Added Value of Liver MRI in Patients Eligible for Surgical Resection or Ablation of Colorectal Liver Metastases Based on CT: A Systematic Review and Meta-Analysis by Burak Görgec, MD, Inez M. Verpalen, MD, PhD, Jasper P. Sijberden, MD, Mohammad Abu Hilal, MD, PhD, Shandra Bipat, PhD, Cornelis Verhoef, MD, PhD, Rutger-Jan Swijnenburg, MD, PhD, Marc G. Besselink, MD, MSc, PhD, Jaap Stoker, MD, PhD

“…A systematic search was performed in the PubMed, Embase, and Cochrane Library databases through June 23, 2023. …”
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CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation by Peter Tobias Felixberger, Peter Tobias Felixberger, Geoffroy Andrieux, Andrea Maul-Pavicic, Andrea Maul-Pavicic, Sigune Goldacker, Sigune Goldacker, Ina Harder, Ina Harder, Sylvia Gutenberger, Sylvia Gutenberger, Jonathan J. M. Landry, Vladimir Benes, Till Fabian Jakob, Melanie Boerries, Melanie Boerries, Lars Nitschke, Reinhard Edmund Voll, Reinhard Edmund Voll, Klaus Warnatz, Klaus Warnatz, Baerbel Keller, Baerbel Keller

“…The glycosylation pattern of B cells in CVID patients has not been addressed to date.ObjectiveThe objective of this study was to examine the surface glycome of B cells in patients with CVID and associated immune dysregulation.MethodsWe performed surface lectin staining on B cells from peripheral blood and tonsils, both ex vivo and after in vitro stimulation. …”
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Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis by Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng

“…Meta-analysis and subgroup analysis were performed using Revman 5.4 software, while publication bias was evaluated through funnel plots and Egger’s test in STATA 15.0 software. …”
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From bench to bedside: elucidating VEGF(R) inhibitor-related heart failure in cancer treatment by Shengkun Peng, MinHong Cai, Hongyu Kuang, Anqi Lin, Qinghua Ma, Xiaoqin Dai, Peng Luo, Yijun Liu, Guo Zhang, Yifeng Bai

“…The phenotypic features and molecular mechanisms of VirHF were characterized using VEGF(R)i-treated mouse models through a combination of echocardiography, histopathological analysis, and transcriptome sequencing. Furthermore, we performed a retrospective analysis of cardiac function parameters in patients undergoing VEGF(R)i treatment at local hospitals. …”
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Transcriptomic responses of sponge holobionts to in situ, seasonal anoxia and hypoxia by Strehlow, Brian W., Schuster, Astrid, Francis, Warren R., Eckford-Soper, Lisa, Kraft, Beate, McAllen, Rob, Nielsen, Ronni, Mandrup, Susanne, Canfield, Donald E.

“…To understand their tolerance mechanisms, we performed differential gene expression analyses on the sponges, their mitochondria and their microbial symbionts under in situ conditions of normoxia, hypoxia and anoxia. …”
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Application of three statistical approaches to explore effects of dietary intake of multiple persistent organic pollutants on ER-positive breast cancer risk in the French E3N cohor... by Pauline Frenoy, Ismaïl Ahmed, Chloé Marques, Xuan Ren, Gianluca Severi, Vittorio Perduca, Francesca Romana Mancini

“…In the first approach, hierarchical clustering was performed to identify clusters of correlated POPs. …”
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FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle by Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Yudie Zhang, Fan Wang, Fan Wang, Fan Wang, Fan Wang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Chongyang Zhang, Fan Yao, Fan Yao, Fan Yao, Fan Yao, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Yongping Zhang, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun

“…To investigate the mechanism of action of FGF21 in the treatment of glycolytic kidney, transcriptome sequencing of renal tissues and KEGG pathway enrichment analysis of differential genes were performed.ResultsThe study’s findings demonstrated that FGF21 intervention increased clotting time, decreased oxidative stress and inflammation, and avoided thrombosis in addition to considerably improving glomerular filtration damage. …”
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Balloon Valvuloplasty for Congenital Aortic Stenosis: Experience at a Tertiary Center in a Developing Country by Fatme A. Charafeddine, Haytham Bou Houssein, Nadine B. Kibbi, Issam M. El-Rassi, Anas M. Tabbakh, Mohammad S. Abutaqa, Ziad F. Bulbul, Nour K. Younis, Mariam T. Arabi, Fadi F. Bitar

