Age, frequency, and strategy optimization for organized colorectal cancer screening: a decision analysis conducted in China for the years 2023–2038 by Zixing Wang, Wei Han, Ran Fei, Yaoda Hu, Fang Xue, Wentao Gu, Cuihong Yang, Yubing Shen, Luwen Zhang, Jingmei Jiang

“…We projected the incidence and mortality of CRC, cost, and quality-adjusted life years for 2023–2038; and performed incremental cost-effectiveness, probability acceptability, and sensitivity analyses to identify the optimal scheme and the factors affecting this choice. …”
Get full text

Microbiological Analysis Conducted on Raw Milk Collected During Official Sampling in Liguria (North-West Italy) over a Ten-Year Period (2014–2023) by Sara Antonia Chiarlone, Andrea Gori, Serena Ravetta, Andrea Armani, Lisa Guardone, Francesca Pedonese, Salvatore Bavetta, Caterina Fiannacca, Nicola Pussini, Cristiana Maurella, Elisabetta Razzuoli

“…In this retrospective study, the results of the analyses performed on 355 raw milk samples collected in Liguria between 2014 and 2023 for the detection of <i>Campylobacter</i> spp., <i>Salmonella</i> spp., <i>Listeria monocytogenes</i>, <i>Staphylococcus aureus</i>, and <i>Escherichia coli</i> O157 were analysed to better characterise the associated risk for consumers. …”
Get full text

Support in digital health skill development for vulnerable groups in a public library setting: perspectives of trainers by Lucille M. B. Standaar, Lucille M. B. Standaar, Lucille M. B. Standaar, Adriana M. C. Israel, Rosalie van der Vaart, Brigitta Keij, Roland D. Friele, Roland D. Friele, Mariëlle A. Beenackers, L. H. D. van Tuyl

“…A deductive analysis based upon the interview guide topics was performed. A second inductive analysis was applied to identify underlying patterns. …”
Get full text

CRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp by Jie Zhang, Liqiang Zhang, Xiaoman Wu, Minhui Tao, Yang Chen, Mingxian Chang

“…Since the negative regulatory role of gcPI4KB in GCRV infection was confirmed by in vitro data, we performed gene editing of gcPI4KB in grass carp. We found that PI4KB F0 juvenile grass carp crispants have obvious advantages in promoting growth and in resisting GCRV-II infection. …”
Get full text

Combined use of respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in sickle-cell adult patients with acute chest syndrome (The ANTIBIO-STA study): a randomi... by Alexandre Sabaté-Elabbadi, Armand Mekontso-Dessap, François Lionnet, Aline Santin, Charlotte Verdet, Paul-Louis Woerther, Julien Lopinto, Matthieu Turpin, Alexandra Rousseau, Romane Lacoste-Badie, Keyvan Razazi, Guillaume Voiriot, Muriel Fartoukh

“…Consecutive adult patients with ACS were randomly assigned to the conventional or interventional strategy, where antibiotic therapy was targeted on the results of mPCR performed on lower respiratory tract secretions (LRTS) samples, and antibiotic discontinuation based on PCT values and kinetics at Day 1 (D1), D3 and D7. …”
Get full text

Longitudinal changes in the 6-minute walk test and the Glittre-activities of daily living test in adults with cystic fibrosis by Vera Lucia Barros Abelenda, Cláudia Henrique da Costa, Mônica de Cássia Firmida, Raphael Freitas Jaber de Oliveira, Rogério Rufino, Agnaldo José Lopes

“…In conclusion, awCF performed better on TGlittre than on 6MWT. They experienced an improvement in body composition. …”
Get full text

Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study by Pedro Puerta-Alcalde, Jessica O'Keefe, Rachel Woolstencroft, Shipraa Kaul, Néstor López, Katie Cronin, Andrew Lim, Nicole Garcia-Pouton, Míriam Álvarez, Lynette Chee, Mateu Espasa, Ignacio Grafia, Maria Suárez-Lledó, Olivia Smibert, Carolina Garcia-Vidal, Monica A. Slavin, Michelle K. Yong, Alex Soriano, Leon J. Worth

“…Logistic regression analyses were performed. Results: A total of 547 CDI episodes in cancer patients were documented. …”
Get full text

Reproductive Efficiency of Nelore Cows in Fixed-Time Artificial Insemination Programs with Early Resynchronization by Larissa de Paiva Nunes Gonçalves, Alisson Jordão Prado, Aline Pacheco, Yana Eliza Feitosa de Almeida, Pietro Sampaio Baruselli, Welligton Conceição da Silva, Antônio Humberto Hamad Minervino, Jucelane Salvino de Lima, Kedson Alessandri Lobo Neves

“…These findings indicate that both early and conventional resynchronization protocols perform similarly, with early resynchronization offering advantages in reducing the calving interval. …”
Get full text

Design of Command and Dispatch System for Automatic Reading of Meter Images in Substations by UAV Inspection Photos by Guanghong Deng, Liangpei Lin, Baihao Lin, Wenlong Jing, Xiaodan Zhao, Yong Li, Rui Yang, Shidun Xie, Pengfeng Wei

“…This paper proposes a method based on the combination of YOLOv6n object detection and Deeplabv3[Formula: see text] image segmentation and performs post-processing on the segmented images to obtain meter readings. …”
Get full text

Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model by Panadda Yotsomnuk, Amarnath Praphakar Rajendran, Daniel Nisakar Meenakshi Sundaram, Luis Carlos Morales, Cezary Kucharski, Mohammad Nasrullah, Wanwisa Skolpap, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Hasan Uludağ

“…The quantitative analysis of gene silencing performed by qPCR as well as immunostaining/flow cytometry indicated significant reduction in both FLT3 expression and FLT3 protein after specific siRNA delivery. …”
Get full text

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis by Ziying Wu, Xiang Ding, Guanghua Lei, Chao Zeng, Jie Wei, Jiatian Li, Hui Li, Tuo Yang, Yang Cui, Yilin Xiong, Yilun Wang, Dongxing Xie

“…RevMan V.5.2 was used to perform statistical analyses.Results Twelve trials were included, among which ten trials involved knee OA, two involved cervical OA and one involved hand OA. …”
Get full text

Incidence and prevalence of traumatic and non-traumatic wounds and burns and access to wound care in Sierra Leone; data from a nationwide household survey (PRESSCO) 2020 by Jonathan H. Vas Nunes, Alex J. van Duinen, Daniel Boateng, Amidu J. Tommy, Osman Sankoh, Martin P. Grobusch, Håkon A. Bolkan

“…Methods: Between October 2019 and March 2020, a nationwide cross-sectional household survey was performed. The survey was based on Surgeons OverSeas Assessment of Surgical Need (SOSAS). …”
Get full text

Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells by Tim Heemskerk, Celebrity Groenendijk, Marta Rovituso, Ernst van der Wal, Wouter van Burik, Konstantinos Chatzipapas, Danny Lathouwers, Roland Kanaar, Jeremy M.C. Brown, Jeroen Essers

“…Materials and methods: Proton irradiations are performed at the HollandPTC R&D proton beamline, using a double passively scattered setup. …”
Get full text

Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Materials and methods: In this study, we employed in silico methods to assess the inhibitory activity of natural products from traditional Chinese medicine (TCM) against four EBOV proteins that are crucial for viral replication and assembly: VP40, VP35, VP30, and VP24. We performed molecular docking of TCM compounds with the EBOV proteins and screened them based on their docking scores, binding free energies, and pharmacokinetic properties. …”
Get full text

The Human Milk-derived Peptide Drives Rapid Regulation of Macrophage Inflammation Responses in the Neonatal IntestineSummary by Fuqiang Yuan, Xu Han, Masha Huang, Yinglin Su, Yiting Zhang, Mengyuan Hu, Xiang Yu, Weilai Jin, Yun Li, Le Zhang

“…Methods: A comprehensive screening of peptides within human milk EVs was performed, leading to the identification of a beta-casein-derived peptide (CASB135-150). …”
Get full text

Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study by Atsushi Nakajima, Yasushi Honda, Kento Imajo, Masato Yoneda, Yuji Ogawa, Takaomi Kessoku, Takashi Kobayashi, Anna Ozaki, Asako Nogami, Satoru Saito, Michihiro Iwaki, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Noritoshi Kobayashi

“…Blood tests and MRI will be performed 16 weeks after commencement of treatment. …”
Get full text

Out-of-Pocket Expenditure (OOPE) on Selected Surgeries in the Obstetrics and Gynaecology Department incurred by Ayushman Bharat Pradhan Mantri Jan Arogya  Yojana (AB-PMJAY), Privat... by Dr. Kumar Sumit, Reena Verma, Prajwal Salins, Helmut Brand, Siddhartha Sankar Acharya, Sagarika Kamath, rajesh kamath, Dr. Vidya Prabhu

“…These were the top five most performed obstetrics and gynecology surgeries in the tertiary care teaching hospital between January 2023 and July 2023. …”
Get full text

Arthralgia and Extraintestinal Manifestations in Crohn’s Disease Elevate the Risk of IBD-Related Arthritis over Sacroiliitis by Ivan Giovannini, Nicola Cabas, Marco Marino, Annarita Tullio, Ilaria Tinazzi, Angela Variola, Carmelo Cicciò, Fabro Cinzia, Berretti Debora, Chiara Zuiani, Rossano Girometti, Luca Quartuccio, Alen Zabotti, Lorenzo Cereser

“…Methods Between December 2012 and May 2020, consecutive patients with CD who performed MRE were enrolled in the study. Patients with a previous diagnosis of IBD-related arthritis were excluded. …”
Get full text

Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer by Fangze Wei, Xiaotian Xu, Jing Wang, Shi Wen Mei, Fu Qiang Zhao, Fei Huang, Ti Xian Xiao, Guo Jing Wang, Baojun Wei, Shengkai Huang, Wei Cui

“…The prediction model for CRC performed well in the training and validation cohorts (KM plot p < 0.001). …”
Get full text

Caloric labels do not influence taste pleasantness and neural responses to erythritol and sucrose by Aleksandra Budzinska, Laura Byl, Fabienne Teysseire, Emilie Flad, Patrick Dupont, Bettina Wölnerhanssen, Anne Christin Meyer-Gerspach, Lukas Van Oudenhove, Nathalie Weltens

“…., sucrose). Methods: We performed a within-subject, single-blind, counterbalanced fMRI study in 30 healthy males (mean ± SD: age 23 ± 0.6 years, BMI 22.5 ± 0.3 kg/m²). …”
Get full text