A Look at Commonly Utilized Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in Chronic Pain by Christopher Robinson, Suhani Dalal, Ahish Chitneni, Anand Patil, Amnon A. Berger, Syed Mahmood, Vwaire Orhurhu, Alan D. Kaye, Jamal Hasoon

“… # Recent Findings SNRIs, including duloxetine, venlafaxine, and milnacipran, have demonstrated efficacy in reducing pain in musculoskeletal pain (chronic low back pain and osteoarthritis), fibromyalgia, and neuropathic pain conditions (peripheral diabetic neuropathy). # Summary The article describes the function, role, and use of SNRIs to treat chronic and neuropathic pain by altering the noradrenergic descending inhibitory pathways.…”
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MARINE EDUCATION IN INTERNATIONAL INDUSTRY by Ivan I. Kostylev, Mikhail K. Ovsyannikov

“…based education should not be considered as secondary or peripheral. Training of personnel for shipping industry is carried out on the basis of the national standards and in compliance with the requirements of the International Marine Organization, which is a part of the United Nations Organization. …”
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Profunda Brachii Pseudoaneurysm following Supracondylar Fracture of Humerus Repair in an 8-Year-Old Boy: A Case Report and Review of Literature by Hamed Ghoddusi Johari, Mohammad-Ali Erfani, Amirhossein Erfani, Reza Shahriarirad, Mohammad-Mehdi Karami

“…Arterial pseudoaneurysm can manifest in almost all arteries, but peripheral ones such as brachial artery pseudoaneurysm are rare and typically happen after trauma or infections. …”
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Climats et premiers peuplements des Alpes du Nord françaises : des derniers chasseurs aux premiers paysans (15 000 à 5 000 ans av. JC.) by Pierre Bintz, Christophe Griggo

“…A map clearly shows the progressive appropriation of the Western Alps from the peripheral regions.…”
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Changes in TNF and IL-6 production after diphtheria toxoid vaccination: drug modulation of the cytokine levels by A. L. Pukhalsky, M. S. Bliacher, A. V. Danilina, E. A. Kalashnikova, T. K. Lopatina, I. M. Fedorova

“…In the present study it was demonstrated that immunization with AD-M resulted in changes of in vitro TNF and IL-6 production by peripheral blood mononuclear cells. TNF release was suppressed but IL-6 production was stimulated. …”
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Unravelling the Impact of an Additional Sex Chromosome in an Adult Female by Sigin George, Vikas Dagar, Barun Kumar Chakrabarty, N. Nagaraja

“…The patient was initially evaluated by a low-cost peripheral blood (PB) conventional karyotyping using standard cytogenetic protocols. …”
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Identification of Specific Cell Surface Markers on Immune Cells of Squirrel Monkeys (Saimiri sciureus) by Bharti P. Nehete, Ashley DeLise, Pramod N. Nehete

“…Here, we report specific expression of HLA-DR, PD-1, and CD123 on different circulating immune cell subsets in the peripheral blood that included T cells (CD3+), T cells subsets (CD4+ and CD8+), B cells (CD20+), natural killer (NK) cells (CD3–CD16+), and natural killer T cells (CD3+CD16+) along with different monocyte subsets in squirrel monkey (Saimiri sciureus). …”
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TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review by Juan Montejo-Hernández, Jorge Rico-Fontalvo, Jose Cabrales, Shuchi Anand, María Cristina Martínez-Ávila, Claudia Duran-Merino, Luis Arias-Restrepo, Camilo Andrés Gómez Duran

“…Fluorescein angiogram revealed peripheral retinal vasculitis. Discussion. TINU is a rare disorder that needs to be distinguished from sarcoidosis, Sjogren’s disease, and tuberculosis. …”
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The Emerging Perspective of Morphine Tolerance: MicroRNAs by Teng J. Zhang, Yong Qiu, Zhen Hua

“…MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems. This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles.…”
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Persistence of Retinopathy of Prematurity in an Infant with Tetralogy of Fallot by Murat Gunay, Taner Yavuz, Gokhan Celik, Gunay Uludag

“…At 6 months of postnatal age, the infant still had an avascular peripheral retina with the demarcation line in Zone II. …”
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Uptake of Non-Transferrin Iron by Erythroid Cells by Eugenia Prus, Eitan Fibach

“…We probed the uptake of non-Tf iron and its consequences on the oxidative status of peripheral RBC and reticulocytes as well as developing erythroid precursors grown in vitro. …”
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Combining AI Techniques for Recognizing Aerobics Sport Videos by Meiling Duan

