TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease by Menghao Zhang, Na Kang, Xin Yu, Xiaoyang Zhang, Qinghui Duan, Xianqiang Ma, Qiancheng Zhao, Zhimian Wang, Xiao’ou Wang, Yeling Liu, Yuxiao Zhang, Can Zhu, Ruiyu Gao, Xin Min, Cuifeng Li, Jin Jin, Qian Cao, Rongbei Liu, Xiaoyin Bai, Hong Yang, Lidan Zhao, Jinjing Liu, Hua Chen, Yonghui Zhang, Wanli Liu, Wenjie Zheng

“…Using serum metabolomics and peripheral immunocyte transcriptomics, we find that polymorphonuclear neutrophil (PMN) from patients with BD (BD-PMN) has dysregulated mevalonate pathway and subsequently increased farnesyl pyrophosphate (FPP) levels. …”
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Cyborg Adolescents and Digital Data: Examining Education and Revenue Generation in the Digital Lives of Youth through More-than-Human Ethnography by Davood Zahrani, Ali Hashemianfar, Ahmad Mehrshad

“…New actors have emerged in this space, including game developers, online game sales platforms, peripheral sales websites, e-commerce shops, and exchange offices. …”
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Comprehensive epidemiological evaluation of ruminant brucellosis and associated risk factors in some Egyptian Governorates by Nesreen Allam Tantawy Allam, Mahinour Ezzeldin Abdelsalam, Hend I. Elsharkawy, Mai Mohamed Kandil, Amany Mohamed Mohamed Mohamed, Fatma Ali, Mohamed A. Gebely, Safaa Y. Nour, Doaa Sedky, Mona Ebrahim Hussien Abd El-Gawad, Hoda M. Zaki, Nazek Al-Gallas, Amal M. Aboelmaaty, Mona Mohamed Sobhy, Nagwa Sayed Ata, Marwa Salah Abdel-Hamid, Ghada A. Badawy

“…There were 8 types of chromosomal aberrations detected in peripheral white blood cells. The highest frequency was for dicentric aberrations 0.025% (25/1000), whereas the lowest 0.009% (9/1000) was for acentric, ring, fusion, and polyploidy. …”
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60-month follow-up of Long Limb vs. Standard Limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT by Saleem Ansari, Anna Kamocka, Tina Mazaheri, Ibiyemi Ilesanmi, Lara Jimenez-Pacheco, Kleopatra Alexiadou, Joanna Tan, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Anne Margot Umpleby, Stephen Robert Bloom, Francesco Rubino, Alexander Dimitri Miras, Ahmed Rashid Ahmed, Tricia Tan

“…There was no difference between the Standard Limb and Long Limb groups for postprandial active glucagon-like peptide-1 secretion (70 ± 32 pmol/L vs. 70 ± 19 pmol/L, respectively; p = 0.43), hepatic insulin sensitivity (3.4 ± 0.9 µmol/kg/min vs. 3.4 ± 1.4 µmol/kg/min, respectively; p = 0.94) and peripheral insulin sensitivity (29.0 ± 9.1 µmol/kg/min vs. 29.2 ± 9.9 µmol/kg/min, respectively; p = 0.98) at 2 weeks post intervention. …”
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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

“…., iron deficiency anaemia and peripheral arterial disease: genetic correlation Rg = 0.45 [95% Confidence Intervals 0.27:0.64]). 33 pairs displayed negative genetic correlations, such as skin cancer and rheumatoid arthritis (Rg = −0.14 [−0.21:−0.06]), due to potential adverse drug effects. …”
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Providing a model of emotional and rational appeals in video marketing based on social networks by Moohan Mohammadi, payam paslari, saeed moradpour, sadegh masjoodi

