Bexarotene-induced hypothyroidism and dyslipidemia; a nation-wide study by Katsunori Manaka, Junichiro Sato, Yusuke Hikima, Hirofumi Horikoshi, Maho Taguchi, Akimichi Morita, Hiraku Suga, Hikari Boki, Taku Fujimura, Yoji Hirai, Takatoshi Shimauchi, Chiharu Tateishi, Eiji Kiyohara, Ikko Muto, Hideki Nakajima, Riichiro Abe, Kazuyasu Fujii, Chikako Nishigori, Eiji Nakano, Kentaro Yonekura, Takeru Funakoshi, Masahiro Amano, Tomomitsu Miyagaki, Reiko Yamashita, Makoto Sugaya, Toshihisa Hamada, Masaomi Nangaku, Taroh Iiri, Noriko Makita

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Differentiation of high risk prostate cancer with a facile urinary exosome detection workflow by Shuai Qiu, Yue Li, Zheng Zhang, Chunchang Li, Haoyu Wang, Ao Chen, Zhi Yan, Yang Liu, Zifei Li, Hua Huang, Yi Liu, Yiqi Seow, Ruibing Chen, Jinhong Guo, Simeng Wen, Jing Tian, Hongtuan Zhang, Ranlu Liu, Gang Han, Baolong Wang, Yong Wang, Yuanjie Niu, HaiFang Yin

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NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression by Wenchao Xu, Jianzhou Liu, Qiaofei Liu, Jia Xu, Li Zhou, Zhiyong Liang, Haoran Huang, Bowen Huang, Gary Guishan Xiao, Junchao Guo

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Effectiveness for remission maintenance rate and safety of different rituximab regimens for treating anti-neutrophil cytoplasmic antibody-associated vasculitis in Japan: a J-CANVAS... by Chie Ogita, Kazuteru Noguchi, Jiro Takeuchi, Naoto Azuma, Satoshi Omura, Daiki Nakagomi, Yoshiyuki Abe, Masatoshi Kadoya, Naoho Takizawa, Atsushi Nomura, Yuji Kukida, Naoya Kondo, Yasuhiko Yamano, Takuya Yanagida, Koji Endo, Shintaro Hirata, Tohru Takeuchi, Kunihiro Ichinose, Masaru Kato, Ryo Yanai, Yusuke Matsuo, Yasuhiro Shimojima, Ryo Nishioka, Ryota Okazaki, Tomoaki Takata, Takafumi Ito, Mayuko Moriyama, Ayuko Takatani, Yoshia Miyawaki, Yutaka Kawahito, Toshiko Ito-Ihara, Takashi Kida, Nobuyuki Yajima, Takashi Kawaguchi, Kiyoshi Matsui

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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

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The Impacts of Breakthrough Drug Classes on Total Healthcare Expenditures by Zeynal Karaca, Steven N. Wiggins

“…**Background:** Pharmaceutical firms spend billions of dollars developing new therapies, which are often sold at a substantial premium over older therapies. …”
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Catastrophic health expenditure associated with non-inpatient costs among middle-aged and older individuals in China by Xiaojuan Zhang, Kun Zhu

“…BackgroundSince their establishment, the two predominant social health insurance schemes in China, Urban Employee Medical Insurance (UEMIS) and Urban and Rural Residents’ Medical Insurance (URRMS), have primarily focused on covering non-inpatient expenditure, while costs associated with outpatient care and pharmaceutical purchases have been largely excluded from the insurance benefit package. …”
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Catalytic effect of Fe@Fe2O3 nanowires and Fenton process on carbamazepine removal from aqueous solutions using response surface methodology by M.M. Amin, S. Yousefinejad, M. Dehghani, S. Rahimi

“…Due to toxicity and bio-stability of this psychotropic pharmaceutical in the environment and humans, its removal efficiency and mineralization are important. …”
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A Randomized, Double-Blind, Placebo-Controlled Trial Protocol Using the Fuzhengxiaoliu Patch for the Management of Primary Liver Cancer Pain by Li S, Wang B, Deng J, Li H, Wu Y, Fang Y, Yan B, Chen Y

“…Siman Li,1 Binding Wang,1 Jiayao Deng,2 Haiyan Li,2 Yong Wu,3 Yu Fang,2 Bohua Yan,2 Yu Chen2 1School of Clinical Medicine, Chengdu University of TCM, Chengdu, Sichuan, People’s Republic of China; 2Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 3Chengdu Zhongxiang Pharmaceutical Technology Co., Ltd., Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Bohua Yan; Yu Chen, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China, Email yanbohuagcp@163.com; 735405661@qq.comObjective: Chronic pain strongly affects the quality of life of patients with liver cancer pain. …”
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The management and clinical outcome of paracetamol poisoning in South African adults: A single-centre retrospective review by C Kotze, J Swanepoel, E C Kruger, E Decloedt

“…Paracetamol is a commonly prescribed drug, and often implicated in pharmaceutical overdoses. Paracetamol-induced hepatotoxicity is a common cause of acute liver failure in many high-income countries, but little is known about the factors associated with severity of liver injury and poor clinical outcomes among those treated in sub-Saharan African settings. …”
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Trends for Clinical Trials on Medicinal Products for Neurological Disorders in Lithuania and Europe by Emilijus Žilinskas, Arūnas Vaitkevičius

“…The majority of the trials (72.18%) were sponsored by commercial pharmaceutical companies. Most trials (31.73%) were registered as phase I trials. …”
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Optimised extraction of antioxidant components from Calophyllum inophyllum L. seeds using response surface methodology by L. Fitriyana, M.D. Supardan, Y. Aisyah, Irfan .

