In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology by Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti

“…Molecular docking analysis was performed to assess the interaction of the selected proteins. …”
Get full text

Budget Impact of Rivaroxaban for the Prevention of Thromboembolic Events after Hip or Knee Replacement in Spain by Xavier Granero Xiberta, Antonio Murcia, José Ricardo Troncoso Durán, Claudio Gómez Zubeldia, Aleix Llorac Moix, Ruth Graefenhain De Codes, Maria Giovana Ferrario, Luis Lizán

“…In Spain, pharmacological prophylaxis is performed with low-molecular-weight heparin, enoxaparin being the most commonly used. …”
Get full text

Effectiveness of Gastric Cancer Endoscopic Screening in Intermediate-Risk Countries: Protocol for a Systematic Review and Meta-Analysis by Maria Beatriz Mourato, Nuno Pratas, Andreia Branco Pereira, Filipa Taré, Raphael Chança, Inês Fronteira, Rui Dinis, Miguel Areia

“…The data collected will be cataloged in 2 categories: efficacy or effectiveness data and economic data, and separate meta-analyses will be performed for each category if appropriate. …”
Get full text

In vivo and in silico study of europinidin against streptozotocin-isoproterenol-induced myocardial damage via alteration of hs-CRP/CPK-MB/Caspase-3/Bcl-2 pathways by Khalid Saad Alharbi, Muhammad Afzal, Fahad A. Al-Abbasi, Ehssan Moglad, Salwa D. Al-Qahtani, Naif A. R. Almalki, Faisal Imam, Nadeem Sayyed, Imran Kazmi

“…In addition, molecular docking (AUTODOCK Tools 1.5.6.) and dynamics were performed. Europinidin (10 and 20 mg/day) reduced blood glucose, HbA1c, hs-CRP, and CPK-MB. …”
Get full text

Prevalence of sexually transmitted infections and associated factors among male prisoners in Great Tehran Prison by active case finding by Behnam Farhoudi, Elnaz Shahmohamadi, Seyedahmad Seyedalinaghi, SeyedAlireza Nadji, Fatemeh Pahlaviani, Mehrzad Tashakorian

“…Therefore, recognizing and reducing risky behaviors among prisoners may have remarkable effects in this regard. This study was performed to evaluate the prevalence and risk factors of STIs among incarcerated men through clinical examination and molecular tests, and to recommend possible and proper solutions for controlling STIs in prisons. …”
Get full text

Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

“…Filipin III cholesterol staining was employed to visualize membrane and intracellular cholesterol in the different cell models, and fluorescence intensity was assessed using confocal microscopy. Additionally, we performed immunoblotting to quantify the expression of DHCR24, total calmodulin-dependent protein kinase 2 (CAMK-2), p-CAMK2 (T286), caveolin-1, total synapsin-1, phosphorylated synapsin-1 (p-synapsin-1; S605), and synaptophysin in each experimental group. …”
Get full text

Clinical burden of obstructive hypertrophic cardiomyopathy in France by Philippe Charron, Carla Zema, François-Emery Cotté, Eléonore Herquelot, Taryn Krause, Florent Daydé, Jean-Noël Trochu

“…Therefore, this study 23 aimed to describe the clinical burden of patients hospitalized with obstructive HCM from a 24 nationwide study in France.MethodsThis retrospective, longitudinal, observational study was performed using data from the French National Health Data System. …”
Get full text

Elite Alleles of EPE1 Identified via Genome-wide Association Studies Increase Panicle Elongation Length in Rice by Hao Sun, Qiqi Yao, Mei Hai, Tianhu Li, Jinghan Sun, Zhengbo Liu, Yang Ang, Yingying Zhao, Yanan Zhang, Xianping Cheng, Tao Huang, Yinping Chang, Mingyu Du, Erbao Liu

“…Genome-wide association studies (GWAS) were performed on the PELs of 440 rice accessions in 2022 and 2023, considering 3.17 million single-nucleotide polymorphisms (SNPs) to detect the effects of different genes on PEL. …”
Get full text

Evaluasi Heuristik Website berbasis Framework Sirius dengan Pengaturan Prioritas menggunakan Teknik Moscow by Gita Indah Marthasari, Nur Hayatin

“…MoSCoW can categorize all of the requirements into 4 distinct classes based on priority. This paper was performed for extending the Sirius Framework for implementing the ranking system by using MoSCoW. …”
Get full text

Sistem Pendeteksi Banjir dan Badai Angin serta Monitoring Cuaca Berbasis Internet of Things by Ida Bagus Made Lingga Pradirta, I Nyoman Piarsa, I Putu Arya Dharmaadi

“…It is necessary to have technology that can provide early warning to minimize the impact, one of which is the Internet of Things which is a technology that allows humans to control and perform tasks automatically on an object that is connected via the internet. …”
Get full text