“…Zhuang (2022) showed that screen mode, subtitles, and video title length significantly affect consumer engagement by influencing the central information processing pathway; and music and narration positively influence consumer engagement by functioning in the peripheral information processing pathway. This study contributes to the social media marketing and consumer engagement literature by uncovering the influencers for consumer engagement in the context of a brand's short-form video. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…The discovery that the pharmacological activation of LRH‐1/NR5A2 can reverse hyperglycaemia in mouse models of T1D by attenuating the autoimmune attack coupled to beta cell survival/regeneration prompted us to investigate whether immune tolerisation could be translated to individuals with T1D by LRH‐1/NR5A2 activation and improve islet survival. Methods Peripheral blood mononuclear cells (PBMCs) were isolated from individuals with and without T1D and derived into various immune cells, including macrophages and dendritic cells. …”
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Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium by Jessy Xinyi Han, Min Jung Koh, Leora Boussi, Mark Sorial, Sean M. McCabe, Luke Peng, Shambhavi Singh, Ijeoma Julie Eche-Ugwu, Judith Gabler, Maria J. Fernandez Turizo, Caroline T. MacVicar, Aditya Garg, Alexander Disciullo, Kusha Chopra, Alexandra Lenart, Emmanuel Nwodo, Jeffrey Barnes, Min Ji Koh, Eliana Miranda, Carlos Chiattone, Robert Stuver, Steven M. Horwitz, Mwanasha Merrill, Eric Jacobsen, Martina Manni, Monica Civallero, Tetiana Skrypets, Athina Lymboussaki, Massimo Federico, Yuri Kim, Jin Seok Kim, Jae Yong Cho, Thomas Eipe, Tanuja Shet, Epari Sridhar, Alok Shetty, Saswata Saha, Hasmukh Jain, Manju Sengar, Carrie Van Der Weyden, Henry Miles Prince, Ramzi Hamouche, Tinatin Murdashvili, Francine Foss, Marianna Gentilini, Beatrice Casadei, Pier Luigi Zinzani, Takeshi Okatani, Noriaki Yoshida, Sang Eun Yoon, Won-Seog Kim, Girisha Panchoo, Zainab Mohamed, Estelle Verburgh, Jackielyn Cuenca Alturas, Mubarak Al-Mansour, Josie Ford, Maria Elena Cabrera, Amy Ku, Govind Bhagat, Helen Ma, Ahmed Sawas, Khyati Maulik Kariya, Makoto Iwasaki, Forum Bhanushali, Owen A. O’Connor, Enrica Marchi, Changyu Shen, Devavrat Shah, Salvia Jain

“…We conducted an international retrospective cohort study of 925 patients with R/R MTCL and MNKCL. In peripheral T-cell lymphoma–not otherwise specified and anaplastic lymphoma kinase–negative anaplastic large cell lymphoma (ALK– ALCL), patients with relapsed lymphoma demonstrated a superior median overall survival (OS) relative to refractory from the time of second-line treatment. …”
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Designing a Forecasting Model and Evaluating the Strategic Cooperation between the Banking System and Fintech Startups using the Adaptive Neural Fuzzy Inference System (ANFIS) by Arash Onsori, Abbas Khamseh, Taghi Torabi, Hamid Reza Yazdani

“…Table 1: Research Dimensions and ComponentsComponentsSymbolDimensionsMain componentMarket development needs (MD), Financial aspects (FA),Innovation motivations (IM), Emerging business ecosystem (BE)SCMStrategic Cooperation Motivations Strategic cooperation between the banking system and fin-tech startups (SCOBF)Digital transformation (DT), Technology infrastructures (TI), Structural factors (SF), Organizational factors (OF), Cultural factors (CF), Manager tact (MT),Trust making (TM), Legal features (LF)EFOCEffective Factors on CooperationConventional cooperation (CC), Strategic cooperation (SC),Dynamic cooperation (DC)LCBFLevels of Cooperation Between Banks and FintechPeripheral factors (PF). International factors (IF), Law making (LM),Policy making (PM), Government and parliament (GP), Banking syndication (BS)EOFExternal Organizational FactorsTechnology limitations (TL), Economic barriers (EB), Procedure barriers (PB), Security challenges (SC), Legal barriers (LB)SCBStrategic Cooperation BarriersBusiness development (BD), Value making (VM), Efficiency improvement (EI), Transparency improvement (TM), Risk indicators (RI)SCOStrategic Cooperation Outcomes Moreover, the ANFIS design integrates Gaussian functions, ensuring differentiability and adaptability to diverse data patterns. …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Methods: We conducted a Mendelian randomization (MR) and colocalization analysis using 26,597 single-cell expression quantitative trait loci (sc-eQTL) to proxy effects of expressions of 16,597 genes in 14 peripheral blood immune cells and tested them against four COVID-19 outcomes from COVID-19 Genetic Housing Initiative GWAS meta-analysis Round 7. …”
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User Experiences While Playing Dance-Based Exergames and the Influence of Different Body Motion Sensing Technologies by Alasdair G. Thin, Craig Brown, Paul Meenan

