Peptide Design for Enhanced Anti-Melanogenesis: Optimizing Molecular Weight, Polarity, and Cyclization by Putri SA, Maharani R, Maksum IP, Siahaan TJ

“…Selvi Apriliana Putri,1 Rani Maharani,1 Iman Permana Maksum,1 Teruna J Siahaan2 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Bandung, 40173, Indonesia; 2Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, 66047, USACorrespondence: Iman Permana Maksum, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Bandung, 40173, Indonesia, Email iman.permana@unpad.ac.idAbstract: Melanogenesis is a biochemical process that regulates skin pigmentation, which is crucial role in protecting against ultraviolet radiation. …”
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METHODICAL APPROACH TO THE DETERMINATION OF THE ANTIOXIDANT ACTIVITY OF THE ECHINACEA PURPUREA AND MONARDA FISTULOSA TINCTURES AS A QUALITY CRITERION OF THE DEVELOPMENT OF THEIR CO... by Oksana Yezerska, Nataliia Hudz, Lesya Kobylinska, Anna Filipska, Vira Turkina, Jan Brindza, Piotr Pawel Wieczorek

“…The ratios of herbal raw materials (HRM) to the final tincture were close to ratios that are widely employed in the pharmaceutical industry, namely 1 to 5 and 1 to 10. The coefficients of alcohol absorption for the roots of Echinacea purpurea (size 2-5 mm), flowers of Echinacea purpurea (size 1-3 mm), herb of Monarda fistulosa (size 0.5-3 mm) were measured. …”
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Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Pancreatic enzymes represents the basis of pharmaceutical treatment nowadays. Their application is based on multiple negative feedback mechanisms involved in pancreatic secretion regulation. …”
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UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research by Zhan R, Liu Y, Wu J, Shen Y, Xu X, Lin G, Chen X

“…Ruanjuan Zhan,1,* Yanan Liu,1,2,* Jun Wu,1,2 Yuxin Shen,1,2 Xinhao Xu,1,2 Guanyang Lin,1,2 Xiaocheng Chen1 1The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyang Lin; Xiaocheng Chen, Email 13867702133@163.com; cxcwzcn@139.comBackground: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.Methods: Sample preparation was performed via protein precipitation using acetonitrile. …”
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Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites by Mauricio Piñeiro, Mauricio Piñeiro, Sofía Manrique, Jessica Gómez, Jessica Gómez, Juan Manuel Rodriguez, Patricia Barrera, Duilio Caballero, Miguel A. Sosa, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Alejandro Tapia, Beatriz Lima, Beatriz Lima, Mario J. Simirgiotis

“…The results indicated that U. lethariiformis may constitute a potential source of diverse bioactivities with application in the food, pharmaceutical, and agronomic industries.…”
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The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface by Claudio Costantini, Giorgia Renga, Vasilis Oikonomou, Giuseppe Paolicelli, Monica Borghi, Marilena Pariano, Antonella De Luca, Matteo Puccetti, Claudia Stincardini, Paolo Mosci, Andrea Bartoli, Teresa Zelante, Luigina Romani

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Histopathological investigation of the effect of coenzyme q10 on intestinal mucosa and tight junction proteins in experimental colitis model by Saadet Ozen Akarca Dizakar, Murside Ayse Demirel

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Collective Housing of Mice of Different Age Groups before Maturity Affects Mouse Behavior by Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

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Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid by Hidetaka Maegawa, Masayuki Kohashi, Yasuo Harada, Akira Tanaka, Shimpei Kajiwara, Takashi Fujimoto, Hidehiro Atagi, Kenta Kaneda

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Dereplication of Natural Product Antifungals via Liquid Chromatography–Tandem Mass Spectrometry and Chemical Genomics by Nathaniel J. Brittin, David J. Aceti, Doug R. Braun, Josephine M. Anderson, Spencer S. Ericksen, Scott R. Rajski, Cameron R. Currie, David R. Andes, Tim S. Bugni

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Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review by Adekunle Babajide Rowaiye, Lorretha Chinonye Emenyonu, Ezinne Janefrances Nwonu, Okiemute Ajiroghene Okpalefe, Joseph Akwoba Ogugua, Victor Oluwatoyin Akinseye, Gordon Chukwuma Ibeanu

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Methotrexate for the Treatment of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation by Amr Nassar, Ghada Elgohary, Tusneem Elhassan, Zubeir Nurgat, Said Y. Mohamed, Mahmoud Aljurf

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Corallocarpus glomeruliflorus: Pharmacological potential revealed by phytochemical and in silico investigations by Fatima Saleh Naji Bin-Asal, Adel A.M. Saeed, Abdul-Rahman Alawi Bin Yahia

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Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration through IL-1 and BMP-2... by Asdar Gani, Risfah Yulianty, Supiaty Supiaty, Machirah Rusdy, Gustivanny Dwipa Asri, Dian Eka Satya, Ayu Rahayu Feblina, Harun Achmad

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Utilization of wheat straw for fungal phytase production by Zohre Shahryari, Mohammad H. Fazaelipoor, Payam Setoodeh, Ramkumar B. Nair, Mohammad J. Taherzadeh, Younes Ghasemi

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Respecting dignity: A fundamental element of the ethical being's existence by Ljupcho Chakar*, Aleksandar Stankov, Goran Pavlovski, Natasha Bitoljanu, Viktorija Belakaposka Srpanova, Ana Ivcheva, Rosica Siamkouri, Zlatko Jakovski

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Knowledge and Self-Reported Practice of Insulin Injection Device Disposal among Diabetes Patients in Gondar Town, Ethiopia: A Cross-Sectional Study by Abebe Basazn Mekuria, Begashaw Melaku Gebresillassie, Daniel Asfaw Erku, Kaleab Taye Haile, Eshetie Melese Birru

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Multi-center, prospective, non-interventional, observational study on the efficacy and safety of Mirabek® in adult patients with overactive bladder by Jee Soo Park, Won Sik Jang, Jongchan Kim, Moon-Hwa Park, Won Sik Ham

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From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota by Hamed Tahmasebi, Neda Arjmand, Marzieh Monemi, Ali Babaeizad, Farnaz Alibabaei, Negar Alibabaei, Aisa Bahar, Valentyn Oksenych, Majid Eslami

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Bibliometric analysis of 100 most cited papers on oral proliferative verrucous leukoplakia by Namrata Sengupta, Gargi S. Sarode, Sachin C. Sarode

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