Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…Furthermore, phytochemical characterization and tentative identification was performed using FTIR, 1HNMR and UHPLCOrbitrap HRMS, FTIR, whilst computational studies were also employed to determine the biochemical interaction, antidiabetic and inhibitory potential of the extracts with the α-amylase enzyme. …”
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Exploring the mechanisms of Devonian oceanic anoxia: impact of ocean dynamics, palaeogeography, and orbital forcing by J. Gérard, L. Sablon, J. J. C. Huygh, A.-C. Da Silva, A. Pohl, C. Vérard, M. Crucifix

“…While growing geological evidence has demonstrated a temporal correlation between astronomical forcing and anoxia during this period, underlying physical mechanisms remain unknown, hence questioning causality. Here, we perform multiple sensitivity experiments, using an Earth system model of intermediate complexity (cGENIE), to isolate the influences of specific Devonian climate and palaeogeography components on ocean oxygen levels, contributing to the better understanding of the intricate interplay of factors preconditioning the ocean to anoxia. …”
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Prevalence and Related Risk Factors of Intestinal Parasitosis among Private School-Going Pupils of Dharan Submetropolitan City, Nepal by Bijay Kumar Shrestha, Manita Tumbahangphe, Jenish Shakya, Anu Rai, Kabita Dhakal, Bidhya Dhungana, Romika Shrestha, Jyoti Limbu, Kabiraj Khadka, Santoshi Ghimire, Sujata Chauhan, Lata Chalise, Ashu Ghimire

“…Statistical analysis was performed by using SPSS version 16.0. Pearson’s Chi-square test was used to establish association between dependent and independent variables. …”
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Health-related quality of life and health state utility value in idiopathic pulmonary fibrosis: a systematic review and meta-analysis by Guixiang Zhao, Siyuan Lei, Ya Li, Zhenzhen Feng, Jiansheng Li

“…After two researchers independently screened the literature, extracted the data, and evaluated the risk of bias in the included studies, pooled analysis was performed on the measurement tools adopted in more than two studies. …”
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Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel by Rachelle E. Koch, Jackson Barth, Andrew E. Clark, Dhara Desai, Jiwoong Kim, Christine A. Pybus, Xiaowei Zhan, Leonard Leibovici, Dafna Yahav, David E. Greenberg

“…However, a better understanding of the relationship between bacterial genetic markers, phenotypic resistance, and clinical outcomes is needed. We performed whole-genome sequencing on five medically important pathogens (Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa) to investigate how resistance genes impact patient outcomes. …”
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Penerapan Mekanisme Continuous Deployment dalam Pengembangan dan Pembaruan Perangkat Lunak Sistem Benam Berbasis Internet of Things by Yohanna Fransiska Aladina, Adhitya Bhawiyuga, Reza Andria Siregar, Primantara Hari Trisnawan

“…The average time it takes to perform an update is only 63.5 seconds. Based on the results of these tests, this solution can answer the problem of updating IoT device software which is still done manually. …”
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Effect of Acupuncture on the Expression of Heme Oxygenase 1 and Inflammatory Factors in Rats with Intracerebral Hemorrhage by CHEN Qiuxin, KONG Ying, YU Tingting, ZHANG Yu, LIU Peng, ZHANG Xin

“…The sham operation group received various surgical operations similar to the model group, but no blood injection was performed; the model group received intracerebral hemorrhage model production without any intervention; the acupuncture group was used to create a intracerebral hemorrhage model, and treatment began 12 hours after the model was created. …”
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Association between relative telomere length and a genetic variant of SIRT1 gene and age-related macular degeneration by L.K. Moshetova, O.P. Dmitrenko, O.I. Abramova, N.S. Karpova, K.I. Turkina, I.N. Saburina

“…Genotyping of SIRT1 rs12778366 polymorphic locus was performed by TaqMan^® real-time PCR. Telomere length was measured by real-time PCR as described earlier [Cawthon, 2002] using specific primers. …”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…FindingsIn this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine.MeaningEnvironmental exposures such as drugs are relevant players in the pathogenesis of autoimmune diseases and clinicians who treat patients with autoimmune blistering diseases such as pemphigus should consider performing a detailed medication history leveraging this information regarding deleterious drug-disease interactions at initial evaluation as well as longitudinal monitoring of patients to better inform clinical care decisions.ImportancePemphigus vulgaris (PV) is a rare, potentially fatal autoimmune disease with pathogenic contributions from both genetic as well as environmental factors, notably drug exposures. …”
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Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development by G. F. Korytina, L. Z. Akhmadishina, V. A. Markelov, Y. G. Aznabaeva, O. V. Kochetova, T. R. Nasibullin, A. P. Larkina, N. N. Khusnutdinova, N. Sh. Zagidullin, T. V. Victorova

