Cytotoxic and Apoptotic Effects of Different Extracts of Artemisia turanica Krasch. on K562 and HL-60 Cell Lines by Zahra Tayarani-Najaran, Mahla Sareban, Atefeh Gholami, Seyed Ahmad Emami, Mahdi Mojarrab

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Intra- and Interspecies Conjugal Transfer of Plasmids in Gram-Negative Bacteria by Julia R. Savelieva, Daria A. Kondratieva, Maria V. Golikova

“…<i>P. aeruginosa</i> did not acquire plasmids from <i>K. pneumoniae</i>. In pharmacodynamic experiments, an <i>E. coli</i> transconjugant with MIC of 2 mg/L within the “susceptibility range”, failed to respond to meropenem treatment. …”
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The theses for MD degree by article Editorial

“…Aleksandrova – Extracorporeal hemocorrection in the complex treatment of liver failure.O.V.Dobrovolsky – Pharmakokinetics and potentials of endoscopic evaluation of esomeprazole pharmacodynamics.O.V. Paklina – Morphogenesis of chronic pancreatitis and pancreatic ductal adenocarcinoma.…”
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Does SIRT-1 Mediate Calorie Restriction and Prolong Life? – A Mini Review by Kordala Anna, Pietrzak Bogusława

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The theses for MD degree by article Editorial

“…Fedorov – Pharmakokinetics and pharmacodynamics of rabeprazole.…”
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A Novel Murine Model for the In Vivo Study of Transdermal Drug Penetration by Gábor Eros, Petra Hartmann, Szilvia Berkó, Eszter Csizmazia, Erzsébet Csányi, Anita Sztojkov-Ivanov, István Németh, Piroska Szabó-Révész, István Zupkó, Lajos Kemény

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Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model by Sergio Li Calzi, Todd Cook, Domenico G. Della Rocca, Juan Zhang, Vinayak Shenoy, Yuanqing Yan, Andrew Espejo, Anandharajan Rathinasabapathy, Max H. Jacobsen, Tatiana Salazar, George E. Sandusky, Lynn C. Shaw, Keith March, Mohan K. Raizada, Carl J. Pepine, Michael J. Katovich, Maria B. Grant

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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…The pharmacokinetics and pharmacodynamics were assessed on day 1 and day 6 at several time intervals.Results Overall result of pharmacodynamic parameters showed that mean %inhibition of platelet aggregation between AT-10 and clopidogrel in all subjects at 6 hours postdose (loading dose) (AT-10: clopidogrel; 73.30% vs 18.53%) and 6 hours postdose on day 6 (maintenance dose) (AT-10: clopidogrel; 83.41% vs 51.19 %) obtained from the AT-10 group was significantly higher than the clopidogrel group. …”
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CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Acellbia is non-inferior to MabThera in terms of efficacy, pharmacokinetics, pharmacodynamics and immunogenicity. Acellbia was well tolerated, with the safety profile comparable with MabThera’s parameters.…”
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Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach by Maryana Salamah, Bence Sipos, Zsuzsanna Schelz, István Zupkó, Ágnes Kiricsi, Ágnes Szalenkó-Tőkés, László Rovó, Gábor Katona, György Tibor Balogh, Ildikó Csóka

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Buprenorphine and its formulations: a comprehensive review by Salomon Poliwoda, Nazir Noor, Jack S. Jenkins, Cain W. Stark, Mattie Steib, Jamal Hasoon, Giustino Varrassi, Ivan Urits, Omar Viswanath, Adam M. Kaye, Alan D Kaye

“…Buprenorphine, a novel long-acting analgesic, was developed with the intention of two purposes: analgesia and opioid use disorder. Regarding its pharmacodynamics, it is a partial agonist at mu receptors, an inverse agonist at kappa receptors, and an antagonist at delta receptors. …”
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Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System by Pashtoon Murtaza Kasi, Rawad Mounzer, George H. Gleeson

“…Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug.…”
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Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature by Jason A. Chen, Katherine M. Unverferth, Erick H. Cheung

“…The pharmacokinetics and pharmacodynamics of quetiapine may explain this unusual phenomenon.…”
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Review of adult gender transition medications: mechanisms, efficacy measures, and pharmacogenomic considerations by Inder Sehgal

“…This review summarizes pharmacodynamics, comparative dosing, adverse effects, monitoring, and potential pharmacogenetic influence of current pharmacotherapy. …”
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Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metast... by Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski

“…Objectives included assessment of safety, antitumor activity, pharmacodynamics, and pharmacokinetic profile.Results Fifty-eight participants started treatment. …”
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Sex-related differences in heart failure patients: physiological mechanisms of cardiovascular ageing and evidence-based sex-specific medical therapies by Andra Maria Ciutac, Tiberiu Pana, Dana Dawson, Phyo Kyaw Myint

“…The pharmacokinetics and pharmacodynamics of the common HF medications, classified according to the established sub-types, are summarised with respect to sex-specific documented findings. …”
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Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept by Bernd Raffeiner, Francesca Ometto, Livio Bernardi, Costantino Botsios, Leonardo Punzi

“…The available TNFα blockers show different pharmacokinetics and pharmacodynamics yielding different biological effects. …”
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Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine by Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan

“…Since stereoselectivity plays an important role in MDMA’s pharmacokinetics and pharmacodynamics, in this study we investigated its stereoselectivity in protein binding. …”
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Multifunctional Synthetic Poly(-Glutamic Acid)–Based Cancer Therapeutic and Imaging Agents by Marites P. Melancon, Chun Li

“…Having both an anticancer drug and an imaging reporter in a single polymer chain allows noninvasive real-time visualization of the pharmacokinetics of polymeric drug delivery systems, which can uncover and explain the complicated mechanisms of in vivo drug delivery and their correlation to pharmacodynamics. This review examines the use of the synthetic biocompatible polymer poly( l -glutamic acid) (PG) as an efficient carrier of cancer therapeutics and imaging agents. …”
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How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies by Yi Yang, Fu Kuang, XueYing Zhu, Li Li, Yao Huang, Yang Liu, Xian Yu

“…Abstract Background The euglycemic clamp test stands as the best method for assessing the pharmacokinetic and pharmacodynamic properties of long-acting insulin. However, despite its widespread use, there remains a notable absence of an established gold standard for evaluating the test’s quality. …”
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