Phenotypic analysis of sorghum [Sorghum bicolor (L) Moench] genotypes for drought responsive traits by Atnafu Kebede, Geleta Dugassa Barka, Mulugeta Kebede, Temesgen Matiwos Menamo, Taye Tadesse

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Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection by Gabriela Gonzalez Aleman, George D. Vavougios, George D. Vavougios, Carmela Tartaglia, Carmela Tartaglia, Nalakath A. Uvais, Alla Guekht, Alla Guekht, Akram A. Hosseini, Akram A. Hosseini, Vincenzina Lo Re, Vincenzina Lo Re, Catterina Ferreccio, Catterina Ferreccio, Giovanni D'Avossa, Hernan P. Zamponi, Mariana Figueredo Aguiar, Agustin Yecora, Agustin Yecora, Mohammad Zia Ul Haq Katshu, Vasileios T. Stavrou, Vasileios T. Stavrou, Stylianos Boutlas, Konstantinos I. Gourgoulianis, Camila Botero, Francisco González Insúa, Santiago Perez-Lloret, Mikhail Zinchuk, Anna Gersamija, Sofya Popova, Yulia Bryzgalova, Ekaterina Sviatskaya, Giovanna Russelli, Giovanna Russelli, Federica Avorio, Federica Avorio, Sophia Wang, Sophia Wang, Paul Edison, Paul Edison, Yoshiki Niimi, Hamid R. Sohrabi, Elizabeta B. Mukaetova Ladinska, Elizabeta B. Mukaetova Ladinska, Daria Neidre, Gabriel A. de Erausquin, Gabriel A. de Erausquin, Gabriel A. de Erausquin

“…We found distinct age-related phenotypes of cognitive impairment in patients recovering from COVID-19. …”
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Phenotypic detection of carbapenem-resistant Enterobacterales in clinical isolates at a tertiary care hospital by Astha Sinha, Mamta Gour, Riti Jain Seth

“…The maximum carbapenem resistance was seen in the age group of 16–45 years and the most number of CRE isolates were from ICUs. Phenotypic test results indicated that 54.28% (38/70) of isolates were positive for carbapenemase production by either of the phenotypic methods. …”
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A continuous phenotype space model of RNA virus evolution within a host by Andrei Korobeinikov, Conor Dempsey

“…Due to their very high replication and mutation rates, RNA virusescan serve as an excellent testing model for verifying hypothesis andaddressing questions in evolutionary biology.In this paper, we suggest a simple deterministic mathematical modelof the within-host viral dynamics, where a possibility for random mutations incorporates.This model assumes a continuous distribution of viral strainsin a one-dimensional phenotype space where random mutations aremodelled by Brownian motion (that is, by diffusion).Numerical simulations show that randommutations combined with competition for a resource result in evolutiontowards higher Darwinian fitness: a stable pulse traveling waveof evolution, moving towards higher levels of fitness,is formed in the phenotype space.The advantage of this model, compared with the previously constructedmodels, is that this model is mechanistic and is based on commonlyaccepted model of virus dynamics within a host, and thus it allowsan incorporation of features of the real-life host-virus system such as immuneresponse, antiviral therapy, etc.…”
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Phenotypic insights into genetic risk factors for immune-related adverse events in cancer immunotherapy by Haochuan Ma, Dili Song, Haibo Zhang, Taidong Li, Xing Jin

“…To address the urgent need for identifying risk factors associated with irAEs, we conducted a comprehensive phenotype-wide Mendelian randomization analysis (MR-PheWAS). …”
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Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype by Li-jun Xie, Dan-dan Ruan, Jian-hui Zhang, Yi Li, Li Chen, Mao-lin Yan, Ming-dian Yu, Jie-wei Luo, Hui-zhen Zhang

“…Two subjects presented a rare common bile duct polyp phenotype. No extraintestinal manifestations were observed. …”
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Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Here, we present a network-based statistical approach, Pathopticon, that uses CMap to build cell type-specific gene-drug perturbation networks and integrates these networks with cheminformatic data and diverse disease phenotypes to prioritize drugs in a cell type-dependent manner. …”
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Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance by Maristela Ruberti, Luis Gustavo Romani Fernandes, Patricia Ucelli Simioni, Dirce Lima Gabriel, Áureo Tatsumi Yamada, Wirla Maria da Silva Cunha Tamashiro

“…In this work, we evaluated the effects of administration of OVA on phenotype and function of intraepithelial lymphocytes (IELs) from small intestine of transgenic (TGN) DO11.10 and wild-type BALB/c mice. …”
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Mixed-phenotype Acute Leukemia with Trilineage Differentiation in a 3-year-old Child by I Gusti Ayu Mardewi, Anak Agung Wiradewi Lestari, I Nyoman Wande, Ni Nyoman Mahartini

