Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes by Fresia Pareja, Rohit Bhargava, Virginia F. Borges, Edi Brogi, Rita Canas Marques, Fatima Cardoso, Christine Desmedt, Malini Harigopal, Sunil R. Lakhani, Adrian Lee, Jose Pablo Leone, Hannah Linden, Christopher J. Lord, Caterina Marchio, Sofia D. Merajver, Emad Rakha, Jorge S. Reis-Filho, Andrea Richardson, Elinor Sawyer, Pepper Schedin, Christopher J. Schwartz, Andrew Tutt, Naoto T. Ueno, Anne Vincent-Salomon, Britta Weigelt, Y. Hannah Wen, Stuart J. Schnitt, Steffi Oesterreich

“…Abstract Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. …”
Get full text

TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma by Hanrui Guo, Meiling Wang, Caiya Ni, Chun Yang, Chunxue Fu, Xiaoman Zhang, Xueling Chen, Xiangwei Wu, Jun Hou, Lianghai Wang

“…HCC cells were treated with conditioned medium from WT or Trem2 −/− macrophages, and their malignant phenotypes and underlying mechanisms were analyzed. …”
Get full text

Enhanced infectivity of bovine viral diarrhoea virus (BVDV) in arginase-producing bovine monocyte-derived macrophages by Lucas José Barone, Nancy Patricia Cardoso, Florencia Celeste Mansilla, Mariángeles Castillo, Alejandra Victoria Capozzo

“…Macrophages are not a homogenous population; they exist in different phenotypes, typically divided into two main categories: classically (pro-inflammatory) and alternatively activated (anti-inflammatory) or M1 and M2, respectively. …”
Get full text

Molecular Identification, Histopathology and Antibiotic Susceptibility Profiling of Aeromonas veronii Isolated from Oreochromis niloticus in Bangladesh by Sayed Mashequl Bari, Mohammad Muttakinul Islam, Aktia Amina, Marufa Khatun, A. M. Shahabuddin

“…Results Phenotypic and biochemical characterization showed similarities of the ‐collected isolates with Aeromonas veronii. …”
Get full text

Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci by Xingling Tan, MD, Zhouyouyou Xiao, MB, Yao Wen, MD, Han Liu, MD, Wei Yu, MD

“…Methods: This study conducted a phenome-wide association study (PheWAS) using known AR risk loci to explore the impact of known AR risk variants on a broad spectrum of phenotypes. Subsequently, linkage disequilibrium score regression (LDSC) and bidirectional two-sample mendelian randomization (TSMR) analyses were used to further analyze the genetic correlation and causal relationships between significant and potentially related phenotypes and AR. …”
Get full text

Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy by Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti

“…The lack of robustly validated targets and the complexity of parasite’s diseases have made phenotypic screening a preferential drug discovery strategy for the identification of new chemical entities. …”
Get full text

PRPF3-Associated Autosomal Dominant Retinitis Pigmentosa and CYP4V2-Associated Bietti’s Crystalline Corneoretinal Dystrophy Coexist in a Multigenerational Chinese Family by Xiaohong Meng, Qiyou Li, Hong Guo, Haiwei Xu, Shiying Li, Zhengqin Yin

“…To characterize the clinical and molecular genetic characteristics of a large, multigenerational Chinese family showing different phenotypes. Methods. A pedigree consisted of 56 individuals in 5 generations was recruited. …”
Get full text

Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Mouse Model of Autism by Shiyu Tang PhD, Elizabeth M. Powell PhD, Wenjun Zhu MS, Fu-Sun Lo MD, Reha S. Erzurumlu PhD, Su Xu PhD

“…Here, we focus on the somatosensory thalamocortical circuitry because distinct somatosensory sensitivity phenotypes accompany ASD, and this system plays a major role in sensorimotor and social behaviors in mice. …”
Get full text

Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

“…The SpsTAC2 gene was overexpressed in Arabidopsis and analyzed for phenotypic changes. The subcellular localization of SpsTAC2 was analyzed via Agrobacterium-mediated transient expression in onion (Allium cepa L.) epidermal cells. …”
Get full text

Evidence of vancomycin-resistant Staphylococcus aureus, multidrug-resistant S. aureus, and Enterococcus faecium-causing mastitis in Thailand and Cambodia by Sambo Na, Montira Intanon, Anyaphat Srithanasuwan, Wasana Chaisri, Witaya Suriyasathaporn

