Estradiol-dependent and independent effects of FGF21 in obese female mice by T. V. Jakovleva, A. Yu. Kazantseva, A. D. Dubinina, N. Yu. Balybina, K. O. Baranov, E. N. Makarova, N. M. Bazhan

“…However, estradiol affects the transcriptional effects of FGF21 in the liver, white adipose tissue, and hypothalamus, which may underlie sex differences in the FGF21 effect on the expression of metabolic genes and, possibly, in pharmacological FGF21 effects.…”
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Animal Models of Diabetes and Metabolic Disease by Tomohiko Sasase, Marcus G. Pezzolesi, Norihide Yokoi, Takahisa Yamada, Kozo Matsumoto

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A systematic review of outcomes reported in studies to optimise the medication use of patients at hospital discharge by Joke Wuyts, Veerle Foulon, Samuel Sebastian Allemann, Fabienne Boeni

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Posttranslational Nitration of Tyrosine Residues Modulates Glutamate Transmission and Contributes to N-Methyl-D-aspartate-Mediated Thermal Hyperalgesia by Carolina Muscoli, Concetta Dagostino, Sara Ilari, Filomena Lauro, Micaela Gliozzi, Erlisa Bardhi, Ernesto Palma, Vincenzo Mollace, Daniela Salvemini

“…The broader implication of our findings reinforces the notion that free radicals may contribute to various forms of pain events and the importance of the development of new pharmacological tool that can modulate the glutamate transmission without blocking its actions directly.…”
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A Novel Chemically Modified Curcumin “Normalizes” Wound-Healing in Rats with Experimentally Induced Type I Diabetes: Initial Studies by Yazhou Zhang, Steve A. McClain, Hsi-Ming Lee, Muna S. Elburki, Huiwen Yu, Ying Gu, Yu Zhang, Mark Wolff, Francis Johnson, Lorne M. Golub

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Ocular Inflammation in Uveal Tract in Aged Obese Type 2 Diabetic Rats (Spontaneously Diabetic Torii Fatty Rats) by Yusuke Kemmochi, Katsuhiro Miyajima, Takeshi Ohta, Tomohiko Sasase, Yuzo Yasui, Kaoru Toyoda, Kochi Kakimoto, Toshiyuki Shoda, Akihiro Kakehashi

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Intravenous sedation for adults with profound acquired brain injury undergoing dental treatment - a seven-year service evaluation by Mili Doshi, Ahmed Kahatab, Louise Gallagher, Ria Prasad, Richard Fitzgerald

“…Abstract Background Dental treatment may not be possible for patients with a profound acquired brain injury without pharmacological support. Intravenous (IV) sedation with midazolam is a widely accepted, safe, and effective mode of treatment for people with a disability, but there is limited evidence in this patient cohort. …”
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Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach by Yedi Herdiana, Yoga Windhu Wardhana, Insan Sunan Kurniawansyah, Dolih Gozali, Nasrul Wathoni, Ferry Ferdiansyah Sofian

“…The preventive approach again cannot be ignored, mainly keeping up certain modifications in diet and weight, along with pharmacological therapies to reduce uric acid (UA) levels and to decrease the frequency of acute attacks. …”
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Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress by Robert Fürst, Ilse Zündorf

“…The number of new, pharmacologically active herbal ingredients, in particular that of anti-inflammatory compounds, rises continuously. …”
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Abdominal plexiform neurofibroma. Case report by José Rolando Rodríguez Núñez, Fernando Karel Fonseca Sosa, Juan Guillermo Bauzá López, Pedro Rafael Casado Mendez

“…It was evaluated in a multidisciplinary consultation and pharmacological treatment was decided. Conclusions: Abdominal plexiform neurofibroma is a rare condition with a high risk of tumor recurrence and malignant transformation. …”
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Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option by Benedikt Zujalovic, Eberhard Barth