Predictors of failure of DISE-directed adenotonsillectomy in children with sleep disordered breathing by Noura Alsufyani, Andre Isaac, Manisha Witmans, Paul Major, Hamdy El-Hakim

“…Abstract Background Adenotonsillectomy (AT) is the most commonly performed procedure for sleep disordered breathing (SDB) in pediatrics. …”
Get full text

Evolution and effectiveness of bilateral and multilateral development assistance for health: a mixed-methods review of trends and strategic shifts (1990–2022) by Yan Luo, Ying Chen, Beibei Yuan, Ming Xu, Shuduo Zhou, Zhijie Zheng, Siwei Xie, Sijin Du, Yuxin Huang

“…A systematic literature search was performed across PubMed, Embase, Web of Science and the Cochrane databases, yielding 102 eligible studies. …”
Get full text

miR-129-5p Promotes Osteogenic Differentiation of BMSCs and Bone Regeneration via Repressing Dkk3 by Changming Zhao, Yulin Gu, Yan Wang, Qiaozhen Qin, Ting Wang, Meng Huang, Heyang Zhang, Yannv Qu, Jingwen Zhang, Zhangzhen Du, Xiao-Xia Jiang, Lulu Xu

“…The luciferase reporter gene assay was performed to confirm the binding between Dkk3 and miR-129-5p. …”
Get full text

The StbHLH47 transcription factor negatively regulates drought tolerance in potato (Solanum tuberosum L.) by Peijie Wang, Xiaojuan Wu, Nan Li, Hushuai Nie, Yu Ma, Juan Wu, Zhicheng Zhang, Yanhong Ma

“…Subcellular localization assays revealed that the gene StbHLH47 performs transcriptional functions in the nucleus, as evidenced by increased malondialdehyde (MDA) content and relative conductivity under drought stress. …”
Get full text

Learning Curve of Uniportal Compared With Biportal Endoscopic Techniques for the Treatment of Lumbar Disc Herniation by Yuquan Liu, Xiang Li, Haining Tan, Xinyi Hao, Bin Zhu, Yong Yang, Lingjia Yu

“…After gaining UBE experience, the UFE performed by S1BF showed significantly better outcomes in fluoroscopy usage times (p = 0.024), surgical complications (p = 0.036), last follow‐up VAS back pain (p = 0.003), and leg pain (p < 0.001) compared to S2FB. …”
Get full text

Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS) by Alessandra Trojani, Alessandro Beghini, Luca Emanuele Bossi, Marta Rachele Stefanucci, Cassandra Palumbo, Antonino Greco, Annamaria Frustaci, Barbara Di Camillo, Roberto Cairoli

“…Methods We investigated the mutation status of WM (n = 8), sWM (n = 7), and IgM MGUS (n = 5) patients, by performing high‐throughput targeted AmpliSeq NGS on 117 target genes. …”
Get full text

Impact of diagnosis-related group payment on medical expenditure and treatment efficiency on people with drug-resistant tuberculosis: a quasi-experimental study design by Yingbei Xiong, Yifan Yao, Yuehua Li, Shanquan Chen, Yunfei Li, Kunhe Lin, Li Xiang

“…These patients are all receiving standardized treatment specified by the NTP in designated tuberculosis hospitals. We performed the difference-in-differences (DID) model to investigate 6 primary outcomes. …”
Get full text

Genomic Diversity and Potential Transmission and Persistence of Salmonella in the Cambodian Vegetable Supply Chain by Abimel Salazar, Navin Sreng, Chanthol Peng, Yehzi Fu, Erin M. Nawrocki, Taejung Chung, Jessie Vipham, Edward G. Dudley, Jasna Kovac

“…In silico identification of serotypes and detection of antimicrobial resistance genes was performed using SISTR and ABRicate, respectively. Isolates’ relatedness was assessed based on high-quality single nucleotide polymorphisms (hqSNPs) identified within each serotype using the CFSAN SNP pipeline. …”
Get full text

Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes by Mengmeng Sang, Jia Ge, Juan Ge, Juan Ge, Gu Tang, Qiwen Wang, Jiarun Wu, Liming Mao, Liming Mao, Xiaoling Ding, Xiaorong Zhou

“…Furthermore, drug sensitivity and molecular docking analyses were performed to identify potential drug candidates capable of transforming cold tumors into hot tumors. …”
Get full text

Is the flipped classroom more effective than the traditional classroom in clinical medical education: a systematic review and meta-analysis by Xu-Ying Shi, Qing Yin, Qiu-Wen Wang, Bing-Rui Lu, Guo-Xiang Li, Shu-Hong Huang, Zhi-Gang Sun

“…Data extraction and subsequent meta-analysis were performed using Stata 17.0 software.ResultsA total of 12 studies were included in the analysis. …”
Get full text