Subjects: “…mixed-phenotype acute leukemia…”
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Species evolution: cryptic species and phenotypic noise with a particular focus on fungal systematics by Anusha H. Ekanayaka, Anusha H. Ekanayaka, Samantha C. Karunarathna, Samantha C. Karunarathna, Saowaluck Tibpromma, Arun Kumar Dutta, Danushka Sandaruwan Tennakoon, Anuruddha Karunarathna, Ekachai Chukeatirote, Dong-Qin Dai, Steven L. Stephenson, Sajeewa S. N. Maharachchikumbura, Chao Liu, Alan J. L. Phillips

“…The evolution of a species can be understood in the context of two major concepts—the cryptic species concept and the phenotypic noise concept. The former represents morphologically indistinguishable but genetically distinct evolutionary lineages, while the latter represents the phenotypic variations of an isogenic population. …”
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Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients by Suzanne Samarani, Patrick Sagala, Prevost Jantchou, Guy Grimard, Christophe Faure, Colette Deslandres, Devendra K. Amre, Ali Ahmad

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Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages by Yuchen Ma, Xiaoli Qian, Qun Yu, Yadan Dong, Jiapeng Wang, Heng Liu, Huai Xiao

“…This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26 through modulation of macrophage phenotypes. Aside from the already reported effects of inosine on T cells, in this study, in vitro experiments revealed that inosine could modulate macrophage phenotype. …”
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Block selection in multiblock partial least squares for modeling genotype-phenotype relations in Saccharomyces by Muhammad Tahir, Bu Yude, Tahir Mehmood, Saima Bashir, Zeeshan Ashraf

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Phenotyping determination of cyp1a2 enzyme activity using caffeine in sheep by Kamil Uney, Bünyamin Tras

“…Correlations between the plasma (PX/CF)MR&#8594;3-16 h and (PX/CF)AUC ratios were determined to investigate of the CYP1A2 phenotyping by single blood sampling in practice.<p> <b>Results:</b> It was determined that the more reliable sampling time within the plasma (PX/CF)MR&#8594;3-16 h ratios in the determination of the CYP1A2 phenotyping was 10 h after CF administration. …”
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Block selection in multiblock partial least squares for modeling genotype-phenotype relations in Saccharomyces. by Muhammad Tahir, Bu Yude, Tahir Mehmood, Saima Bashir, Zeeshan Ashraf

“…Both proposed variants consistently outperform conventional approaches such as partial least squares and multi-block partial least squares in predicting phenotypes. These results highlight the potential of our methods for advancing data-based modeling and genotype-phenotype mapping.…”
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Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR by Francisco J. Rios, Marianna M. Koga, Mateus Pecenin, Matheus Ferracini, Magnus Gidlund, S. Jancar

“…Since PAFR in macrophages is associated with suppressor function, we examined the effect of oxLDL on macrophage phenotype. It was found that the presence of oxLDL during macrophage differentiation induced high mRNA levels to IL-10, mannose receptor, PPARγ and arginase-1 and low levels of IL-12 and iNOS. …”
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Altered Phenotype of Circulating Dendritic Cells and Regulatory T Cells from Patients with Acute Myocarditis by Paola del Carmen Guerra-de-Blas, Daniela Cruz-González, Elena B. Martínez-Shio, Roberto González-Amaro, Héctor González-Pacheco, Esther Layseca-Espinosa, Carlos D. Escobedo-Uribe, Adriana E. Monsiváis-Urenda

“…However, a particular DC phenotype in this disease has not been assessed. Herein, we aim to evaluate myeloid (mDCs) and plasmacytoid DC (pDC) phenotype, as well as Treg levels from myocarditis patients and healthy controls. …”
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BerryPortraits: Phenotyping Of Ripening Traits in cranberry (Vaccinium macrocarpon Ait.) with YOLOv8 by Jenyne Loarca, Tyr Wiesner-Hanks, Hector Lopez-Moreno, Andrew F. Maule, Michael Liou, Maria Alejandra Torres-Meraz, Luis Diaz-Garcia, Jennifer Johnson-Cicalese, Jeffrey Neyhart, James Polashock, Gina M. Sideli, Christopher F. Strock, Craig T. Beil, Moira J. Sheehan, Massimo Iorizzo, Amaya Atucha, Juan Zalapa

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Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks by Kishore Hari, Pradyumna Harlapur, Aashna Saxena, Kushal Haldar, Aishwarya Girish, Tanisha Malpani, Herbert Levine, Mohit Kumar Jolly

“…This low dimensionality in phenotypic space arises from extensive feedback loops in these networks arranged to effectively enable the formation of two teams of mutually inhibiting nodes. …”
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18 The role of PSMA expression in predicting aggressive disease phenotypes in patients with prostate cancer by G. Gandaglia, S. Scuderi, F. Barletta, A. Stabile, V. Cucchiara, F. Montorsi, A. Briganti

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