“…Materials and Methods. We performed a retrospective single-center study involving consecutive eligible neonates and infants with congenital aortic stenosis admitted for percutaneous BAV between January 2005 and January 2016 to our tertiary center. …”
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Effects of Immune System-Related Medications on COVID-19 Outcome in a Cohort of Iranian Patients: Preliminary Report of a Data Mining Study by Ehsan Bitaraf, Seyyed Amir Yasin Ahmadi, Alireza Gandomi-Mohammadabadi, Zahra Noorani Mejareh, Bahare Abdollahi, Javad Balasi, Farzan Moodi, Nima Hemmati, Ali Kabir

“…A data mining study was performed on 6417 cases of COVID-19 covered by 17 educational hospitals of Iran University of Medical Sciences, Tehran. …”
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Updated Bayesian network meta-analysis on the efficacy and safety of PD−1 versus PD−L1 inhibitors in first−line treatment with chemotherapy for extensive−stage small-cell lung canc... by Ke Wang, Ke Wang, Chuangjie Zheng, Chuangjie Zheng, Xinrong Chen, Xinrong Chen, Penghui Lin, Mengge Lin, Cuizhen Chen, Linzhu Zhai

“…ObjectiveTo compare the efficacy and safety of programmed cell death 1 inhibitors plus chemotherapy (PD-1 + Chemo) and programmed cell death ligand 1 inhibitors plus chemotherapy (PD-L1 + Chemo) for the treatment of extensive-stage small-cell lung cancer (ES-SCLC).MethodsWe performed a meta-analysis of relevant data using R software, considering overall survival (OS), progression-free survival (PFS), and grade ≥ 3 treatment-related adverse events (TRAES).ResultsPD-1 + Chemo (OS: hazard ratio [HR] 0.71; PFS: HR 0.59) and PD-L1 + Chemo (OS: HR 0.72; PFS: HR 0.73) significantly prolonged survival and did not increase the incidence of grade ≥3 TRAEs compared with chemotherapy. …”
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Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder by Mengmeng Yang, Yuxuan Lu, Shufan Jin, Wanqiu Liu, Miaoshi Yao, Zhiwei Jiang, Yachun Shu

“…Subsequently, Western blot analysis was performed to examine the p38 MAPK signaling pathway. …”
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Candidate SNP markers of changes in the expression levels of the human <i>SCN9A</i> gene as a hub gene for pain generation, perception, response and anesthesia by P. A. Dotsenko, K. A. Zolotareva, R. A. Ivanov, I. V. Chadaeva, N. L. Podkolodnyy, V. A. Ivanisenko, P. S. Demenkov, S. A. Lashin, M. P. Ponomarenko

“…In this work, we for the first time performed a comprehensive bioinformatics analysis of 568 human genes that, according to the NCBI Gene database as on September 15, 2024, were associated with pain generation, perception and anesthesia. …”
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Adult HIV/AIDS patients are more likely to experience anxiety symptoms by Zakir Abdu, Wondwossen Belayneh, Aman Dule, Solomon Seyife Alemu, Lema Fikadu Wedajo, Mohammedamin Hajure, Gebremeskel Mulatu Tesfaye, Yadeta Alemayehu Workneh, Wubishet Gezimu, Mustefa Adem Hussen, Bilisumamulifna Tefera, Sadik Habib

“…The Beck Anxiety Inventory (BAI) scale, Fagerström Test for Nicotine Dependence (FTND), Severity of Dependence Scale (SDS), and the Alcohol Use Disorder Identification Test (AUDIT) were used to collect the data. Data analysis was performed using SPSS version 25. Bivariate and multivariable logistic regressions were employed to identify independently associated variables, and statistical significance was determined at a p-value &lt;0.05.ResultsOut of a total of 323 samples, 320 respondents completed all items, resulting in a response rate of 99.07%. …”
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Inhibition of platelet activation alleviates diabetes-associated cognitive dysfunction via attenuating blood-brain barrier injury by Fuxing Xu, Juan Hu, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao, Yansong Li, Yaomin Zhu