“…By extracting and constructing the 3D peripheral structure reconstruction scheme of the concept of aerobics footprint, we combine the fuzzy feature decomposition method to decompose the aerobics footprint image with multi-pane and suggest fusion. …”
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GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem by Cecilia Hes, Lu Ting Gui, Alexandre Bay, Fernando Alvarez, Pierce Katz, Tanushree Paul, Nadejda Bozadjieva-Kramer, Randy J. Seeley, Ciriaco A. Piccirillo, Paul V. Sabatini

“…While Gfral-expressing cells are known to be present in the area postrema and nucleus of the solitary tract (AP/NTS) located in the brainstem, the presence of Gfral-expressing cells in other sites within the central nervous system and peripheral tissues is not been fully addressed. Our objective was to thoroughly investigate whether GFRAL is expressed in peripheral tissues and in brain sites different from the brainstem. …”
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Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis by Esther Álvarez-Sánchez, Álvaro Carbayo, Natalia Valle-Tamayo, Laia Muñoz, Joaquim Aumatell, Soraya Torres, Sara Rubio-Guerra, Jesús García-Castro, Judit Selma-González, Daniel Alcolea, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Ricard Rojas-García, Oriol Dols-Icardo

“…However, no study has investigated the role of peripheral blood immune cells in ALS pathophysiology using single-cell RNA sequencing (scRNAseq). …”
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Erythropoietin supplementation induces dysbiosis of the gut microbiota and impacts mucosal immunity in a non-diseased mouse model by Guillaume Sarrabayrouse, Corentin Joulain, Stéphanie Bessoles, Andrada S. Chiron, Andrada S. Chiron, Amine M. Abina, Salima Hacein-Bey-Abina, Salima Hacein-Bey-Abina

“…Alterations in intestinal homeostasis are now well known to affect peripheral immune responses and favor the occurrence of a number of pathologies such as allergies and cancers. …”
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Impacts of stem cells from different sources on wound healing rate in diabetic foot ulcers: a systematic review and meta-analysis by Le Tong, Le Tong, Le Tong, Lin Tang, Lin Tang, Lin Tang, Bangli Tang, Jianna Zhang, Jianna Zhang, Jianna Zhang

“…The heterogeneity ranged from non-existent in the adipose and peripheral blood groups (I2 = 0.00%) to moderate in the bone groups (I2 = 26.31%) and other groups (I2 = 30.62%), and substantial in the umbilical cord groups (I2 = 88.37%). …”
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Longitudinal associations between air pollution and incident dementia as mediated by MRI-measured brain volumes in the UK Biobank by Rhiannon Thompson, Xinning Tong, Xueyi Shen, Jinjun Ran, Shengzhi Sun, Xiaoxin Iris Yao, Chen Shen

“…Results: Small but significant mediating effects (2%-8% of relationships mediated) were observed between PM2.5abs exposure and dementia risk by reduced total brain volume, NOx and Alzheimer’s disease risk by reduced peripheral cortical grey matter, PM2.5abs and vascular dementia risk by reduced peripheral cortical grey matter, PM2.5abs and other dementia risk by reduced total grey matter, and PM10 and other dementia risk by reduced total grey matter. …”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…While assessed in neurons, astrocytes, and microglia, its role is far less investigated in myelinating glia, including Schwann cells (SCs), responsible for peripheral nerve myelination. Remarkably, the dysregulation in endosomal trafficking is emerging as a pathophysiological mechanism underlying peripheral neuropathies, such as demyelinating Charcot‐Marie‐Tooth (CMT) diseases. …”
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The rat's sciatic nerve functional index dynamics after its transection and recovery by means of epineural neurorrhaphy by Ziia K. Melikov, Volodymyr V. Medvediev

“… Introduction. Peripheral nerve injury (PNI) is a common wartime pathology, the presence of which significantly complicates the course and treatment of combat injuries to the limbs. …”
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Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…The aim of this study was to explore whether A. fumigatus influences Gasdermin-D-dependent pyroptosis of the lung by regulating Toll-like receptor 2-mediated regulatory T cell differentiation. Methods. Collect peripheral blood from patients with A. fumigatus. ELISA kits we used to detect the expression levels of IL-1β, IL-6, IL-2R, and IL-10 in the serum and flow cytometry to detect the percentage of CD4+CD25+Foxp3+ Tregs in the patients’ peripheral blood mononuclear cells (PBMCs). …”
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