“…Linear regression analyses were performed to estimate the relationship between SNPs and lung function parameters and smoking pack-years. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…In addition, conditional knockout mice for Nrf2 and p62 were used to detect these markers, together with the monitoring of in vivo tumor growth. RNA sequencing was performed for CD8TILs and tumor cells. Melanoma cells containing an IFN-γ receptor (IFNγR) cytoplasmic domain deletion mutant was overexpressed and used for characterization of the metabolic profile of those tumor cells using a Seahorse Flux Analyzer.Results Met administration elevates mtROS and cell surface Glut-1, resulting in the production of IFN-γ in CD8TILs. mtROS activates Nrf2 in a glycolysis-dependent manner, inducing activation of autophagy, glutaminolysis, mTORC1, and p62/SQSTM1. mTORC1-dependent phosphorylation of p62 at serine 351 (p-p62(S351)) is also involved in activation of Nrf2. …”
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NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder by Bin Gong, Chenxu Xiao, Yu Feng, Yu Feng, Jing Shen

“…Furthermore, two-sample Mendelian randomization (TSMR) analyses were performed to explore causal links between protein quantitative trait loci (pQTL) and these disorders.ResultsThe SMR analysis revealed 41 druggable genes associated with BD, of which five genes appeared in both brain tissue and blood eQTL datasets and were significantly associated with BD risk. …”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…Spatial transcriptomics was performed on normal veins and 19‐day grafts to explore gene expression in neointimal regions. …”
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Clinical observation on effect of endurance exercise for elderly patients with maintenance hemodialysis (耐力运动在老年维持性血液透析患者中的应用效果观察) by HOU Ying (侯颖)

“…In the study group, the gymnastics exercise combined with low-intensity aerobic training was carried out on dialysis days, and individualized exercise training was performed on non-dialysis days. The 6-Minute Waling Test (6MWT), Berg Balance Scale and hand grip strength measuring were used to assess the patients’ motor function. …”
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Safe distances for transforaminal posterior lumbar interbody fusion under one-hole split endoscopy: three-dimensional reconstruction measurement of 1-degree degenerative lumbar spo... by Changzhen Liu, Jiabin Ren, Zhaozhong Sun, Sa Li, Zhimeng Feng, Yuefei Li

“…To improve safety, individualized imaging evaluation can be performed before the operation to select the appropriate grinding drill.…”
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Desnutrición y obesidad en mayores autónomos y determinantes de salud relacionados con ambos trastornos nutricionales by Claudia Haitzell Bonilla-Barrera, Laura Bea Berges, Jesús Seco-Calvo

“…Binary logistic regression was performed to predict dichotomous dependent variables. …”
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Development and Validation of a Cost-Effective Machine Learning Model for Screening Potential Rheumatoid Arthritis in Primary Healthcare Clinics by Wu W, Hu X, Yan L, Li Z, Li B, Chen X, Lin Z, Zeng H, Li C, Mo Y, Wu Y, Wang Q

“…Employing multivariatelogistic regression results and the best-performing model to identify the least costly features, ensuring applicability in primary healthcare clinics. …”
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Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini, L. Brussino

“…Multivariable logistic regression was performed to adjust for potential confounders. Model fit was evaluated using the Hosmer–Lemeshow test, and interactions between variables were tested. …”
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Mechanism study of KCMF1 promoting proliferation and NF-κB signaling transduction in colorectal cancer cells by WU Zhibai, XU Guiqin, ZHANG Li, YANG Zhaojuan, LIU Yun, JIAO Kun, CHEN Zehong, XU Chen, ZUO You, ZHENG Ningqian, YE Zhiqian, LIU Yongzhong

“…Furthermore, immunohistochemical staining was performed to detect the protein level of KCMF1 in 90 paired human CRC tissues and adjacent non-tumor tissues. …”
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Optimization of the Screw Conveyor Device Based on a GA-BP Neural Network by Qiang Guo, Yunpeng Zhuang, Houzhuo Xu, Wei Li, Haitao Li, Zhidong Wu

“…In MATLAB, an optimization calculation and analysis were performed. The optimization results of the traditional BP (Back Propagation) and GA—BP were compared. …”
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