Outcomes of Idecabtagene Vicleucel Therapy in Patients with Relapsed/Refractory Multiple Myeloma: A Single-Institution Experience by Aaron Trando, Farid Ghamsari, Philip Yeung, Caitlin Costello, Ila Saunders, Ah-Reum Jeong

“…Nevertheless, given its limitations, including the risk of adverse effects and unclear durability of efficacy, there remains a need to report the real-world clinical outcomes of ide-cel therapy in patients with R/R MM, as well as explore host predictive factors for therapy. <b>Methods:</b> We performed a single-center retrospective analysis of 25 adult patients with R/R MM who received ide-cel between 2021 and 2023 at the University of California San Diego Health. …”
Get full text

Exploring Chronic Pain in Hemodialysis Patients: An Observational Study Based on the New IASP Classification for ICD-11 by Vittorio Schweiger, Martina Cacciapuoti, Marta Nizzero, Salvatore Simari, Gianmarco Lombardi, Leonardo Gottin, Lisa Stefani, Alvise Martini, Giustino Varrassi, Gabriele Finco, Enrico Polati, Giovanni Gambaro

“…However, chronic pain assessment in HD patients is rarely performed by specialists in pain medicine, with relevant consequences in terms of diagnostic and treatment accuracy. …”
Get full text

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia by Olga Plisko, Jana Žodžika, Irina Jermakova, Inta Liepniece-Karele, Jeļena Eglīte, Dace Rezeberga

“…Material from the cervix was taken for subsequent HLA genotyping of 13 DRB1*, 8 DQA1*, and 12 DQB1* alleles. Colposcopy was performed on all participants. In case of visual suspicion for CIN cervical biopsy was done.Results: There were 57 “no CIN” patients, 23 histologically proven CIN 1 and 61 CIN2+ cases in the study population. …”
Get full text

Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission by Hafez Al-Momani, Andrew Nelson, Hadeel Al Balawi, Dua’a Al Balawi, Iman Aolymat, Ashraf I. Khasawneh, Hala Tabl, Ayman Alsheikh, AbdelRahman M. Zueter, Jeffrey Pearson, Christopher Ward

“…DNA sequencing of the V4 region of the 16 S rRNA gene was performed for microbiome analysis. No differences were observed between the fecal microbiome’s alpha and Shannon diversity indices; however, a distinct microbial composition was observed in COVID-19 patients (when compared to the controls). …”
Get full text

Ginseng-derived Nanoparticles Inhibit Lung Cancer Cell Growth by Promoting Macrophage M1 Polarization by Liangliang FAN, Limei REN, Song YANG, Wenjing LI, Yueming ZHAO, Ronghua ZHAO, Daqing ZHAO, Jiawen WANG

“…Western blotting was performed to investigate the effect of GDNPs-CM on the expression of TLR4/MyD88 pathway-related proteins in A549 cells. …”
Get full text

Relationship of the gene pool of the Khants with the peoples of Western Siberia, Cis-Urals and the Altai-Sayan Region according to the data on the polymorphism of autosomic locus a... by V. N. Kharkov, N. A. Kolesnikov, L. V. Valikhova, A. A. Zarubin, M. G. Svarovskaya, A. V. Marusin, I. Yu. Khitrinskaya, V. A. Stepanov

“…To address the issues of genetic proximity of the Khanty with other indigenous peoples, we performed genotyping of a wide genomic set of autosomal markers using high-density biochips, as well as an expanded set of SNP and STR markers of the Y-chromosome in various ethnic groups: Khakas, Tuvans, Southern Altaians, Siberian Tatars, Chulyms (Turkic language family) and Kets (Yeniseian language family). …”
Get full text

Revealing the role of natural killer cells in ankylosing spondylitis: identifying diagnostic biomarkers and therapeutic targets by Yuling Chen, Yan Li, Yuan Xu, Qing Lv, Yuanchun Ye, Jieruo Gu

“…Differentially expressed genes (DEGs) and functional enrichment analysis were performed respectively. Weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules of co-expressed genes and genes involved in NK cell function. …”
Get full text

Vaccination in Nile tilapia broodstock with whole cell vaccine and disease resistance in its fry against Aeromonas hydrophila by Sukenda Sukenda, Odang Carman, Rahman Rahman, Dendi Hidayatullah, Nurfitriani Siti Yumaidawati

“…Challenge test in fry tilapia performed at the age of 5, 10, and 15 days. The results showed that vaccination in tilapia broodstock delivered a significant antibody level in broodstock, eggs, and fry (P<0.05) compared to the control. …”
Get full text

Implementasi Model Pembelajaran Rekreasi-Prokreasi dalam Membaca Kritis Teks Eksplanasi di SMK by Bambang Eko Hari Cahyono, Lulus Irawati, Devit Tri Candrawati

“…Validity through extending the participation of researchers, making observations diligently and carefully, and triangulating data sources. Data analysis was performed using an interactive analysis model. The results showed that: (1) critical reading learning has not been implemented well due to the low student interest in reading, and the inaccuracy of teachers in choosing learning methods, materials, and media, (2) learning to read critical explanatory texts with recreational-procreation models can create an atmosphere new learning that is fun for students, encourages the growth and development of critical thinking skills, encourages students to express their opinions critically, and improves other language skills, (3) the obstacles faced by teachers and students, namely the lack of tools and learning media, students are less active, the teacher has not been able to become a facilitator of critical reading learning well, as well as the limited language skills of students.…”
Get full text

Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism by Handan Tan, Zhenyu Zhong, Xiaojie Feng, Xiang Luo, Qingfeng Cao, Peizeng Yang

