Impact of Food Physical Properties on Oral Drug Absorption: A Comprehensive Review by Wang Z, Xu W, Liu D, Li X, Liu S, Wu X, Wang H

“…., Ltd, Shijiazhuang, People’s Republic of China; 3College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence: Hongyun Wang, Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China, Tel +8610-69154637, Email wanghy@pumch.cnAbstract: Food-Drug Interaction (FDI) refers to the phenomenon where food affects the pharmacokinetic or pharmacodynamic characteristics of a drug, significantly altering the drug’s absorption rate or absorption extent. …”
Get full text

Molecular Docking Appraisal of Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment by Magdalene Eno Effiong, Mercy Bella-Omunagbe, Israel Sunmola Afolabi, Shalom Nwodo Chinedu

“…The drug likeness, pharmacokinetic, and pharmacodynamic features of prospective docking leads were all anticipated. …”
Get full text

Hu-lu-su-pian ameliorates hepatic steatosis by regulating CIDEA expression in AKT-driven MASLD mice by Rumeng Ren, Rumeng Ren, Qi Wang, Qi Wang, Dongjie Deng, Dongjie Deng, Aoao Guo, Aoao Guo, Xin Chen, Xin Chen, Yan Meng, Yan Meng, Ying Fang, Ying Fang, Guohua Zheng, Guohua Zheng, Zhong Xu, Zhong Xu, Man Li, Junjie Hu, Junjie Hu

“…Serum biochemical indices and liver pathological assessments were employed to evaluate the pharmacodynamic effects of HLSP on MASLD. Transcriptomic analysis of the liver was conducted to detect differentially expressed genes (DEGs). …”
Get full text

INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

“…Preclinical safety, as well as pharmacodynamic (PD) and PK profiling was carried out in non-human primates.Results INBRX-120 effectively expanded and enhanced the cytotoxic capacity of CD8 T cells and natural killer cells towards tumor cells without affecting regulatory T cells in vitro and in vivo. …”
Get full text

Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Interestingly, LAG-3 protein upregulation was detected as a unique pharmacodynamic effect mediated by PD1-LAG3, but not by PD1-TIM3 or anti-PD-1.Conclusions Our in vitro system reliably assessed responses to bispecific antibodies co-targeting PD-1 together with LAG-3 or TIM-3 using patients’ tumor infiltrating immune cells and revealed transcriptional and phenotypic imprinting by bispecific antibody formats currently tested in early clinical trials.…”
Get full text

Population Pharmacokinetics of Pegcetacoplan in Patients with Geographic Atrophy or Neovascular Age-related Macular Degeneration by Ryan L. Crass, PharmD, Komal Prem, MD, Francois Gauderault, PhD, Ramiro Ribeiro, MD, PhD, Caroline R. Baumal, MD, Brandon Smith, PhD, Daniel Epling, PhD, Sunny Chapel, PhD

“…Vitreous exposure was predicted to be >1300-fold higher than serum exposure, with maximum concentrations in serum below the threshold required to elicit systemic pharmacodynamic effects. Drug accumulation from first dose to steady state was predicted to be minimal in serum (mean accumulation ratio = 1.50 with monthly dosing, 1.10 with every-other-month dosing) and vitreous humor (mean accumulation ratio = 1.30 with monthly dosing, 1.10 with every-other-month dosing). …”
Get full text

The dual anti-inflammatory and anticoagulant effects of Jianpi Huashi Tongluo prescription on Rheumatoid Arthritis through inhibiting the activation of the PI3K/AKT signaling pathw... by Fanfan Wang, Fanfan Wang, Jian Liu

“…Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) results suggested that the pharmacodynamic mechanism of XFC may be closely related to the regulation of the PI3K/AKT signaling pathway. …”
Get full text

Antimicrobial susceptibility testing of Dermabacter hominis by Tim Kintzinger, Dennis Knaack, Sören Schubert, Uwe Groß, Robin Köck, Frieder Schaumburg

“…MICs were interpreted according to current clinical breakpoints for Corynebacterium spp. or pharmacokinetic–pharmacodynamic breakpoints (EUCAST). To deduce breakpoints for disk diffusion, MICs were correlated with inhibition zone diameters. …”
Get full text

