Up-to-date methods of stomach functions investigation and their diagnostic potentials by Ya. S. Tsimmerman

“…Advantages of modern multichannel рН-meters, potential of acquiring of the supplemental information by original methods of intragastric рН-grams analysis with application of various pharmacological and stimulaion tests are analyzed. Methods of studying of gastric juice proteolytic activity are compared. …”
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UHPLC‐Q‐TOF‐MS/MS Dereplication to Identify Chemical Constituents of Hedera helix Leaves in Vietnam by Hong Ngoc Pham, Chieu An Tran, Thi Diep Trinh, Ngoc Lan Nguyen Thi, Huynh Nhu Tran Phan, Van Nhan Le, Ngoc Hung Le, Van Trung Phung

“…Hedera helix has been reported to contain a wide range of metabolites and produce many pharmacological effects. This research demonstrates the determination and evaluation of the phytochemical profiling of H. helix grown in central Vietnam. …”
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CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer by Dorian V. Ziegler, Kanishka Parashar, Lucia Leal-Esteban, Jaime López-Alcalá, Wilson Castro, Nadège Zanou, Laia Martinez-Carreres, Katharina Huber, Xavier Pascal Berney, María M. Malagón, Catherine Roger, Marie-Agnès Berger, Yves Gouriou, Giulia Paone, Hector Gallart-Ayala, George Sflomos, Carlos Ronchi, Julijana Ivanisevic, Cathrin Brisken, Jennifer Rieusset, Melita Irving, Lluis Fajas

“…Our study, using genetic and pharmacological approaches, reveals that CDK4 inactivation only modestly impacts TNBC cell proliferation and tumor formation. …”
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Sedoanalgesia Strategies and their Potential Benefits in the Intensive Care Unit: Narrative Review of the Literature by Arango-Martínez, Alejandro, Penagos-Sanchez, Sebastian, Restrepo-Arismendy, Simón, Arias-Correa, Ruber Hernando

“…Objectives: To critically review the available evidence on the selection of drugs used in sedoanalgesia and describe their potential pharmacological benefits in the critically ill patients. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…ACSL4 emerged as a critical biomarker of this proliferative subtype, driving HB cell proliferation both in vitro and in vivo. Furthermore, pharmacological inhibition of ACSL4 using abemaciclib significantly suppressed tumor growth in xenograft models. …”
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Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention by Xutao Yang, Li Zhu, Hong Pan, Yi Yang

“…Finally, we explore current interventions aimed at preventing and attenuating renal impairment related to CPB, and presenting these measures from three perspectives: (1) avoiding CPB to eliminate the fundamental impact on renal function; (2) optimizing CPB by adjusting equipment parameters, optimizing surgical procedures, or using improved materials to mitigate kidney damage; (3) employing pharmacological or interventional measures targeting pathogenic factors.…”
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Electrochemical Behavior of Quinoxalin-2-one Derivatives at Mercury Electrodes and Its Analytical Use by Milan Zimpl, Jana Skopalova, David Jirovsky, Petr Bartak, Tomas Navratil, Jana Sedonikova, Milan Kotoucek

“…Derivatives of quinoxalin-2-one are interesting compounds with potential pharmacological activity. From this point of view, understanding of their electrochemical behavior is of great importance. …”
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Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma by Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese, Rosa Terracciano, Rosario Maselli

“…The recent advances in the knowledge of the cellular and molecular mechanisms underlying asthmatic inflammation are contributing to the identification of novel therapeutic targets, potentially suitable for the implementation of future improvements in antiasthma pharmacologic treatments.…”
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Review: performance of jujube and its extracts in cancer: therapeutic, toxicity-reducing and potentiating effects by Boyun Gou, Guoqing Chen, Shicong Huang, Na Ning, Qian Gu, Shuai Duan, Yuhua Du, Yi Nan, Ling Yuan

“…In addition, jujube has received much attention around the world for its excellent pharmacological effects and food value. This article reviews the anticancer effects of a fruit, food, and drug, jujube, which have been shown in current studies, and analyzes its therapeutic mechanism, active ingredients, extraction and isolation methods, as well as its synergistic and attenuation performance in cancer. …”
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Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection by Priscilla Aparecida Tartari Pereira, Bruno Caetano Trindade, Adriana Secatto, Roberto Nicolete, Camila Peres-Buzalaf, Simone Gusmão Ramos, Ruxana Sadikot, Claudia da Silva Bitencourt, Lúcia Helena Faccioli