“…E. faecium isolates exhibited high resistance to tetracycline (100%) and penicillin (90%), with 60% classified as MDR. Phenotypic analysis identified VRSA in 11% of S. aureus isolates. …”
Get full text

Optimization of Breeding Tools in Quinoa (<i>Chenopodium quinoa</i>) and Identification of Suitable Breeding Material for NW Europe by Tim Vleugels, Chris Van Waes, Ellen De Keyser, Gerda Cnops

“…In addition, our study provides valuable phenotypic information and breeding tools that breeders can harness for breeding efforts in NW European quinoa.…”
Get full text

Uncovering genetic determinants of antioxidant properties in Thai landrace rice through genome-wide association analysis by Putut Rakhmad Purnama, Pipob Suwanchaikasem, Supaporn Junbuathong, Somsong Chotechuen, Peerapon Moung-Ngam, Waraluk Kasettranan, Chanita Paliyavuth, Monnat Pongpanich, Sittiruk Roytrakul, Luca Comai, Teerapong Buaboocha, Supachitra Chadchawan

“…Ten loci, including the OsRc gene, were consistently co-associated with all phenotypic traits. Two genetic markers for polymerase chain reaction detection were developed for the OsTT8 gene and the OsRc promoter, both of which were positively correlated with antioxidant properties. …”
Get full text

CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis by Meijun Zhu, Bo-Ya Du, Yan-Qiu Tan, Yang Yang, Yang Zhang, Yong-Fei Wang

“…The loss-of-function mutants cpk1-1, cpk1-2, cngc5-1 cngc6-2 cngc9-1 (shrh1/short root hair 1), and cpk1 shrh1 show similar RH phenotypes, including shorter RHs, more RH branching, and dramatically attenuated cytosolic Ca2+ gradients at RH tips. …”
Get full text

LATE BLIGHT RESISTANCE OF HYBRIDS OBTAINED IN CROSSES OF <i> SOLANUM TUBEROSUM </i> L. WITH THE BOLIVIAN DIPLOID POTATO SPECIES by N. M. Zoteyeva, Yu. I. Karabitsina

“…In field and laboratory evaluation large share of resistant phenotypes was found. Both hybrids produced tubers in the field under long daylight conditions. …”
Get full text

POPULATION ASPECT IN ORGANIC AGRICULTURE by S. K. Temirbekova, J. D. Van Mansvelt

“…Variability of populations phenotypical structure was investigated with use of different effects: various dates of crops sawing, temperature factors, an light mode. …”
Get full text

Case Report: A rare case of Noonan syndrome with multiple lentigines manifesting as cardiac enlargement by Linghua Fan, Jie Jiang, Yan Zhang, Xiaoning Han, Wenhui Ding, Xiaodi Xue, Yimeng Jiang

“…We report a 58-year-old female diagnosed with NSML presenting with bilateral atrial and ventricular chamber enlargement and atrial fibrillation, which are uncommon cardiac phenotypes of NSML.…”
Get full text

Genre, couple et violence dans Love me tender de Jean-Hugues Mirédin by Karine Bénac-Giroux

“…In his play, Love me tender created in 2017, Jean-Hugues Mirédin summons both parody, humour and stereotypes, as well as the questioning of phenotypes and representations of gendered identities. …”
Get full text

Simple Imaging Techniques for Plant Growth Assessment by Shinsuke Agehara

“… Quantification of plant phenotypic traits, such as height, width, stem diameter, and leaf area, is often performed manually in the field; however, these measurements can be performed more quickly and precisely through simple imaging techniques using an image processing program. …”
Get full text

Simple Imaging Techniques for Plant Growth Assessment by Shinsuke Agehara

“… Quantification of plant phenotypic traits, such as height, width, stem diameter, and leaf area, is often performed manually in the field; however, these measurements can be performed more quickly and precisely through simple imaging techniques using an image processing program. …”
Get full text

Genetic investigation of patients with autosomal recessive ataxia and identification of two novel variants in the SQSTM1 and SYNE1 genes by Diana Mokhtari, Mohammad Jahanpanah, Nasim Jabbari, Hamed Azari, Sana Davarnia, Haleh Mokaber, Sara Arish, Rasol Molatefi, Vahid Abbasi, Behzad Davarnia

“…A large group of adult hereditary ataxias have autosomal dominant inheritance, and autosomal recessive cerebellar ataxias (ARCAs) are rare, with greater diversity in phenotypic and genotypic features. Therefore, comprehensive genetic testing is useful for identifying the genes responsible for ARCAs. …”
Get full text