“…Since platelets play an important role in regulating endothelial cell barrier function and over 95 % of the circulating soluble CD40 ligand (sCD40L) is derived from activated platelets, we speculated that the release of CD40L from activated platelets induced by diabetes was the key mechanism that aggravated BBB injury and leaded to DACD. We performed inhibition of platelet activation on diabetic and non-diabetic mice, with or without cilostazol treatment, and then compared cognitive function, platelet activation, BBB structure and permeability. …”
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Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study by Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu

“…Methods “Blood +” high depth blood proteomics analysis was performed on plasma from female LUAD patients and female healthy controls, and combined with proteomics data from tumors and adjacent non‐tumor tissues of female LUAD patients to screen proteins uniformly expressed in plasma and tissues. pQTL‐SNPs were then screened through multiple databases and subjected to multilevel screening. …”
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Serological Diagnosis of <i>Brucella</i> Infection in Cetaceans by Rapid Serum Agglutination Test and Competitive ELISA with <i>Brucella abortus</i> and <i>Brucella ceti</i> as Ant... by Tiziana Di Febo, Gabriella Di Francesco, Carla Grattarola, Luigina Sonsini, Ludovica Di Renzo, Giuseppe Lucifora, Roberto Puleio, Cristina Esmeralda Di Francesco, Camilla Smoglica, Giovanni Di Guardo, Manuela Tittarelli

“…Results obtained from the two tests were compared in order to identify the most suitable antigen for the serological diagnosis of <i>Brucella</i> infection in cetaceans. The RBT performed with the “homologous” antigen showed the best results in comparison with the “heterologous” antigen: diagnostic sensitivity, specificity, and accuracy were 80.0%, 44.1%, and 46.9% for the “homologous” antigen and 80.0%, 17.0%, and 21.9% for the “heterologous” antigen. …”
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The operative cooperation and nursing in transradial intervention for cerebrovascular diseases (经桡动脉入路行脑血管介入治疗的手术配合与护理) by SHI Lijuan (施李娟), HU Yaqin (胡亚琴), MIAO Dan (苗丹), SONG Zongye (宋宗叶), WANG Xiaoyan (王晓燕), JIANG Wei (江薇)

“…Nurses should take good cooperation in performing catheter placement, surgical position placement, heparinization, microcatheter shaping and other nursing procedure. …”
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Anti-sperm Antibody Positivity in Men with Varicocele: A Systematic Review and Meta-Analysis by Marco Falcone, Kadir Bocu, Hakan Keskin, Jesus Fernando Solorzano Vazquez, Ravi Banthia, Tara Mahendran, Muslim Dogan Deger, Vinod Kv, Preto Mirko, Ahmed M. Harraz, Ramadan Saleh, Rupin Shah, Ashok Agarwal

“…A literature search was performed using the Scopus and PubMed databases following the Population Exposure Comparison Outcome, Study Design model. …”

Yorkshire Enhanced Stop Smoking (YESS) study: a protocol for a randomised controlled trial to evaluate the effect of adding a personalised smoking cessation intervention to a lung... by Richard D Neal, David Baldwin, Sarah Lewis, John Britton, Rachael L Murray, Qi Wu, Kate Brain, Samantha L Quaife, Matthew EJ Callister, Philip A J Crosbie, Harriet D Quinn-Scoggins, Grace M McCutchan, Alex Ashurst, Suzanne Rogerson, Rebecca Thorley

“…The Yorkshire Enhanced Stop Smoking study will measure the effectiveness of an SC service integrated within the Yorkshire Lung Screening Trial (YLST) and will test the efficacy of a personalised SC intervention, incorporating incidental findings detected on the low-dose CT scan performed as part of YLST.Methods and analysis Unless explicitly declined, all smokers enrolled in YLST will see an SC practitioner at baseline and receive SC support over 4 weeks comprising behavioural support, pharmacotherapy and/or a commercially available e-cigarette. …”
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Comparative study of robotic-assisted vs. laparoscopic surgery for colorectal cancer: a single-center experience by Wenpeng Wang, Jia Liu, Jiefu Wang, Li Li, Dalu Kong, Junfeng Wang

“…BackgroundColorectal cancer (CRC) surgeries are commonly performed using either robotic-assisted colorectal surgery (RACS) or laparoscopic colorectal surgery (LCS). …”
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