Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab by Settimio Rossi, Carlo Gesualdo, Ernesto Marano, Raffaele Perrotta, Maria Consiglia Trotta, Antonio Del Giudice, Francesca Simonelli

“…We identified two groups: group 1 (24 treatment-naïve eyes) that received a loading dose of 3 monthly intravitreal injections of Broluciziumab 6 mg (0.05 mL solution) + Q8w/Q12w regimen, and a Group 2 (20 non-naïve eyes) which performed 1 injection + ProReNata (PRN) scheme. Monthly, all participants underwent comprehensive ophthalmological evaluation until 12 months follow-up.ResultsWe observed a significant improvement in best corrected visual acuity (39 ± 15 L vs. 30 ± 17 L; p < 0.01) and central retinal thickness (265 ± 89 μ vs. 360 ± 129 μ; p < 0.0001) at the end of follow-up without any differences between treatment-naïve and non-naïve patients. …”
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Isotope analysis of birds’ eye lens provides early-life information by Emi A. Hasegawa, Jun Matsubayashi, Ichiro Tayasu, Tatsuhiko Goto, Haruka Inoue, Axel G. Rossberg, Chikage Yoshimizu, Masaru Hasegawa, Takumi Akasaka

“…In this study, we broadened its applicability by developing a novel approach and verifying its usability for the reconstruction of early-life environments. We performed a feeding experiment using Japanese quail (Coturnix japonica), in which we administered two diets: one composed mainly of C3 plants (low δ13C and high δ15N) and the other of C4 plants (high δ13C and low δ15N). …”
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Modulating the anti-inflammatory and barrier protective effects on intestinal epithelial cells utilizing an aqueous Aspalathus linearis extract in vitro by Shana De Bruyn-Orr, Stefan Abel, Mariam Rado, Mariska Lilly

“…Methods: Aqueous extracts of unfermented and fermented rooibos were prepared, and chemical and antioxidant analysis were performed of each extract. Intestinal porcine epithelial cells (IPEC-J2) were pre-treated with either unfermented or fermented aqueous rooibos extracts (0.1 and 0.05 mg/ml) then exposed to 10 µg/ml of Escherichia coli lipopolysaccharide (LPS). …”
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Smokeless tobacco: knowledge, attitudes and usage in Pakistan by Hammad Atif Irshad, Sajjan Raja, Hamzah Jehanzeb, Wamiq Ali Shaikh, Umair Saleem, Shahzil Abdur Rehman Malik, Akmal Shahzad, Mamoon Shaikh, Nousheen Iqbal, Javaid Ahmed Khan

“…Participants’ responses were described using descriptive statistics, and SPSS version 26 was used to perform linear and logistic regression. A p-value of less than 0.05 was considered statistically significant. …”
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Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature by Eric Wierda, Cathelijne Dickhoff, Martin Louis Handoko, Liane Oosterom, Wouter Emmanuel Kok, Y. deRover, B.A.J.M. deMol, Loek vanHeerebeek, Jutta Maria Schroeder‐Tanka

“…Methods and results In this systematic review, the available evidence for the efficacy and safety of outpatient treatment with intravenous or subcutaneous diuretics of patients with worsening HF is analysed. A search was performed in the electronic databases MEDLINE and EMBASE. …”
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Seasonal Dynamics of Sand Flies (Diptera, Pshycodidae), Vectors of Cutaneous Leishmaniasis, in the City of Fez, Northern Morocco by Najoua Darkaoui, Abdellatif Janati Idrissi, Fatima Zahra Talbi, Youness El Fattouhi, Hajar El Omari, Mohamed Najy, Abdelkarim Taam, Abdellatif Alami, Fouad El-Akhal, Abdelhakim El Ouali Lalami

“…The monthly impact of Fez sand fly density has been studied using all multivariate statistical analyses, including multiple factor correspondence analysis (MCA), which were performed using XLSTAT and the version of SPSS 20.0 test. …”
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Optimizing Microneutralization and IFN-γ ELISPOT Assays to Evaluate Mpox Immunity by Yinyi Yu, Krystal Meza, Chase Colbert, Daniel F. Hoft, Anna Jaunarajs, Azra Blazevic, Sharon E. Frey, Getahun Abate

“…The focused reduction neutralization test (FRNT) was performed using the mpox-specific A29 monoclonal antibody. …”
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Improving ROP management: insights from a comparative analysis of screening and treatment modalities in a tertiary hospital, Pakistan by Muhammad Moin, Aisha Azam, Lubna Siddiq Mian, Ashal Pal, Rutaab Kareem, Noor Us Sehar

“…Statistical analysis was performed using SPSS version 27.0, significance was set at p < 0.05. …”
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COVID-19 Pandemic Experiences in Pediatric Intensive Care Unit: An Iranian Referral Hospital-Based Study by Masoud Mohammadpour, Seyed Abbas Hassani, Meisam Sharifzadeh, Leila Tahernia, Setareh Mamishi, Bahareh Yaghmaie, Zeinab Najafi, Farzaneh Beirami, Mehrnoush Afsharipour, Maryam Minuyeefar, Mina Dolatzadeh, Neda Pak, Anahita Majmaa, Zahra Zamani, Shima Mahmoudi

“…Materials and Methods. This study was performed between February 2020 and May 2020 in the COVID PICU of the Children’s Medical Center Hospital in Tehran, Iran. …”
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Utilizing Partial Non-Orthogonal Multiple Access (P-NOMA) in Drone-Enabled Internet-of-Things Wireless Networks by Hazim Shakhatreh, Sharief Abdel-Razeq, Ala Al-Fuqaha