“…We identified the altered AChE activity as a plausible pathophysiological mechanism. The pharmacological intervention with the indirect parasympathomimetic physostigmine led to a quick and lasting improvement of the patient’s cognitive, hemodynamic, and renal status. …”
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Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models by Alexander J. Szalai, Mark A. McCrory, Dongqi Xing, Fadi G. Hage, Andrew Miller, Suzanne Oparil, Yiu-Fai Chen, Michelle Mazzone, Richard Early, Scott P. Henry, Thomas A. Zanardi, Mark J. Graham, Rosanne M. Crooke

“…The latter would best be defined by pharmacological inhibition of the protein in the context of a randomized case-control study. …”
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Galangin-Loaded Gold Nanoparticles: Molecular Mechanisms of Antiangiogenesis Properties in Breast Cancer by Malik H. Qaddoori, Hanady S. Al-Shmgani

“…Due to their lower cytotoxicity and stronger pharmacological advantage, phytochemical anticancer medications have a number of advantages over chemical chemotherapeutic drugs. …”
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The PPAR Ω Pocket: Renewed Opportunities for Drug Development by Åsmund Kaupang, Trond Vidar Hansen

“…Moreover, recently developed pharmacological tools that can be utilized in the search for ligands with new binding modes are also presented.…”
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Lungs in Heart Failure by Anna Apostolo, Giuliano Giusti, Paola Gargiulo, Maurizio Bussotti, Piergiuseppe Agostoni

“…This paper describes the pulmonary abnormalities at rest and during exercise in the patients with heart failure, highlighting the principal diagnostic tools for evaluation of lungs function, the possible pharmacological interventions, and the parameters that could be useful in prognostic assessment of heart failure patients.…”
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The importance of pain assessment: The specifics of medical care by Pavić Katarina, Perović Dušica, Antonić Roland, Bogdanović-Vasić Slobodanka, Vešić Marija, Savić Nikola

“…However, the application of pharmacological agents to treat pain has to be carried out in collaboration with the doctor.…”
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Nanomédicaments pour le traitement de maladies graves et recherches duales by Couvreur, Patrick

“…The use of nanotechnologies for the encapsulation of pharmacologically active molecules (nanomedicines) has enhanced the delivery of these molecules within the body after administration. …”
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Pramipexole Extended Release: A Novel Treatment Option in Parkinson's Disease by Wolfram Eisenreich, Bernd Sommer, Sebastian Hartter, Wolfgang H. Jost

“…The present study summarizes pharmacokinetics and all essential pharmacological and clinical characteristics of the extended-release formulation. …”
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Aspirin Modulates Innate Inflammatory Response and Inhibits the Entry of Trypanosoma cruzi in Mouse Peritoneal Macrophages by Aparecida Donizette Malvezi, Rosiane Valeriano da Silva, Carolina Panis, Lucy Megumi Yamauchi, Maria Isabel Lovo-Martins, Nagela Ghabdan Zanluqui, Vera Lúcia Hideko Tatakihara, Luiz Vicente Rizzo, Waldiceu A. Verri, Marli Cardoso Martins-Pinge, Sueli Fumie Yamada-Ogatta, Phileno Pinge-Filho

“…Here, we present evidence suggesting the involvement of the host’s cyclooxygenase (COX) enzyme during T. cruzi invasion. Pharmacological antagonist for COX-1, aspirin (ASA), caused marked inhibition of T. cruzi infection when peritoneal macrophages were pretreated with ASA for 30 min at 37°C before inoculation. …”
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Aromatic Amines Exert Contrasting Effects on the Anticoagulant Effect of Acetaldehyde upon APTT by La'Teese Hall, Sarah J. Murrey, Arthur S. Brecher

“…The pharmacological effects of amphetamine, procaine, procainamide, DOPA, isoproterenol, and atenolol upon activated partial thromboplastin time in the absence and presence of acetaldehyde have been investigated. …”
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