“…Methods: To analyse the genetic susceptibility to BD mediated by IL10RA causal polymorphisms, we performed a study on data from our previous genome-wide association studies (GWAS), the bioinformatic analysis of post-annotation of GWAS and relevant mechanism verification experiments, including chromatin immunoprecipitation, luciferase gene-reporter assay, electrophoretic mobility shift assays, and enzyme-linked immunosorbent assay. …”
Get full text

Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood by Rongmu Luo, Rongmu Luo, Guannan Ma, Qian Yu, Zhengqin Tian, Qihang Man, Xiangrong Shu, Xuetong Liu, Yupeng Shi, Lei Zhang, Jingbo Wang

“…Antimicrobial susceptibility testing was performed to determine resistance patterns. Comprehensive genomic analysis was conducted to identify plasmid types, virulence factors, and antimicrobial resistance genes, as well as potential resistance mechanisms associated with mutations and plasmid-mediated variants.ResultsThe isolated hv-CRKP strain exhibited multidrug resistance to carbapenem, tigecycline, and polymyxin. …”
Get full text

Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis by Manting Liu, Jiexiang Ye, Runtian Wu, Dongqiang Luo, Tao Huang, Dandan Dai, Kexin Wang, Yanping Du, Junwen Ou

“…GO/KEGG enrichment and ssGSEA analyses were performed to identify critical pathways. Cytoscape and machine learning (SVM) were used for target prediction and molecular docking validation. …”
Get full text

Meteorological Anomalies During Earthquake Preparation: A Case Study for the 1995 Kobe Earthquake (M = 7.3) Based on Statistical and Machine Learning-Based Analyses by Masashi Hayakawa, Shinji Hirooka, Koichiro Michimoto, Stelios M. Potirakis, Yasuhide Hobara

“…In order to obtain a clearer identification of any seismogenic effect, we have used the AMeDAS station data at local midnight (LT = 01 h) and our initial target EQ was chosen to be the famous 1995 Kobe EQ of 17 January 1995 (M = 7.3). Initially, we performed conventional statistical analysis with confidence bounds and it was found that the Kobe station (very close to the EQ epicenter) exhibited conspicuous anomalies in both physical parameters on 10 January 1995, just one week before the EQ, exceeding m (mean) + 3σ (standard deviation) in T/Hum and well above m + 2σ in ACP within the short-term window of one month before and two weeks after an EQ. …”
Get full text

Roles of the rpoEc-chrR-chrA operon in superoxide tolerance and β-lactam susceptibility of Stenotrophomonas maltophilia by Ren-Hsuan Ku, Hsu-Feng Lu, Li-Hua Li, Li-Hua Li, Ting-Yu Yeh, Yi-Tsung Lin, Yi-Tsung Lin, Tsuey-Ching Yang

“…RNA-seq transcriptome assay of wild-type KJ, KJΔChrR (chrR mutant), and KJΔChrRΔRpoEc (chrR/rpoEc double mutant) was performed to reveal the σEc regulon.ResultsThe rpoEc-chrR pair and downstream chrA formed an operon. …”
Get full text

First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation by Handoko, Adham M, Rachmadi L, Tobing DL, Asmarinah A, Fadilah F, Dai W, Lee AWM, Gondhowiardjo SA

“…Methylation analysis was performed using modkit and statistical analysis with R software. …”
Get full text

Impacts of stem cells from different sources on wound healing rate in diabetic foot ulcers: a systematic review and meta-analysis by Le Tong, Le Tong, Le Tong, Lin Tang, Lin Tang, Lin Tang, Bangli Tang, Jianna Zhang, Jianna Zhang, Jianna Zhang

“…The Stata 16.0 (Stata Corp, TX) software was used to perform the meta-analysis. Risk of bias in all included studies was evaluated by Cochrane Risk of Bias version 2.ResultsA total of 24 studies involving 1,321 patients were included. …”
Get full text

Family planning and preimplantation testing: family experiences in congenital adrenal hyperplasia by Jessica L. Sandy, Jessica L. Sandy, Jessica L. Sandy, Grant Betts, Jessica L. Harper, Suzanne M. Nevin, Suzanne M. Nevin, Suzanne M. Nevin, Rebecca Deans, Rebecca Deans, Rebecca Deans, Kristen A. Neville, Kristen A. Neville

“…Thematic analysis was performed using an inductive, semantic approach.ResultsThirty families (34 children) were identified. …”
Get full text

Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations by Wu X, Pan J, Pan X, Kang J, Ren J, Huang Y, Gong L, Li Y

“…Subsequently, immune infiltration analysis and gene set enrichment analysis (GESA) were performed. 61 machine learning models were developed to screen for Hub genes. …”
Get full text

Sistem Monitoring Tekanan Darah Berbasis Maximum Amplitude Algorithm Menggunakan Android Secara Realtime by Barlian Henryranu Prasetio, Brylliano Maza Putra, Dahnial Syauqy

“…In this study writer used a non-invasive method by utilizing oscillometric value readings of pressure changes in the cuff are read by the MPX5500DP pressure sensor to perform blood pressure readings are then displayed on the android device. …”
Get full text

Comparative outcomes of corticosteroids, neuromuscular blocking agents, and inhaled nitric oxide in ARDS: a systematic review and network meta-analysis by Zhiyuan Xu, Xiao Liu, Liang Zhang, Xianliang Yan, Xianliang Yan

“…Frequentist network meta-analysis (NMA) was performed to identify the most effective intervention, and treatments were ranked using the surface under the cumulative ranking (SUCRA) curve. …”
Get full text