, Payel Biswas, Payel Biswas, Shampa M. Ghosh

“…IntroductionHow selection influences phenotypic plasticity is an important question in evolutionary biology. …”
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Analysis of quantitative trait loci and candidate gene exploration associated with cold tolerance in rice (Oryza sativa L.) during the seedling stage by Sumin Jo, Seong-Gyu Jang, Sais-Beul Lee, Ji-Yoon Lee, Jun-Hyeon Cho, Ju-Won Kang, Yeongho Kwon, So-Myeong Lee, Dong-Soo Park, Soon-Wook Kwon, Jong-Hee Lee

“…QTL analysis was conducted on a doubled haploid (DH) population derived from a cross between the cold-sensitive indica cultivar 93-11 and the cold-tolerant japonica cultivar Milyang352. Phenotypic analysis was conducted over 2 years (2022–2023) under cold water treatment (13°C) at the Chuncheon Substation, South Korea. …”
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Comparative analysis of the chemical composition and size of starch granules in grain between diploid and tetraploid sweetcorn cultivars by E. B. Khatefov, V. I. Khoreva, Yu. A. Kerv, T. V. Shelenga, V. V. Sidorova, Y. N. Demurin, V. G. Goldstein

“…The differences in phenotypic traits between diploid (2n) and tetraploid (4n) maize plants were assessed. …”
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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Finally, significant correlations were found between obesity-related phenotypes and gut microbiota through correlation analysis.ConclusionOur findings suggest that the potential mechanism by which high-dose thiamine supplementation alleviated HFFD-induced obesity might involve reshaping gut microbiota and restoring the intestinal barrier, thereby ameliorating gut microbiota-related endotoxemia.…”
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End-stage ADPKD with a low-frequency PKD1 mosaic variant accelerated by chemoradiotherapy by Hiroaki Hanafusa, Hiroshi Yamaguchi, Naoya Morisada, Ming Juan YE, Riki Matsumoto, Hiroaki Nagase, Kandai Nozu

“…Abstract Autosomal dominant polycystic kidney disease (ADPKD) is commonly caused by PKD1, and mosaic PKD1 variants result in milder phenotypes. We present the case of a 32 year-old male with chronic active Epstein–Barr virus who underwent bone marrow transplantation with chemoradiotherapy at age 9. …”
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Familial Florid Cemento-Osseous Dysplasia: A Rare Manifestation in an Indian Family by Adit Srivastava, Rahul Agarwal, Romesh Soni, Avesh Sachan, G. C. Shivakumar, T. P. Chaturvedi

“…The mode of transmission appeared to be autosomal dominant with variable phenotypic expression.…”
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Evolutionary dynamics of prey-predator systems with Holling type II functional response by Jian Zu, Wendi Wang, Bo Zu

“…This paper considers the coevolution of phenotypes in a communitycomprising the populations of predators and prey. …”
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High-risk Pseudomonas aeruginosa clones harboring β-lactamases: 2024 update by Verónica Roxana Flores-Vega, Santiago Partida-Sanchez, Miguel A. Ares, Vianney Ortiz-Navarrete, Roberto Rosales-Reyes

“…Genomic variants of P. aeruginosa that display phenotypes of MDR/XDR have been defined as high-risk global clones. …”
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Marfan Syndrome: Regarding Two Cases by Elsy Roxana Geroy Moya, María Quiñones Hernández, Anaelys Acosta Hernández

“…A literature review was carried out regarding the report of 2 teenager clinical cases with suggestive phenotypic characteristics, the first case with an associated arachnoidocele and the second case with Gilbert's disease.…”
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THE BIOTECHNOLOGICAL POTENTIAL OF THE NEW CROP, Miscanthus cv . SORANOVSKII by N. M. Slynko, T. N. Goryachkovskaya, S. V. Shekhovtsov, S. V. Bannikova, N. V. Burmakina, K. V. Starostin, A. S. Rozanov, N. N. Nechiporenko, S. G. Veprev, V. K. Shumny, N. A. Kolchanov, S. E. Peltek

“…Soranovskii was registered as a state breeding achievement in 2013. On the base of phenotyping and DNA sequencing, the new crop was identified as Miscanthus sacchariflorus. …”
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Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease by Shruti Singh Kakan, Sara Abdelhamid, Sara Abdelhamid, Yaping Ju, Yaping Ju, J. Andrew MacKay, J. Andrew MacKay, J. Andrew MacKay, Maria C. Edman, Indu Raman, Chengsong Zhu, Prithvi Raj, Sarah F. Hamm-Alvarez, Sarah F. Hamm-Alvarez

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Intersexual stages. Ambiguous genitals. by Salvador G. Carrillo Soriano

“…It is considered that every newborn that presents a confused aspect of external genitalia, that does not permit to define his phenotypic sex, has Ambiguous Genitals. It includes real cases of intersex abnormalities, or those with severe hypospadia and bilateral chryptorchidism. …”
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Sex in Penicillium series Roqueforti by J. Houbraken, J.C. Frisvad, R.A. Samson

“…A detailed study using a combination of phenotypic characters, sequences and extrolite patterns showed that these isolates belong to a new species within the series Roqueforti. …”
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