Phage therapy as an alternative strategy for oral bacterial infections: a systematic review by Mingqi Zhu, Chunxiu Hao, Ting Zou, Shan Jiang, Buling Wu

“…Abstract Background Oral infectious diseases, such as dental caries, periodontitis and periapical periodontitis, are often complicated by causative bacterial biofilm formation and significantly impact human oral health and quality of life. …”
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Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance. by Magdalena Widziolek, Anna Mieszkowska, Magdalena Marcinkowska, Bartlomiej Salamaga, Justyna Folkert, Krzysztof Rakus, Magdalena Chadzinska, Jan Potempa, Graham P Stafford, Tomasz K Prajsnar, Craig Murdoch

“…During periodontitis pathobionts such as Pg can enter the bloodstream and growing evidence correlates periodontitis with increased risk of cardiovascular and neurodegenerative diseases. …”
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Predictors for Gingival Index in Middle-Aged Asian Indians with Type 2 Diabetes from South India: A Cross-Sectional Observational Study by S. Jai Karthik, Shajith Anoop, R. Suresh Kumar, M. V. Usha Rani

“…T2DM patients (n=232, mean age: 50.6±10.4 years) with periodontitis (n=123, mean age: 54.3±2.4 years) and without periodontitis (n=109, mean age: 55.2±3.1 years) were recruited between 2014 and 2016 by purposive sampling method. …”
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Leptomeningeal Cells Transduce Peripheral Macrophages Inflammatory Signal to Microglia in Reponse to Porphyromonas gingivalis LPS by Yicong Liu, Zhou Wu, Xinwen Zhang, Junjun Ni, Weixian Yu, Yanmin Zhou, Hiroshi Nakanishi

“…Together with the inhibitory effect on microglial activation, propolis may be beneficial in preventing neuroinflammation during chronic periodontitis.…”
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Differential gene expression profile in Porphyromonas gingivalis treated human gingival keratinocytes and their role in the development of HNSCC by Dakshinya M, Anitha P, A.S. Smiline Girija, Paramasivam A, Vijayashree Priyadharsini J

“…Background: Periodontitis is considered to be one of the major risk factors associated with cancers of the oral cavity. …”
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M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p by Shan Chen, Jian Liu, Lilei Zhu

“…Macrophages play a pivotal role in regulating inflammatory response in periodontitis, a condition characterized by excessive osteoclast differentiation. …”
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Ehlers-Danlos Syndrome Type VIII: A Rare Cause of Leg Ulcers in Young Patients by Sophie Ronceray, Juliette Miquel, Antoine Lucas, Gérald E. Piérard, Trinh Hermanns-Lê, Anne De Paepe, Alain Dupuy

“…Ehlers-Danlos syndrome type VIII (EDS-VIII) is a very rare autosomal dominant disease characterized by early-onset periodontitis associated with features of Ehlers-Danlos syndrome. …”
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Correlation of Serum and Gingival Crevicular Fluid Levels of Caspase-3 and Milk Fat Globule–Epidermal Growth Factor 8 on Gingival Health by Manonmani Pavithra Ravindran, A Geetha, Sathish Rajendran, Jaideep Mahendra, M Jyothi, Ambalavanan Namasivayam

“…Spearman’s correlation showed a strong positive correlation between the serum and GCF levels of caspase-3 and periodontal parameters, whereas serum and GCF levels of MFG-E8 showed a strong negative correlation with the periodontal parameters. …”
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Evaluating the Preventive and Therapeutic Roles of Active Irrigation Systems in Root Canal Treatment: A Narrative Review and Critical Appraisal of Theory and Methodology by Ignacio Barbero-Navarro, Iuliana Sofian-Pauliuc, Maria Esther Irigoyen-Camacho, Marco Antonio Zepeda-Zepeda, David Ribas-Perez, Antonio Luis Castaño-Seiquer

“…Endodontic therapy aims at preventing or curing apical periodontitis. To conduct this, the cleaning and shaping of the canals are essential. …”
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Comparison of Oral Microbe Quantities from Tongue Samples and Subgingival Pockets by André Göhler, Stefanie Samietz, Carsten Oliver Schmidt, Thomas Kocher, Ivo Steinmetz, Birte Holtfreter

“…To improve understanding of periodontitis pathology, we need more profound knowledge of relative abundances of single prokaryotic species and colonization dynamics between habitats. …”
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IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture by Moore TC, Pinkerton TS, Petro TM