Activity of Aztreonam-avibactam and other β-lactamase inhibitor combinations against Gram-negative bacteria isolated from patients hospitalized with pneumonia in United States medi... by Helio S. Sader, Rodrigo E. Mendes, S. J. Ryan Arends, Timothy B. Doyle, Mariana Castanheira

“…Aztreonam-avibactam was tested with avibactam at fixed 4 mg/L and a pharmacokinetic/pharmacodynamic susceptible (S) breakpoint of ≤ 8 mg/L was applied for comparison. …”
Get full text

Assessment of Birth Preparedness and Complication Readiness among Pregnant Women: A Cross-sectional Study by T Elamathi, K Ananthi, Rimi Singh

“…It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. …”
Get full text

A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy by Shang J, Chen Y, Wang F, Yang J, Li Y, Yang L, Liu X, Zhong Z, Yue C, Zhou M

“…Jinlu Shang,1,2,* Yongjun Chen,2,* Fangliang Wang,3,* Jing Yang,2 Yi Li,4 Liuxuan Yang,2 Xiuqiong Liu,1 Zhirong Zhong,5 Chaochi Yue,6 Meiling Zhou2 1Department of Pharmacy, West China Hospital Sichuan University Jintang Hospital, Chengdu, Sichuan, 610400, People’s Republic of China; 2Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 3Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, College of Pharmacy Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 4Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 5Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 6Department of Traditional Chinese Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meiling Zhou; Chaochi Yue, Email meilzhou@163.com; yuechaochi18@swmu.edu.cnBackground: Melanoma is an aggressive form of skin cancer, and single-modality treatments often fail to prevent tumor recurrence and metastasis. …”
Get full text

Poly (ADP-ribose) (PAR) levels in Peripheral Blood Mononuclear Cells (PBMC) during peri-implantation and early pregnancy in buffalo cows by Giovanna De Matteis, Anna Reale, Michele Zampieri, Emanuela Rossi, Federica Signorelli, Olimpia Barbato, Vittoria Lucia Barile

“…The concentration of PAR levels (pg/mL) was determined in PBMC cellular extracts using the HT PARP in vivo Pharmacodynamic Assay II (Trevigen). The repeated measures ANOVA tested differences in mean values across time points and between experimental groups. …”
Get full text

Call for Papers - Advancing Astropharmacy and Sports Pharmacy by Ashley Anderson, Ahmer Raza, Shireen Aziz, Misbah Noreen

“…Her research interest are on pharmacokinetic and pharmacodynamic (PKPD) changes in space, drug stability under space conditions, and the effects of the space environment on human physiopharmacology. …”
Get full text

Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice by Aurélien Marabelle, Louis Meyblum, Lambros Tselikas, Thierry de Baere, Sandrine Susini, Fréderic Deschamps, Baptiste Bonnet, Céline Chevaleyre, Benoit Jego, Dimitri Kereselidze, Vincent Lebon, Charles Truillet

“…Consistent intratumoral pharmacodynamic effects were observed in both intratumoral and intravenous treatment groups, as evidenced by a notable increase in CD8+T cells within the CT26 tumors following treatment.Conclusions ImmunoPET-derived pharmacokinetics supports intratumoral injection of ICBs to decrease systemic exposure while maintaining efficacy compared with intravenous. …”
Get full text

First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer by Lini Pandite, Simon Metenou, Debra L Richardson, Erika Hamilton, Linda Van Le, Bo Ma, Fatima Rangwala, Nehal J Lakhani, Justin Call, Daphne Stewart, Lauren E Dockery, Guanfang Wang, Jade Huguet, Elliot Offman

“…Objectives included evaluation of safety, dose-limiting toxicity, recommended phase II dose, pharmacokinetic (PK) and pharmacodynamic (PD) parameters, and antitumor activity.Results 27 patients (median age 66 years (range, 33–85); median of 4 prior systemic therapies (range, 2–9)) with ovarian (70%), fallopian tube (15%), or primary peritoneal (15%) cancer received SL-172154. …”
Get full text

Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. …”
Get full text

Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Priya Kishnani, Richa Tailor, Sara Mary Thomas

“…It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. …”
Get full text