A novel approach for target deconvolution from phenotype-based screening using knowledge graph by Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun

“…The target-based approach focuses on p53 and its regulators (MDM2, MDMX, USP7, Sirt proteins), but requires separate systems for each target and may miss multi-target compounds. Phenotype-based screening can reveal new targets but involves a lengthy process to elucidate mechanisms and targets, hindering drug development. …”
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Genotype-Phenotype Correlation in Patients with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency in Cuba by Tania Mayvel Espinosa Reyes, Teresa Collazo Mesa, Paulina Arasely Lantigua Cruz, Adriana Agramonte Machado, Emma Domínguez Alonso, Henrik Falhammar

“…There are several studies that show a good genotype-phenotype correlation in congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD). …”
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Genotypes and phenotypes of neurofibromatosis type 1 patients in Japan: A Hereditary Tumor Cohort Study by Mashu Futagawa, Tetsuya Okazaki, Eiji Nakata, Chika Fukano, Risa Osumi, Fumino Kato, Yusaku Urakawa, Hideki Yamamoto, Toshifumi Ozaki, Akira Hirasawa

“…Comprehensive data on genotype‒phenotype correlations in patients with NF1 are limited. …”
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Macrophage phenotype after human refluxate exposure, esophageal dysmotility and their correlation with gastroesophageal reflux disease by A. V. Paraskevova, A. S. Trukhmanov, O. A. Storonova, S. V. Lyamina, S. V. Kalish, S. S. Pirogov, A. B. Ponomarev, D. E. Rumyantseva, I. Yu. Malyshev, I. V. Maev, V. T. Ivashkin

“…An analysis of receptor characteristics of monocyte-derived macrophages showed the prevalence of CD25 and CD80 expression in all groups of patients.Conclusion. An analysis of the phenotype of macrophages derived from blood monocytes of GERD patients revealed a prevalence of М1 macrophages that was typical for the Th1 type of immune response. …”
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Phenotypic and Allelic Distribution of the ABO and Rhesus Blood Groups among students at Hawassa University, Ethiopia by Mihret A. Hailu, Wendawek A. Mengesha, Zelalem G. Tolesa

Subjects: “…ABO blood; Allele frequency; Ethiopia; Phenotypic frequency; Rh blood…”
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Effects of environmental factors on the phenotypic traits and seed element accumulation of wild Elymus nutans in Tibet by Jianting Long, Xianlei Gao, Yanjun Miao

“…This study systematically analyzes how soil nutrients and meteorological factors influence the phenotypic growth and seed production of wild Elymus nutans in Tibet. …”
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Stem and Leaf Segmentation and Phenotypic Parameter Extraction of Tomato Seedlings Based on 3D Point by Xuemei Liang, Wenbo Yu, Li Qin, Jianfeng Wang, Peng Jia, Qi Liu, Xiaoyu Lei, Minglai Yang

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Exploring force-driven stochastic folding dynamics in mechano-responsive proteins and implications in phenotypic variation by Pritam Saha, Vishavdeep Vashisht, Ojas Singh, Amin Sagar, Gaurav Kumar Bhati, Surbhi Garg, Sabyasachi Rakshit

“…Our study thus deciphers the molecular mechanisms underlying the variations in force-adaptations and proposes a mechanical relation between genotype and phenotype.…”
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Role of Inhibin B and Ratio of Luteinizing: Follicle-Stimulating Hormones in Phenotyping Polycystic Ovarian Syndrome by Zainab G. Falh, Basil O. Saleh, Afraa M. Al Naddawi, Ghada Mohammed

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Transmission of synthetic seed bacterial communities to radish seedlings: impact on microbiota assembly and plant phenotype by Simonin, Marie, Préveaux, Anne, Marais, Coralie, Garin, Tiffany, Arnault, Gontran, Sarniguet, Alain, Barret, Matthieu

“…Still, the identity and phenotypic effects of these taxa that constitute a primary inoculum of plant microbiota is mostly unknown. …”
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Phenotypic diversity of sorghum [Sorghum bicolor (L.) Moench] genotypes based on qualitative and quantitative traits by Wedajo Gebre, Firew Mekbib, Alemu Tirfessa, Agdew Bekele

“…There is limited information on genetic resource collection, phenotypic characterization, and conservation of sorghum genotypes in Ethiopia, particularly in the southern region. …”
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Obtaining patient phenotypes in SARS-CoV-2 pneumonia, and their association with clinical severity and mortality by Fernando García-García, Dae-Jin Lee, Mónica Nieves-Ermecheo, Olaia Bronte, Pedro Pablo España, José María Quintana, Rosario Menéndez, Antoni Torres, Luis Alberto Ruiz Iturriaga, Isabel Urrutia, COVID-19 & Air Pollution Working Group

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Genetic Background and Phenotypic Aspects of Light-Induced Carotenoid Biosynthesis in <i>Isosphaeraceae</i> Planctomycetes by Anastasia A. Ivanova, Igor Y. Oshkin, Aleksandr A. Ashikhmin, Olga V. Danilova, Svetlana N. Dedysh

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Adaptive Immunity in Ankylosing Spondylitis: Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy by Balázs Szalay, Gergő Mészáros, Áron Cseh, Lilla Ács, Magdolna Deák, László Kovács, Barna Vásárhelyi, Attila Balog

“…Our aim was to assess the phenotype of T-cell subsets in patients with ankylosing spondylitis (AS), a chronic inflammatory rheumatic disease. …”
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High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population by Hongyang Wang, Dan Bing, Jin Li, Linyi Xie, Fen Xiong, Lan Lan, Dayong Wang, Jing Guan, Qiuju Wang

“…To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. …”
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Phenotypic Characterization of Tiger Nuts (Cyperus esculentus L.) from Major Growing Areas in Ghana by Paul Agu Asare, Roger Kpankpari, Michael Osei Adu, Emmanuel Afutu, Adeyinka Saburi Adewumi

“…To contribute to the conservation process of tiger nut and identify elite genotypes, this study was conducted to assess phenotypic variability in tiger nut genotypes in Ghana. …”
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Assessment of Negative Symptoms in Schizophrenia: From the Consensus Conference-Derived Scales to Remote Digital Phenotyping by Armida Mucci, Stefan Leucht, Giulia M. Giordano, Luigi Giuliani, Sophia Wehr, Lucia Weigel, Silvana Galderisi

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Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics by Tiago Ribeiro, Mariana Reis, Vitor Vasconcelos, Ralph Urbatzka

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Correction: Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells by Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang, Lining Wei

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Phenotypic and Allelic Distribution of the ABO and Rhesus Blood Groups among students at Hawassa University, Ethiopia by Mihret A. Hailu, Wendawek A. Mengesha, Zelalem G. Tolesa

Subjects: “…ABO blood; Allele frequency; Ethiopia; Phenotypic frequency; Rh blood…”
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