Plucked Human Hair Shafts and Biomolecular Medical Research by Kevin Schembri, Christian Scerri, Duncan Ayers

“…Furthermore, current diagnostic and clinical applications of plucked hair follicles include their use as autologous and/or three-dimensional epidermal equivalents, together with their utilization as surrogate tissue in pharmacokinetic and pharmacodynamics studies. Consequently, the use of noninvasive diagnostic procedures on hair follicle shafts, posing as a surrogate molecular model for internal organs in the individual patient for a spectrum of human disease conditions, can possibly become a reality in the near future.…”
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Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies by Michael A. Partridge, Shobha Purushothama, Chinnasamy Elango, Yanmei Lu

“…Anti-drug antibodies induced by biologic therapeutics often impact drug pharmacokinetics, pharmacodynamics response, clinical efficacy, and patient safety. …”
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Management of Pain in Children with Burns by M. Gandhi, C. Thomson, D. Lord, S. Enoch

“…This clinical review article discusses the essential aspects of the pathophysiology of burns in children provides an overview of pain assessment, the salient principles in managing pain, and the essential pharmacodynamics of commonly used drugs in children with burn injuries. …”
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Once-Daily Dosing of Aminoglycosides by William A Craig

“…OBJECTIVE: To review the pharmacodynamic rationale for once-daily dosing of aminoglycosides and to summarize thee results of comparative trials in animals and humans. …”
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A Loading Dose of IV Salbutamol in an Adolescent with Severe Acute Asthma and Cardiac Arrest by Shelley A. Boeschoten, Ruben S. van der Crabben, Annemie L. M. Boehmer, Matthijs de Hoog, Corinne M. P. Buysse

“…For rational use of intravenous (IV) bronchodilators, evidence regarding the pharmacokinetics and pharmacodynamics is lacking in children. The use of a loading dose IV salbutamol is not mentioned in any international guideline, and its use varies greatly between PICUs worldwide. …”
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Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms by Jane C. Caldwell, Marina V. Evans, Kannan Krishnan

“…Specifically, issues addressed include: (a) increased understanding of human variability of pharmacokinetics and pharmacodynamics in the population, (b) exploration of mode of action hypotheses (MOA), (c) application of biological modeling in the risk assessment of individual chemicals and chemical mixtures, and (d) identification and discussion of uncertainties in the modeling process.…”
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The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids by Hui Tang, Jing Lu, Yazhuo Duan, Dejun Li

“…It is noteworthy that mirogabalin should be administrated cautiously when combined with probenecid and cimetidine on account of a slight increase in pharmacodynamics effects of mirogabalin. Conclusion. The development of mirogabalin allows further optimization of individual treatment strategies so as to provide more therapeutic choices in this medical domain.…”
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Caffeine as an Active Molecule in Cosmetic Products for Hair Loss: Its Mechanisms of Action in the Context of Hair Physiology and Pathology by Ewelina Szendzielorz, Radoslaw Spiewak

“…In the present review, we look into the molecule’s possible mechanisms of action and pharmacodynamics. At the molecular level, it appears that the physiological effects of caffeine are mainly due to the molecule’s interaction with adenosine pathways which leads to an increase in cAMP level and the stimulation of metabolic activity in the hair follicle. …”
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Continuous Delivery of D-Luciferin by Implanted Micro-osmotic Pumps Enables True Real-Time Bioluminescence Imaging of Luciferase Activity in Vivo by Shimon Gross, Ute Abraham, Julie L. Prior, Erik D. Herzog, David Piwnica-Worms

“…Pumps allowed direct repetitive imaging at < 5-minute intervals of the pharmacodynamics of proteasome- and IKK-inhibiting drugs in mice bearing tumors stably expressing ubiquitin-firefly luciferase or IκBα-firefly luciferase fusion reporters. …”
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A model of optimal dosing of antibiotic treatment in biofilm by Mudassar Imran, Hal L. Smith

“…The growth rateof bacteria in biofilm is taken as Monod type for the limitingnutrient. The pharmacodynamics function is taken to be dependentboth on limiting nutrient and antibiotic concentration. …”
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Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters by Hamed Barabadi, Hesam Noqani, Maha Soltani, Ayeh Sabbagh Kashani

“…This review presents the novelty of bioengineered NPs as potential therapeutic agents for hepatic and renal protection while highlighting the need for further research into their pharmacokinetics and pharmacodynamics to advance clinical translation.…”
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Direct oral anticoagulants (DOACs): From the laboratory point of view by Margetić Sandra, Goreta Sandra Šupraha, Ćelap Ivana, Razum Marija

“…Compared to the vitamin K antagonists, DOACs are superior in terms of onset of action, pharmacokinetic and pharmacodynamics properties and fixed daily dose without the need for routine coagulation monitoring. …”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…We set out to describe what is known and unknown about the mechanisms underlying the interplay between antigenicity and immune response and their effect on the safety, efficacy, pharmacokinetics, and pharmacodynamics of these therapeutic agents.…”
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Effect of in vitro gastrointestinal digestion on the chemical composition and antioxidant properties of Ginkgo biloba leaves decoction and commercial capsules by Zhou Yubo, Yang Yingxin, Ma Minyan, Xie Lingyun, Yan Aijuan, Cao Wen

“…Overall, these results may help provide a valid foundation for further investigations on bioactive compounds and the pharmacodynamics of GBL.…”
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Corticosteroid-sparing topical treatment with cyclosporin for juvenile keratoconjunctivitis by Amarilla Barcsay-Veres, Anita Csorba, Illes Kovacs, Laszlo Tothfalusi, Otto Alexander Maneschg

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Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma by R. Francik, M. Krosniak, M. Barlik, A. Kudla, R. Grybos, T. Librowski

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Interaction studies unveil potential binding sites on bovine serum albumin for gut metabolite trimethylamine n-oxide (TMAO) by Awadhesh Kumar Verma, Payal Gulati, GBVS Lakshmi, Anand Mohan, Neeta Raj Sharma, Pratima R. Solanki, Anil Kumar

“…These findings provide a foundation for understanding the pharmacodynamics and pharmacokinetics of TMAO and may aid in developing strategies for treating diseases, such as chronic kidney disease and neurological disorder where TMAO-serum albumins interaction are implicated.…”
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A Multi-Method Comparison of Machine Learning in predicting pharmacokinetic parameters: A simulation study by marziyeh Doostfatemeh, kamal Amini, Elham Haem

“… Background: One important aim of population pharmacokinetics (PK) and pharmacodynamics (PD) is the identification and quantification of the relationships between the parameter and covariates to improve the predictive performance of the population PK/PD modeling. …”
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Monitoring Guidelines for Home and Outpatient Parenteral Antibiotic Therapy by Alain Y Martel

“…Additional knowledge must include pharmacokinetics (absorption, distribution and elimination) and the pharmacodynamics (biochemical and physiological effects and mechanisms of action) of the commonly used antibiotics. …”
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A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting by Naeem Mubarak, Muhammad Ahsan Waqar, Asad Majeed Khan, Zainab Asif, Aima Subia Alvi, Aqsa Arshad Virk, Sakeena Amir

“…With recent advancements, intranasal delivery coupled with nanocarriers seems to be a promising combination that can provide better clinical profiles, pharmacokinetics, and pharmacodynamics for neurodegenerative disorders. This study focuses on exploring the nose-to-brain drug delivery system, emphasizing the use of various nanocarriers designed for this purpose. …”
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