“…No differences were found in the physiological measures of exertion between the peripherals/consoles. However, there were significant variations in the difficulty and enjoyment ratings between peripherals. …”
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Desertos alimentares e a sua espacialização na metrópole de Curitiba, Brasil by Marina Sutile de Lima

“…The results obtained show that the food deserts in the metropolis of Curitiba can be found in the central areas with high income and extensive infrastructure and in the peripheric area as well.…”
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„Nowe znamiona” Kościoła według papieża Franciszka by Przemysław Artemiuk

“…They are poverty, solidarity, peripherality and charity. Each of them is theologically justified by Francis and embedded in the papal ministry. …”
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Randomized controlled trials in central vascular access devices: A scoping review. by Mari Takashima, Gillian Ray-Barruel, Amanda Ullman, Samantha Keogh, Claire M Rickard

“…<h4>Results</h4>In total, 178 trials were included (78 non-tunneled [44%]; 40 peripherally inserted central catheters [22%]; 20 totally implanted [11%]; 12 tunneled [6%]; 6 non-specified [3%]; and 22 combined device trials [12%]). …”
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Bacteremia with an Unusual Pathogen: Mycobacterium neoaurum by Hesham Awadh, Munthir Mansour, Mahmoud Shorman

“…We report a case of M. neoaurum bacteremia in an immune competent host, with a chronically placed peripherally inserted central catheter (PICC line).…”
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L’affirmation de l’exemplarité environnementale comme stratégie de métropolisation des villes nordiques by Camille Girault

“…For cities characterized by some European and world periphericity, the assertion of such an environmental exemplarity actually contributes to a metropolitan integration wish in Europe and in the world. …”
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Mexican Pointy Boots and the Tribal Scene: Global Appropriations of Local Cultural Practices in the Virtual Age by Helena Simonett, César Burgos Dávila

“…In this essay, we examine music and its performative power by engaging in issues such as the localization of global cultural practices, the embracing of cultural practices based on a shared sense of marginalization and peripheralization, as well as the appropriation and resignification of “odd” cultural practices for global consumption, resulting in a cultural mutation of such practices and their objects from “low” to “art.” …”
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Research on Migration or Deployment of Telecom Network Management System on Cloud Computing Network by Afang Song, Lian Lin, Faguang Wang

“…According to the present situation of cloud computing technology and communication network management system，the existing network management system on the server hardware type，storage mode，special peripherals，and disaster recovery aspects of clouding related features were analyzed. …”
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A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia by Punam P. Parikh, Zhao-Jun Liu, Omaida C. Velazquez

“…Peripheral artery disease (PAD) is one of the major vascular complications in individuals suffering from diabetes and in the elderly that can progress to critical limb ischemia (CLI), portending significant burden in terms of patient morbidity and mortality. …”
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Is Surgery Still an Option in Pulmonary Arteriovenous Malformations Management? by Karim Nehme, Lamisse Karam, Joseph Nakad, Nader Saad, Georges Tabet

“…We present here the case of a 69-year-old man with a complex PAVM, peripherally localized with a feeding artery diameter bigger than 3 mm intentionally treated via an open middle lobe wedge resection via axillary mini thoracotomy over embolotherapy, showing that it comes with less risk and at a lower cost.…”
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