“…However, an IoT device that receives low transmit power from that drone must perform the SIC process on a non-orthogonal channel portion to recover its signal. …”
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Pulmonary and systemic immune alterations in rats exposed to airborne lunar dust by Brian E. Crucian, Heather Quiriarte, Chiu-wing Lam, Mayra Nelman, Audrie A. Colorado, Douglass M. Diak, John T. James

“…Mitogen-stimulated cytokine production profiles, as a measure of cellular function, were performed on whole blood samples only.ResultsUntreated lavage fluid was comprised primarily of pulmonary macrophages. …”
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Additive interaction of conjoint tobacco smoking and heavy drinking on hypertension prevalence in rural Uganda: a community-based cross-sectional study by Paineto Masengere, Nynke Halbesma, Rawlance Ndejjo, Bonny Enock Balugaba, Rhoda K. Wanyenze, Fred Nuwaha, Hilde Bastiaens, Geofrey Musinguzi

“…To determine effect modification due to combined tobacco smoking and heavy drinking, the relative excess risk due to interaction (RERI) was computed. All analyses were performed via R programming software version 4.2.3. …”
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Community structure and diversity of myxobacteria in soils from Inner Mongolia, China by Zhihua Wu, Zhihua Wu, Songyuan Li, Xuehan Wang, Xuehan Wang, Huirong Liu

“…The quantitative assessment of the abundance of myxobacteria in the soil sample was performed by quantitative real-time PCR. The composition of myxobacteria in the soil was determined by 16S rRNA high-throughput sequencing technology to analyze the differences in the community structure of myxobacteria among different groups, explore the relationship between the diversity of myxobacteria resources and the distribution and physical and chemical properties of the soil, and predict and analyze its community function. …”
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Zwitterion Effect of Cow Brain Protein towards Efficiency Improvement of Dye-Sensitized Solar Cell (DSSC) by Denny Widhiyanuriyawan, Prihanto Trihutomo, Sudjito Soeparman, Lilis Yuliati

“…Tests carried out on DSSC that have been performed were X-Ray Diffractometer (XRD) testing to determine the crystal structure formed, Fourier Transform Infrared Spectroscopy (FTIR) testing to determine the functional groups formed on DSSC, Scanning Electron Microscopy (SEM) testing to determine the surface morphological characteristics of the DSSC layer, and testing the efficiency using AM 1.5 G solar simulator (1000 W/m2) to determine the efficiency changes that occur in DSSC. …”
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Which combination of medical expulsive therapy is more effective for treatment of distal ureteral stone in adults? A systematic review and network meta-analysis by Maryam Taheri, Nasrin Borumandnia, Hamidreza Abdi, Amir H Kashi, Setareh Nourani, Sogand Sheikholeslami, Yasamin Maleki Gilvaei, Pardis Ziaeefar, Abbas Basiri

“…We excluded articles that looked at MET for upper ureteral stone passage or after shock wave lithotripsy (SWL). NMA was performed to compare the effect of combination MET on stone expulsion rate (SER), stone expulsion time (SET), and need for analgesia. …”
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Modelación numérica del concreto simple con elementos finitos mediante la teoría de la plasticidad y la función de fluencia de Hu y Schnobrich Numerical modeling of the simple conc... by Luis Rodríguez, Dorian Linero

“…The constitutive model presented in this paper was implemented in the nonlinear analysis finite element program with open source HYPLAS (de Souza Neto et al. 2008) and the post-process was performed using GiD (CIMNE 2008). Finally we present the comparison of the structural response of panels subjected to forces contained in its plane tested experimentally by Kupfer and others (1969), against the numerical simulation using the proposed model. …”
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MiR-155-Mediated Deregulation of GPER1 Plays an Important Role in the Gender Differences Related to Inflammatory Bowel Disease by Xiaojuan Shao, Jintao Li, Fumin Xu, Dongfeng Chen, Kaijun Liu

“…From July 2018 to July 2019, in the Department of Gastroenterology at Daping Hospital, Army Military Medical University, a total of 50 patients with IBD were included in this study, and 24 healthy examinees were randomly selected as the control group. Colonoscopies were performed, and clinical characteristics and blood samples were collected from all of the subjects. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Finally, immunofluorescence staining for CD8, CD45, and CXCR4 was performed on human GC tissue samples. Results A total of 1,298 GC patients were included in this comprehensive analysis. …”
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ApWD40a, a Member of the WD40-Repeat Protein Family, Is Crucial for Fungal Development, Toxin Synthesis, and Pathogenicity in the Ginseng Alternaria Leaf Blight Fungus <i>Alternari... by Jinling Lan, Shengjie Mei, Yingxue Du, Meili Chi, Jiayi Yang, Shuliu Guo, Mingliang Chu, Ronglin He, Jie Gao

“…Pathogenicity assays performed on detached ginseng leaves and roots revealed that the disruption of <i>ApWD40a</i> significantly decreased the fungal virulence through attenuating melanin and mycotoxin production by <i>A. panax</i>. …”
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Age-related changes in DNA methylation in a sample of elderly Brazilians by Hayley Welsh, Caio M. P. F. Batalha, Weili Li, Nadja C. Souza-Pinto, Yeda A. O. Duarte, Michel S. Naslavsky, Esteban J. Parra

“…Gene ontology (GO) pathway enrichment analyses were performed to explore the functional significance of identified DMPs and DMRs. …”
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