Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism by Michelle C.D. Bridi, Nancy Luo, Grace Kim, Benjamin J. Menarchek, Rachel A. Lee, Bryan Rodriguez, Daniel Severin, Christian Wesselborg, Caroline O’Ferrall, Ruchit Patel, Sarah Bertrand, Sujatha Kannan, Alfredo Kirkwood, Cristian Moreno, Altagracia Contreras

“…Summary: Alterations to the excitation/inhibition (E/I) ratio are postulated to underlie behavioral phenotypes in autism spectrum disorder (ASD) patients and mouse models. …”
Get full text

The comparative characteristic of pheno- and genotypical signs in neonates with atresia of duodenum and other parts of the small intestine by O. K. Botvin'yev, A. V. Eremeeva

“…Aim of investigation. Analysis of phenotypical and genotypical signs in neonates with atresia of duodenum and other parts of the small intestine.Material and methods. …”
Get full text

Genetic parameters and parental and early-life effects of boar semen traits by Pedro Sá, Rodrigo M. Godinho, Marta Gòdia, Claudia A. Sevillano, Barbara Harlizius, Ole Madsen, Henk Bovenhuis

“…A repeatability model accounting for effects at collection was used to (1) estimate heritabilities and repeatabilities for semen traits and genetic and phenotypic correlations between traits, (2) test the significance of early-life effects, (3) quantify the contribution of exclusive dam and sire inheritances to the phenotypic variation, i.e., mitochondrial DNA and the Y chromosome, identified using a pedigree-based approach, and (4) quantify the contribution of maternal and paternal environment effects to the phenotypic variation of semen traits. …”
Get full text

Quantifying synthetic bacterial community composition with flow cytometry: efficacy in mock communities and challenges in co-cultures by Fabian Mermans, Ioanna Chatzigiannidou, Wim Teughels, Nico Boon

“…However, since flow cytometry measures the phenotypic state of cells, measurements can be affected by differing phenotypes. …”
Get full text

Performing whole-genome association analysis of winter wheat plant height using the 55K chip by Yindeng Ding, Guiqiang Fan, Yonghong Gao, Tianrong Huang, Anding Zhou, Shan Yu, Lianjia Zhao, Xiaolei Shi, Sunlei Ding, Jiahao Hao, Wei Wang, Jikun Song, Na Sun, Hui Fang

“…The results revealed significant phenotypic variation in wheat plant height across different years, with coefficients of variation ranging from 0.96% to 1.97%. …”
Get full text

Functional analysis of a novel homozygous missense IVD gene variant: a case report with dual genetic diagnoses by Yuying Zhu, Ke Wu, Hanying Wen

“…This case provides a useful reference for genetic counseling for complex and diverse clinical phenotypes. The presence of two or more likely pathogenic or pathogenic variations in an individual with neurodevelopmental phenotypes is not an “exceptional” phenomenon.…”
Get full text

Role of T cell metabolism in brain tumor development: a genetic and metabolic approach by Bo Yang, Zhenyu Li, Peiliang Li, Bo Liang, Yuhan Liu, Enshan Feng

“…This study aims to clarify the relationships between specific T cell phenotypes, circulating metabolites, and malignant brain tumors. …”
Get full text

Antibiotic resistance among Aerobic Gram-Negative Bacilli isolated from patients with oral inflammatory dysbiotic conditions—a retrospective study by A. Basic, S. Blomqvist, G. Charalampakis, G. Dahlén

“…Ten isolates (4.1%) were phenotypically classified as ESBL positive. The ESBL isolates were predominantly found among isolates of S. maltophilia, while only one ESBL positive isolate was found among Enterobacteriaceae.ConclusionsPhenotypically identified ESBL isolates can occasionally be present among oral AGNB strains isolated in abundance from the dysbiotic microbiota occurring in cases with oral mucosal lesions, severe periodontitis, or peri-implantitis.…”
Get full text

Optimization of grain quality parameters for winter rye breeding by M. L. Ponomareva, S. N. Ponomarev

“…The purpose of this work was to evaluate the phenotypic variability of grain quality indicators and to identify the set of the most informative indicators for the selection of different use varieties of winter rye. …”
Get full text