“…Restoration of IRF3 expression in IRF3KO RAW cells increased IL-6, restored NO, and decreased CCL22 production in response to LPS of E. coli.Discussion: Therefore, IRF3 is critical to the expression of pro- and anti-inflammatory factors produced by macrophages responding to LPS and could be a target during periodontitis treatment.Keywords: IRF3, lipopolysaccharide, macrophages, RAW264.7 cells, cytokines…”
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Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview by Jaroslav Mysak, Stepan Podzimek, Pavla Sommerova, Yelena Lyuya-Mi, Jirina Bartova, Tatjana Janatova, Jarmila Prochazkova, Jana Duskova

“…Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. …”
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Neutrophils and neutrophil extracellular traps in oral health and disease by Tae Sung Kim, Niki M. Moutsopoulos

“…In this review, we provide an overview of the basic concepts related to neutrophil functions, including NET formation, and discuss the mechanisms associated with NET activation and function in the context of the prevalent oral disease periodontitis.…”
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Revolutionizing oral care: Reactive oxygen species (ROS)-Regulating biomaterials for combating infection and inflammation by Wei Zhao, Yu Zhang, Jing Chen, Danrong Hu

“…The human oral cavity is home to a delicate symbiosis between its indigenous microbiota and the host, the balance of which is easily perturbed by local or systemic factors, leading to a spectrum of oral diseases such as dental caries, periodontitis, and pulp infections. Reactive oxygen species (ROS) play crucial roles in the host's innate immune defenses. …”
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STUDY OF THE EFFECT OF METHIONINE HYPERHOMOCYSTEINEMIA AND ITS CORRECTION WITH CHOLINE AND VITAMIN D ON THE CONDITION OF THE PERIODONTIUM, SMALL INTESTINE, AND LIVER OF RATS by Oleh Kutelmakh, Yulia Chumakova, Lina Kovalchuk, Yulia Odnorih, Olexandra Kutelmakh, Anastasiya Spodaruk

“…The experimental study confirmed the data of previous studies that with long-term methionine hyperhomocysteinemia in rats, moderate periodontal damage occurs, which remotely resembles the clinical picture of generalized periodontitis of a mild degree of severity in humans. …”
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Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study by R. Vijayalakshmi, N. Ambalavanan, S. Rajeshkumar, Jaideep Mahendra, Uma Sudhakar, Devi Parameswari

“…Conclusion: Terminalia arjuna mediated SeNPs gel shows promise for more rapid and sustained drug delivery in the management of chronic periodontitis through local drug delivery systems.…”
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Oral Plaque from Type 2 Diabetic Patients Reduces the Clonogenic Capacity of Dental Pulp-Derived Mesenchymal Stem Cells by Antonella Bordin, Francesca Pagano, Eleonora Scaccia, Matteo Saccucci, Iole Vozza, Noemi Incerti, Antonella Polimeni, Elena Cavarretta, Isotta Chimenti, Elena De Falco

“…Periodontitis can impact the structure of the tooth and likely the stem and progenitor cell pool, which actively contributes to the periodontal microenvironment and homeostasis. …”
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Biofilm architecture and dynamics of the oral ecosystem by Rina Rani Ray

“…Undiagnosed and untreated oral biofilm can lead to severe diseases like periodontitis and eventual tooth loss. Therefore, studying the architecture and dynamics of oral biofilms is essential and can be achieved through image analysis and modern technologies, such as AI-enabled technologies and surface topography-adaptive robotic superstructures.…”
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A Rare Case of Orthograde Retrieval of Extruded Instrument following Periapical Tissue Healing by Ahmed Elhakim, Tarek Mohamed Abd El-Wahab

“…When a patient presented for emergency treatment of tooth #37 diagnosed with acute suppurative apical periodontitis, radiographic examination revealed a fractured instrument extruded into the periapex. …”
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Oral health and dental behaviour of patients with left ventricular assist device: a cross‐sectional study by Jens Garbade, Josephine Rast, Gerhard Schmalz, Mirjam Eisner, Justus Wagner, Tanja Kottmann, Andreas Oberbach, Sven Lehmann, Rainer Haak, Michael A. Borger, Christian Binner, Dirk Ziebolz

“…The presence of decayed, missing, and filled teeth; dental treatment need; periodontitis severity; and periodontal treatment need were assessed. …”
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