“…Therefore, using a pharmacological inhibitor, celecoxib, we investigated the role of prostaglandins in host defense against Histoplasma capsulatum infection in C57BL/6 mice. …”
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Use of ECT in Major Vascular Neurocognitive Disorder with Treatment-Resistant Behavioral Disturbance following an Acute Stroke in a Young Patient by Kyle E. Rodenbach, Daniel Varon, Timothey Denko, Ryan Peterson, Carmen Andreescu

“…In most cases, first-line treatment includes pharmacologic intervention tailored to the most likely underlying syndrome. …”
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Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms by Rahul Singh, Ryan C. Turner, Linda Nguyen, Kartik Motwani, Michelle Swatek, Brandon P. Lucke-Wold

“…We discuss potential therapeutic and pharmacologic options as well as potential novel drug targets. …”
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PI3K Functions in Cancer Progression, Anticancer Immunity and Immune Evasion by Tumors by Francesco Dituri, Antonio Mazzocca, Gianluigi Giannelli, Salvatore Antonaci

“…In addition, we discuss, from antitumor immunological point of view, the potential benefits and disadvantages arising from use of anticancer pharmacological agents targeting the PI3K pathway.…”
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Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease by Katherine Luo, Stewart Siyan Cao

“…Based on our increased understanding of ER stress in IBD, new pharmacological approaches can be developed to improve intestinal homeostasis by targeting ER protein-folding in the intestinal epithelial cells (IECs).…”
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Public interest in healthy lifestyle changes before and during the COVID-19 pandemic: Google Trends analysis by Seyma Trabzon, Pelin Ilhan, Havva Sert, Ali Sarıdas

“…Healthy lifestyle behaviors are accepted as non-pharmacological approaches in the management of diseases. …”
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Evaluation of Halogenated Coumarins for Antimosquito Properties by Venugopala K. Narayanaswamy, Raquel M. Gleiser, Kabange Kasumbwe, Bandar E. Aldhubiab, Mahesh V. Attimarad, Bharti Odhav

“…Natural coumarins and synthetic coumarin analogues are known for their several pharmacological properties, including being insecticidal. …”
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GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration by Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec

“…Equalizing GSK-3β activity in these mouse models by genetic or pharmacological interventions is able to rescue some of these abnormalities. …”
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Somatostatin Analogs in the Medical Management of Occult Bleeding of the Lower Digestive Tract by Julie Martin-Grace, Gianluca Tamagno

“…Despite the lack of double-blinded randomized placebo-control trials and despite the limitations of the available evidence in the literature, including small sample size, variable dosing, and administration routes, there is a consistent agreement in the literature that somatostatin analogs are a safe, well-tolerated, and effective therapeutic option for managing refractory or occult bleeding from the lower digestive tract, with particular reference to patients with angiodysplasia, where endoscopic or surgical management is either not feasible or unsuccessful and other pharmacological options are not preferred.…”
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The Videofluorographic Swallowing Study in Rheumatologic Diseases: A Comprehensive Review by Ambra Di Piazza, Federica Vernuccio, Massimo Costanzo, Laura Scopelliti, Dario Picone, Federico Midiri, Francesco Salvaggi, Francesco Cupido, Massimo Galia, Sergio Salerno, Antonio Lo Casto, Massimo Midiri, Giuseppe Lo Re, Roberto Lagalla

“…Gastrointestinal tract involvement in these patients may also due to both a direct action of antibodies against organs and pharmacological therapies. Dysphagia is one of the most important symptom, and it is caused by failure of the swallowing function and may lead to aspiration pneumonia, malnutrition, dehydration, weight loss, and airway obstruction. …”
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Study of the Use of Antinematode Drugs, Mebendazole and Pyrantel, in Galicia (Spain) from 2016 to 2020 by S. Vázquez- Prieto, A. Vaamonde, E. Paniagua

“…The main consequence of the excessive use of this drug compared to pyrantel may be the increased risk of the development of resistance and of therapeutic failure, as well as the consequent limitation of pharmacological options in the future.…”
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