Comparison between Conventional Methods and Molecular Diagnosis for Candida albicans and Candida dubliniensis isolated from Cancer Patients Infected with Oral Candidiasis by Nada Fadhil Abbas

“…Background: Two related pathogenic yeast species, Candida albicans and Candida dubliniensis share many phenotypic and microscopic diagnostic characteristics, in addition to the similarity in the characteristics of diagnosis. …”
Get full text

Quantifying animal social behaviour with ecological field methods by Molly A. Clark, Christos C. Ioannou

“…No evidence for phenotypic assortment based on body size was found. …”
Get full text

Transcription factor-dependent regulatory networks of sexual reproduction in Fusarium graminearum by Wonyong Kim, Da-Woon Kim, Zheng Wang, Meng Liu, Jeffrey P. Townsend, Frances Trail

“…We evaluated in silico knockout impacts to the networks of the developmental phenotypes among the TFs and guided knockout transcriptomics experiments to properly assess regulatory roles of genes with same developmental phenotypes. …”
Get full text

Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease by Jason P. Weick

“…Stem cell-derived neurons from various source materials present unique model systems to examine the fundamental properties of central nervous system (CNS) development as well as the molecular underpinnings of disease phenotypes. In order to more accurately assess potential therapies for neurological disorders, multiple strategies have been employed in recent years to produce neuronal populations that accurately represent in vivo regional and transmitter phenotypes. …”
Get full text

Profiles and predictors of child neurodevelopment and anthropometry: The maternal-infant research on environmental chemicals study by Marisa A Patti, Karl T Kelsey, Amanda J MacFarlane, George D Papandonatos, Bruce P Lanphear, Joseph M Braun

“…Using multinomial regression, we evaluated odds of phenotypic profiles based on maternal, sociodemographic, and child level characteristics. …”
Get full text

Penicillium menonorum, a new species related to P. pimiteouiense by S.W. Peterson, S.S. Orchard, S. Menon

“…Genealogical concordance analysis was applied to P. pimiteouiense and P. parvum, substantiating the phenotypically defined species. The species P. rubidurum, P. guttulosum, and P. menonorum were on distinct branches statistically excluded from inclusion in other species and have distinct phenotypes.…”
Get full text

Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue by Ye Seul Park, Md Jamal Uddin, Lingjuan Piao, Inah Hwang, Jung Hwa Lee, Hunjoo Ha

“…Notably, obesity induces a proinflammatory phenotypic switch in adipose tissue macrophages, and oxidative stress facilitates this switch. …”
Get full text

Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components by Beatriz Carvalho, Tineke E. Buffart, Rui M. Reis, Thomas Mons, Cátia Moutinho, Paula Silva, Nicole C. T. van Grieken, Heike Grabsch, Cornelis J. H. van de Velde, Bauke Ylstra, Gerrit A. Meijer, Fátima Carneiro

“…Mixed gastric carcinomas constitute a rare histological entity, containing the two main histological phenotypes (diffuse and intestinal). Very little is known about the underlying mechanisms of phenotypic divergence in these mixed tumours. …”
Get full text

From Mild Ataxia to Huntington Disease Phenocopy: The Multiple Faces of Spinocerebellar Ataxia 17 by Georgios Koutsis, Marios Panas, George P. Paraskevas, Anastasia M. Bougea, Athina Kladi, Georgia Karadima, Elisabeth Kapaki

“…The SCA 17 expansion is stable during parent-child transmission and intrafamilial phenotypic homogeneity has been reported. However, significant phenotypic variability within families has also been observed. …”
Get full text

Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…It identifies two genetic and immune-related phenotypes and five genetic identifiers associated with periodontitis risk.…”
Get full text

Complete Androgen Insensitivity Syndrome: A Rare Case of Disorder of Sex Development by Alfonsa Pizzo, Antonio Simone Laganà, Irene Borrielli, Nella Dugo

“…It depends on an X-linked mutations in the Androgen Receptor (AR) gene that express a variety of phenotypes ranging from male infertility to completely normal female external genitalia. …”
Get full text