“…In addition, the findings of this study showed the high antioxidant activity of C. inophyllum seed extract lotion, which could be developed for pharmaceutical, nutraceutical, and other applications.…”
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Acceptability and feasibility of pre-exposure prophylaxis for bacterial STIs: a systematic review. by Julie-Anne Carroll, Amy B Mullens, Sarah Warzywoda, Philip R A Baker, Meika Stafford, Faye McMillan, Jacintha Manton, Daniel Demant

“…Similarly, the perspectives of populations beyond GBMSM have been omitted, and there is little understanding of the impact of their differing socio-cultural contexts around sex-related behaviour and Western pharmaceutical healthcare interventions on their acceptance and uptake.…”
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Evaluation of Yield and Physicochemical Quality of Pentadesma butyracea Butter Obtained by Different Traditional Extraction Methods in Ghana by Josephine Akuba Timtey, Francis Alemawor, William Otoo Ellis, Jacob K. Agbenorhevi, Nana Baah Pepra-Ameyaw

“…The butter has potential use in the food, pharmaceutical, and cosmetic industries. The study investigated traditional PBSB processing methods in Ghana and evaluated their effects on yield, physicochemical parameters, and fatty acid composition. …”
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Logistics Management Information System (LMIS) for Health Commodities at Public Health Facilities in Amhara National Regional State of Ethiopia: A Data Quality Evaluation Survey by Mekonen ZT, Cho DJ, Fenta TG

“…Zelalem Tilahun Mekonen,1 Denny J Cho,2 Teferi Gedif Fenta1 1Department of Pharmaceutics and Social Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia; 2Logistics Department, Kyrgyz State Technical University, Bishkek, KyrgyzstanCorrespondence: Zelalem Tilahun Mekonen, Email zelalem.tilahun@aau.edu.etIntroduction: Access to essential medicines is limited in developing countries mainly due to inefficiencies in health supply chain management, such as the absence of standard monitoring frameworks and poorly designed Logistics Management Information Systems (LMIS). …”
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Trends in Mycoplasma pneumoniae infections in pediatric patient preceding, during, and following the COVID-19 pandemic: a comprehensive longitudinal analysis by Jianwei Zhang, Ruoya Wu, Liyan Mo, Jinlong Ding, Ke Huang

“…Throughout the phases preceding, during, and after the COVID-19 pandemic, discernible fluctuations in both age distribution and seasonality of M. pneumoniae infections were identified among hospitalized children with ARI in the East China.IMPORTANCEThe resemblance between the transmission pathways of M. pneumoniae and those of COVID-19 suggests that non-pharmaceutical interventions may have comparable effects on both. …”
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Quality of life among residents of informal urban settlements during the COVID-19 pandemic in Salvador, Brazil by Albert I Ko, Federico Costa, Hammed Mogaji, Nivison Nery, Hernan D Argibay, Jaqueline S Cruz, Ianei O Carneiro, Ricardo Lustosa, Mike Begon, Hussein Khalil

“…However, there is limited information on the health-related quality of life (HRQOL) and indirect consequences of non-pharmaceutical interventions implemented during the pandemic.Methods We leveraged on an ongoing prospective open-cohort survey and performed a cross-sectional analysis of data collected between November 2021 and July 2022 among 793 residents above age 5 in a large slum community in the city of Salvador, Brazil. …”
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New sources of agriculturally valuable traits in hemp from the VIR collection for cultivar development by S. V. Grigoryev

“…Modern hemp cultivation and processing are targeted at the production of textiles for various purposes, hurds, seeds and oil for functional food and pharmaceutical use. The import of textiles to Russia has been observed to grow continuously, reaching $8.96 billion in 2016–2017. …”
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A Novel Model Using ML Techniques for Clinical Trial Design and Expedited Patient Onboarding Process by Iyer A, Narayanaswami S

“…Abhirvey Iyer,1 Sundaravalli Narayanaswami2 1Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU) Varanasi, Varanasi, Uttar Pradesh, India; 2Public Systems Group, Indian Institute of Management Ahmedabad, Ahmedabad, Gujarat, IndiaCorrespondence: Sundaravalli Narayanaswami, Email sundaravallin@iima.ac.inIntroduction: Clinical trials are critical for drug development and patient care; however, they often need more efficient trial design and patient enrolment processes. …”
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Interventions for SARS-CoV-2 prevention among Jailed adults: A network-based modeling analysis by Isaac Schneider, Karina Wallrafen-Sam, Shanika Kennedy, Matthew J. Akiyama, Anne C. Spaulding, Samuel M. Jenness

“…Yet, it had slow COVID vaccine uptake among jail residents, requiring prevention also using non-pharmaceutical interventions. Using a network-based SARS-CoV-2 transmission model parameterized with data from the Fulton County Jail, this study investigates the impact of three SARS-CoV-2 prevention strategies: vaccination, contact tracing and quarantining, and jail release to reduce jail population density. …”
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